Emma van der Westhuizen
Affiliations: | 2008-2013 | Biochemistry and Molecular Medicine | Université de Montréal, Montréal, Canada |
| 2014- | Monash University, Caulfield East, Victoria, Australia |
Website:
https://research.monash.edu/en/persons/emma-van-der-westhuizenGoogle:
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Parents
Sign in to add mentor| Roger Summers | grad student | 2004-2008 | Monash University |
| Michel Bouvier | post-doc | 2008-2013 | Université de Montréal |
| Arthur Christopoulos | post-doc | 2013-2023 | Monash University, Parkville, Australia |
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Publications
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| Jörg M, van der Westhuizen ET, Lu Y, et al. (2023) Design, synthesis and evaluation of novel 2-phenyl-3-(1H-pyrazol-4-yl)pyridine positive allosteric modulators for the M mAChR. European Journal of Medicinal Chemistry. 258: 115588 |
| Vuckovic Z, Wang J, Pham V, et al. (2023) Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics. Elife. 12 |
| Nguyen HTM, van der Westhuizen ET, Langmead CJ, et al. (2022) Opportunities and challenges for the development of M1 muscarinic receptor positive allosteric modulators in the treatment for neurocognitive deficits. British Journal of Pharmacology |
| McDonald JK, van der Westhuizen ET, Pham V, et al. (2022) Biased Profile of Xanomeline at the Recombinant Human M Muscarinic Acetylcholine Receptor. Acs Chemical Neuroscience |
| Burger WAC, Gentry PR, Berizzi AE, et al. (2021) Identification of a Novel Allosteric Site at the M Muscarinic Acetylcholine Receptor. Acs Chemical Neuroscience |
| van der Westhuizen ET, Choy KHC, Valant C, et al. (2020) Fine Tuning Muscarinic Acetylcholine Receptor Signaling Through Allostery and Bias. Frontiers in Pharmacology. 11: 606656 |
| Khajehali E, Bradley S, van der Westhuizen ET, et al. (2020) Restoring Agonist Function at a Chemogenetically Modified M Muscarinic Acetylcholine Receptor. Acs Chemical Neuroscience |
| Scammells PJ, Jörg M, Khajehali E, et al. (2020) Development of Novel 4-Arylpyridin-2-one and 6-Arylpyrimidin-4-one Positive Allosteric Modulators of the M1 Muscarinic Acetylcholine Receptor. Chemmedchem |
| Benredjem B, Gallion J, Pelletier D, et al. (2020) Author Correction: Exploring use of unsupervised clustering to associate signaling profiles of GPCR ligands to clinical response. Nature Communications. 11: 1929 |
| Vuckovic Z, Gentry PR, Berizzi AE, et al. (2019) Crystal structure of the M muscarinic acetylcholine receptor. Proceedings of the National Academy of Sciences of the United States of America |