Karen S. Mark

Affiliations: 
South College - Knoxville 
Area:
Neuropharmacology; neurovascular systems; inflammation
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Parents

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Donald Wayne Miller grad student 1994-1999 University Nebraska - Medical Center (UNMC)
 (Cytokines (TNF-a) effects on disrupting the blood-brain barrier)
Thomas P. Davis post-doc 1999-2003 University of Arizona College of Medicine
 (NRSA/ NIH funded fellowship; Hypoxia/ reoxygenation on neurovasculature and related signaling pathways)
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Publications

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Zhang S, Mark KS. (2012) α1-Acid glycoprotein induced effects in rat brain microvessel endothelial cells. Microvascular Research. 84: 161-8
Witt KA, Mark KS, Sandoval KE, et al. (2008) Reoxygenation stress on blood-brain barrier paracellular permeability and edema in the rat. Microvascular Research. 75: 91-6
Huber JD, Campos CR, Mark KS, et al. (2006) Alterations in blood-brain barrier ICAM-1 expression and brain microglial activation after lambda-carrageenan-induced inflammatory pain. American Journal of Physiology. Heart and Circulatory Physiology. 290: H732-40
Witt KA, Mark KS, Huber J, et al. (2005) Hypoxia-inducible factor and nuclear factor kappa-B activation in blood-brain barrier endothelium under hypoxic/reoxygenation stress. Journal of Neurochemistry. 92: 203-14
Brown RC, Mark KS, Egleton RD, et al. (2004) Protection against hypoxia-induced blood-brain barrier disruption: changes in intracellular calcium. American Journal of Physiology. Cell Physiology. 286: C1045-52
Mark KS, Burroughs AR, Brown RC, et al. (2004) Nitric oxide mediates hypoxia-induced changes in paracellular permeability of cerebral microvasculature. American Journal of Physiology. Heart and Circulatory Physiology. 286: H174-80
Witt KA, Mark KS, Hom S, et al. (2003) Effects of hypoxia-reoxygenation on rat blood-brain barrier permeability and tight junctional protein expression. American Journal of Physiology. Heart and Circulatory Physiology. 285: H2820-31
Brown RC, Mark KS, Egleton RD, et al. (2003) Protection against hypoxia-induced increase in blood-brain barrier permeability: role of tight junction proteins and NFkappaB. Journal of Cell Science. 116: 693-700
Abbruscato TJ, Lopez SP, Mark KS, et al. (2002) Nicotine and cotinine modulate cerebral microvascular permeability and protein expression of ZO-1 through nicotinic acetylcholine receptors expressed on brain endothelial cells. Journal of Pharmaceutical Sciences. 91: 2525-38
Huber JD, Hau VS, Mark KS, et al. (2002) Viability of microvascular endothelial cells to direct exposure of formalin, lambda-carrageenan, and complete Freund's adjuvant. European Journal of Pharmacology. 450: 297-304
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