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Todd D. McIntyre, Ph.D.

Affiliations: 
1990-2018 Global Regulatory Affairs Biopharmaceutical industry 
Area:
Neuroscience, neuroimmunology, neurology, neurogenetics, psychiatry, alcohol genetics, anxiety, anesthetics, pain
Google:
"Todd McIntyre"
Bio:

Obtained my doctorate in neuroscience from CU-Boulder (1986) under the mentorship of Dr. Herb Alpern (U.C. Irvine, 1968), and came to NIH under the mentorship of Dr. Phil Skolnick (George Washington University, 1973), the co-discover of the central benzodiazepine receptor. We studied the pharmacogenetics of ethanol sensitivity showing significant mediation of ethanol response by the GABA-BZ receptor. After joining the pharmaceutical industry, was on teams that developed and obtained global approvals for Risperdal (Bipolar Disorder), Consta Depot (Schizophrenia), Invega (Schizophrenia), Razadyne (Alzheimer's), Effexor (Major Depressive Disorder & Panic Disorder), Pristiq (MDD), and was CNS-RA Leader for the Alzheimer's MAB - bapineuzumab. As a consultant guided teams obtaining FDA approval for Firazyr (hereditary angioedema), Ferriprox (iron chelation), Latuda (schizophrenia) and Xifaxan (C. Difficile induced hepatic encephalopathy).

Mean distance: 15.87 (cluster 19)
 
SNBCP

Parents

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Herbert P. Alpern grad student 1980-1986 CU Boulder
Phil Skolnick post-doc 1986-1990 NIDDK, NIH

Collaborators

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Duane G. McClearn collaborator 1979-1984 CU Boulder
Steven F. Maier collaborator 1974-1986 CU Boulder
Robert C. Drugan collaborator 1980-1986 CU Boulder
Eva Fifkova collaborator 1980-1986 CU Boulder
Anthony S. Basile collaborator 1986-1990 NIH (NIDDK)
Ramon Trullas collaborator 1986-1990 NIDDK, NIH
John M. Petitto collaborator 1988-1990 NIH (NIDDK)
Ian A. Paul collaborator 1989-1990 NIH (NIDDK)
Yoshitatsu Sei collaborator 1988-1991 NIDDK, NIH
Esther Fride collaborator 1988-1993 NIH (NIDDK)
 (Dr. Fride was a bright, hard-working and accomplished scientist who left us far too soon.)
Martin Brecher, MD, DMSc collaborator 1996-2002 Clinical Research in Psychiatry & Neurology, Janssen Research Foundation
 (Graduated from State University of New York)
Jack A. Grebb collaborator 1993-2003 Janssen Research Foundation
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Publications

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McIntyre TD, Pappas M, DiBiasi JJ. (2013) How FDA Advisory Committee Members Prepare and What Influences Them. Therapeutic Innovation & Regulatory Science. 47: 32-40
Fride E, McIntyre T, Skolnick P, et al. (1993) Immunocompetence in the long sleep and short sleep mouse lines: baseline versus primed responses. Brain, Behavior, and Immunity. 7: 231-42
Sei Y, McIntyre T, Skolnick P, et al. (1992) Ethanol inhibits mitogen-induced calcium mobilization in mouse splenocytes. Life Sciences. 50: 419-26
Sei Y, McIntyre T, Fride E, et al. (1991) Inhibition of calcium mobilization is an early event in opiate-induced immunosuppression. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 5: 2194-9
Sei Y, McIntyre T, Skolnick P, et al. (1991) Stress modulates calcium mobilization in immune cells. Life Sciences. 49: 671-6
McIntyre T, Skolnick P. (1991) t-[35S]butylbicyclophosphorothionate binding under equilibrium and nonequilibrium conditions: differential effects of barbiturates and gamma-aminobutyric acid in the long-sleep and short-sleep selected mouse lines. Journal of Neurochemistry. 56: 287-93
Sei Y, Yoshimoto K, McIntyre T, et al. (1991) Morphine-induced thymic hypoplasia is glucocorticoid-dependent. Journal of Immunology (Baltimore, Md. : 1950). 146: 194-8
Petitto JM, McIntyre TD, McRae BL, et al. (1990) Differential immune responsiveness in mouse lines selectively bred for high and low sensitivity to ethanol. Brain, Behavior, and Immunity. 4: 39-49
Sei Y, McIntyre TD, Fride E, et al. (1990) Opiate-induced inhibition of calcium flux in immune cells. Nida Research Monograph. 105: 524-9
McIntyre TD, Alpern HP. (1989) Patterns of convulsive susceptibility in the long-sleep and short-sleep selected mouse lines. Brain Research Bulletin. 22: 859-65
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