Megan F Duffy

National Institutes Health (NIH) 
Parkinson’s disease, aging, genetics, iPSCs, brain organoids
"Megan Duffy"
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Patterson JR, Kochmanski J, Stoll AC, et al. (2024) Transcriptomic profiling of early synucleinopathy in rats induced with preformed fibrils. Npj Parkinson's Disease. 10: 7
Snyder A, Ryan VH, Hawrot J, et al. (2023) An P93S variant dysregulates TDP-43 and causes corticobasal syndrome. Research Square
Duffy MF, Ding J, Langston RG, et al. (2023) Divergent patterns of healthy aging across human brain regions at single-cell resolution reveal links to neurodegenerative disease. Biorxiv : the Preprint Server For Biology
Stoll AC, Kemp CJ, Patterson JR, et al. (2023) Microglial depletion does not impact alpha-synuclein aggregation or nigrostriatal degeneration in the rat preformed fibril model. Research Square
Patterson JR, Hirst WD, Howe JW, et al. (2022) Beta2-adrenoreceptor agonist clenbuterol produces transient decreases in alpha-synuclein mRNA but no long-term reduction in protein. Npj Parkinson's Disease. 8: 61
Howe JW, Sortwell CE, Duffy MF, et al. (2021) Preformed fibrils generated from mouse alpha-synuclein produce more inclusion pathology in rats than fibrils generated from rat alpha-synuclein. Parkinsonism & Related Disorders. 89: 41-47
Landeck N, Conti Mazza M, Duffy M, et al. (2021) Stereotaxic Intracranial Delivery of Chemicals, Proteins or Viral Vectors to Study Parkinson's Disease. Journal of Visualized Experiments : Jove
Mercado NM, Stancati JA, Sortwell CE, et al. (2020) The BDNF Val66Met polymorphism (rs6265) enhances dopamine neuron graft efficacy and side-effect liability in rs6265 knock-in rats. Neurobiology of Disease. 105175
Filippini A, Mutti V, Faustini G, et al. (2020) Extracellular clusterin limits the uptake of α-synuclein fibrils by murine and human astrocytes. Glia
Patterson JR, Duffy MF, Kemp CJ, et al. (2019) Time course and magnitude of alpha-synuclein inclusion formation and nigrostriatal degeneration in the rat model of synucleinopathy triggered by intrastriatal α-synuclein preformed fibrils. Neurobiology of Disease. 104525
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