Susanne Wegmann

Affiliations: 
German Center for Neurodegenerative Disease (DZNE) 
Area:
Tau protein, Alzheimer's disease, FTD, biophysics
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"Susanne Wegmann"
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Publications

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Diez L, Kapinos LE, Hochmair J, et al. (2022) Phosphorylation but Not Oligomerization Drives the Accumulation of Tau with Nucleoporin Nup98. International Journal of Molecular Sciences. 23
Hochmair J, Exner C, Franck M, et al. (2022) Molecular crowding and RNA synergize to promote phase separation, microtubule interaction, and seeding of Tau condensates. The Embo Journal. e108882
Wegmann S, Biernat J, Mandelkow E. (2021) A current view on Tau protein phosphorylation in Alzheimer's disease. Current Opinion in Neurobiology. 69: 131-138
Caballero B, Bourdenx M, Luengo E, et al. (2021) Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice. Nature Communications. 12: 2238
Wegmann S, DeVos SL, Zeitler B, et al. (2021) Persistent repression of tau in the brain using engineered zinc finger protein transcription factors. Science Advances. 7
Ash PEA, Lei S, Shattuck J, et al. (2021) TIA1 potentiates tau phase separation and promotes generation of toxic oligomeric tau. Proceedings of the National Academy of Sciences of the United States of America. 118
Amaral AC, Perez-Nievas BG, Siao Tick Chong M, et al. (2021) Isoform-selective decrease of glycogen synthase kinase-3-beta (GSK-3β) reduces synaptic tau phosphorylation, transcellular spreading, and aggregation. Iscience. 24: 102058
Diez L, Wegmann S. (2020) Nuclear Transport Deficits in Tau-Related Neurodegenerative Diseases. Frontiers in Neurology. 11: 1056
Rauch JN, Luna G, Guzman E, et al. (2020) LRP1 is a master regulator of tau uptake and spread. Nature. 580: 381-385
Wegmann S. (2019) Liquid-Liquid Phase Separation of Tau Protein in Neurobiology and Pathology. Advances in Experimental Medicine and Biology. 1184: 341-357
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