Brenton Paolella
Affiliations: | Dana-Farber Cancer Institute, Boston, MA, United States |
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| Krill-Burger JM, Dempster JM, Borah AA, et al. (2023) Partial gene suppression improves identification of cancer vulnerabilities when CRISPR-Cas9 knockout is pan-lethal. Genome Biology. 24: 192 |
| Bondeson DP, Mullin-Bernstein Z, Oliver S, et al. (2022) Systematic profiling of conditional degron tag technologies for target validation studies. Nature Communications. 13: 5495 |
| Bondeson DP, Paolella BR, Asfaw A, et al. (2022) Phosphate dysregulation via the XPR1-KIDINS220 protein complex is a therapeutic vulnerability in ovarian cancer. Nature Cancer |
| Ito T, Young MJ, Li R, et al. (2021) Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers. Nature Genetics |
| Malone CF, Dharia NV, Kugener G, et al. (2021) Selective modulation of a pan-essential protein as a therapeutic strategy in cancer. Cancer Discovery |
| Dharia NV, Kugener G, Guenther LM, et al. (2021) A first-generation pediatric cancer dependency map. Nature Genetics |
| Neggers JE, Paolella BR, Asfaw A, et al. (2020) Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q. Cell Reports. 33: 108493 |
| McFarland JM, Paolella BR, Warren A, et al. (2020) Multiplexed single-cell transcriptional response profiling to define cancer vulnerabilities and therapeutic mechanism of action. Nature Communications. 11: 4296 |
| Nichols CA, Gibson WJ, Brown MS, et al. (2020) Loss of heterozygosity of essential genes represents a widespread class of potential cancer vulnerabilities. Nature Communications. 11: 2517 |
| Lu Z, Paolella BR, Truex NL, et al. (2020) Targeting cancer gene dependencies with anthrax-mediated delivery of peptide nucleic acids. Acs Chemical Biology |