Thaddeus J Kunkel

Lysosomal Disease, Myelination

Hongbing Wang	research assistant	2015-2017	Michigan State
(Undergraduate Research Training. Studied mouse social hierarchy, also worked on methods to study memory consolidation)
Andrew P. Lieberman	grad student		University of Michigan
(Study myelination defects in Niemann-Pick C)

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Yuan T, Kumar S, Skinner M, et al. (2023) variants from patients with mitochondrial disease are associated with reduced SIRT5 stability and activity, but not with neuropathology. Biorxiv : the Preprint Server For Biology
Kunkel TJ, Townsend A, Sullivan KA, et al. (2023) The cholesterol transporter NPC1 is essential for epigenetic regulation and maturation of oligodendrocyte lineage cells. Nature Communications. 14: 3964
Ilnytska O, Lai K, Gorshkov K, et al. (2021) Enrichment of NPC1-deficient cells with the lipid LBPA stimulates autophagy, improves lysosomal function, and reduces cholesterol storage. The Journal of Biological Chemistry. 100813
Schultz ML, Fawaz MV, Azaria RD, et al. (2019) Synthetic high-density lipoprotein nanoparticles for the treatment of Niemann-Pick diseases. Bmc Medicine. 17: 200
Kunkel T, Wang H. (2017) Socially dominant mice in C57BL6 background show increased social motivation. Behavioural Brain Research