Christopher S. Leonard, Ph.D.

Affiliations: 
Physiology New York Medical College, New York, NY, United States 
Area:
Neurophysiology, Cellular basis of sleeping and waking, cholinergic and monoaminergic brain systems, orexin (hypocretin), Patch Clamp, Ca2+ imaging, Brain slices
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"Christopher S. Leonard"
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Publications

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Cissé Y, Ishibashi M, Jost J, et al. (2020) Discharge and Role of GABA Pontomesencephalic Neurons in Cortical Activity and Sleep-Wake States Examined by Optogenetics and Juxtacellular Recordings in Mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience
Cissé Y, Toossi H, Ishibashi M, et al. (2018) Discharge and Role of Acetylcholine Pontomesencephalic Neurons in Cortical Activity and Sleep-Wake States Examined by Optogenetics and Juxtacellular Recording in Mice. Eneuro. 5
Ishibashi M, Gumenchuk I, Miyazaki K, et al. (2016) Hypocretin/Orexin Peptides Alter Spike Encoding by Serotonergic Dorsal Raphe Neurons through Two Distinct Mechanisms That Increase the Late Afterhyperpolarization. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 10097-115
Ishibashi M, Gumenchuk I, Kang B, et al. (2015) Orexin Receptor Activation Generates Gamma Band Input to Cholinergic and Serotonergic Arousal System Neurons and Drives an Intrinsic Ca(2+)-Dependent Resonance in LDT and PPT Cholinergic Neurons. Frontiers in Neurology. 6: 120
Leonard CS, Ishibashi M. (2015) Orexin receptor functions in the ascending arousal system Orexin and Sleep: Molecular, Functional and Clinical Aspects. 67-80
Christensen MH, Ishibashi M, Nielsen ML, et al. (2014) Age-related changes in nicotine response of cholinergic and non-cholinergic laterodorsal tegmental neurons: implications for the heightened adolescent susceptibility to nicotine addiction. Neuropharmacology. 85: 263-83
Kukkonen JP, Leonard CS. (2014) Orexin/hypocretin receptor signalling cascades. British Journal of Pharmacology. 171: 314-31
Leonard CS, Kukkonen JP. (2014) Orexin/hypocretin receptor signalling: a functional perspective. British Journal of Pharmacology. 171: 294-313
Kohlmeier KA, Tyler CJ, Kalogiannis M, et al. (2013) Differential actions of orexin receptors in brainstem cholinergic and monoaminergic neurons revealed by receptor knockouts: implications for orexinergic signaling in arousal and narcolepsy. Frontiers in Neuroscience. 7: 246
Kohlmeier KA, Ishibashi M, Wess J, et al. (2012) Knockouts reveal overlapping functions of M(2) and M(4) muscarinic receptors and evidence for a local glutamatergic circuit within the laterodorsal tegmental nucleus. Journal of Neurophysiology. 108: 2751-66
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