Christopher S. Leonard, Ph.D.

Physiology New York Medical College, New York, NY, United States 
Neurophysiology, Cellular basis of sleeping and waking, cholinergic and monoaminergic brain systems, orexin (hypocretin), Patch Clamp, Ca2+ imaging, Brain slices
"Christopher S. Leonard"
Mean distance: 13.07 (cluster 6)
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Cissé Y, Toossi H, Ishibashi M, et al. (2018) Discharge and Role of Acetylcholine Pontomesencephalic Neurons in Cortical Activity and Sleep-Wake States Examined by Optogenetics and Juxtacellular Recording in Mice. Eneuro. 5
Ishibashi M, Gumenchuk I, Miyazaki K, et al. (2016) Hypocretin/Orexin Peptides Alter Spike Encoding by Serotonergic Dorsal Raphe Neurons through Two Distinct Mechanisms That Increase the Late Afterhyperpolarization. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 10097-115
Ishibashi M, Gumenchuk I, Kang B, et al. (2015) Orexin Receptor Activation Generates Gamma Band Input to Cholinergic and Serotonergic Arousal System Neurons and Drives an Intrinsic Ca(2+)-Dependent Resonance in LDT and PPT Cholinergic Neurons. Frontiers in Neurology. 6: 120
Leonard CS, Ishibashi M. (2015) Orexin receptor functions in the ascending arousal system Orexin and Sleep: Molecular, Functional and Clinical Aspects. 67-80
Christensen MH, Ishibashi M, Nielsen ML, et al. (2014) Age-related changes in nicotine response of cholinergic and non-cholinergic laterodorsal tegmental neurons: implications for the heightened adolescent susceptibility to nicotine addiction. Neuropharmacology. 85: 263-83
Kukkonen JP, Leonard CS. (2014) Orexin/hypocretin receptor signalling cascades. British Journal of Pharmacology. 171: 314-31
Leonard CS, Kukkonen JP. (2014) Orexin/hypocretin receptor signalling: a functional perspective. British Journal of Pharmacology. 171: 294-313
Kohlmeier KA, Tyler CJ, Kalogiannis M, et al. (2013) Differential actions of orexin receptors in brainstem cholinergic and monoaminergic neurons revealed by receptor knockouts: implications for orexinergic signaling in arousal and narcolepsy. Frontiers in Neuroscience. 7: 246
Kohlmeier KA, Ishibashi M, Wess J, et al. (2012) Knockouts reveal overlapping functions of M(2) and M(4) muscarinic receptors and evidence for a local glutamatergic circuit within the laterodorsal tegmental nucleus. Journal of Neurophysiology. 108: 2751-66
Kalogiannis M, Hsu E, Willie JT, et al. (2011) Cholinergic modulation of narcoleptic attacks in double orexin receptor knockout mice. Plos One. 6: e18697
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