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James Keane Bashkin

Affiliations: 
University of Missouri-St. Louis, St. Louis, MO, United States 
Area:
Chemistry, polyamides, antivirals, gene chemistry, bioorganic, organic, biochemistry, biophysics
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"James Bashkin"
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Parents

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Malcolm L.H. Green grad student 1977-1982 Oxford
 (D.Phil.)
Richard Hadley Holm post-doc 1983-1985 Harvard
 (NIH postdoctoral fellow)

Children

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Todd A. Osiek grad student 1995-2000 Washington University
Bobby N. Trawick grad student 2000-2000 Washington University

Collaborators

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Publications

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Putnam WC, Bashkin JK. (2022) Oligonucleotides containing abasic threoninol-terpyridine residues as potential artificial ribonucleases. Journal of Inorganic Biochemistry. 232: 111831
Song Y, Niederschulte J, Bales KN, et al. (2018) Thermodynamics and Site Stoichiometry of DNA Binding by a Large Antiviral Hairpin Polyamide. Biochimie
Gumpper RH, Li W, Castañeda CH, et al. (2018) A polyamide inhibits replication of vesicular stomatitis virus by targeting RNA in the nucleocapsid. Journal of Virology
Liu B, Wang S, Aston K, et al. (2017) β-Alanine and N-terminal cationic substituents affect polyamide-DNA binding. Organic & Biomolecular Chemistry
Vasilieva E, Niederschulte J, Song Y, et al. (2016) Interactions of Two Large Antiviral Polyamides with the Long Control Region of HPV16. Biochimie
He G, Tolic A, Bashkin JK, et al. (2015) Heterogeneous dynamics in DNA site discrimination by the structurally homologous DNA-binding domains of ETS-family transcription factors. Nucleic Acids Research. 43: 4322-31
Poon GM, Wang S, He G, et al. (2015) Unraveling the Structural, Dynamic, Thermodynamic, and Kinetic Heterogeneity in DNA Site Recognition by Structurally Homologous ETS Transcription Factors Biophysical Journal. 108: 75a-76a
He G, Vasilieva E, Bashkin JK, et al. (2013) Mapping small DNA ligand hydroxyl radical footprinting and affinity cleavage products for capillary electrophoresis. Analytical Biochemistry. 439: 99-101
Bashkin JK, Aston K, Ramos JP, et al. (2013) Promoter scanning of the human COX-2 gene with 8-ring polyamides: unexpected weakening of polyamide-DNA binding and selectivity by replacing an internal N-Me-pyrrole with β-alanine. Biochimie. 95: 271-9
Wang S, Nanjunda R, Aston K, et al. (2012) Correlation of local effects of DNA sequence and position of β-alanine inserts with polyamide-DNA complex binding affinities and kinetics. Biochemistry. 51: 9796-806
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