Mathew M. Blurton-Jones, Ph.D.

Affiliations: 
Neurobiology & Behavior University of California, Irvine, Irvine, CA 
Area:
Alzheimer's disease, Parkinson's disease, stem cells
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"Mathew Blurton-Jones"
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SNBCP

Parents

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Mark Tuszynski grad student 2002 UCSD
 (Estrogen modulates neurotrophin systems in the brain via putative actions on inhibitory neurons.)
Carl W. Cotman post-doc UC Irvine
Frank LaFerla post-doc UC Irvine

Children

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Stephen T. Yeung research assistant UC Irvine (ImmunoTree)
Edsel Abud grad student UC Irvine
Wesley Chen grad student UC Irvine
Morgan A Coburn grad student
Natalie R. S. Goldberg grad student UC Irvine
Samuel E. Marsh grad student 2011-2016 UC Irvine
Hayk Davtyan research scientist 2017- UC Irvine
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Publications

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Claes C, England WE, Danhash EP, et al. (2022) The P522R protective variant of PLCG2 promotes the expression of antigen presentation genes by human microglia in an Alzheimer's disease mouse model. Alzheimer's & Dementia : the Journal of the Alzheimer's Association
You Y, Muraoka S, Jedrychowski MP, et al. (2022) Human neural cell type-specific extracellular vesicle proteome defines disease-related molecules associated with activated astrocytes in Alzheimer's disease brain. Journal of Extracellular Vesicles. 11: e12183
Kim C, Hovakimyan A, Zagorski K, et al. (2022) Efficacy and immunogenicity of MultiTEP-based DNA vaccines targeting human α-synuclein: prelude for IND enabling studies. Npj Vaccines. 7: 1
Chen X, Sun G, Tian E, et al. (2021) Modeling Sporadic Alzheimer's Disease in Human Brain Organoids under Serum Exposure. Advanced Science (Weinheim, Baden-Wurttemberg, Germany). e2101462
Claes C, Danhash EP, Hasselmann J, et al. (2021) Plaque-associated human microglia accumulate lipid droplets in a chimeric model of Alzheimer's disease. Molecular Neurodegeneration. 16: 50
Lall D, Lorenzini I, Mota TA, et al. (2021) C9orf72 deficiency promotes microglial-mediated synaptic loss in aging and amyloid accumulation. Neuron
McQuade A, Kang YJ, Hasselmann J, et al. (2020) Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer's disease. Nature Communications. 11: 5370
Liu T, Zhu B, Liu Y, et al. (2020) Multi-omic comparison of Alzheimer's variants in human ESC-derived microglia reveals convergence at APOE. The Journal of Experimental Medicine. 217
Petrushina I, Hovakimyan A, Harahap I, et al. (2020) Characterization and preclinical evaluation of the cGMP grade DNA based vaccine, AV-1959D to enter the first-in-human clinical trials. Neurobiology of Disease. 104823
Stevens B, Blurton-Jones M, Spires-Jones TL. (2020) Decision letter: Fibrillar Aβ triggers microglial proteome alterations and dysfunction in Alzheimer mouse models Elife
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