Tom Claydon
Affiliations: | 2008-2012 | Biomedical Physiology and Kinesiology | Simon Fraser University, Burnaby, British Columbia, Canada |
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Publications
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| Venkateshappa R, Hunter DV, Muralidharan P, et al. (2023) Targeted activation of hERG channels rescues electrical instability induced by the hERG R56Q+/- Long QT Syndrome variant. Cardiovascular Research |
| Simpson KE, Venkateshappa R, Pang ZK, et al. (2020) Utility of Zebrafish Models of Acquired and Inherited Long QT Syndrome. Frontiers in Physiology. 11: 624129 |
| Shi YP, Thouta S, Claydon TW. (2020) Modulation of hERG K Channel Deactivation by Voltage Sensor Relaxation. Frontiers in Pharmacology. 11: 139 |
| Whittaker DG, Kemp JM, Mirams GR, et al. (2020) Rapid Characterisation of R56Q Mutant hERG Channel Kinetics using Sinusoidal Voltage Protocols Biophysical Journal. 118: 112a |
| Hull CM, Genge CE, Hobbs Y, et al. (2019) Investigating the utility of adult zebrafish ex vivo whole hearts to pharmacologically screen hERG channel activator compounds. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology |
| Shi YP, Thouta S, Cheng YM, et al. (2018) Extracellular protons accelerate hERG channel deactivation by destabilizing voltage sensor relaxation. The Journal of General Physiology |
| Thouta S, Lo G, Grajauskas L, et al. (2018) Investigating the state dependence of drug binding in hERG channels using a trapped-open channel phenotype. Scientific Reports. 8: 4962 |
| Lehman A, Thouta S, Mancini GM, et al. (2018) Mutations in Kv7.5 Channels Associated with Intellectual Disability or Epileptic Encephalopathy Biophysical Journal. 114: 123a |
| Shi YP, Chang C, Gunawan M, et al. (2018) Acidosis Prolongs APD in Optically Mapped Adult Zebrafish Whole Hearts as a Result of hERG Channel Block Biophysical Journal. 114: 490a |
| Hull CM, Genge CE, Tibbits GF, et al. (2018) Comparison of hERG and zERG Potassium Channel Function and Pharmacology Biophysical Journal. 114: 294a |