Philip Biggin
Affiliations: | 2011- | Biochemistry | University of Oxford, Oxford, United Kingdom |
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"Philip Biggin"Mean distance: 106866
Collaborators
Sign in to add collaborator| Lucia Sivilotti | collaborator | UCL | |
| Derek Bowie | collaborator | 2011- | Oxford |
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Publications
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| Larsen AH, Perozzo AM, Biggin PC, et al. (2024) Recovery from desensitization in GluA2 AMPA receptors is affected by a single mutation in the N-terminal domain interface. The Journal of Biological Chemistry. 300: 105717 |
| Bay Y, Venskutonytė R, Frantsen SM, et al. (2023) Small-molecule positive allosteric modulation of homomeric kainate receptors GluK1-3: development of screening assays and insight into GluK3 structure. The Febs Journal |
| Viscarra F, Chrestia JF, Sanchez Y, et al. (2023) Side Groups Convert the α7 Nicotinic Receptor Agonist Ether Quinuclidine into a Type I Positive Allosteric Modulator. Acs Chemical Neuroscience. 14: 2876-2887 |
| Seiferth D, Tucker SJ, Biggin PC. (2023) Limitations of non-polarizable force fields in describing anion binding poses in non-polar synthetic hosts. Physical Chemistry Chemical Physics : Pccp. 25: 17596-17608 |
| Gibbs E, Klemm E, Seiferth D, et al. (2023) Conformational transitions and allosteric modulation in a heteromeric glycine receptor. Nature Communications. 14: 1363 |
| Seiferth D, Biggin PC, Tucker SJ. (2022) When is a hydrophobic gate not a hydrophobic gate? The Journal of General Physiology. 154 |
| Kumar A, Kindig K, Rao S, et al. (2022) Structural basis for cannabinoid-induced potentiation of alpha1-glycine receptors in lipid nanodiscs. Nature Communications. 13: 4862 |
| Chou TH, Epstein M, Michalski K, et al. (2022) Structural insights into binding of therapeutic channel blockers in NMDA receptors. Nature Structural & Molecular Biology. 29: 507-518 |
| Ladefoged LK, Koch R, Biggin PC, et al. (2022) Binding and Activation of Serotonergic G-Protein Coupled Receptors by the Multimodal Antidepressant Vortioxetine. Acs Chemical Neuroscience. 13: 1129-1142 |
| Habgood M, Seiferth D, Zaki AM, et al. (2022) Atomistic mechanisms of human TRPA1 activation by electrophile irritants through molecular dynamics simulation and mutual information analysis. Scientific Reports. 12: 4929 |