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Joel S. Freundlich - Publications

Affiliations: 
2011- Pharmacology and Physiology Rutgers New Jersey Medical School 
Area:
Mycobacterium tuberculosis
Website:
http://njms.rutgers.edu/resource_locator/find_people/profile.cfm?mbmid=freundjs
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43 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Smith TC, Pullen KM, Olson MC, McNellis ME, Richardson I, Hu S, Larkins-Ford J, Wang X, Freundlich JS, Ando DM, Aldridge BB. Morphological profiling of tubercle bacilli identifies drug pathways of action. Proceedings of the National Academy of Sciences of the United States of America. PMID 32680963 DOI: 10.1073/Pnas.2002738117  0.332
2020 Mota F, Jadhav R, Ruiz-Bedoya CA, Ordonez AA, Klunk MH, Freundlich JS, Jain SK. Radiosynthesis and biodistribution of F-Linezolid in -infected mice using PET. Acs Infectious Diseases. PMID 32243132 DOI: 10.1021/Acsinfecdis.9B00473  0.321
2020 Inoyama D, Awasthi D, Capodagli GC, Tsotetsi K, Sukheja P, Zimmerman M, Li SG, Jadhav R, Russo R, Wang X, Grady C, Richmann T, Shrestha R, Li L, Ahn YM, ... ... Freundlich JS, et al. A Preclinical Candidate Targeting Mycobacterium tuberculosis KasA. Cell Chemical Biology. PMID 32197094 DOI: 10.1016/J.Chembiol.2020.02.007  0.375
2019 Wang X, Inoyama D, Russo R, Li SG, Jadhav R, Stratton TP, Mittal N, Bilotta JA, Singleton E, Kim T, Paget SD, Pottorf RS, Ahn YM, Davila-Pagan A, Kandasamy S, ... ... Freundlich JS, et al. Antitubercular Triazines: Optimization and Intrabacterial Metabolism. Cell Chemical Biology. PMID 31711854 DOI: 10.1016/J.Chembiol.2019.10.010  0.329
2019 Wang X, Perryman A, Li SG, Paget S, Stratton T, Lemenze A, Olson AJ, Ekins S, Kumar P, Freundlich JS. Intrabacterial Metabolism Obscures the Successful Prediction of an InhA Inhibitor of Mycobacterium tuberculosis. Acs Infectious Diseases. PMID 31625383 DOI: 10.1021/Acsinfecdis.9B00295  0.407
2019 Ordonez AA, Carroll LS, Abhishek S, Mota F, Ruiz-Bedoya CA, Klunk MH, Singh AK, Freundlich JS, Mease RC, Jain SK. Radiosynthesis and PET Bioimaging of Br-Bedaquiline in a Murine Model of Tuberculosis. Acs Infectious Diseases. PMID 31345032 DOI: 10.1021/Acsinfecdis.9B00207  0.346
2018 Gallardo-Macias R, Kumar P, Jaskowski M, Richmann T, Shrestha R, Russo R, Singleton E, Zimmerman MD, Ho HP, Dartois V, Connell N, Alland D, Freundlich JS. Optimization of N-benzyl-5-nitrofuran-2-carboxamide as an antitubercular agent. Bioorganic & Medicinal Chemistry Letters. PMID 30600207 DOI: 10.1016/J.Bmcl.2018.12.053  0.358
2018 Kumar P, Capodagli GC, Awasthi D, Shrestha R, Maharaja K, Sukheja P, Li SG, Inoyama D, Zimmerman M, Ho Liang HP, Sarathy J, Mina M, Rasic G, Russo R, Perryman AL, ... ... Freundlich JS, et al. Synergistic Lethality of a Binary Inhibitor of Mycobacterium tuberculosis KasA. Mbio. 9. PMID 30563908 DOI: 10.1128/Mbio.02101-17  0.389
2018 Mori G, Orena BS, Franch C, Mitchenall LA, Godbole AA, Rodrigues L, Aguilar-Pérez C, Zemanová J, Huszár S, Forbak M, Lane TR, Sabbah M, Deboosere N, Frita R, Vandeputte A, ... ... Freundlich JS, et al. The EU approved antimalarial pyronaridine shows antitubercular activity and synergy with rifampicin, targeting RNA polymerase. Tuberculosis (Edinburgh, Scotland). 112: 98-109. PMID 30205975 DOI: 10.1016/J.Tube.2018.08.004  0.338
2018 Perryman AL, Patel JS, Russo R, Singleton E, Connell N, Ekins S, Freundlich JS. Naïve Bayesian Models for Vero Cell Cytotoxicity. Pharmaceutical Research. 35: 170. PMID 29959603 DOI: 10.1007/S11095-018-2439-9  0.324
2018 Lane T, Russo DP, Zorn KM, Clark AM, Korotcov A, Tkachenko V, Reynolds RC, Perryman AL, Freundlich JS, Ekins S. Comparing and Validating Machine Learning Models for Mycobacterium tuberculosis Drug Discovery. Molecular Pharmaceutics. PMID 29672063 DOI: 10.1021/Acs.Molpharmaceut.8B00083  0.367
2018 Inoyama D, Paget SD, Russo R, Kandasamy S, Kumar P, Singleton E, Occi J, Tuckman M, Zimmerman MD, Ho HP, Perryman AL, Dartois V, Connell N, Freundlich JS. Novel Pyrimidines as Antitubercular Agents. Antimicrobial Agents and Chemotherapy. PMID 29311070 DOI: 10.1128/Aac.02063-17  0.388
2017 Stratton TP, Perryman AL, Vilchèze C, Russo R, Li SG, Patel JS, Singleton E, Ekins S, Connell N, Jacobs WR, Freundlich JS. Addressing the Metabolic Stability of Antituberculars through Machine Learning. Acs Medicinal Chemistry Letters. 8: 1099-1104. PMID 29057058 DOI: 10.1021/Acsmedchemlett.7B00299  0.331
2017 Kumar P, Chauhan V, Silva JRA, Lameira J, d'Andrea F, Li S, Ginell SL, Freundlich JS, Alves CN, Bailey S, Cohen KA, Lamichhane G. Mycobacterium abscessus L,D-transpeptidases are susceptible to inactivation by carbapenems and cephalosporins but not penicillins. Antimicrobial Agents and Chemotherapy. PMID 28760902 DOI: 10.1128/Aac.00866-17  0.426
2017 Awasthi D, Freundlich JS. Antimycobacterial Metabolism: Illuminating Mycobacterium tuberculosis Biology and Drug Discovery. Trends in Microbiology. PMID 28622844 DOI: 10.1016/J.Tim.2017.05.007  0.382
2017 Vilchèze C, Hartman T, Weinrick B, Jain P, Weisbrod TR, Leung LW, Freundlich JS, Jacobs WR. Enhanced respiration prevents drug tolerance and drug resistance in Mycobacterium tuberculosis. Proceedings of the National Academy of Sciences of the United States of America. PMID 28396391 DOI: 10.1073/Pnas.1704376114  0.368
2017 Sukheja P, Kumar P, Mittal N, Li SG, Singleton E, Russo R, Perryman AL, Shrestha R, Awasthi D, Husain S, Soteropoulos P, Brukh R, Connell N, Freundlich JS, Alland D. A Novel Small-Molecule Inhibitor of the Mycobacterium tuberculosis Demethylmenaquinone Methyltransferase MenG Is Bactericidal to Both Growing and Nutritionally Deprived Persister Cells. Mbio. 8. PMID 28196957 DOI: 10.1128/Mbio.02022-16  0.41
2016 Kumar P, Kaushik A, Lloyd EP, Li SG, Mattoo R, Ammerman NC, Bell DT, Perryman AL, Zandi TA, Ekins S, Ginell SL, Townsend CA, Freundlich JS, Lamichhane G. Non-classical transpeptidases yield insight into new antibacterials. Nature Chemical Biology. PMID 27820797 DOI: 10.1038/Nchembio.2237  0.405
2016 Ekins S, Perryman AL, Clark AM, Reynolds RC, Freundlich JS. Machine Learning Model Analysis and Data Visualization with Small Molecules Tested in a Mouse Model of Mycobacterium tuberculosis Infection (2014-2015). Journal of Chemical Information and Modeling. PMID 27335215 DOI: 10.1021/Acs.Jcim.6B00004  0.365
2016 Ekins S, Mietchen D, Coffee M, Stratton TP, Freundlich JS, Freitas-Junior L, Muratov E, Siqueira-Neto J, Williams AJ, Andrade C. Open drug discovery for the Zika virus. F1000research. 5: 150. PMID 27134728 DOI: 10.12688/F1000Research.8013.1  0.323
2015 Ekins S, Freundlich JS, Clark AM, Anantpadma M, Davey RA, Madrid P. Machine learning models identify molecules active against the Ebola virus in vitro. F1000research. 4: 1091. PMID 26834994 DOI: 10.12688/F1000Research.7217.3  0.382
2015 Ekins S, Madrid PB, Sarker M, Li SG, Mittal N, Kumar P, Wang X, Stratton TP, Zimmerman M, Talcott C, Bourbon P, Travers M, Yadav M, Freundlich JS. Combining Metabolite-Based Pharmacophores with Bayesian Machine Learning Models for Mycobacterium tuberculosis Drug Discovery. Plos One. 10: e0141076. PMID 26517557 DOI: 10.1371/Journal.Pone.0141076  0.516
2015 Perryman AL, Stratton TP, Ekins S, Freundlich JS. Predicting Mouse Liver Microsomal Stability with "Pruned" Machine Learning Models and Public Data. Pharmaceutical Research. PMID 26415647 DOI: 10.1007/S11095-015-1800-5  0.311
2015 Li SG, Vilchèze C, Chakraborty S, Wang X, Kim H, Anisetti M, Ekins S, Rhee KY, Jacobs WR, Freundlich JS. Evolution of a thienopyrimidine antitubercular relying on medicinal chemistry and metabolomics insights. Tetrahedron Letters. 56: 3246-3250. PMID 26257441 DOI: 10.1016/J.Tetlet.2015.02.129  0.309
2015 Forbes L, Ebsworth-Mojica K, DiDone L, Li SG, Freundlich JS, Connell N, Dunman PM, Krysan DJ. A High Throughput Screening Assay for Anti-Mycobacterial Small Molecules Based on Adenylate Kinase Release as a Reporter of Cell Lysis. Plos One. 10: e0129234. PMID 26098625 DOI: 10.1371/Journal.Pone.0129234  0.338
2015 Clark AM, Dole K, Coulon-Spektor A, McNutt A, Grass G, Freundlich JS, Reynolds RC, Ekins S. Open Source Bayesian Models. 1. Application to ADME/Tox and Drug Discovery Datasets. Journal of Chemical Information and Modeling. 55: 1231-45. PMID 25994950 DOI: 10.1021/Acs.Jcim.5B00143  0.315
2015 Perryman AL, Yu W, Wang X, Ekins S, Forli S, Li SG, Freundlich JS, Tonge PJ, Olson AJ. A virtual screen discovers novel, fragment-sized inhibitors of Mycobacterium tuberculosis InhA. Journal of Chemical Information and Modeling. 55: 645-59. PMID 25636146 DOI: 10.1021/Ci500672V  0.407
2014 Ekins S, Freundlich JS, Coffee M. A common feature pharmacophore for FDA-approved drugs inhibiting the Ebola virus. F1000research. 3: 277. PMID 25653841 DOI: 10.12688/F1000Research.5741.2  0.367
2014 Stec J, Vilchèze C, Lun S, Perryman AL, Wang X, Freundlich JS, Bishai W, Jacobs WR, Kozikowski AP. Biological evaluation of potent triclosan-derived inhibitors of the enoyl-acyl carrier protein reductase InhA in drug-sensitive and drug-resistant strains of Mycobacterium tuberculosis. Chemmedchem. 9: 2528-37. PMID 25165007 DOI: 10.1002/Cmdc.201402255  0.384
2014 Ekins S, Freundlich JS, Reynolds RC. Are bigger data sets better for machine learning? Fusing single-point and dual-event dose response data for Mycobacterium tuberculosis. Journal of Chemical Information and Modeling. 54: 2157-65. PMID 24968215 DOI: 10.1021/Ci500264R  0.325
2014 Nixon MR, Saionz KW, Koo MS, Szymonifka MJ, Jung H, Roberts JP, Nandakumar M, Kumar A, Liao R, Rustad T, Sacchettini JC, Rhee KY, Freundlich JS, Sherman DR. Folate pathway disruption leads to critical disruption of methionine derivatives in Mycobacterium tuberculosis. Chemistry & Biology. 21: 819-30. PMID 24954008 DOI: 10.1016/J.Chembiol.2014.04.009  0.337
2014 Ekins S, Pottorf R, Reynolds RC, Williams AJ, Clark AM, Freundlich JS. Looking back to the future: predicting in vivo efficacy of small molecules versus Mycobacterium tuberculosis. Journal of Chemical Information and Modeling. 54: 1070-82. PMID 24665947 DOI: 10.1021/Ci500077V  0.385
2014 Ekins S, Freundlich JS, Hobrath JV, Lucile White E, Reynolds RC. Combining computational methods for hit to lead optimization in Mycobacterium tuberculosis drug discovery. Pharmaceutical Research. 31: 414-35. PMID 24132686 DOI: 10.1007/S11095-013-1172-7  0.398
2013 Ekins S, Freundlich JS, Reynolds RC. Fusing dual-event data sets for Mycobacterium tuberculosis machine learning models and their evaluation. Journal of Chemical Information and Modeling. 53: 3054-63. PMID 24144044 DOI: 10.1021/Ci400480S  0.352
2013 Ekins S, Reynolds RC, Franzblau SG, Wan B, Freundlich JS, Bunin BA. Enhancing hit identification in Mycobacterium tuberculosis drug discovery using validated dual-event Bayesian models. Plos One. 8: e63240. PMID 23667592 DOI: 10.1371/Journal.Pone.0063240  0.417
2013 Ekins S, Freundlich JS. Computational models for tuberculosis drug discovery. Methods in Molecular Biology (Clifton, N.J.). 993: 245-62. PMID 23568475 DOI: 10.1007/978-1-62703-342-8_16  0.378
2013 Anderson JW, Sarantakis D, Terpinski J, Kumar TR, Tsai HC, Kuo M, Ager AL, Jacobs WR, Schiehser GA, Ekins S, Sacchettini JC, Jacobus DP, Fidock DA, Freundlich JS. Novel diaryl ureas with efficacy in a mouse model of malaria. Bioorganic & Medicinal Chemistry Letters. 23: 1022-5. PMID 23313245 DOI: 10.1016/J.Bmcl.2012.12.022  0.349
2012 Sarker M, Talcott C, Madrid P, Chopra S, Bunin BA, Lamichhane G, Freundlich JS, Ekins S. Combining cheminformatics methods and pathway analysis to identify molecules with whole-cell activity against Mycobacterium tuberculosis. Pharmaceutical Research. 29: 2115-27. PMID 22477069 DOI: 10.1007/S11095-012-0741-5  0.417
1996 Freundlich JS, Schrock RR. Synthesis of Triamidoamine Complexes of Niobium. Inorganic Chemistry. 35: 7459-7461. PMID 11666947 DOI: 10.1021/Ic9607088  0.429
1996 Freundlich JS, Schrock RR, Davis WM. Alkyl and Alkylidene Complexes of Tantalum That Contain a Triethylsilyl-Substituted Triamido−Amine Ligand Organometallics. 15: 2777-2783. DOI: 10.1021/Om960149C  0.443
1996 Freundlich JS, Schrock RR, Davis WM. Synthetic and mechanistic investigations of trimethylsilyl-substituted triamidoamine complexes of tantalum that contain metal-ligand multiple bonds Journal of the American Chemical Society. 118: 3643-3655. DOI: 10.1021/Ja953826N  0.416
1994 Freundlich JS, Schrock RR, Cummins CC, Davis WM. Organometallic Complexes of Tantalum That Contain the Triamidoamine Ligand, [(Me3SiNCH2CH2)3N]3-, Including an Ethylidene Complex Formed via a Phosphine-Catalyzed Rearrangement of an Ethylene Complex Journal of the American Chemical Society. 116: 6476-6477. DOI: 10.1021/Ja00093A075  0.546
1994 Freundlich JS, Schrock RR, Cummins CC, Davis WM. Organometallic complexes of tantalum that contain the triamidoamine ligand, [(Me3SiNCH2CH2)3N]3-, including an ethylidene complex formed via a phosphine-catalyzed rearrangement of an ethylene complex Journal of the American Chemical Society. 116: 6476-6477.  0.438
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