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Darren William Begley - Publications

Affiliations: 
2009 University of Washington, Seattle, Seattle, WA 
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21 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Haft DH, Pierce PG, Mayclin SJ, Sullivan A, Gardberg AS, Abendroth J, Begley DW, Phan IQ, Staker BL, Myler PJ, Marathias VM, Lorimer DD, Edwards TE. Mycofactocin-associated mycobacterial dehydrogenases with non-exchangeable NAD cofactors. Scientific Reports. 7: 41074. PMID 28120876 DOI: 10.1038/Srep41074  0.398
2015 Goshu GM, Ghose D, Bain JM, Pierce PG, Begley DW, Hewitt SN, Udell HS, Myler PJ, Meganathan R, Hagen TJ. Synthesis and biological evaluation of pyrazolopyrimidines as potential antibacterial agents. Bioorganic & Medicinal Chemistry Letters. PMID 26584881 DOI: 10.1016/J.Bmcl.2015.10.096  0.572
2015 Baugh L, Phan I, Begley DW, Clifton MC, Armour B, Dranow DM, Taylor BM, Muruthi MM, Abendroth J, Fairman JW, Fox D, Dieterich SH, Staker BL, Gardberg AS, Choi R, et al. Increasing the structural coverage of tuberculosis drug targets. Tuberculosis (Edinburgh, Scotland). 95: 142-8. PMID 25613812 DOI: 10.1016/J.Tube.2014.12.003  0.411
2014 Moen SO, Abendroth J, Fairman JW, Baydo RO, Bullen J, Kirkwood JL, Barnes SR, Raymond AC, Begley DW, Henkel G, McCormack K, Tam VC, Phan I, Staker BL, Stacy R, et al. Structural analysis of H1N1 and H7N9 influenza A virus PA in the absence of PB1. Scientific Reports. 4: 5944. PMID 25089892 DOI: 10.1038/Srep05944  0.367
2014 Begley DW, Fox D, Jenner D, Juli C, Pierce PG, Abendroth J, Muruthi M, Safford K, Anderson V, Atkins K, Barnes SR, Moen SO, Raymond AC, Stacy R, Myler PJ, et al. A structural biology approach enables the development of antimicrobials targeting bacterial immunophilins. Antimicrobial Agents and Chemotherapy. 58: 1458-67. PMID 24366729 DOI: 10.1128/Aac.01875-13  0.501
2013 Begley DW, Moen SO, Pierce PG, Zartler ER. Saturation transfer difference NMR for fragment screening. Current Protocols in Chemical Biology. 5: 251-68. PMID 24391096 DOI: 10.1002/9780470559277.Ch130118  0.465
2013 Zhang Z, Jakkaraju S, Blain J, Gogol K, Zhao L, Hartley RC, Karlsson CA, Staker BL, Edwards TE, Stewart LJ, Myler PJ, Clare M, Begley DW, Horn JR, Hagen TJ. Cytidine derivatives as IspF inhibitors of Burkolderia pseudomallei. Bioorganic & Medicinal Chemistry Letters. 23: 6860-3. PMID 24157367 DOI: 10.1016/J.Bmcl.2013.09.101  0.642
2013 Armour BL, Barnes SR, Moen SO, Smith E, Raymond AC, Fairman JW, Stewart LJ, Staker BL, Begley DW, Edwards TE, Lorimer DD. Multi-target parallel processing approach for gene-to-structure determination of the influenza polymerase PB2 subunit. Journal of Visualized Experiments : Jove. PMID 23851357 DOI: 10.3791/4225  0.413
2013 Baugh L, Gallagher LA, Patrapuvich R, Clifton MC, Gardberg AS, Edwards TE, Armour B, Begley DW, Dieterich SH, Dranow DM, Abendroth J, Fairman JW, Fox D, Staker BL, Phan I, et al. Combining functional and structural genomics to sample the essential Burkholderia structome. Plos One. 8: e53851. PMID 23382856 DOI: 10.1371/Journal.Pone.0053851  0.45
2011 Zhang Y, Edwards TE, Begley DW, Abramov A, Thompkins KB, Ferrell M, Guo WJ, Phan I, Olsen C, Napuli A, Sankaran B, Stacy R, Van Voorhis WC, Stewart LJ, Myler PJ. Structure of nitrilotriacetate monooxygenase component B from Mycobacterium thermoresistibile. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 67: 1100-5. PMID 21904057 DOI: 10.1107/S1744309111012541  0.335
2011 Begley DW, Edwards TE, Raymond AC, Smith ER, Hartley RC, Abendroth J, Sankaran B, Lorimer DD, Myler PJ, Staker BL, Stewart LJ. Inhibitor-bound complexes of dihydrofolate reductase-thymidylate synthase from Babesia bovis. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 67: 1070-7. PMID 21904052 DOI: 10.1107/S1744309111029009  0.368
2011 Begley DW, Davies DR, Hartley RC, Hewitt SN, Rychel AL, Myler PJ, Van Voorhis WC, Staker BL, Stewart LJ. Probing conformational states of glutaryl-CoA dehydrogenase by fragment screening. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 67: 1060-9. PMID 21904051 DOI: 10.1107/S1744309111014436  0.468
2011 Smith ER, Begley DW, Anderson V, Raymond AC, Haffner TE, Robinson JI, Edwards TE, Duncan N, Gerdts CJ, Mixon MB, Nollert P, Staker BL, Stewart LJ. The Protein Maker: an automated system for high-throughput parallel purification. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 67: 1015-21. PMID 21904043 DOI: 10.1107/S1744309111028776  0.34
2011 Stacy R, Begley DW, Phan I, Staker BL, Van Voorhis WC, Varani G, Buchko GW, Stewart LJ, Myler PJ. Structural genomics of infectious disease drug targets: the SSGCID. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 67: 979-84. PMID 21904037 DOI: 10.1107/S1744309111029204  0.554
2011 Davidson A, Begley DW, Lau C, Varani G. A small-molecule probe induces a conformation in HIV TAR RNA capable of binding drug-like fragments. Journal of Molecular Biology. 410: 984-96. PMID 21763501 DOI: 10.1016/J.Jmb.2011.03.039  0.65
2011 Begley DW, Davies DR, Hartley RC, Edwards TE, Staker BL, Van Voorhis WC, Myler PJ, Stewart LJ. Fragment screening of infectious disease targets in a structural genomics environment. Methods in Enzymology. 493: 533-56. PMID 21371605 DOI: 10.1016/B978-0-12-381274-2.00021-2  0.437
2011 Davies DR, Begley DW, Hartley RC, Staker BL, Stewart LJ. Predicting the success of fragment screening by X-ray crystallography. Methods in Enzymology. 493: 91-114. PMID 21371588 DOI: 10.1016/B978-0-12-381274-2.00004-2  0.428
2011 Begley DW, Hartley RC, Davies DR, Edwards TE, Leonard JT, Abendroth J, Burris CA, Bhandari J, Myler PJ, Staker BL, Stewart LJ. Leveraging structure determination with fragment screening for infectious disease drug targets: MECP synthase from Burkholderia pseudomallei. Journal of Structural and Functional Genomics. 12: 63-76. PMID 21359640 DOI: 10.1007/S10969-011-9102-6  0.568
2010 Begley DW, Zheng S, Varani G. Fragment-based discovery of novel thymidylate synthase leads by NMR screening and group epitope mapping. Chemical Biology & Drug Design. 76: 218-33. PMID 20626411 DOI: 10.1111/J.1747-0285.2010.01010.X  0.632
2009 Begley DW, Varani G. Locking out viral replication. Nature Chemical Biology. 5: 782-3. PMID 19841624 DOI: 10.1038/Nchembio.245  0.565
2008 Liu J, Begley D, Mitchell DD, Verlinde CL, Varani G, Fan E. Multivalent drug design and inhibition of cholera toxin by specific and transient protein-ligand interactions. Chemical Biology & Drug Design. 71: 408-19. PMID 18373548 DOI: 10.1111/J.1747-0285.2008.00648.X  0.643
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