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Nathalie Saurat, Ph.D B.Sc - Related publications

2010-2014 Gurdon Institute University of Cambridge, Cambridge, England, United Kingdom 
 2015- Memorial Sloan-Kettering Cancer Center, Rockville Centre, NY, United States 
Stem Cells, Neuroscience, Neurodegeneration, Aging, Disease Modelling
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50 most relevant papers in past 60 days:
Year Citation  Score
2021 Habekost M, Qvist P, Denham M, Holm IE, Jørgensen AL. Directly Reprogrammed Neurons Express MAPT and APP Splice Variants Pertinent to Ageing and Neurodegeneration. Molecular Neurobiology. PMID 33415685 DOI: 10.1007/s12035-020-02258-w   
2021 Arber C, Alatza A, Leckey CA, Paterson RW, Zetterberg H, Wray S. Mass spectrometry analysis of tau and amyloid-beta in iPSC-derived models of Alzheimer's disease and dementia. Journal of Neurochemistry. PMID 33539581 DOI: 10.1111/jnc.15315   
2021 Jonathan MC, Adrián SH, Gonzalo A. Type II nuclear receptors with potential role in Alzheimer disease. Molecular Aspects of Medicine. 100940. PMID 33397589 DOI: 10.1016/j.mam.2020.100940   
2021 Si Z, Wang X. . The Journal of Pharmacology and Experimental Therapeutics. PMID 33558427 DOI: 10.1124/jpet.120.000324   
2021 Song YH, De R, Lee KT. Uptake of Polyelectrolyte Functionalized Upconversion Nanoparticles by Tau-Aggregated Neuron Cells. Pharmaceutics. 13. PMID 33466898 DOI: 10.3390/pharmaceutics13010102   
2021 Leng K, Li E, Eser R, Piergies A, Sit R, Tan M, Neff N, Li SH, Rodriguez RD, Suemoto CK, Leite REP, Ehrenberg AJ, Pasqualucci CA, Seeley WW, Spina S, et al. Molecular characterization of selectively vulnerable neurons in Alzheimer's disease. Nature Neuroscience. PMID 33432193 DOI: 10.1038/s41593-020-00764-7   
2021 Chang CW, Shao E, Mucke L. Tau: Enabler of diverse brain disorders and target of rapidly evolving therapeutic strategies. Science (New York, N.Y.). 371. PMID 33632820 DOI: 10.1126/science.abb8255   
2021 Jablonski AM, Warren L, Usenovic M, Zhou H, Sugam J, Parmentier-Batteur S, Voleti B. Astrocytic expression of the Alzheimer's disease risk allele, ApoEε4, potentiates neuronal tau pathology in multiple preclinical models. Scientific Reports. 11: 3438. PMID 33564035 DOI: 10.1038/s41598-021-82901-1   
2021 Schmidt MF, Gan ZY, Komander D, Dewson G. Ubiquitin signalling in neurodegeneration: mechanisms and therapeutic opportunities. Cell Death and Differentiation. PMID 33414510 DOI: 10.1038/s41418-020-00706-7   
2021 Park J, Choi H, Kim YD, Kim SH, Kim Y, Gwon Y, Lee DY, Park SH, Heo WD, Jung YK. Aberrant role of ALK in tau proteinopathy through autophagosomal dysregulation. Molecular Psychiatry. PMID 33452442 DOI: 10.1038/s41380-020-01003-y   
2021 Amponsah AE, Guo R, Kong D, Feng B, He J, Zhang W, Liu X, Du X, Ma Z, Liu B, Ma J, Cui H. Patient-derived iPSCs, a reliable model for the investigation of Alzheimer's disease. Reviews in the Neurosciences. PMID 33550785 DOI: 10.1515/revneuro-2020-0065   
2021 Martínez-Maldonado A, Ontiveros-Torres MÁ, Harrington CR, Montiel-Sosa JF, Prandiz RG, Bocanegra-López P, Sorsby-Vargas AM, Bravo-Muñoz M, Florán-Garduño B, Villanueva-Fierro I, Perry G, Garcés-Ramírez L, de la Cruz F, Martínez-Robles S, Pacheco-Herrero M, et al. Molecular Processing of Tau Protein in Progressive Supranuclear Palsy: Neuronal and Glial Degeneration. Journal of Alzheimer's Disease : Jad. PMID 33459640 DOI: 10.3233/JAD-201139   
2021 Hartnell IJ, Blum D, Nicoll JAR, Dorothee G, Boche D. Glial cells and adaptive immunity in frontotemporal dementia with tau pathology. Brain : a Journal of Neurology. PMID 33527991 DOI: 10.1093/brain/awaa457   
2021 Sobue A, Komine O, Hara Y, Endo F, Mizoguchi H, Watanabe S, Murayama S, Saito T, Saido TC, Sahara N, Higuchi M, Ogi T, Yamanaka K. Microglial gene signature reveals loss of homeostatic microglia associated with neurodegeneration of Alzheimer's disease. Acta Neuropathologica Communications. 9: 1. PMID 33402227 DOI: 10.1186/s40478-020-01099-x   
2021 Sharma VK, Singh TG. CREB: A Multifaceted Target for Alzheimer's Disease. Current Alzheimer Research. PMID 33602089 DOI: 10.2174/1567205018666210218152253   
2021 Sahu B, Mackos AR, Floden AM, Wold LE, Combs CK. Particulate Matter Exposure Exacerbates Amyloid-β Plaque Deposition and Gliosis in APP/PS1 Mice. Journal of Alzheimer's Disease : Jad. PMID 33554902 DOI: 10.3233/JAD-200919   
2021 Polanco JC, Hand GR, Briner A, Li C, Götz J. Exosomes induce endolysosomal permeabilization as a gateway by which exosomal tau seeds escape into the cytosol. Acta Neuropathologica. PMID 33417012 DOI: 10.1007/s00401-020-02254-3   
2021 Burbulla LF, Mc Donald JM, Valdez C, Gao F, Bigio EH, Krainc D. Modeling Brain Pathology of Niemann-Pick Disease Type C Using Patient-Derived Neurons. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 33438272 DOI: 10.1002/mds.28463   
2021 Raut S, Patel R, Al-Ahmad AJ. Presence of a mutation in PSEN1 or PSEN2 gene is associated with an impaired brain endothelial cell phenotype in vitro. Fluids and Barriers of the Cns. 18: 3. PMID 33413468 DOI: 10.1186/s12987-020-00235-y   
2021 Goldstein LSB, Das U. The cellular machinery of post-endocytic APP trafficking in Alzheimer's disease: A future target for therapeutic intervention? Progress in Molecular Biology and Translational Science. 177: 109-122. PMID 33453937 DOI: 10.1016/bs.pmbts.2020.08.001   
2021 Suresh P, Phasuk S, Liu IY. Modulation of microglia activation and Alzheimer's disease: CX3 chemokine ligand 1/CX3CR and P2XR signaling. Tzu Chi Medical Journal. 33: 1-6. PMID 33505871 DOI: 10.4103/tcmj.tcmj_144_20   
2021 Yi S, Chen S, Xiang J, Tan J, Huang K, Zhang H, Wang Y, Wu H. Genistein exerts a cell-protective effect via Nrf2/HO-1/PI3K signaling in Aβ25-35-induced Alzheimer's disease models in vitro. Folia Histochemica Et Cytobiologica. PMID 33605427 DOI: 10.5603/FHC.a2021.0006   
2021 Alausa A, Ogundepo S, Olaleke B, Adeyemi R, Olatinwo M, Ismail A. Chinese nutraceuticals and physical activity; their role in neurodegenerative tauopathies. Chinese Medicine. 16: 1. PMID 33407732 DOI: 10.1186/s13020-020-00418-7   
2021 Di J, Siddique I, Li Z, Malki G, Hornung S, Dutta S, Hurst I, Ishaaya E, Wang A, Tu S, Boghos A, Ericsson I, Klärner FG, Schrader T, Bitan G. The molecular tweezer CLR01 improves behavioral deficits and reduces tau pathology in P301S-tau transgenic mice. Alzheimer's Research & Therapy. 13: 6. PMID 33397489 DOI: 10.1186/s13195-020-00743-x   
2021 Kobro-Flatmoen A, Lagartos-Donate MJ, Aman Y, Edison P, Witter MP, Fang EF. Re-emphasizing early Alzheimer's disease pathology starting in select entorhinal neurons, with a special focus on mitophagy. Ageing Research Reviews. 101307. PMID 33621703 DOI: 10.1016/j.arr.2021.101307   
2021 Lim KH, Kim SH, Yang S, Chun S, Joo JY. Advances in multiplex PCR for Alzheimer's disease diagnostics targeting CDK genes. Neuroscience Letters. 135715. PMID 33600906 DOI: 10.1016/j.neulet.2021.135715   
2021 Zhao J, Wu H, Tang XQ. Tau internalization: A complex step in tau propagation. Ageing Research Reviews. 67: 101272. PMID 33571704 DOI: 10.1016/j.arr.2021.101272   
2021 Acioglu C, Li L, Elkabes S. Contribution of astrocytes to neuropathology of neurodegenerative diseases. Brain Research. 147291. PMID 33516810 DOI: 10.1016/j.brainres.2021.147291   
2021 Phan LMT, Hoang TX, Vo TAT, Pham HL, Le HTN, Chinnadayyala SR, Kim JY, Lee SM, Cho WW, Kim YH, Choi SH, Cho S. Nanomaterial-based Optical and Electrochemical Biosensors for Amyloid beta and Tau: Potential for early diagnosis of Alzheimer's Disease. Expert Review of Molecular Diagnostics. PMID 33560154 DOI: 10.1080/14737159.2021.1887732   
2021 McGrowder DA, Miller F, Vaz K, Nwokocha C, Wilson-Clarke C, Anderson-Cross M, Brown J, Anderson-Jackson L, Williams L, Latore L, Thompson R, Alexander-Lindo R. Cerebrospinal Fluid Biomarkers of Alzheimer's Disease: Current Evidence and Future Perspectives. Brain Sciences. 11. PMID 33578866 DOI: 10.3390/brainsci11020215   
2021 Amaral AC, Perez-Nievas BG, Siao Tick Chong M, Gonzalez-Martinez A, Argente-Escrig H, Rubio-Guerra S, Commins C, Muftu S, Eftekharzadeh B, Hudry E, Fan Z, Ramanan P, Takeda S, Frosch MP, Wegmann S, et al. Isoform-selective decrease of glycogen synthase kinase-3-beta (GSK-3β) reduces synaptic tau phosphorylation, transcellular spreading, and aggregation. Iscience. 24: 102058. PMID 33554064 DOI: 10.1016/j.isci.2021.102058   
2021 Remya C, Dileep KV, Variyar EJ, Zhang KYJ, Omkumar RV, Sadasivan C. Chemical similarity assisted search for acetylcholinesterase inhibitors: Molecular modeling and evaluation of their neuroprotective properties. International Journal of Biological Macromolecules. PMID 33497692 DOI: 10.1016/j.ijbiomac.2021.01.148   
2021 Maeda J, Minamihisamatsu T, Shimojo M, Zhou X, Ono M, Matsuba Y, Ji B, Ishii H, Ogawa M, Akatsu H, Kaneda D, Hashizume Y, Robinson JL, Lee VM, Saito T, et al. Distinct microglial response against Alzheimer's amyloid and tau pathologies characterized by P2Y12 receptor. Brain Communications. 3: fcab011. PMID 33644757 DOI: 10.1093/braincomms/fcab011   
2021 Neff RA, Wang M, Vatansever S, Guo L, Ming C, Wang Q, Wang E, Horgusluoglu-Moloch E, Song WM, Li A, Castranio EL, Tcw J, Ho L, Goate A, Fossati V, et al. Molecular subtyping of Alzheimer's disease using RNA sequencing data reveals novel mechanisms and targets. Science Advances. 7. PMID 33523961 DOI: 10.1126/sciadv.abb5398   
2021 Liu X, Wang K, Wei X, Xie T, Lv B, Zhou Q, Wang X. Interaction of NF-κB and Wnt/β-catenin Signaling Pathways in Alzheimer's Disease and Potential Active Drug Treatments. Neurochemical Research. PMID 33523396 DOI: 10.1007/s11064-021-03227-y   
2021 Carosi JM, Denton D, Kumar S, Sargeant TJ. Retromer dysfunction at the nexus of tauopathies. Cell Death and Differentiation. PMID 33473181 DOI: 10.1038/s41418-020-00727-2   
2021 Litvinchuk A, Huynh TV, Shi Y, Jackson RJ, Finn MB, Manis M, Francis CM, Tran A, Sullivan PM, Ulrich JD, Hyman BT, Cole T, Holtzman DM. ApoE4 reduction with ASOs decreases neurodegeneration in a tauopathy model. Annals of Neurology. PMID 33550655 DOI: 10.1002/ana.26043   
2021 Zhang G, Wu J, Huang C, Cheng J, Su Z, Zhu Z, Yang X, Guo B, Wu L, Zhang Z, Zhang G, Chen H, Sun Y, Wang Y. The Tetramethylpyrazine Analogue T-006 Alleviates Cognitive Deficits by Inhibition of Tau Expression and Phosphorylation in Transgenic Mice Modeling Alzheimer's Disease. Journal of Molecular Neuroscience : Mn. PMID 33403592 DOI: 10.1007/s12031-020-01762-x   
2021 Chiocchetti R, Hitrec T, Giancola F, Sadeghinezhad J, Squarcio F, Galiazzo G, Piscitiello E, De Silva M, Cerri M, Amici R, Luppi M. Phosphorylated Tau protein in the myenteric plexus of the ileum and colon of normothermic rats and during synthetic torpor. Cell and Tissue Research. PMID 33511469 DOI: 10.1007/s00441-020-03328-0   
2021 Gerrits E, Brouwer N, Kooistra SM, Woodbury ME, Vermeiren Y, Lambourne M, Mulder J, Kummer M, Möller T, Biber K, Dunnen WFAD, De Deyn PP, Eggen BJL, Boddeke EWGM. Distinct amyloid-β and tau-associated microglia profiles in Alzheimer's disease. Acta Neuropathologica. PMID 33609158 DOI: 10.1007/s00401-021-02263-w   
2021 Takaichi Y, Chambers JK, Takahashi K, Soeda Y, Koike R, Katsumata E, Kita C, Matsuda F, Haritani M, Takashima A, Nakayama H, Uchida K. Amyloid β and tau pathology in brains of aged pinniped species (sea lion, seal, and walrus). Acta Neuropathologica Communications. 9: 10. PMID 33413691 DOI: 10.1186/s40478-020-01104-3   
2021 Ulm BS, Borchelt DR, Moore BD. Remodeling Alzheimer-amyloidosis models by seeding. Molecular Neurodegeneration. 16: 8. PMID 33588898 DOI: 10.1186/s13024-021-00429-4   
2021 Ye T, Duan Y, Tsang HWS, Xu H, Chen Y, Cao H, Chen Y, Fu AKY, Ip NY. Efficient manipulation of gene dosage in human iPSCs using CRISPR/Cas9 nickases. Communications Biology. 4: 195. PMID 33580208 DOI: 10.1038/s42003-021-01722-0   
2021 Chen Y, Zhao S, Fan Z, Li Z, Zhu Y, Shen T, Li K, Yan Y, Tian J, Liu Z, Zhang B. Metformin attenuates plaque-associated tau pathology and reduces amyloid-β burden in APP/PS1 mice. Alzheimer's Research & Therapy. 13: 40. PMID 33563332 DOI: 10.1186/s13195-020-00761-9   
2021 de Rus Jacquet A, Denis HL, Cicchetti F, Alpaugh M. Current and future applications of induced pluripotent stem cell-based models to study pathological proteins in neurodegenerative disorders. Molecular Psychiatry. PMID 33495544 DOI: 10.1038/s41380-020-00999-7   
2021 Bengoa-Vergniory N, Velentza-Almpani E, Silva AM, Scott C, Vargas-Caballero M, Sastre M, Wade-Martins R, Alegre-Abarrategui J. Tau-proximity ligation assay reveals extensive previously undetected pathology prior to neurofibrillary tangles in preclinical Alzheimer's disease. Acta Neuropathologica Communications. 9: 18. PMID 33509301 DOI: 10.1186/s40478-020-01117-y   
2021 Giovinazzo D, Bursac B, Sbodio JI, Nalluru S, Vignane T, Snowman AM, Albacarys LM, Sedlak TW, Torregrossa R, Whiteman M, Filipovic MR, Snyder SH, Paul BD. Hydrogen sulfide is neuroprotective in Alzheimer's disease by sulfhydrating GSK3β and inhibiting Tau hyperphosphorylation. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33431651 DOI: 10.1073/pnas.2017225118   
2021 Li S, Yi Y, Cui K, Zhang Y, Chen Y, Han D, Sun L, Zhang X, Chen F, Zhang Y, Yang Y. A Single-Chain Variable Fragment Antibody Inhibits Aggregation of Phosphorylated Tau and Ameliorates Tau Toxicity in vitro and in vivo. Journal of Alzheimer's Disease : Jad. PMID 33459708 DOI: 10.3233/JAD-191266   
2021 Kim S, Kim K, Nho K, Myung W, Won HH. Shared Genetic Background Between Cerebrospinal Fluid Biomarkers and Risk for Alzheimer's Disease: A Two-Sample Mendelian Randomization Study. Journal of Alzheimer's Disease : Jad. PMID 33646147 DOI: 10.3233/JAD-200671   
2021 Matchett BJ, Grinberg LT, Theofilas P, Murray ME. The mechanistic link between selective vulnerability of the locus coeruleus and neurodegeneration in Alzheimer's disease. Acta Neuropathologica. PMID 33427939 DOI: 10.1007/s00401-020-02248-1