Iain Clarke - Publications

Affiliations: 
Monash University, Caulfield East, Victoria, Australia 

132 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Allen-Worthington K, Xie J, Brown JL, Edmunson AM, Dowling A, Navratil AM, Scavelli K, Yoon H, Kim DG, Bynoe MS, Clarke I, Roberson MS. The F0F1 ATP synthase complex localizes to membrane rafts in gonadotrope cells. Molecular Endocrinology (Baltimore, Md.). me20151324. PMID 27482602 DOI: 10.1210/me.2015-1324  0.8
2016 Maiden MJ, Chapman MJ, Torpy DJ, Kuchel TR, Clarke IJ, Nash CH, Fraser JD, Ludbrook GL. Triiodothyronine Administration in a Model of Septic Shock: A Randomized Blinded Placebo-Controlled Trial. Critical Care Medicine. PMID 26963323 DOI: 10.1097/CCM.0000000000001644  0.8
2015 Fraser GL, Hoveyda HR, Clarke IJ, Ramaswamy S, Plant TM, Rose C, Millar RP. The NK3 Receptor Antagonist ESN364 Interrupts Pulsatile LH Secretion and Moderates Levels of Ovarian Hormones Throughout the Menstrual Cycle. Endocrinology. 156: 4214-25. PMID 26305889 DOI: 10.1210/en.2015-1409  0.8
2015 Hetz JA, Menzies BR, Shaw G, Rao A, Clarke IJ, Renfree MB. Growth axis maturation is linked to nutrition, growth and developmental rate. Molecular and Cellular Endocrinology. 411: 38-48. PMID 25896544 DOI: 10.1016/j.mce.2015.04.009  0.8
2015 Ezzat A, Pereira A, Clarke IJ. Kisspeptin is a component of the pulse generator for GnRH secretion in female sheep but not the pulse generator. Endocrinology. 156: 1828-37. PMID 25710282 DOI: 10.1210/en.2014-1756  0.8
2015 Li Q, Millar RP, Clarke IJ, Smith JT. Evidence that Neurokinin B Controls Basal Gonadotropin-Releasing Hormone Secretion but Is Not Critical for Estrogen-Positive Feedback in Sheep. Neuroendocrinology. 101: 161-74. PMID 25677216 DOI: 10.1159/000377702  0.8
2015 Clarke IJ. Hypothalamus as an endocrine organ. Comprehensive Physiology. 5: 217-53. PMID 25589270 DOI: 10.1002/cphy.c140019  0.8
2015 Yau SW, Russo VC, Clarke IJ, Dunshea FR, Werther GA, Sabin MA. IGFBP-2 inhibits adipogenesis and lipogenesis in human visceral, but not subcutaneous, adipocytes. International Journal of Obesity (2005). 39: 770-81. PMID 25370576 DOI: 10.1038/ijo.2014.192  0.8
2015 Hewagalamulage SD, Clarke IJ, Young IR, Rao A, Henry BA. High cortisol response to adrenocorticotrophic hormone identifies ewes with reduced melanocortin signalling and increased propensity to obesity. Journal of Neuroendocrinology. 27: 44-56. PMID 25315658 DOI: 10.1111/jne.12233  0.8
2014 Lee TK, Lee C, Bischof R, Lambert GW, Clarke IJ, Henry BA. Stress-induced behavioral and metabolic adaptations lead to an obesity-prone phenotype in ewes with elevated cortisol responses. Psychoneuroendocrinology. 47: 166-77. PMID 25001966 DOI: 10.1016/j.psyneuen.2014.05.015  0.8
2014 Chauhan SS, Celi P, Leury BJ, Clarke IJ, Dunshea FR. Dietary antioxidants at supranutritional doses improve oxidative status and reduce the negative effects of heat stress in sheep. Journal of Animal Science. 92: 3364-74. PMID 24894002 DOI: 10.2527/jas.2014-7714  0.8
2014 Yau SW, Henry BA, Russo VC, McConell GK, Clarke IJ, Werther GA, Sabin MA. Leptin enhances insulin sensitivity by direct and sympathetic nervous system regulation of muscle IGFBP-2 expression: evidence from nonrodent models. Endocrinology. 155: 2133-43. PMID 24654786 DOI: 10.1210/en.2013-2099  0.8
2014 Soga T, Kitahashi T, Clarke IJ, Parhar IS. Gonadotropin-inhibitory hormone promoter-driven enhanced green fluorescent protein expression decreases during aging in female rats. Endocrinology. 155: 1944-55. PMID 24605826 DOI: 10.1210/en.2013-1786  0.8
2014 Clarke IJ. Interface between metabolic balance and reproduction in ruminants: focus on the hypothalamus and pituitary. Hormones and Behavior. 66: 15-40. PMID 24568750 DOI: 10.1016/j.yhbeh.2014.02.005  0.8
2014 Merry TL, Tran M, Stathopoulos M, Wiede F, Fam BC, Dodd GT, Clarke I, Watt MJ, Andrikopoulos S, Tiganis T. High-fat-fed obese glutathione peroxidase 1-deficient mice exhibit defective insulin secretion but protection from hepatic steatosis and liver damage. Antioxidants & Redox Signaling. 20: 2114-29. PMID 24252128 DOI: 10.1089/ars.2013.5428  0.8
2014 Lee TK, Clarke IJ, St John J, Young IR, Leury BL, Rao A, Andrews ZB, Henry BA. High cortisol responses identify propensity for obesity that is linked to thermogenesis in skeletal muscle. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 28: 35-44. PMID 24022403 DOI: 10.1096/fj.13-238345  0.8
2014 Clarke IJ, Parkington HC. Gonadotropin inhibitory hormone (GnIH) as a regulator of gonadotropes. Molecular and Cellular Endocrinology. 385: 36-44. PMID 23994028 DOI: 10.1016/j.mce.2013.08.017  0.8
2013 Jacobi JS, Coleman HA, Enriori PJ, Parkington HC, Li Q, Pereira A, Cowley MA, Clarke IJ. Paradoxical effect of gonadotrophin-inhibiting hormone to negatively regulate neuropeptide Y neurones in mouse arcuate nucleus. Journal of Neuroendocrinology. 25: 1308-17. PMID 24118324 DOI: 10.1111/jne.12114  0.8
2013 Clarke IJ, Caraty A. Kisspeptin and seasonality of reproduction. Advances in Experimental Medicine and Biology. 784: 411-30. PMID 23550017 DOI: 10.1007/978-1-4614-6199-9_19  0.8
2013 De Bond JA, Li Q, Millar RP, Clarke IJ, Smith JT. Kisspeptin signaling is required for the luteinizing hormone response in anestrous ewes following the introduction of males. Plos One. 8: e57972. PMID 23469121 DOI: 10.1371/journal.pone.0057972  0.8
2013 Oheim R, Beil FT, Köhne T, Wehner T, Barvencik F, Ignatius A, Amling M, Clarke IJ, Pogoda P. Sheep model for osteoporosis: sustainability and biomechanical relevance of low turnover osteoporosis induced by hypothalamic-pituitary disconnection. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 31: 1067-74. PMID 23440966 DOI: 10.1002/jor.22327  0.8
2013 Fraley GS, Coombs E, Gerometta E, Colton S, Sharp PJ, Li Q, Clarke IJ. Distribution and sequence of gonadotropin-inhibitory hormone and its potential role as a molecular link between feeding and reproductive systems in the Pekin duck (Anas platyrhynchos domestica). General and Comparative Endocrinology. 184: 103-10. PMID 23354058 DOI: 10.1016/j.ygcen.2012.11.026  0.8
2013 Clarke SD, Clarke IJ, Rao A, Evans RG, Henry BA. Differential effects of acute and chronic estrogen treatment on thermogenic and metabolic pathways in ovariectomized sheep. Endocrinology. 154: 184-92. PMID 23183185 DOI: 10.1210/en.2012-1758  0.8
2013 Tariq AR, Shahab M, Clarke IJ, Pereira A, Smith JT, Khan SuH, Sultan J, Javed S, Anwar T. Kiss1 and Kiss1 receptor expression in the rhesus monkey testis: A possible local regulator of testicular function Central European Journal of Biology. 8: 968-974. DOI: 10.2478/s11535-013-0219-4  0.8
2013 Dunshea FR, Leury BJ, Fahri F, Digiacomo K, Hung A, Chauhan S, Clarke IJ, Collier R, Little S, Baumgard L, Gaughan JB. Amelioration of thermal stress impacts in dairy cows Animal Production Science. 53: 965-975. DOI: 10.1071/AN12384  0.8
2013 Henry BA, Clarke IJ. Animal Models for Manipulation of Thermogenesis Animal Models For the Study of Human Disease. 305-330. DOI: 10.1016/B978-0-12-415894-8.00014-2  0.8
2013 Li Q, Clarke IJ, Smith AI. Acetylation Handbook of Biologically Active Peptides. 1711-1714. DOI: 10.1016/B978-0-12-385095-9.00234-7  0.8
2012 Adler ES, Hollis JH, Clarke IJ, Grattan DR, Oldfield BJ. Neurochemical characterization and sexual dimorphism of projections from the brain to abdominal and subcutaneous white adipose tissue in the rat. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 15913-21. PMID 23136429 DOI: 10.1523/JNEUROSCI.2591-12.2012  0.8
2012 Clarke SD, Lee K, Andrews ZB, Bischof R, Fahri F, Evans RG, Clarke IJ, Henry BA. Postprandial heat production in skeletal muscle is associated with altered mitochondrial function and altered futile calcium cycling. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 303: R1071-9. PMID 23019214 DOI: 10.1152/ajpregu.00036.2012  0.8
2012 Smith JT, Young IR, Veldhuis JD, Clarke IJ. Gonadotropin-inhibitory hormone (GnIH) secretion into the ovine hypophyseal portal system. Endocrinology. 153: 3368-75. PMID 22549225 DOI: 10.1210/en.2012-1088  0.8
2012 Oheim R, Beil FT, Barvencik F, Egermann M, Amling M, Clarke IJ, Pogoda P. Targeting the lateral but not the third ventricle induces bone loss in ewe: an experimental approach to generate an improved large animal model of osteoporosis. The Journal of Trauma and Acute Care Surgery. 72: 720-6. PMID 22491560 DOI: 10.1097/TA.0b013e318238b3bd  0.8
2012 Li Q, Roa A, Clarke IJ, Smith JT. Seasonal variation in the gonadotropin-releasing hormone response to kisspeptin in sheep: possible kisspeptin regulation of the kisspeptin receptor. Neuroendocrinology. 96: 212-21. PMID 22343304 DOI: 10.1159/000335998  0.8
2012 Clarke IJ, Smith JT, Henry BA, Oldfield BJ, Stefanidis A, Millar RP, Sari IP, Chng K, Fabre-Nys C, Caraty A, Ang BT, Chan L, Fraley GS. Gonadotropin-inhibitory hormone is a hypothalamic peptide that provides a molecular switch between reproduction and feeding. Neuroendocrinology. 95: 305-16. PMID 22286004 DOI: 10.1159/000332822  0.8
2012 Beil FT, Oheim R, Barvencik F, Hissnauer TN, Pestka JM, Ignatius A, Rueger JM, Schinke T, Clarke IJ, Amling M, Pogoda P. Low turnover osteoporosis in sheep induced by hypothalamic-pituitary disconnection. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 30: 1254-62. PMID 22234948 DOI: 10.1002/jor.22066  0.8
2012 Clarke SD, Clarke IJ, Rao A, Cowley MA, Henry BA. Sex differences in the metabolic effects of testosterone in sheep. Endocrinology. 153: 123-31. PMID 22128020 DOI: 10.1210/en.2011-1634  0.8
2012 Clarke IJ, Campbell R, Smith JT, Prevot V, Wray S. Neuroendocrine control of reproduction Handbook of Neuroendocrinology. 197-235. DOI: 10.1016/B978-0-12-375097-6.10009-5  0.8
2012 McKinley MJ, Clarke IJ, Oldfield BJ. Circumventricular Organs The Human Nervous System. 594-617. DOI: 10.1016/B978-0-12-374236-0.10018-5  0.8
2011 Pedersen JS, Clarke I, Mills J. Improved detection of mycobacteria species in formalin-fixed tissue sections. Histopathology. 59: 993-1005. PMID 22092411 DOI: 10.1111/j.1365-2559.2011.04015.x  0.8
2011 Keenan DM, Clarke IJ, Veldhuis JD. Noninvasive analytical estimation of endogenous GnRH drive: analysis using graded competitive GnRH-receptor antagonism and a calibrating pulse of exogenous GnRH. Endocrinology. 152: 4882-93. PMID 22028450 DOI: 10.1210/en.2011-1461  0.8
2011 Li Q, Rao A, Pereira A, Clarke IJ, Smith JT. Kisspeptin cells in the ovine arcuate nucleus express prolactin receptor but not melatonin receptor. Journal of Neuroendocrinology. 23: 871-82. PMID 21793946 DOI: 10.1111/j.1365-2826.2011.02195.x  0.8
2011 Szymanski LA, Schneider JE, Satragno A, Dunshea FR, Clarke IJ. Mesenteric infusion of a volatile fatty acid prevents body weight loss and transiently restores luteinising hormone pulse frequency in ovariectomised, food-restricted ewes. Journal of Neuroendocrinology. 23: 699-710. PMID 21668532 DOI: 10.1111/j.1365-2826.2011.02173.x  0.8
2011 Henry BA, Andrews ZB, Rao A, Clarke IJ. Central leptin activates mitochondrial function and increases heat production in skeletal muscle. Endocrinology. 152: 2609-18. PMID 21558317 DOI: 10.1210/en.2011-0143  0.8
2011 Sabin MA, Yau SW, Russo VC, Clarke IJ, Dunshea FR, Chau J, Cox M, Werther GA. Dietary monounsaturated fat in early life regulates IGFBP2: implications for fat mass accretion and insulin sensitivity. Obesity (Silver Spring, Md.). 19: 2374-81. PMID 21436793 DOI: 10.1038/oby.2011.55  0.8
2011 Smith JT, Li Q, Yap KS, Shahab M, Roseweir AK, Millar RP, Clarke IJ. Kisspeptin is essential for the full preovulatory LH surge and stimulates GnRH release from the isolated ovine median eminence. Endocrinology. 152: 1001-12. PMID 21239443 DOI: 10.1210/en.2010-1225  0.8
2011 Clarke IJ. Control of GnRH secretion: one step back. Frontiers in Neuroendocrinology. 32: 367-75. PMID 21216259 DOI: 10.1016/j.yfrne.2011.01.001  0.8
2011 Laker RC, Henry BA, Wadley GD, Clarke IJ, Canny BJ, McConell GK. Central infusion of leptin does not increase AMPK signaling in skeletal muscle of sheep. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 300: R511-8. PMID 21148475 DOI: 10.1152/ajpregu.00079.2010  0.8
2011 Papargiris MM, Rivalland ET, Clarke IJ, Smith JT, Pereira A, Tilbrook AJ. Evidence that RF-amide related peptide-3 is not a mediator of the inhibitory effects of psychosocial stress on gonadotrophin secretion in ovariectomised ewes. Journal of Neuroendocrinology. 23: 208-15. PMID 21073555 DOI: 10.1111/j.1365-2826.2010.02094.x  0.8
2010 Clarke IJ, Smith JT. The role of kisspeptin and gonadotropin inhibitory hormone (GnIH) in the seasonality of reproduction in sheep. Society of Reproduction and Fertility Supplement. 67: 159-69. PMID 21755670  0.8
2010 Turner AI, Rivalland ET, Clarke IJ, Tilbrook AJ. Stressor specificity of sex differences in hypothalamo-pituitary-adrenal axis activity: cortisol responses to exercise, endotoxin, wetting, and isolation/restraint stress in gonadectomized male and female sheep. Endocrinology. 151: 4324-31. PMID 20668025 DOI: 10.1210/en.2010-0234  0.8
2010 Smith JT, Shahab M, Pereira A, Pau KY, Clarke IJ. Hypothalamic expression of KISS1 and gonadotropin inhibitory hormone genes during the menstrual cycle of a non-human primate. Biology of Reproduction. 83: 568-77. PMID 20574054 DOI: 10.1095/biolreprod.110.085407  0.8
2010 Henry BA, Blache D, Rao A, Clarke IJ, Maloney SK. Disparate effects of feeding on core body and adipose tissue temperatures in animals selectively bred for Nervous or Calm temperament. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 299: R907-17. PMID 20573991 DOI: 10.1152/ajpregu.00809.2009  0.8
2010 Tschöp J, Nogueiras R, Haas-Lockie S, Kasten KR, Castañeda TR, Huber N, Guanciale K, Perez-Tilve D, Habegger K, Ottaway N, Woods SC, Oldfield B, Clarke I, Chua S, Farooqi IS, et al. CNS leptin action modulates immune response and survival in sepsis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 6036-47. PMID 20427662 DOI: 10.1523/JNEUROSCI.4875-09.2010  0.8
2010 Soga T, Wong DW, Clarke IJ, Parhar IS. Citalopram (antidepressant) administration causes sexual dysfunction in male mice through RF-amide related peptide in the dorsomedial hypothalamus. Neuropharmacology. 59: 77-85. PMID 20381503 DOI: 10.1016/j.neuropharm.2010.03.018  0.8
2010 Qi Y, Henry BA, Oldfield BJ, Clarke IJ. The action of leptin on appetite-regulating cells in the ovine hypothalamus: demonstration of direct action in the absence of the arcuate nucleus. Endocrinology. 151: 2106-16. PMID 20308532 DOI: 10.1210/en.2009-1283  0.8
2010 Smith JT, Clarke IJ. Seasonal breeding as a neuroendocrine model for puberty in sheep. Molecular and Cellular Endocrinology. 324: 102-9. PMID 20298744 DOI: 10.1016/j.mce.2010.03.007  0.8
2010 Backholer K, Smith JT, Rao A, Pereira A, Iqbal J, Ogawa S, Li Q, Clarke IJ. Kisspeptin cells in the ewe brain respond to leptin and communicate with neuropeptide Y and proopiomelanocortin cells. Endocrinology. 151: 2233-43. PMID 20207832 DOI: 10.1210/en.2009-1190  0.8
2010 Clarke IJ. Whatever way weight goes, inflammation shows. Endocrinology. 151: 846-8. PMID 20172971 DOI: 10.1210/en.2009-1470  0.8
2010 Smith JT, Clarke IJ. Gonadotropin inhibitory hormone function in mammals. Trends in Endocrinology and Metabolism: Tem. 21: 255-60. PMID 20060314 DOI: 10.1016/j.tem.2009.11.010  0.8
2010 Anukulkitch C, Rao A, Pereira A, McEwan J, Clarke IJ. Expression of genes for appetite-regulating peptides in the hypothalamus of genetically selected lean and fat sheep. Neuroendocrinology. 91: 223-38. PMID 19940452 DOI: 10.1159/000262283  0.8
2010 Backholer K, Bowden M, Gamber K, Bjørbaek C, Iqbal J, Clarke IJ. Melanocortins mimic the effects of leptin to restore reproductive function in lean hypogonadotropic ewes. Neuroendocrinology. 91: 27-40. PMID 19923792 DOI: 10.1159/000260060  0.8
2010 Pereira A, Rawson J, Jakubowska A, Clarke IJ. Estradiol-17beta-responsive A1 and A2 noradrenergic cells of the brain stem project to the bed nucleus of the stria terminalis in the ewe brain: a possible route for regulation of gonadotropin releasing hormone cells. Neuroscience. 165: 758-73. PMID 19857554 DOI: 10.1016/j.neuroscience.2009.10.027  0.8
2010 Henry BA, Blache D, Dunshea FR, Clarke IJ. Altered "set-point" of the hypothalamus determines effects of cortisol on food intake, adiposity, and metabolic substrates in sheep. Domestic Animal Endocrinology. 38: 46-56. PMID 19733031 DOI: 10.1016/j.domaniend.2009.07.006  0.8
2010 Clarke IJ, Henry BA. Targeting energy expenditure in muscle as a means of combating obesity. Clinical and Experimental Pharmacology & Physiology. 37: 121-4. PMID 19650796 DOI: 10.1111/j.1440-1681.2009.05259.x  0.8
2010 Henry BA, Clarke IJ. Food Intake and Stress, Non-Human Encyclopedia of Stress. 82-87. DOI: 10.1016/B978-012373947-6.00165-3  0.8
2010 Clarke IJ, Tilbrook AJ. Gonadotropin, Neural and Hormonal Control Encyclopedia of Neuroscience. 959-965. DOI: 10.1016/B978-008045046-9.01165-7  0.8
2009 Backholer K, Smith J, Clarke IJ. Melanocortins may stimulate reproduction by activating orexin neurons in the dorsomedial hypothalamus and kisspeptin neurons in the preoptic area of the ewe. Endocrinology. 150: 5488-97. PMID 19819961 DOI: 10.1210/en.2009-0604  0.8
2009 Smith JT, Li Q, Pereira A, Clarke IJ. Kisspeptin neurons in the ovine arcuate nucleus and preoptic area are involved in the preovulatory luteinizing hormone surge. Endocrinology. 150: 5530-8. PMID 19819940 DOI: 10.1210/en.2009-0712  0.8
2009 Sari IP, Rao A, Smith JT, Tilbrook AJ, Clarke IJ. Effect of RF-amide-related peptide-3 on luteinizing hormone and follicle-stimulating hormone synthesis and secretion in ovine pituitary gonadotropes. Endocrinology. 150: 5549-56. PMID 19808777 DOI: 10.1210/en.2009-0775  0.8
2009 Smith JT, Saleh SN, Clarke IJ. Seasonal and cyclical change in the luteinizing hormone response to kisspeptin in the ewe. Neuroendocrinology. 90: 283-91. PMID 19590160 DOI: 10.1159/000227806  0.8
2009 Qi Y, Oldfield BJ, Clarke IJ. Projections of RFamide-related peptide-3 neurones in the ovine hypothalamus, with special reference to regions regulating energy balance and reproduction. Journal of Neuroendocrinology. 21: 690-7. PMID 19500220 DOI: 10.1111/j.1365-2826.2009.01886.x  0.8
2009 Qi Y, Namavar MR, Iqbal J, Oldfield BJ, Clarke IJ. Characterization of the projections to the hypothalamic paraventricular and periventricular nuclei in the female sheep brain, using retrograde tracing and immunohistochemistry. Neuroendocrinology. 90: 31-53. PMID 19478473 DOI: 10.1159/000221304  0.8
2009 Iqbal J, Latchoumanin O, Sari IP, Lang RJ, Coleman HA, Parkington HC, Clarke IJ. Estradiol-17beta inhibits gonadotropin-releasing hormone-induced Ca2+ in gonadotropes to regulate negative feedback on luteinizing hormone release. Endocrinology. 150: 4213-20. PMID 19477939 DOI: 10.1210/en.2009-0092  0.8
2009 Clarke IJ, Qi Y, Puspita Sari I, Smith JT. Evidence that RF-amide related peptides are inhibitors of reproduction in mammals. Frontiers in Neuroendocrinology. 30: 371-8. PMID 19362107 DOI: 10.1016/j.yfrne.2009.04.001  0.8
2009 Roseweir AK, Kauffman AS, Smith JT, Guerriero KA, Morgan K, Pielecka-Fortuna J, Pineda R, Gottsch ML, Tena-Sempere M, Moenter SM, Terasawa E, Clarke IJ, Steiner RA, Millar RP. Discovery of potent kisspeptin antagonists delineate physiological mechanisms of gonadotropin regulation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 3920-9. PMID 19321788 DOI: 10.1523/JNEUROSCI.5740-08.2009  0.8
2009 Pierce BN, Clarke IJ, Turner AI, Rivalland ET, Tilbrook AJ. Cortisol disrupts the ability of estradiol-17beta to induce the LH surge in ovariectomized ewes. Domestic Animal Endocrinology. 36: 202-8. PMID 19185443 DOI: 10.1016/j.domaniend.2008.11.003  0.8
2009 Anukulkitch C, Rao A, Dunshea FR, Clarke IJ. A test of the lipostat theory in a seasonal (ovine) model under natural conditions reveals a close relationship between adiposity and melanin concentrating hormone expression. Domestic Animal Endocrinology. 36: 138-51. PMID 19179037 DOI: 10.1016/j.domaniend.2008.12.002  0.8
2009 Haylor JL, Parker E, Risbridger GP, Beale D, Brown BL, Dobson PR, Clarke IJ, Hart JE. Inhibition of compensatory renal growth by the N-terminus of a sheep-derived peptide. Regulatory Peptides. 152: 48-53. PMID 19028530 DOI: 10.1016/j.regpep.2008.10.011  0.8
2009 Clarke IJ, Smith JT, Caraty A, Goodman RL, Lehman MN. Kisspeptin and seasonality in sheep. Peptides. 30: 154-63. PMID 18838092 DOI: 10.1016/j.peptides.2008.08.022  0.8
2009 Oakley AE, Breen KM, Clarke IJ, Karsch FJ, Wagenmaker ER, Tilbrook AJ. Cortisol reduces gonadotropin-releasing hormone pulse frequency in follicular phase ewes: influence of ovarian steroids. Endocrinology. 150: 341-9. PMID 18801903 DOI: 10.1210/en.2008-0587  0.8
2009 Pierce BN, Stackpole CA, Breen KM, Clarke IJ, Karsch FJ, Rivalland ET, Turner AI, Caddy DJ, Wagenmaker ER, Oakley AE, Tilbrook AJ. Estradiol enables cortisol to act directly upon the pituitary to suppress pituitary responsiveness to GnRH in sheep. Neuroendocrinology. 89: 86-97. PMID 18714145 DOI: 10.1159/000151543  0.8
2008 Clarke IJ, Sari IP, Qi Y, Smith JT, Parkington HC, Ubuka T, Iqbal J, Li Q, Tilbrook A, Morgan K, Pawson AJ, Tsutsui K, Millar RP, Bentley GE. Potent action of RFamide-related peptide-3 on pituitary gonadotropes indicative of a hypophysiotropic role in the negative regulation of gonadotropin secretion. Endocrinology. 149: 5811-21. PMID 18617613 DOI: 10.1210/en.2008-0575  0.8
2008 Smith JT, Coolen LM, Kriegsfeld LJ, Sari IP, Jaafarzadehshirazi MR, Maltby M, Bateman K, Goodman RL, Tilbrook AJ, Ubuka T, Bentley GE, Clarke IJ, Lehman MN. Variation in kisspeptin and RFamide-related peptide (RFRP) expression and terminal connections to gonadotropin-releasing hormone neurons in the brain: a novel medium for seasonal breeding in the sheep. Endocrinology. 149: 5770-82. PMID 18617612 DOI: 10.1210/en.2008-0581  0.8
2008 Henry BA, Clarke IJ. Adipose tissue hormones and the regulation of food intake. Journal of Neuroendocrinology. 20: 842-9. PMID 18601708 DOI: 10.1111/j.1365-2826.2008.1730.x  0.8
2008 Pierce BN, Hemsworth PH, Rivalland ET, Wagenmaker ER, Morrissey AD, Papargiris MM, Clarke IJ, Karsch FJ, Turner AI, Tilbrook AJ. Psychosocial stress suppresses attractivity, proceptivity and pulsatile LH secretion in the ewe. Hormones and Behavior. 54: 424-34. PMID 18519136 DOI: 10.1016/j.yhbeh.2008.04.005  0.8
2008 Scott CJ, Clarke IJ, Tilbrook AJ. The effect of testosterone and season on prodynorphin messenger RNA expression in the preoptic area-hypothalamus of the ram. Domestic Animal Endocrinology. 34: 440-50. PMID 18308503 DOI: 10.1016/j.domaniend.2008.01.001  0.8
2008 Tilbrook AJ, Rivalland EA, Turner AI, Lambert GW, Clarke IJ. Responses of the hypothalamopituitary adrenal axis and the sympathoadrenal system to isolation/restraint stress in sheep of different adiposity. Neuroendocrinology. 87: 193-205. PMID 18285679 DOI: 10.1159/000117576  0.8
2008 Clarke IJ. Models of 'obesity' in large animals and birds. Frontiers of Hormone Research. 36: 107-17. PMID 18230898 DOI: 10.1159/0000115359  0.8
2008 Henry BA, Dunshea FR, Gould M, Clarke IJ. Profiling postprandial thermogenesis in muscle and fat of sheep and the central effect of leptin administration. Endocrinology. 149: 2019-26. PMID 18162524 DOI: 10.1210/en.2007-1311  0.8
2008 Smith JT, Rao A, Pereira A, Caraty A, Millar RP, Clarke IJ. Kisspeptin is present in ovine hypophysial portal blood but does not increase during the preovulatory luteinizing hormone surge: evidence that gonadotropes are not direct targets of kisspeptin in vivo. Endocrinology. 149: 1951-9. PMID 18162520 DOI: 10.1210/en.2007-1425  0.8
2008 Qi Y, Iqbal J, Oldfield BJ, Clarke IJ. Neural connectivity in the mediobasal hypothalamus of the sheep brain. Neuroendocrinology. 87: 91-112. PMID 17938564 DOI: 10.1159/000109944  0.8
2008 Wagner GC, Johnston JD, Clarke IJ, Lincoln GA, Hazlerigg DG. Redefining the limits of day length responsiveness in a seasonal mammal. Endocrinology. 149: 32-9. PMID 17901234 DOI: 10.1210/en.2007-0658  0.8
2007 Goodman RL, Lehman MN, Smith JT, Coolen LM, de Oliveira CV, Jafarzadehshirazi MR, Pereira A, Iqbal J, Caraty A, Ciofi P, Clarke IJ. Kisspeptin neurons in the arcuate nucleus of the ewe express both dynorphin A and neurokinin B. Endocrinology. 148: 5752-60. PMID 17823266 DOI: 10.1210/en.2007-0961  0.8
2007 Iqbal J, Latchoumanin O, Clarke IJ. Rapid in vivo effects of estradiol-17beta in ovine pituitary gonadotropes are displayed by phosphorylation of extracellularly regulated kinase, serine/threonine kinase, and 3',5'-cyclic adenosine 5'-monophosphate-responsive element-binding protein. Endocrinology. 148: 5794-802. PMID 17823264 DOI: 10.1210/en.2007-0986  0.8
2007 Caraty A, Smith JT, Lomet D, Ben Saïd S, Morrissey A, Cognie J, Doughton B, Baril G, Briant C, Clarke IJ. Kisspeptin synchronizes preovulatory surges in cyclical ewes and causes ovulation in seasonally acyclic ewes. Endocrinology. 148: 5258-67. PMID 17702853 DOI: 10.1210/en.2007-0554  0.8
2007 Szymanski LA, Schneider JE, Friedman MI, Ji H, Kurose Y, Blache D, Rao A, Dunshea FR, Clarke IJ. Changes in insulin, glucose and ketone bodies, but not leptin or body fat content precede restoration of luteinising hormone secretion in ewes. Journal of Neuroendocrinology. 19: 449-60. PMID 17504439 DOI: 10.1111/j.1365-2826.2007.01551.x  0.8
2007 Smith JT, Clarke IJ. Kisspeptin expression in the brain: catalyst for the initiation of puberty. Reviews in Endocrine & Metabolic Disorders. 8: 1-9. PMID 17334929 DOI: 10.1007/s11154-007-9026-4  0.8
2007 Rivalland ET, Clarke IJ, Turner AI, Pompolo S, Tilbrook AJ. Isolation and restraint stress results in differential activation of corticotrophin-releasing hormone and arginine vasopressin neurons in sheep. Neuroscience. 145: 1048-58. PMID 17289277 DOI: 10.1016/j.neuroscience.2006.12.045  0.8
2007 Smith JT, Clay CM, Caraty A, Clarke IJ. KiSS-1 messenger ribonucleic acid expression in the hypothalamus of the ewe is regulated by sex steroids and season. Endocrinology. 148: 1150-7. PMID 17185374 DOI: 10.1210/en.2006-1435  0.8
2007 Anukulkitch C, Rao A, Dunshea FR, Blache D, Lincoln GA, Clarke IJ. Influence of photoperiod and gonadal status on food intake, adiposity, and gene expression of hypothalamic appetite regulators in a seasonal mammal. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 292: R242-52. PMID 16917018 DOI: 10.1152/ajpregu.00417.2006  0.8
2006 Lincoln GA, Clarke IJ, Hut RA, Hazlerigg DG. Characterizing a mammalian circannual pacemaker. Science (New York, N.Y.). 314: 1941-4. PMID 17185605 DOI: 10.1126/science.1132009  0.8
2006 Rivalland ET, Tilbrook AJ, Turner AI, Iqbal J, Pompolo S, Clarke IJ. Projections to the preoptic area from the paraventricular nucleus, arcuate nucleus and the bed nucleus of the stria terminalis are unlikely to be involved in stress-induced suppression of GnRH secretion in sheep. Neuroendocrinology. 84: 1-13. PMID 17047317 DOI: 10.1159/000096372  0.8
2006 Estrada KM, Clay CM, Pompolo S, Smith JT, Clarke IJ. Elevated KiSS-1 expression in the arcuate nucleus prior to the cyclic preovulatory gonadotrophin-releasing hormone/lutenising hormone surge in the ewe suggests a stimulatory role for kisspeptin in oestrogen-positive feedback. Journal of Neuroendocrinology. 18: 806-9. PMID 16965299 DOI: 10.1111/j.1365-2826.2006.01485.x  0.8
2006 Stackpole CA, Clarke IJ, Breen KM, Turner AI, Karsch FJ, Tilbrook AJ. Sex difference in the suppressive effect of cortisol on pulsatile secretion of luteinizing hormone in sheep. Endocrinology. 147: 5921-31. PMID 16959831 DOI: 10.1210/en.2006-0667  0.8
2006 Clarke IJ, Scott CJ, Pereira A, Pompolo S. The role of noradrenaline in the generation of the preovulatory LH surge in the ewe. Domestic Animal Endocrinology. 30: 260-75. PMID 16139986 DOI: 10.1016/j.domaniend.2005.07.006  0.8
2005 Dufourny L, Caraty A, Clarke IJ, Robinson JE, Skinner DC. Progesterone-receptive dopaminergic and neuropeptide Y neurons project from the arcuate nucleus to gonadotropin-releasing hormone-rich regions of the ovine preoptic area. Neuroendocrinology. 82: 21-31. PMID 16330883 DOI: 10.1159/000090122  0.8
2005 Dufourny L, Caraty A, Clarke IJ, Robinson JE, Skinner DC. Progesterone-receptive beta-endorphin and dynorphin B neurons in the arcuate nucleus project to regions of high gonadotropin-releasing hormone neuron density in the ovine preoptic area. Neuroendocrinology. 81: 139-49. PMID 15976512 DOI: 10.1159/000086527  0.8
2005 Anderson ST, Kusters DH, Clarke IJ, Pow DV, Curlewis JD. Expression of pituitary adenylate cyclase activating polypeptide type 1 receptor (PAC1R) in the ewe hypothalamus: distribution and colocalization with tyrosine hydroxylase-immunoreactive neurones. Journal of Neuroendocrinology. 17: 298-305. PMID 15869565 DOI: 10.1111/j.1365-2826.2005.01305.x  0.8
2004 Scott CJ, Clarke IJ, Rao A, Tilbrook AJ. Sex differences in the distribution and abundance of androgen receptor mRNA-containing cells in the preoptic area and hypothalamus of the ram and ewe. Journal of Neuroendocrinology. 16: 956-63. PMID 15667450 DOI: 10.1111/j.1365-2826.2005.01261.x  0.8
2004 Keenan DM, Alexander S, Irvine CH, Clarke I, Scott C, Turner A, Tilbrook AJ, Canny BJ, Veldhuis JD. Reconstruction of in vivo time-evolving neuroendocrine dose-response properties unveils admixed deterministic and stochastic elements. Proceedings of the National Academy of Sciences of the United States of America. 101: 6740-5. PMID 15090645 DOI: 10.1073/pnas.0300619101  0.8
2004 Henry BA, Goding JW, Tilbrook AJ, Dunshea FR, Blache D, Clarke IJ. Leptin-mediated effects of undernutrition or fasting on luteinizing hormone and growth hormone secretion in ovariectomized ewes depend on the duration of metabolic perturbation. Journal of Neuroendocrinology. 16: 244-55. PMID 15049855 DOI: 10.1111/j.0953-8194.2004.01157.x  0.8
2004 Breen KM, Stackpole CA, Clarke IJ, Pytiak AV, Tilbrook AJ, Wagenmaker ER, Young EA, Karsch FJ. Does the type II glucocorticoid receptor mediate cortisol-induced suppression in pituitary responsiveness to gonadotropin-releasing hormone? Endocrinology. 145: 2739-46. PMID 15033919 DOI: 10.1210/en.2004-0123  0.8
2003 Scott CJ, Mariani M, Clarke IJ, Tilbrook AJ. Effect of testosterone and season on proenkephalin messenger RNA expression in the preoptic area of the hypothalamus in the ram. Biology of Reproduction. 69: 2015-21. PMID 12930728 DOI: 10.1095/biolreprod.103.016956  0.8
2003 Pompolo S, Pereira A, Scott CJ, Fujiyma F, Clarke IJ. Evidence for estrogenic regulation of gonadotropin-releasing hormone neurons by glutamatergic neurons in the ewe brain: An immunohistochemical study using an antibody against vesicular glutamate transporter-2. The Journal of Comparative Neurology. 465: 136-44. PMID 12926021 DOI: 10.1002/cne.10805  0.8
2003 Lincoln GA, Andersson H, Clarke IJ. Prolactin cycles in sheep under constant photoperiod: evidence that photorefractoriness develops within the pituitary gland independently of the prolactin output signal. Biology of Reproduction. 69: 1416-23. PMID 12826582 DOI: 10.1095/biolreprod.103.017673  0.8
2003 Scott CJ, Clarke IJ, Tilbrook AJ. Neuronal inputs from the hypothalamus and brain stem to the medial preoptic area of the ram: neurochemical correlates and comparison to the ewe. Biology of Reproduction. 68: 1119-33. PMID 12606458 DOI: 10.1095/biolreprod.102.010595  0.8
2003 Clarke IJ, Rao A, Chilliard Y, Delavaud C, Lincoln GA. Photoperiod effects on gene expression for hypothalamic appetite-regulating peptides and food intake in the ram. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 284: R101-15. PMID 12388437 DOI: 10.1152/ajpregu.00424.2002  0.8
2002 Gatford KL, Clarke IJ, De Blasio MJ, McMillen IC, J S Robinson, Owens JA. Perinatal growth and plasma GH profiles in adolescent and adult sheep. The Journal of Endocrinology. 173: 151-9. PMID 11927394 DOI: 10.1677/joe.0.1730151  0.8
2002 Turner AI, Canny BJ, Hobbs RJ, Bond JD, Clarke IJ, Tilbrook AJ. Influence of sex and gonadal status of sheep on cortisol secretion in response to ACTH and on cortisol and LH secretion in response to stress: importance of different stressors. The Journal of Endocrinology. 173: 113-22. PMID 11927390 DOI: 10.1677/joe.0.1730113  0.8
2002 Lincoln GA, Clarke IJ. Noradrenaline and dopamine regulation of prolactin secretion in sheep: role in prolactin homeostasis but not photoperiodism. Journal of Neuroendocrinology. 14: 36-44. PMID 11903811 DOI: 10.1046/j.0007-1331.2001.00734.x  0.8
2002 Pompolo S, Scott CJ, Clarke IJ. Selective regulation of glutamic decarboxylase isoform 65, but not isoform 67, in the bed nucleus of the stria terminalis and the preoptic area of the ewe brain across the estrous cycle. Endocrinology. 143: 544-50. PMID 11796509 DOI: 10.1210/endo.143.2.8610  0.8
2001 Clarke IJ, Pompolo S, Scott CJ, Rawson JA, Caddy D, Jakubowska AE, Pereira AM. Cells of the arcuate nucleus and ventromedial nucleus of the ovariectomized ewe that respond to oestrogen: a study using Fos immunohistochemistry. Journal of Neuroendocrinology. 13: 934-41. PMID 11737551 DOI: 10.1046/j.1365-2826.2001.00694.x  0.8
2001 Pompolo S, Rawson JA, Clarke IJ. Projections from the arcuate/ventromedial region of the hypothalamus to the preoptic area and bed nucleus of stria terminalis in the brain of the ewe; lack of direct input to gonadotropin-releasing hormone neurons. Brain Research. 904: 1-12. PMID 11516406 DOI: 10.1016/S0006-8993(01)02372-1  0.8
2001 Lincoln GA, Rhind SM, Pompolo S, Clarke IJ. Hypothalamic control of photoperiod-induced cycles in food intake, body weight, and metabolic hormones in rams. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 281: R76-90. PMID 11404281  0.8
2001 Clarke IJ, Tilbrook AJ, Turner AI, Doughton BW, Goding JW. Sex, fat and the tilt of the earth: effects of sex and season on the feeding response to centrally administered leptin in sheep. Endocrinology. 142: 2725-8. PMID 11356725 DOI: 10.1210/endo.142.6.8318  0.44
2001 Scott CJ, Pereira AM, Tilbrook AJ, Rawson JA, Clarke IJ. Changes in preoptic and hypothalamic levels of progesterone receptor mRNA across the oestrous cycle of the ewe. Journal of Neuroendocrinology. 13: 401-6. PMID 11328448 DOI: 10.1046/j.1365-2826.2001.00641.x  0.8
2001 Turner AI, Tilbrook AJ, Clarke IJ, Scott CJ. Progesterone and testosterone in combination act in the hypothalamus of castrated rams to regulate the secretion of LH. The Journal of Endocrinology. 169: 291-8. PMID 11312146 DOI: 10.1677/joe.0.1690291  0.8
2001 Anderson ST, Walsh JP, Tillet Y, Clarke IJ, Curlewis JD. Dopaminergic input to the ventromedial hypothalamus facilitates the oestrogen-induced luteinizing hormone surge in ewes. Neuroendocrinology. 73: 91-101. PMID 11244296 DOI: 10.1159/000054625  0.8
2001 Rawson JA, Scott CJ, Pereira A, Jakubowska A, Clarke IJ. Noradrenergic projections from the A1 field to the preoptic area in the brain of the ewe and Fos responses to oestrogen in the A1 cells. Journal of Neuroendocrinology. 13: 129-38. PMID 11168838 DOI: 10.1046/j.1365-2826.2001.00588.x  0.8
2001 Henry BA, Goding JW, Tilbrook AJ, Dunshea FR, Clarke IJ. Intracerebroventricular infusion of leptin elevates the secretion of luteinising hormone without affecting food intake in long-term food-restricted sheep, but increases growth hormone irrespective of bodyweight. The Journal of Endocrinology. 168: 67-77. PMID 11139771  0.8
2000 Tast A, Love RJ, Clarke IJ, Evans G. Effects of active and passive gonadotrophin-releasing hormone immunization on recognition and establishment of pregnancy in pigs. Reproduction, Fertility, and Development. 12: 277-82. PMID 11451018  0.8
1986 Clarke IJ, Burman KJ, Doughton BW, Cummins JT. Effects of constant infusion of gonadotrophin-releasing hormone in ovariectomized ewes with hypothalamo-pituitary disconnection: further evidence for differential control of LH and FSH secretion and the lack of a priming effect. The Journal of Endocrinology. 111: 43-9. PMID 3097234  0.8
1984 Clarke IJ, Cummins JT, Findlay JK, Burman KJ, Doughton BW. Effects on plasma luteinizing hormone and follicle-stimulating hormone of varying the frequency and amplitude of gonadotropin-releasing hormone pulses in ovariectomized ewes with hypothalamo-pituitary disconnection. Neuroendocrinology. 39: 214-21. PMID 6438544  0.8
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