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Watson James Lees - Publications

Affiliations: 
1996-2003 Chemistry Syracuse University, Syracuse, NY, United States 
 2003- Chemistry and Biochemistry Florida International University, Miami, FL, United States 
Area:
protein folding
Website:
http://chemistry.fiu.edu/faculty/watson-lees/
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44 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2014 Lothrop AP, Snider GW, Ruggles EL, Patel AS, Lees WJ, Hondal RJ. Selenium as an electron acceptor during the catalytic mechanism of thioredoxin reductase. Biochemistry. 53: 654-63. PMID 24422500 DOI: 10.1021/Bi400658G  0.585
2012 Patel AS, Lees WJ. Oxidative folding of lysozyme with aromatic dithiols, and aliphatic and aromatic monothiols. Bioorganic & Medicinal Chemistry. 20: 1020-8. PMID 22197395 DOI: 10.1016/J.Bmc.2011.11.049  0.556
2009 Chen X, Islamova NI, Garcia SP, DiGirolamo JA, Lees WJ. Synthesis and optical properties of aqueous soluble indolylfulgimides. The Journal of Organic Chemistry. 74: 6777-83. PMID 19642626 DOI: 10.1021/Jo900909D  0.334
2009 Madar DJ, Patel AS, Lees WJ. Comparison of the oxidative folding of lysozyme at a high protein concentration using aromatic thiols versus glutathione. Journal of Biotechnology. 142: 214-9. PMID 19477205 DOI: 10.1016/J.Jbiotec.2009.05.003  0.55
2008 Kibria FM, Lees WJ. Balancing conformational and oxidative kinetic traps during the folding of bovine pancreatic trypsin inhibitor (BPTI) with glutathione and glutathione disulfide. Journal of the American Chemical Society. 130: 796-7. PMID 18166059 DOI: 10.1021/Ja077468N  0.368
2006 Gough JD, Barrett EJ, Silva Y, Lees WJ. ortho- and meta-substituted aromatic thiols are efficient redox buffers that increase the folding rate of a disulfide-containing protein. Journal of Biotechnology. 125: 39-47. PMID 16616966 DOI: 10.1016/j.jbiotec.2006.02.007  0.733
2005 Gough JD, Lees WJ. Increased catalytic activity of protein disulfide isomerase using aromatic thiol based redox buffers. Bioorganic & Medicinal Chemistry Letters. 15: 777-81. PMID 15664856 DOI: 10.1016/j.bmcl.2004.11.005  0.72
2005 Gough JD, Lees WJ. Effects of redox buffer properties on the folding of a disulfide-containing protein: dependence upon pH, thiol pKa, and thiol concentration. Journal of Biotechnology. 115: 279-90. PMID 15639090 DOI: 10.1016/j.jbiotec.2004.09.005  0.704
2003 Gough JD, Gargano JM, Donofrio AE, Lees WJ. Aromatic thiol pKa effects on the folding rate of a disulfide containing protein. Biochemistry. 42: 11787-97. PMID 14529290 DOI: 10.1021/Bi034305C  0.739
2003 Wolak MA, Gillespie NB, Birge RR, Lees WJ. Thermolysis of fluorinated cycloalkylidene fulgides yields a new class of photochromic compounds. Chemical Communications (Cambridge, England). 992-3. PMID 12744335 DOI: 10.1039/B300010A  0.636
2003 Wolak MA, Thomas CJ, Gillespie NB, Birge RR, Lees WJ. Tuning the optical properties of fluorinated indolylfulgimides. The Journal of Organic Chemistry. 68: 319-26. PMID 12530855 DOI: 10.1021/Jo026374N  0.728
2002 Wolak MA, Finn RC, Rarig RS, Thomas CJ, Hammond RP, Birge RR, Zubieta J, Lees WJ. Structural properties of a series of photochromic fluorinated indolylfulgides. Acta Crystallographica. Section C, Crystal Structure Communications. 58: o389-93. PMID 12094055 DOI: 10.1107/S0108270102008041  0.684
2002 Gough JD, Williams RH, Donofrio AE, Lees WJ. Folding disulfide-containing proteins faster with an aromatic thiol. Journal of the American Chemical Society. 124: 3885-92. PMID 11942825 DOI: 10.1021/Ja016938P  0.737
2002 Wolak MA, Gillespie NB, Thomas CJ, Birge RR, Lees WJ. Optical and thermal properties of photochromic fluorinated adamantylidene indolylfulgides Journal of Photochemistry and Photobiology a: Chemistry. 147: 39-44.  0.623
2001 Musa H, Gough JD, Lees WJ, Veenstra RD. Ionic blockade of the rat connexin40 gap junction channel by large tetraalkylammonium ions. Biophysical Journal. 81: 3253-74. PMID 11720990 DOI: 10.1016/S0006-3495(01)75960-7  0.671
2001 Wolak MA, Sullivan JM, Thomas CJ, Finn RC, Birge RR, Lees WJ. Thermolysis of a fluorinated indolylfulgide features a novel 1,5-indolyl shift. The Journal of Organic Chemistry. 66: 4739-41. PMID 11421804 DOI: 10.1021/Jo015693W  0.391
2001 DeCollo TV, Lees WJ. Effects of aromatic thiols on thiol-disulfide interchange reactions that occur during protein folding. The Journal of Organic Chemistry. 66: 4244-9. PMID 11397160 DOI: 10.1021/Jo015600A  0.364
2001 Thomas CJ, Wolak MA, Birge RR, Lees WJ. Improved synthesis of indolyl fulgides. The Journal of Organic Chemistry. 66: 1914-8. PMID 11262147 DOI: 10.1021/Jo005722N  0.696
2001 Wolak MA, Sullivan JM, Thomas CJ, Finn RC, Birge RR, Lees WJ. Thermolysis of a fluorinated indolyfulgide features a novel 1,5-indolyl shift Journal of Organic Chemistry. 66: 4739-4741. DOI: 10.1021/jo015693w  0.615
2001 Wolak MA, Gillespie NB, Thomas CJ, Birge RR, Lees WJ. Optical properties of photochromic fluorinated indolylfulgides Journal of Photochemistry and Photobiology a: Chemistry. 144: 83-91.  0.621
1998 Skarzynski T, Kim DH, Lees WJ, Walsh CT, Duncan K. Stereochemical course of enzymatic enolpyruvyl transfer and catalytic conformation of the active site revealed by the crystal structure of the fluorinated analogue of the reaction tetrahedral intermediate bound to the active site of the C115A mutant of MurA. Biochemistry. 37: 2572-7. PMID 9485407 DOI: 10.1021/Bi9722608  0.631
1996 Walsh CT, Benson TE, Kim DH, Lees WJ. The versatility of phosphoenolpyruvate and its vinyl ether products in biosynthesis. Chemistry & Biology. 3: 83-91. PMID 8807832 DOI: 10.1016/S1074-5521(96)90282-3  0.597
1996 Kim DH, Lees WJ, Kempsell KE, Lane WS, Duncan K, Walsh CT. Characterization of a Cys115 to Asp substitution in the Escherichia coli cell wall biosynthetic enzyme UDP-GlcNAc enolpyruvyl transferase (MurA) that confers resistance to inactivation by the antibiotic fosfomycin. Biochemistry. 35: 4923-8. PMID 8664284 DOI: 10.1021/Bi952937W  0.621
1996 Lees WJ, Benson TE, Hogle JM, Walsh CT. (E)-enolbutyryl-UDP-N-acetylglucosamine as a mechanistic probe of UDP-N-acetylenolpyruvylglucosamine reductase (MurB). Biochemistry. 35: 1342-51. PMID 8634262 DOI: 10.1021/Bi952287W  0.455
1996 Kim DH, Tucker-Kellogg GW, Lees WJ, Walsh CT. Analysis of fluoromethyl group chirality establishes a common stereochemical course for the enolpyruvyl transfers catalyzed by EPSP synthase and UDP-GlcNAc enolpyruvyl transferase. Biochemistry. 35: 5435-40. PMID 8611533 DOI: 10.1021/Bi952978S  0.635
1996 Gehring AM, Lees WJ, Mindiola DJ, Walsh CT, Brown ED. Acetyltransfer precedes uridylyltransfer in the formation of UDP-N-acetylglucosamine in separable active sites of the bifunctional GlmU protein of Escherichia coli. Biochemistry. 35: 579-85. PMID 8555230 DOI: 10.1021/Bi952275A  0.488
1995 Singh R, Lamoureux GV, Lees WJ, Whitesides GM. Reagents for rapid reduction of disulfide bonds. Methods in Enzymology. 251: 167-73. PMID 7651195 DOI: 10.1016/0076-6879(95)51119-9  0.439
1995 Lees WJ, Walsh CT. Analysis of the Enol Ether Transfer Catalyzed by UDP-GlcNAc Enolpyruvyl Transferase Using (E)- and (Z)-Isomers of Phosphoenolbutyrate: Stereochemical, Partitioning, and Isotope Effect Studies Journal of the American Chemical Society. 117: 7329-7337. DOI: 10.1021/Ja00133A006  0.436
1995 Kim DH, Lees WJ, Walsh CT. Stereochemical analysis of the tetrahedral adduct formed at the active site of UDP-GlcNAc enolpyruvyl transferase from the pseudosubstrates, (E)- and (Z)-3-fluorophosphoenolpyruvate, in D2O Journal of the American Chemical Society. 117: 6380-6381. DOI: 10.1021/Ja00128A037  0.589
1995 Kim DH, Lees WJ, Haley TM, Walsh CT. Kinetic characterization of the inactivation of UDP-GlcNAc enolpyruvyl transferase by (Z)-3-fluorophosphoenolpyruvate: Evidence for two oxocarbenium ion intermediates in enolpyruvyl transfer catalysis Journal of the American Chemical Society. 117: 1494-1502. DOI: 10.1021/Ja00110A005  0.602
1994 Chu YH, Lees WJ, Stassinopoulos A, Walsh CT. Using affinity capillary electrophoresis to determine binding stoichiometries of protein-ligand interactions. Biochemistry. 33: 10616-21. PMID 8075061 DOI: 10.1021/Bi00201A007  0.55
1994 Lees WJ, Spaltenstein A, Kingery-Wood JE, Whitesides GM. Polyacrylamides bearing pendant alpha-sialoside groups strongly inhibit agglutination of erythrocytes by influenza A virus: multivalency and steric stabilization of particulate biological systems. Journal of Medicinal Chemistry. 37: 3419-33. PMID 7932570 DOI: 10.1021/Jm00046A027  0.397
1994 Kim DH, Lees WJ, Walsh CT. Formation of two enzyme-bound reaction intermediate analogs during inactivation of UDP-GlcNAc enolpyruvyl transferase by (E)- or (Z)-3-fluorophosphoenolpyruvate Journal of the American Chemical Society. 116: 6478-6479. DOI: 10.1021/Ja00093A076  0.628
1993 Lees WJ, Whitesides GM. Diastereoselectivity (enantioselectivity) of aldol condensations catalyzed by rabbit muscle aldolase at C-2 of RCHOHCHO if R has an appropriately placed negatively charged group Journal of Organic Chemistry. 58: 1887-1894. DOI: 10.1021/Jo00059A047  0.419
1993 Lees WJ, Whitesides GM. Equilibrium constants for thiol-disulfide interchange reactions: a coherent, corrected set Journal of Organic Chemistry. 58: 642-647. DOI: 10.1021/Jo00055A016  0.379
1993 Lees WJ, Whitesides GM. Interpretation of the reduction potential of 6,6'-dithiosucrose cyclic disulfide by comparison of the conformations of 6,6'-dithiosucrose cyclic disulfide, 6,6'-dithiosucrose, and sucrose in aqueous solution Journal of the American Chemical Society. 115: 1860-1869. DOI: 10.1021/Ja00058A034  0.407
1992 Heidlas JE, Lees WJ, Whitesides GM. Practical enzyme-based syntheses of uridine 5'-diphosphogalactose and uridine 5'-diphospho-N-acetylgalactosamine on a gram scale Journal of Organic Chemistry. 57: 152-157. DOI: 10.1021/Jo00027A029  0.411
1992 Heidlas JE, Lees WJ, Pale P, Whitesides GM. Gram-scale synthesis of uridine 5'-diphospho-N-acetylglucosamine: comparison of enzymic and chemical routes Journal of Organic Chemistry. 57: 146-151. DOI: 10.1021/Jo00027A028  0.598
1992 Lees WJ, Whitesides GM. The enzymatic synthesis of 1,5-dideoxy-1,5-diimino-d-talitol and 1-deoxygalactostatin using fuculose-1-phosphate aldolase Bioorganic Chemistry. 20: 173-179. DOI: 10.1016/0045-2068(92)90037-4  0.43
1991 Lees WJ, Singh R, Whitesides GM. meso-2,5-Dimercapto-N,N,N',N'-tetramethyladipamide: a readily available, kinetically rapid reagent for the reduction of disulfides in aqueous solution Journal of Organic Chemistry. 56: 7328-7331. DOI: 10.1021/Jo00026A026  0.376
1989 Bednarski MD, Simon ES, Bischofberger N, Fessner WD, Kim MJ, Lees W, Saito T, Waldmann H, Whitesides GM. Rabbit muscle aldolase as a catalyst in organic synthesis Journal of the American Chemical Society. 111: 627-635. DOI: 10.1021/Ja00184A034  0.392
1989 Bednarski MD, Simon ES, Bischofberger N, Fessner WD, Kim MJ, Lees W, Saito T, Waldmann H, Whitesides GM. Rabbit muscle aldolase as a catalyst in organic synthesis Journal of the American Chemical Society. 111: 627-635.  0.621
1988 Bischofberger N, Waldmann H, Saito T, Simon ES, Lees W, Bednarski MD, Whitesides GM. Synthesis of analogs of 1,3-dihydroxyacetone phosphate and glyceraldehyde 3-phosphate for use in studies of fructose-1,6-diphosphate aldolase The Journal of Organic Chemistry. 53: 3457-3465. DOI: 10.1021/Jo00250A010  0.691
1988 Bischofberger N, Waldmann H, Saito T, Simon ES, Lees W, Bednarski MD, Whitesides GM. Synthesis of analogues of 1,3-dihydroxyacetone phosphate and glyceraldehyde 3-phosphate for use in studies of fructose-1,6-diphosphate aldolase Journal of Organic Chemistry. 53: 3457-3465.  0.572
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