Fred J. Sigworth - Publications

Affiliations: 
Yale University, New Haven, CT 
Area:
Ion channels

135 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Jensen KH, Brandt SS, Shigematsu H, Sigworth FJ. Statistical Modeling and Removal of Lipid Membrane Projections for Cryo-EM Structure Determination of Reconstituted Membrane Proteins. Journal of Structural Biology. PMID 26835990 DOI: 10.1016/j.jsb.2016.01.012  1
2015 Singh SK, Sigworth FJ. Cryo-EM: Spinning the Micelles Away. Structure (London, England : 1993). 23: 1561. PMID 26331455 DOI: 10.1016/j.str.2015.08.001  1
2015 Tagare HD, Kucukelbir A, Sigworth FJ, Wang H, Rao M. Directly reconstructing principal components of heterogeneous particles from cryo-EM images. Journal of Structural Biology. PMID 26049077 DOI: 10.1016/j.jsb.2015.05.007  1
2015 Dvornek NC, Sigworth FJ, Tagare HD. SubspaceEM: A fast maximum-a-posteriori algorithm for cryo-EM single particle reconstruction. Journal of Structural Biology. 190: 200-14. PMID 25839831 DOI: 10.1016/j.jsb.2015.03.009  1
2014 Liu Y, Sigworth FJ. Automatic cryo-EM particle selection for membrane proteins in spherical liposomes. Journal of Structural Biology. 185: 295-302. PMID 24468290 DOI: 10.1016/j.jsb.2014.01.004  1
2014 Kucukelbir A, Sigworth FJ, Tagare HD. Quantifying the local resolution of cryo-EM density maps. Nature Methods. 11: 63-5. PMID 24213166 DOI: 10.1038/nmeth.2727  1
2013 Dongsoo Kim, Goldstein B, Wei Tang, Sigworth FJ, Culurciello E. Noise analysis and performance comparison of low current measurement systems for biomedical applications. Ieee Transactions On Biomedical Circuits and Systems. 7: 52-62. PMID 23853279 DOI: 10.1109/TBCAS.2012.2192273  1
2013 Shigematsu H, Sigworth FJ. Noise models and cryo-EM drift correction with a direct-electron camera. Ultramicroscopy. 131: 61-9. PMID 23748163 DOI: 10.1016/j.ultramic.2013.04.001  1
2013 Miranda P, Contreras JE, Plested AJ, Sigworth FJ, Holmgren M, Giraldez T. State-dependent FRET reports calcium- and voltage-dependent gating-ring motions in BK channels. Proceedings of the National Academy of Sciences of the United States of America. 110: 5217-22. PMID 23479636 DOI: 10.1073/pnas.1219611110  1
2012 Yan Y, Yang Y, Bian S, Sigworth FJ. Expression, purification and functional reconstitution of slack sodium-activated potassium channels. The Journal of Membrane Biology. 245: 667-74. PMID 22729647 DOI: 10.1007/s00232-012-9425-7  1
2012 Shang Z, Sigworth FJ. Hydration-layer models for cryo-EM image simulation. Journal of Structural Biology. 180: 10-6. PMID 22609687 DOI: 10.1016/j.jsb.2012.04.021  1
2012 Kucukelbir A, Sigworth FJ, Tagare HD. A Bayesian adaptive basis algorithm for single particle reconstruction. Journal of Structural Biology. 179: 56-67. PMID 22564910 DOI: 10.1016/j.jsb.2012.04.012  1
2011 Barthel AC, Tagare H, Sigworth FJ. Surface-Constrained 3D Reconstruction in Cryo-EM. Conference Record / Asilomar Conference On Signals, Systems & Computers. Asilomar Conference On Signals, Systems & Computers. 1026-1030. PMID 24477184 DOI: 10.1109/ACSSC.2011.6190167  1
2011 Bian S, Bai JP, Chapin H, Le Moellic C, Dong H, Caplan M, Sigworth FJ, Navaratnam DS. Interactions between β-catenin and the HSlo potassium channel regulates HSlo surface expression. Plos One. 6: e28264. PMID 22194818 DOI: 10.1371/journal.pone.0028264  1
2011 Ye M, Hong J, Zhou M, Huang L, Shao X, Yang Y, Sigworth FJ, Chi C, Lin D, Wang C. A novel conotoxin, qc16a, with a unique cysteine framework and folding. Peptides. 32: 1159-65. PMID 21524672 DOI: 10.1016/j.peptides.2011.04.008  1
2011 Goldstein B, Choe K, Sigworth FJ, Culurciello E. A four-channel integrated patch-clamp amplifier with current-clamp capability Midwest Symposium On Circuits and Systems. DOI: 10.1109/MWSCAS.2011.6026393  1
2010 Syed S, Müllner FE, Selvin PR, Sigworth FJ. Improved hidden Markov models for molecular motors, part 2: extensions and application to experimental data. Biophysical Journal. 99: 3696-703. PMID 21112294 DOI: 10.1016/j.bpj.2010.09.066  1
2010 Müllner FE, Syed S, Selvin PR, Sigworth FJ. Improved hidden Markov models for molecular motors, part 1: basic theory. Biophysical Journal. 99: 3684-95. PMID 21112293 DOI: 10.1016/j.bpj.2010.09.067  1
2010 Sigworth FJ, Doerschuk PC, Carazo JM, Scheres SH. An introduction to maximum-likelihood methods in cryo-EM. Methods in Enzymology. 482: 263-94. PMID 20888965 DOI: 10.1016/S0076-6879(10)82011-7  1
2010 Wang L, Sigworth FJ. Liposomes on a streptavidin crystal: a system to study membrane proteins by cryo-EM. Methods in Enzymology. 481: 147-64. PMID 20887857 DOI: 10.1016/S0076-6879(10)81007-9  1
2010 Weerakoon P, Culurciello E, Yang Y, Santos-Sacchi J, Kindlmann PJ, Sigworth FJ. Patch-clamp amplifiers on a chip. Journal of Neuroscience Methods. 192: 187-92. PMID 20637803 DOI: 10.1016/j.jneumeth.2010.06.030  1
2010 Tagare HD, Barthel A, Sigworth FJ. An adaptive Expectation-Maximization algorithm with GPU implementation for electron cryomicroscopy. Journal of Structural Biology. 171: 256-65. PMID 20538058 DOI: 10.1016/j.jsb.2010.06.004  1
2010 Brown MR, Kronengold J, Gazula VR, Chen Y, Strumbos JG, Sigworth FJ, Navaratnam D, Kaczmarek LK. Fragile X mental retardation protein controls gating of the sodium-activated potassium channel Slack. Nature Neuroscience. 13: 819-21. PMID 20512134 DOI: 10.1038/nn.2563  1
2010 Barmeyer C, Rahner C, Yang Y, Sigworth FJ, Binder HJ, Rajendran VM. Cloning and identification of tissue-specific expression of KCNN4 splice variants in rat colon. American Journal of Physiology. Cell Physiology. 299: C251-63. PMID 20445171 DOI: 10.1152/ajpcell.00091.2009  1
2010 Coifman RR, Shkolnisky Y, Sigworth FJ, Singer A. Reference Free Structure Determination through Eigenvectors of Center of Mass Operators. Applied and Computational Harmonic Analysis. 28: 296-312. PMID 20436952 DOI: 10.1016/j.acha.2009.11.003  1
2010 Xu J, Sigworth FJ, LaVan DA. Synthetic protocells to mimic and test cell function. Advanced Materials (Deerfield Beach, Fla.). 22: 120-7. PMID 20217710 DOI: 10.1002/adma.200901945  1
2010 Singer A, Coifman RR, Sigworth FJ, Chester DW, Shkolnisky Y. Detecting consistent common lines in cryo-EM by voting. Journal of Structural Biology. 169: 312-22. PMID 19925867 DOI: 10.1016/j.jsb.2009.11.003  1
2010 Weerakoon P, Sigworth F, Kindlmann P, Santos-Sacchi J, Yang Y, Culurciello E. An integrated patch-clamp system with dual input Iscas 2010 - 2010 Ieee International Symposium On Circuits and Systems: Nano-Bio Circuit Fabrics and Systems. 1523-1526. DOI: 10.1109/ISCAS.2010.5537382  1
2010 Weerakoon P, Sigworth FJ, Kindlmann PJ, Culurciello E. A 3nV/√Hz rail-to-rail operational amplifier in silicon-on-sapphire with constant transconductance Analog Integrated Circuits and Signal Processing. 65: 311-319. DOI: 10.1007/s10470-010-9484-6  1
2009 Weerakoon P, Culurciello E, Klemic KG, Sigworth FJ. An integrated patch-clamp potentiostat with electrode compensation. Ieee Transactions On Biomedical Circuits and Systems. 3: 117-25. PMID 23853203 DOI: 10.1109/TBCAS.2008.2005419  1
2009 Wang L, Sigworth FJ. Structure of the BK potassium channel in a lipid membrane from electron cryomicroscopy. Nature. 461: 292-5. PMID 19718020 DOI: 10.1038/nature08291  1
2009 Chen H, Kronengold J, Yan Y, Gazula VR, Brown MR, Ma L, Ferreira G, Yang Y, Bhattacharjee A, Sigworth FJ, Salkoff L, Kaczmarek LK. The N-terminal domain of Slack determines the formation and trafficking of Slick/Slack heteromeric sodium-activated potassium channels. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 5654-65. PMID 19403831 DOI: 10.1523/JNEUROSCI.5978-08.2009  1
2008 Tagare HD, Sigworth F, Barthel A. Fast, adaptive expectation-maximization alignment for Cryo-EM Medical Image Computing and Computer-Assisted Intervention : Miccai ... International Conference On Medical Image Computing and Computer-Assisted Intervention. 11: 855-862. PMID 18982685 DOI: 10.1007/978-3-540-85990-1-103  1
2008 Coifman RR, Shkolnisky Y, Sigworth FJ, Singer A. Graph Laplacian tomography from unknown random projections. Ieee Transactions On Image Processing : a Publication of the Ieee Signal Processing Society. 17: 1891-9. PMID 18784036 DOI: 10.1109/TIP.2008.2002305  1
2008 Wang L, Ounjai P, Sigworth FJ. Streptavidin crystals as nanostructured supports and image-calibration references for cryo-EM data collection. Journal of Structural Biology. 164: 190-8. PMID 18707004 DOI: 10.1016/j.jsb.2008.07.008  1
2008 Weerakoon P, Klemic K, Sigworth FJ, Culurciello E. A low-noise miniaturized patch-clamp amplifier 2007 Ieee/Nih Life Science Systems and Applications Workshop, Lisa. 164-167. DOI: 10.1109/LSSA.2007.4400910  1
2008 Weerakoon P, Culurciello E, Klemic K, Sigworth FJ. An integrated patch-clamp amplifier for high-throughput planar patch-clamp systems Proceedings - Ieee International Symposium On Circuits and Systems. 1808-1811. DOI: 10.1109/ISCAS.2008.4541791  1
2008 Weerakoon P, Sigworth F, Culurciello E. Integrated patch-clamp biosensor for high-density screening of cell conductance Electronics Letters. 44: 81-82. DOI: 10.1049/el:20083151  1
2007 Stern E, Wagner R, Sigworth FJ, Breaker R, Fahmy TM, Reed MA. Importance of the Debye screening length on nanowire field effect transistor sensors. Nano Letters. 7: 3405-9. PMID 17914853 DOI: 10.1021/nl071792z  1
2007 Sigworth FJ. The last few frames of the voltage-gating movie. Biophysical Journal. 93: 2981-3. PMID 17704178 DOI: 10.1529/biophysj.107.115741  1
2007 Ounjai P, Unger VM, Sigworth FJ, Angsuthanasombat C. Two conformational states of the membrane-associated Bacillus thuringiensis Cry4Ba delta-endotoxin complex revealed by electron crystallography: implications for toxin-pore formation. Biochemical and Biophysical Research Communications. 361: 890-5. PMID 17681273 DOI: 10.1016/j.bbrc.2007.07.086  1
2007 Chester DW, Klemic JF, Stern E, Sigworth FJ, Klemic KG. Holey carbon micro-arrays for transmission electron microscopy: a microcontact printing approach. Ultramicroscopy. 107: 685-91. PMID 17331648 DOI: 10.1016/j.ultramic.2007.01.004  1
2007 Sigworth FJ. From cryo-EM, multiple protein structures in one shot. Nature Methods. 4: 20-1. PMID 17195021 DOI: 10.1038/nmeth0107-20  1
2007 Carragher B, Potter CS, Sigworth FJ. Software tools for macromolecular microscopy. Journal of Structural Biology. 157: 1-2. PMID 17169744 DOI: 10.1016/j.jsb.2006.11.001  1
2007 Weerakoon P, Klemic K, Sigworth FJ, Culurciello E. Electrical noise analysis of an integrated patch-clamp amplifier Conference Proceedings - Ieee Biomedical Circuits and Systems Conference Healthcare Technology, Biocas2007. 33-36. DOI: 10.1109/BIOCAS.2007.4463302  1
2007 Weerakoon P, Klemic K, Sigworth FJ, Culurciello E. An integrated patch-clamp amplifier for high-density whole-cell recordings Proceedings - Ieee International Symposium On Circuits and Systems. 1205-1208.  1
2006 Wang L, Bose PS, Sigworth FJ. Using cryo-EM to measure the dipole potential of a lipid membrane. Proceedings of the National Academy of Sciences of the United States of America. 103: 18528-33. PMID 17116859 DOI: 10.1073/pnas.0608714103  1
2006 Yang B, Gribkoff VK, Pan J, Damagnez V, Dworetzky SI, Boissard CG, Bhattacharjee A, Yan Y, Sigworth FJ, Kaczmarek LK. Pharmacological activation and inhibition of Slack (Slo2.2) channels. Neuropharmacology. 51: 896-906. PMID 16876206 DOI: 10.1016/j.neuropharm.2006.06.003  1
2006 Li X, Klemic KG, Reed MA, Sigworth FJ. Microfluidic system for planar patch clamp electrode arrays. Nano Letters. 6: 815-9. PMID 16608289 DOI: 10.1021/nl060165r  1
2006 Wang L, Sigworth FJ. Cryo-EM and single particles. Physiology (Bethesda, Md.). 21: 13-8. PMID 16443818 DOI: 10.1152/physiol.00045.2005  1
2006 Zhang P, Sigworth FJ, Canessa CM. Gating of acid-sensitive ion channel-1: release of Ca2+ block vs. allosteric mechanism. The Journal of General Physiology. 127: 109-17. PMID 16418400 DOI: 10.1085/jgp.200509396  1
2006 Laiwalla F, Klemic KG, Sigworth FJ, Culurciello E. An integrated patch-clamp amplifier in silicon-on-sapphire CMOS Proceedings - Ieee International Symposium On Circuits and Systems. 4054-4057. DOI: 10.1109/TCSI.2006.884459  1
2006 Culurciello E, Laiwalla F, Fu Z, Klemic KG, Sigworth FJ. An integrated silicon-on-sapphire patch-clamp amplifier 2006 Ieee/Nlm Life Science Systems and Applications Workshop, Lisa 2006. DOI: 10.1109/LSSA.2006.250429  1
2005 Giraldez T, Hughes TE, Sigworth FJ. Generation of functional fluorescent BK channels by random insertion of GFP variants. The Journal of General Physiology. 126: 429-38. PMID 16260837 DOI: 10.1085/jgp.200509368  1
2005 Sigworth FJ, Klemic KG. Microchip technology in ion-channel research. Ieee Transactions On Nanobioscience. 4: 121-7. PMID 15816178 DOI: 10.1109/TNB.2004.842471  1
2005 Klemic KG, Klemic JF, Sigworth FJ. An air-molding technique for fabricating PDMS planar patch-clamp electrodes. PflüGers Archiv : European Journal of Physiology. 449: 564-72. PMID 15578213 DOI: 10.1007/s00424-004-1360-8  1
2005 Sigworth FJ. Opportunities for microtechnology in ion channel research 2005 3rd Ieee/Embs Special Topic Conference On Microtechnology in Medicine and Biology. 2005: 2. DOI: 10.1109/MMB.2005.1548365  1
2004 Yang Y, Yan Y, Sigworth FJ. Can Shaker potassium channels be locked in the deactivated state? The Journal of General Physiology. 124: 163-71. PMID 15277577 DOI: 10.1085/jgp.200409057  1
2004 Sigworth FJ. Classical detection theory and the cryo-EM particle selection problem. Journal of Structural Biology. 145: 111-22. PMID 15065679 DOI: 10.1016/j.jsb.2003.10.025  1
2004 Zhu Y, Carragher B, Glaeser RM, Fellmann D, Bajaj C, Bern M, Mouche F, de Haas F, Hall RJ, Kriegman DJ, Ludtke SJ, Mallick SP, Penczek PA, Roseman AM, Sigworth FJ, et al. Automatic particle selection: results of a comparative study. Journal of Structural Biology. 145: 3-14. PMID 15065668 DOI: 10.1016/j.jsb.2003.09.033  1
2003 Bhattacharjee A, Joiner WJ, Wu M, Yang Y, Sigworth FJ, Kaczmarek LK. Slick (Slo2.1), a rapidly-gating sodium-activated potassium channel inhibited by ATP. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 11681-91. PMID 14684870  1
2003 Sigworth FJ. Structural biology: Life's transistors. Nature. 423: 21-2. PMID 12721605 DOI: 10.1038/423021a  1
2002 Jiang QX, Thrower EC, Chester DW, Ehrlich BE, Sigworth FJ. Three-dimensional structure of the type 1 inositol 1,4,5-trisphosphate receptor at 24 A resolution. The Embo Journal. 21: 3575-81. PMID 12110570 DOI: 10.1093/emboj/cdf380  1
2002 Sigworth FJ, Klemic KG. Patch clamp on a chip. Biophysical Journal. 82: 2831-2. PMID 12023207  1
2002 Klemic KG, Klemic JF, Reed MA, Sigworth FJ. Micromolded PDMS planar electrode allows patch clamp electrical recordings from cells. Biosensors & Bioelectronics. 17: 597-604. PMID 11959483 DOI: 10.1016/S0956-5663(02)00015-5  1
2002 Venkataramanan L, Sigworth FJ. Applying hidden Markov models to the analysis of single ion channel activity. Biophysical Journal. 82: 1930-42. PMID 11916851 DOI: 10.1016/S0006-3495(02)75542-2  1
2001 Sigworth FJ. Potassium channel mechanics. Neuron. 32: 555-6. PMID 11719196 DOI: 10.1016/S0896-6273(01)00509-8  1
2001 Zheng J, Vankataramanan L, Sigworth FJ. Hidden Markov model analysis of intermediate gating steps associated with the pore gate of shaker potassium channels. The Journal of General Physiology. 118: 547-64. PMID 11696611 DOI: 10.1085/jgp.118.5.547  1
2001 Jiang QX, Chester DW, Sigworth FJ. Spherical reconstruction: a method for structure determination of membrane proteins from cryo-EM images. Journal of Structural Biology. 133: 119-31. PMID 11472084 DOI: 10.1006/jsbi.2001.4376  1
2001 Cascio M, Shenkel S, Grodzicki RL, Sigworth FJ, Fox RO. Functional reconstitution and characterization of recombinant human alpha 1-glycine receptors. The Journal of Biological Chemistry. 276: 20981-8. PMID 11145968 DOI: 10.1074/jbc.M010968200  1
2001 Islas LD, Sigworth FJ. Electrostatics and the gating pore of Shaker potassium channels. The Journal of General Physiology. 117: 69-89. PMID 11134232 DOI: 10.1085/jgp.117.1.69  1
2000 Venkataramanan L, Kuc R, Sigworth FJ. Identification of hidden markov models for ion channel currents-part iii: bandlimited, sampled data Ieee Transactions On Signal Processing. 48: 376-385. DOI: 10.1109/78.823965  1
1999 Islas LD, Sigworth FJ. Voltage sensitivity and gating charge in Shaker and Shab family potassium channels. The Journal of General Physiology. 114: 723-42. PMID 10539976 DOI: 10.1085/jgp.114.5.723  1
1999 Baumgartner W, Islas L, Sigworth FJ. Two-microelectrode voltage clamp of Xenopus oocytes: voltage errors and compensation for local current flow. Biophysical Journal. 77: 1980-91. PMID 10512818 DOI: 10.1016/S0006-3495(99)77039-6  1
1999 Andersen OS, Apell HJ, Bamberg E, Busath DD, Koeppe RE, Sigworth FJ, Szabo G, Urry DW, Woolley A. Gramicidin channel controversy--the structure in a lipid environment. Nature Structural Biology. 6: 609; discussion 611-. PMID 10404209 DOI: 10.1038/10648  1
1998 Yang Y, Sigworth FJ. Single-channel properties of IKs potassium channels. The Journal of General Physiology. 112: 665-78. PMID 9834139 DOI: 10.1085/jgp.112.6.665  1
1998 Sigworth FJ. A maximum-likelihood approach to single-particle image refinement. Journal of Structural Biology. 122: 328-39. PMID 9774537 DOI: 10.1006/jsbi.1998.4014  1
1998 Zheng J, Sigworth FJ. Intermediate conductances during deactivation of heteromultimeric Shaker potassium channels. The Journal of General Physiology. 112: 457-74. PMID 9758864 DOI: 10.1085/jgp.112.4.457  1
1998 Schoppa NE, Sigworth FJ. Activation of Shaker potassium channels. III. An activation gating model for wild-type and V2 mutant channels. The Journal of General Physiology. 111: 313-42. PMID 9450946 DOI: 10.1085/jgp.111.2.313  1
1998 Schoppa NE, Sigworth FJ. Activation of Shaker potassium channels. II. Kinetics of the V2 mutant channel. The Journal of General Physiology. 111: 295-311. PMID 9450945 DOI: 10.1085/jgp.111.2.295  1
1998 Schoppa NE, Sigworth FJ. Activation of shaker potassium channels. I. Characterization of voltage-dependent transitions. The Journal of General Physiology. 111: 271-94. PMID 9450944 DOI: 10.1085/jgp.111.2.271  1
1998 Venkataramanan L, Kuc R, Sigworth FJ. Identification of hidden markov models for ion channel currents-Part II: State-dependent excess noise Ieee Transactions On Signal Processing. 46: 1916-1929. DOI: 10.1109/78.700964  1
1998 Venkataramanan L, Walsh JL, Kuc R, Sigworth FJ. Identification of hidden markov models for ion channel currents-Part I: Colored background noise Ieee Transactions On Signal Processing. 46: 1901-1915. DOI: 10.1109/78.700963  1
1997 Zheng J, Sigworth FJ. Selectivity changes during activation of mutant Shaker potassium channels. The Journal of General Physiology. 110: 101-17. PMID 9236204 DOI: 10.1085/jgp.110.2.101  1
1997 Yang Y, Yan Y, Sigworth FJ. How does the W434F mutation block current in Shaker potassium channels? The Journal of General Physiology. 109: 779-89. PMID 9222903 DOI: 10.1085/jgp.109.6.779  1
1997 Ayer RK, Sigworth FJ. Enhanced closed-state inactivation in a mutant Shaker K+ channel. The Journal of Membrane Biology. 157: 215-30. PMID 9178609 DOI: 10.1007/s002329900230  1
1997 Mathur R, Zheng J, Yan Y, Sigworth FJ. Role of the S3-S4 linker in Shaker potassium channel activation. The Journal of General Physiology. 109: 191-9. PMID 9041448 DOI: 10.1085/jgp.109.2.191  1
1996 Cummins TR, Sigworth FJ. Impaired slow inactivation in mutant sodium channels. Biophysical Journal. 71: 227-36. PMID 8804606 DOI: 10.1016/S0006-3495(96)79219-6  1
1996 Andreose JS, Fumagalli G, Sigworth FJ, Caplan MJ. Real-time detection of the surface delivery of newly synthesized membrane proteins. Proceedings of the National Academy of Sciences of the United States of America. 93: 7661-6. PMID 8755532 DOI: 10.1073/pnas.93.15.7661  1
1996 Venkataramanan L, Walsh JL, Kuc R, Sigworth FJ. Identification of hidden markov models for ion-channel currents containing colored background noise Ieee Transactions On Signal Processing. 44: 2371.  1
1996 Venkataramanan L, Kuc R, Sigworth FJ. Identification of hidden markov models for ion channel currents containing state-dependent excess noise Ieee Transactions On Signal Processing. 44: 2658-2659.  1
1996 Venkataramanan L, Walsh JL, Kuc R, Sigworth FJ. Identification of hidden markov models for ion channel currents containing colored background noise Ieee Transactions On Signal Processing. 44: 2659.  1
1995 Sigworth FJ. Charge movement in the sodium channel. The Journal of General Physiology. 106: 1047-51. PMID 8786349  1
1995 Sigworth FJ, Affolter H, Neher E. Design of the EPC-9, a computer-controlled patch-clamp amplifier. 2. Software. Journal of Neuroscience Methods. 56: 203-15. PMID 7538621 DOI: 10.1016/0165-0270(94)00129-5  1
1995 SIGWorth FJ. Design of the EPC-9, a computer-controlled patch-clamp amplifier. 1. Hardware. Journal of Neuroscience Methods. 56: ES/*ME2. PMID 7538620 DOI: 10.1016/0165-0270(94)00128-4  1
1994 Jiang C, Sigworth FJ, Haddad GG. Oxygen deprivation activates an ATP-inhibitable K+ channel in substantia nigra neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 14: 5590-602. PMID 8083755  1
1994 Sigworth FJ. Voltage gating of ion channels. Quarterly Reviews of Biophysics. 27: 1-40. PMID 7520590  1
1993 Cascio M, Schoppa NE, Grodzicki RL, Sigworth FJ, Fox RO. Functional expression and purification of a homomeric human alpha 1 glycine receptor in baculovirus-infected insect cells. The Journal of Biological Chemistry. 268: 22135-42. PMID 8408073  1
1993 Cummins TR, Zhou J, Sigworth FJ, Ukomadu C, Stephan M, Ptácek LJ, Agnew WS. Functional consequences of a Na+ channel mutation causing hyperkalemic periodic paralysis. Neuron. 10: 667-78. PMID 8386527 DOI: 10.1016/0896-6273(93)90168-Q  1
1993 Crouzy SC, Sigworth FJ. Fluctuations in ion channel gating currents. Analysis of nonstationary shot noise. Biophysical Journal. 64: 68-76. PMID 8381683 DOI: 10.1016/S0006-3495(93)81341-9  1
1993 McCormack K, Lin L, Sigworth FJ. Substitution of a hydrophobic residue alters the conformational stability of Shaker K+ channels during gating and assembly. Biophysical Journal. 65: 1740-8. PMID 8274662 DOI: 10.1016/S0006-3495(93)81202-5  1
1992 Schoppa NE, McCormack K, Tanouye MA, Sigworth FJ. The size of gating charge in wild-type and mutant Shaker potassium channels. Science (New York, N.Y.). 255: 1712-5. PMID 1553560  1
1992 McCormack K, Lin L, Iverson LE, Tanouye MA, Sigworth FJ. Tandem linkage of Shaker K+ channel subunits does not ensure the stoichiometry of expressed channels. Biophysical Journal. 63: 1406-11. PMID 1477286 DOI: 10.1016/S0006-3495(92)81703-4  1
1992 Sigworth FJ, Zhou J. Ion channels. Analysis of nonstationary single-channel currents. Methods in Enzymology. 207: 746-62. PMID 1382211  1
1992 Ukomadu C, Zhou J, Sigworth FJ, Agnew WS. muI Na+ channels expressed transiently in human embryonic kidney cells: biochemical and biophysical properties. Neuron. 8: 663-76. PMID 1314619 DOI: 10.1016/0896-6273(92)90088-U  1
1991 Bouzat C, Barrantes FJ, Sigworth FJ. Changes in channel properties of acetylcholine receptors during the time course of thiol chemical modifications. PflüGers Archiv : European Journal of Physiology. 418: 51-61. PMID 2041725 DOI: 10.1007/BF00370451  1
1991 Heinemann SH, Sigworth FJ. Open channel noise. VI. Analysis of amplitude histograms to determine rapid kinetic parameters. Biophysical Journal. 60: 577-87. PMID 1718467 DOI: 10.1016/S0006-3495(91)82087-2  1
1991 Zhou JY, Potts JF, Trimmer JS, Agnew WS, Sigworth FJ. Multiple gating modes and the effect of modulating factors on the microI sodium channel. Neuron. 7: 775-85. PMID 1660285 DOI: 10.1016/0896-6273(91)90280-D  1
1991 Shenkel S, Sigworth FJ. Patch recordings from the electrocytes of Electrophorus electricus. Na currents and PNa/PK variability. The Journal of General Physiology. 97: 1013-41. PMID 1650809  1
1991 Sigworth FJ, Schoppa NE, McCormack K, Tanouye MA. How do voltage-gated channels work? Analyzing some remarkable mutations in Shaker potassium channels Annals of Biomedical Engineering. 19: 618.  1
1990 Sine SM, Claudio T, Sigworth FJ. Activation of Torpedo acetylcholine receptors expressed in mouse fibroblasts. Single channel current kinetics reveal distinct agonist binding affinities. The Journal of General Physiology. 96: 395-437. PMID 1698917  1
1990 Crouzy SC, Sigworth FJ. Yet another approach to the dwell-time omission problem of single-channel analysis. Biophysical Journal. 58: 731-43. PMID 1698473 DOI: 10.1016/S0006-3495(90)82416-4  1
1990 Heinemann SH, Sigworth FJ. Open channel noise. V. Fluctuating barriers to ion entry in gramicidin A channels. Biophysical Journal. 57: 499-514. PMID 1689592 DOI: 10.1016/S0006-3495(90)82566-2  1
1989 Trimmer JS, Cooperman SS, Tomiko SA, Zhou JY, Crean SM, Boyle MB, Kallen RG, Sheng ZH, Barchi RL, Sigworth FJ. Primary structure and functional expression of a mammalian skeletal muscle sodium channel. Neuron. 3: 33-49. PMID 2559760 DOI: 10.1016/0896-6273(89)90113-X  1
1989 Shenkel S, Cooper EC, James W, Agnew WS, Sigworth FJ. Purified, modified eel sodium channels are active in planar bilayers in the absence of activating neurotoxins. Proceedings of the National Academy of Sciences of the United States of America. 86: 9592-6. PMID 2556720 DOI: 10.1073/pnas.86.23.9592  1
1989 Heinemann SH, Sigworth FJ. Estimation of Na+ dwell time in the gramicidin A channel. Na+ ions as blockers of H+ currents. Biochimica Et Biophysica Acta. 987: 8-14. PMID 2480817 DOI: 10.1016/0005-2736(89)90448-3  1
1989 Stankovic CJ, Heinemann SH, Delfino JM, Sigworth FJ, Schreiber SL. Transmembrane channels based on tartaric acid-gramicidin A hybrids. Science (New York, N.Y.). 244: 813-7. PMID 2471263  1
1988 Heinemann SH, Sigworth FJ. Open channel noise. IV. Estimation of rapid kinetics of formamide block in gramicidin A channels. Biophysical Journal. 54: 757-64. PMID 2465033 DOI: 10.1016/S0006-3495(88)83013-3  1
1988 Claudio T, Paulson HL, Hartman D, Sine S, Sigworth FJ. Chapter 11 Establishing a Stable Expression System for Studies of Acetylcholine Receptors Current Topics in Membranes and Transport. 33: 219-247. DOI: 10.1016/S0070-2161(08)60901-6  1
1988 Sigworth FJ, Shenkel S. Chapter 6 Rapid Gating Events and Current Fluctuations in Gramicidin A Channel Current Topics in Membranes and Transport. 33: 113-130. DOI: 10.1016/S0070-2161(08)60896-5  1
1988 Agnew WS, Claudio T, Sigworth FJ. Preface Current Topics in Membranes and Transport. 33: xiii-xvi. DOI: 10.1016/S0070-2161(08)60889-8  1
1987 Claudio T, Green WN, Hartman DS, Hayden D, Paulson HL, Sigworth FJ, Sine SM, Swedlund A. Genetic reconstitution of functional acetylcholine receptor channels in mouse fibroblasts. Science (New York, N.Y.). 238: 1688-94. PMID 3686008  1
1987 Sigworth FJ, Urry DW, Prasad KU. Open channel noise. III. High-resolution recordings show rapid current fluctuations in gramicidin A and four chemical analogues. Biophysical Journal. 52: 1055-64. PMID 2447969 DOI: 10.1016/S0006-3495(87)83299-X  1
1987 Sigworth FJ, Sine SM. Data transformations for improved display and fitting of single-channel dwell time histograms. Biophysical Journal. 52: 1047-54. PMID 2447968 DOI: 10.1016/S0006-3495(87)83298-8  1
1986 Sigworth FJ. The patch clamp is more useful than anyone had expected. Federation Proceedings. 45: 2673-7. PMID 2429870  1
1986 Sigworth FJ. Open channel noise. II. A test for coupling between current fluctuations and conformational transitions in the acetylcholine receptor. Biophysical Journal. 49: 1041-6. PMID 2423148 DOI: 10.1016/S0006-3495(86)83732-8  1
1985 Sigworth FJ. Open channel noise. I. Noise in acetylcholine receptor currents suggests conformational fluctuations. Biophysical Journal. 47: 709-20. PMID 2410044 DOI: 10.1016/S0006-3495(85)83968-0  1
1981 Hamill OP, Marty A, Neher E, Sakmann B, Sigworth FJ. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. PflüGers Archiv : European Journal of Physiology. 391: 85-100. PMID 6270629 DOI: 10.1007/BF00656997  1
1981 Sigworth FJ. Interpreting power spectra from nonstationary membrane current fluctuations. Biophysical Journal. 35: 289-300. PMID 6268213 DOI: 10.1016/S0006-3495(81)84790-X  1
1981 Sigworth FJ. Covariance of nonstationary sodium current fluctuations at the node of Ranvier. Biophysical Journal. 34: 111-33. PMID 6260261 DOI: 10.1016/S0006-3495(81)84840-0  1
1980 Sigworth FJ, Spalding BC. Chemical modification reduces the conductance of sodium channels in nerve. Nature. 283: 293-5. PMID 6965422  1
1980 Sigworth FJ. The variance of sodium current fluctuations at the node of Ranvier. The Journal of Physiology. 307: 97-129. PMID 6259340  1
1980 Sigworth FJ. The conductance of sodium channels under conditions of reduced current at the node of Ranvier. The Journal of Physiology. 307: 131-42. PMID 6259331  1
1980 Sigworth FJ, Neher E. Single Na+ channel currents observed in cultured rat muscle cells. Nature. 287: 447-9. PMID 6253802 DOI: 10.1038/287447a0  1
1977 Sigworth FJ. Sodium channels in nerve apparently have two conductance states. Nature. 270: 265-7. PMID 593345  1
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