Takeshi Iwatsubo, MD - Related publications

Neuropathology and Neuroscience The University of Tokyo 
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50 most relevant papers in past 60 days:
Year Citation  Score
2021 Salahuddin P, Fatima MT, Uversky VN, Khan RH, Islam Z, Furkan M. The role of amyloids in Alzheimer's and Parkinson's diseases. International Journal of Biological Macromolecules. 190: 44-55. PMID 34480905 DOI: 10.1016/j.ijbiomac.2021.08.197   
2021 Rather MA, Khan A, Alshahrani S, Rashid H, Qadri M, Rashid S, Alsaffar RM, Kamal MA, Rehman MU. Inflammation and Alzheimer's Disease: Mechanisms and Therapeutic Implications by Natural Products. Mediators of Inflammation. 2021: 9982954. PMID 34381308 DOI: 10.1155/2021/9982954   
2021 Wei X, Xie L, Du P, Zhao Z. Impacts of DNA methylation on Tau protein related genes in the brains of patients with Alzheimer's Disease. Neuroscience Letters. 136196. PMID 34437990 DOI: 10.1016/j.neulet.2021.136196   
2021 Zhang Z, Yang X, Song YQ, Tu J. Autophagy in Alzheimer's Disease Pathogenesis: Therapeutic Potential and Future Perspectives. Ageing Research Reviews. 101464. PMID 34551326 DOI: 10.1016/j.arr.2021.101464   
2021 Chuang Y, Van I, Zhao Y, Xu Y. Icariin Ameliorate Alzheimer's Disease by Influencing SIRT1 and Inhibiting Aβ cascade Pathogenesis. Journal of Chemical Neuroanatomy. 102014. PMID 34407393 DOI: 10.1016/j.jchemneu.2021.102014   
2021 Qiu S, Palavicini JP, Wang J, Gonzalez NS, He S, Dustin E, Zou C, Ding L, Bhattacharjee A, Van Skike CE, Galvan V, Dupree JL, Han X. Adult-onset CNS myelin sulfatide deficiency is sufficient to cause Alzheimer's disease-like neuroinflammation and cognitive impairment. Molecular Neurodegeneration. 16: 64. PMID 34526055 DOI: 10.1186/s13024-021-00488-7   
2021 Kunitomi R, Pradipta AR, Kawabe H, Lobsiger N, Tanaka K, Zako T. Inhibition of amyloid formation of amyloid β (1-42), amylin and insulin by 1,5-diazacyclooctanes, a spermine-acrolein conjugate. Bioorganic & Medicinal Chemistry. 46: 116391. PMID 34488020 DOI: 10.1016/j.bmc.2021.116391   
2021 Festa BP, Barbosa AD, Rob M, Rubinsztein DC. The pleiotropic roles of autophagy in Alzheimer's disease: From pathophysiology to therapy. Current Opinion in Pharmacology. 60: 149-157. PMID 34419832 DOI: 10.1016/j.coph.2021.07.011   
2021 Wu M, Liu CZ, Barrall EA, Rissman RA, Joiner WJ. Unbalanced regulation of α7 nAChRs by Ly6h and NACHO contributes to neurotoxicity in Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 34446574 DOI: 10.1523/JNEUROSCI.0494-21.2021   
2021 Confer MP, Holcombe BM, Foes AG, Holmquist JM, Walker SC, Deb S, Ghosh A. Label-Free Infrared Spectroscopic Imaging Reveals Heterogeneity of β-Sheet Aggregates in Alzheimer's Disease. The Journal of Physical Chemistry Letters. 9662-9671. PMID 34590866 DOI: 10.1021/acs.jpclett.1c02306   
2021 Armijo E, Edwards G, Flores A, Vera J, Shahnawaz M, Moda F, Gonzalez C, Sanhueza M, Soto C. Induced Pluripotent Stem Cell-Derived Neural Precursors Improve Memory, Synaptic and Pathological Abnormalities in a Mouse Model of Alzheimer's Disease. Cells. 10. PMID 34359972 DOI: 10.3390/cells10071802   
2021 Uddin MS, Kabir MT, Jalouli M, Rahman MA, Jeandet P, Behl T, Alexiou A, Albadrani GM, Abdel-Daim MM, Perveen A, Ashraf GM. Neuroinflammatory Signaling in the Pathogenesis of Alzheimer's Disease. Current Neuropharmacology. PMID 34525932 DOI: 10.2174/1570159X19666210826130210   
2021 Arias JC, Edwards M, Vitali F, Beach TG, Serrano GE, Weinkauf CC. Extracranial carotid atherosclerosis is associated with increased neurofibrillary tangle accumulation. Journal of Vascular Surgery. PMID 34478810 DOI: 10.1016/j.jvs.2021.07.238   
2021 Luo R, Fan Y, Yang J, Ye M, Zhang DF, Guo K, Li X, Bi R, Xu M, Yang LX, Li Y, Ran X, Jiang HY, Zhang C, Tan L, et al. A novel missense variant in ACAA1 contributes to early-onset Alzheimer's disease, impairs lysosomal function, and facilitates amyloid-β pathology and cognitive decline. Signal Transduction and Targeted Therapy. 6: 325. PMID 34465723 DOI: 10.1038/s41392-021-00748-4   
2021 Sharma A, Anand JS, Kumar Y. Immunotherapeutics for AD: A Work in Progress. Cns & Neurological Disorders Drug Targets. PMID 34477533 DOI: 10.2174/1871527320666210903101522   
2021 Singh CSB, Choi KB, Munro L, Wang HY, Pfeifer CG, Jefferies WA. Reversing pathology in a preclinical model of Alzheimer's disease by hacking cerebrovascular neoangiogenesis with advanced cancer therapeutics. Ebiomedicine. 71: 103503. PMID 34534764 DOI: 10.1016/j.ebiom.2021.103503   
2021 Carbone MG, Pagni G, Tagliarini C, Imbimbo BP, Pomara N. Can platelet activation result in increased plasma Aβ levels and contribute to the pathogenesis of Alzheimer's disease? Ageing Research Reviews. 71: 101420. PMID 34371202 DOI: 10.1016/j.arr.2021.101420   
2021 Wittung-Stafshede P. Gut power: Modulation of human amyloid formation by amyloidogenic proteins in the gastrointestinal tract. Current Opinion in Structural Biology. 72: 33-38. PMID 34450484 DOI: 10.1016/j.sbi.2021.07.009   
2021 Ibanez L, Cruchaga C, Fernández MV. Advances in Genetic and Molecular Understanding of Alzheimer's Disease. Genes. 12. PMID 34440421 DOI: 10.3390/genes12081247   
2021 Sun Y, Xu S, Jiang M, Liu X, Yang L, Bai Z, Yang Q. Role of the Extracellular Matrix in Alzheimer's Disease. Frontiers in Aging Neuroscience. 13: 707466. PMID 34512308 DOI: 10.3389/fnagi.2021.707466   
2021 Grundman J, Spencer B, Sarsoza F, Rissman RA. Transcriptome analyses reveal tau isoform-driven changes in transposable element and gene expression. Plos One. 16: e0251611. PMID 34587152 DOI: 10.1371/journal.pone.0251611   
2021 Mahdiabadi S, Momtazmanesh S, Perry G, Rezaei N. Immune modulations and immunotherapies for Alzheimer's disease: a comprehensive review. Reviews in the Neurosciences. PMID 34506700 DOI: 10.1515/revneuro-2021-0092   
2021 Song Z, Qu Y, Xu Y, Zhang L, Zhou L, Han Y, Zhao W, Yu P, Zhang Y, Li X, Qin C. Microarray microRNA profiling of urinary exosomes in a 5XFAD mouse model of Alzheimer's disease. Animal Models and Experimental Medicine. 4: 233-242. PMID 34557649 DOI: 10.1002/ame2.12175   
2021 Gupta GL, Samant NP. Current druggable targets for therapeutic control of Alzheimer's disease. Contemporary Clinical Trials. 106549. PMID 34464763 DOI: 10.1016/j.cct.2021.106549   
2021 Kaur D, Behl T, Chigurupati S, Sehgal A, Singh S, Sharma N, Badavath VN, Vargas-De-La-Cruz C, Bhatia S, Al-Harrasi A, Dey A, Aleya L, Bungau S. Deciphering the focal role of endostatin in Alzheimer's disease. Environmental Science and Pollution Research International. PMID 34561808 DOI: 10.1007/s11356-021-16567-7   
2021 Wang H, Zhang Y, Zheng C, Yang S, Chen X, Wang H, Gao S. A 3-Gene-Based Diagnostic Signature in Alzheimer's Disease. European Neurology. 1-8. PMID 34521086 DOI: 10.1159/000518727   
2021 Apátiga-Pérez R, Soto-Rojas LO, Campa-Córdoba BB, Luna-Viramontes NI, Cuevas E, Villanueva-Fierro I, Ontiveros-Torres MA, Bravo-Muñoz M, Flores-Rodríguez P, Garcés-Ramirez L, de la Cruz F, Montiel-Sosa JF, Pacheco-Herrero M, Luna-Muñoz J. Neurovascular dysfunction and vascular amyloid accumulation as early events in Alzheimer's disease. Metabolic Brain Disease. PMID 34406560 DOI: 10.1007/s11011-021-00814-4   
2021 Seo SJ, Chang WS, Jeon JG, Choi Y, Kim E, Kim JK. Proton Stimulation Targeting Plaque Magnetite Reduces Amyloid-β Plaque and Iron Redox Toxicity and Improves Memory in an Alzheimer's Disease Mouse Model. Journal of Alzheimer's Disease : Jad. PMID 34569962 DOI: 10.3233/JAD-210739   
2021 Cardona K, Medina J, Orrego-Cardozo M, Restrepo de Mejía F, Elcoroaristizabal X, Naranjo Galvis CA. Inflammatory gene expression profiling in peripheral blood from patients with Alzheimer's disease reveals key pathways and hub genes with potential diagnostic utility: a preliminary study. Peerj. 9: e12016. PMID 34484988 DOI: 10.7717/peerj.12016   
2021 Gkanatsiou E, Nilsson J, Toomey CE, Vrillon A, Kvartsberg H, Portelius E, Zetterberg H, Blennow K, Brinkmalm A, Lashley T, Brinkmalm G. Amyloid pathology and synaptic loss in pathological aging. Journal of Neurochemistry. PMID 34473357 DOI: 10.1111/jnc.15487   
2021 Li S, Wang C, Wang Z, Tan J. Involvement of cerebrovascular abnormalities in the pathogenesis and progression of Alzheimer's disease: an adrenergic approach. Aging. 13. PMID 34479211 DOI: 10.18632/aging.203482   
2021 Brenowitz WD, Xiang Y, McEvoy CT, Yang C, Yaffe K, Le WD, Leng Y. Current Alzheimer disease research highlights: evidence for novel risk factors. Chinese Medical Journal. PMID 34507318 DOI: 10.1097/CM9.0000000000001706   
2021 Li X, Zhang X, Xing R, Qi F, Dong J, Li D, Tian X, Yu B, Huang M, Zhang L, Yuan X, Yang Y, Wu H, Zang L, Mao X, et al. Syringic acid demonstrates promising protective effect against tau fibrillization and cytotoxicity through regulation of endoplasmic reticulum stress-mediated pathway as a prelude to Alzheimer's disease. International Journal of Biological Macromolecules. PMID 34599991 DOI: 10.1016/j.ijbiomac.2021.09.173   
2021 Nisa FY, Rahman MA, Hossen MA, Khan MF, Khan MAN, Majid M, Sultana F, Haque MA. Role of neurotoxicants in the pathogenesis of Alzheimer's disease: a mechanistic insight. Annals of Medicine. 53: 1476-1501. PMID 34433343 DOI: 10.1080/07853890.2021.1966088   
2021 Britton RJ, Hutchison JM, Sanders CR. The transmembrane amyloid precursor C99 protein exhibits non-specific interaction with tau. Biochemical and Biophysical Research Communications. 576: 48-52. PMID 34481234 DOI: 10.1016/j.bbrc.2021.08.075   
2021 Donner L, Feige T, Freiburg C, Toska LM, Reichert AS, Chatterjee M, Elvers M. Impact of Amyloid-β on Platelet Mitochondrial Function and Platelet-Mediated Amyloid Aggregation in Alzheimer's Disease. International Journal of Molecular Sciences. 22. PMID 34502546 DOI: 10.3390/ijms22179633   
2021 Herring WL, Gould IG, Fillit H, Lindgren P, Forrestal F, Thompson R, Pemberton-Ross P. Predicted Lifetime Health Outcomes for Aducanumab in Patients with Early Alzheimer's Disease. Neurology and Therapy. PMID 34426940 DOI: 10.1007/s40120-021-00273-0   
2021 Yin X, Qiu Y, Zhao C, Zhou Z, Bao J, Qian W. The Role of Amyloid-Beta and Tau in the Early Pathogenesis of Alzheimer's Disease. Medical Science Monitor : International Medical Journal of Experimental and Clinical Research. 27: e933084. PMID 34471085 DOI: 10.12659/MSM.933084   
2021 Tsai HH, Chen YF, Yen RF, Lo YL, Yang KC, Jeng JS, Tsai LK, Chang CF. Plasma soluble TREM2 is associated with white matter lesions independent of amyloid and tau. Brain : a Journal of Neurology. PMID 34515756 DOI: 10.1093/brain/awab332   
2021 Kaur D, Behl T, Sehgal A, Singh S, Sharma N, Badavath VN, Ul Hassan SS, Hasan MM, Bhatia S, Al-Harassi A, Khan H, Bungau S. Unravelling the potential neuroprotective facets of erythropoietin for the treatment of Alzheimer's disease. Metabolic Brain Disease. PMID 34436747 DOI: 10.1007/s11011-021-00820-6   
2021 Rea Martinez J, Šelo G, Fernández-Arche MÁ, Bermudez B, García-Giménez MD. Dual Role of Phenyl Amides from Hempseed on BACE 1, PPARγ, and PGC-1α in N2a-APP Cells. Journal of Natural Products. PMID 34460260 DOI: 10.1021/acs.jnatprod.1c00435   
2021 Potashman M, Buessing M, Levitchi Benea M, Cummings J, Borson S, Pemberton-Ross P, Epstein AJ. Estimating Progression Rates Across the Spectrum of Alzheimer's Disease for Amyloid-Positive Individuals Using National Alzheimer's Coordinating Center Data. Neurology and Therapy. PMID 34431074 DOI: 10.1007/s40120-021-00272-1   
2021 Xie Y, Wang Y, Jiang S, Xiang X, Wang J, Ning L. Novel Strategies for the fight of Alzheimer's disease targeting amyloid-β protein. Journal of Drug Targeting. 1-20. PMID 34435898 DOI: 10.1080/1061186X.2021.1973482   
2021 Dai S, Zhou F, Sun J, Li Y. NPD1 Enhances Autophagy and Reduces Hyperphosphorylated Tau and Amyloid-β42 by Inhibiting GSK3β Activation in N2a/APP695swe Cells. Journal of Alzheimer's Disease : Jad. PMID 34602482 DOI: 10.3233/JAD-210729   
2021 Stepanchuk AA, Joseph JT, Stys PK. Spectral photokinetic conversion of the fluorescent probes BSB and K114 for improved detection of amyloid assemblies. Journal of Biophotonics. e202100203. PMID 34499422 DOI: 10.1002/jbio.202100203   
2021 Setti SE, Reed MN. Network activity changes in the pathophysiology of Alzheimer's disease: the role of aging and early entorhinal cortex dysfunction. Metabolic Brain Disease. PMID 34591222 DOI: 10.1007/s11011-021-00848-8   
2021 Wightman DP, Jansen IE, Savage JE, Shadrin AA, Bahrami S, Holland D, Rongve A, Børte S, Winsvold BS, Drange OK, Martinsen AE, Skogholt AH, Willer C, Bråthen G, Bosnes I, ... , et al. A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease. Nature Genetics. 53: 1276-1282. PMID 34493870 DOI: 10.1038/s41588-021-00921-z   
2021 Tijms BM, Gobom J, Teunissen C, Dobricic V, Tsolaki M, Verhey F, Popp J, Martinez-Lage P, Vandenberghe R, Lleó A, Molinuévo JL, Engelborghs S, Freund-Levi Y, Froelich L, Bertram L, et al. CSF Proteomic Alzheimer's Disease-Predictive Subtypes in Cognitively Intact Amyloid Negative Individuals. Proteomes. 9. PMID 34449748 DOI: 10.3390/proteomes9030036   
2021 Ugbaja S, Lawal I, Kumalo H, Lawal M. Alzheimer's Disease and β-Secretase Inhibition: An Update With a Focus on Computer-Aided Inhibitor Design. Current Drug Targets. PMID 34370634 DOI: 10.2174/1389450122666210809100050   
2021 Ledreux A, Thomas S, Hamlett ED, Trautman C, Gilmore A, Rickman Hager E, Paredes DA, Margittai M, Fortea J, Granholm AC. Small Neuron-Derived Extracellular Vesicles from Individuals with Down Syndrome Propagate Tau Pathology in the Wildtype Mouse Brain. Journal of Clinical Medicine. 10. PMID 34501378 DOI: 10.3390/jcm10173931