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Myles H. Akabas - Publications

Affiliations: 
Albert Einstein College of Medicine, New York, New York, United States 
Area:
NEUROTRANSMITTER-GATED ION CHANNELS, MALARIA PARASITE PHYSIOLOGY AND MECHANISMS OF CHLOROQUINE RESISTANCE
Website:
http://akabaslab.aecom.yu.edu/index.html

84 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Nishtala SN, Arora A, Reyes J, Akabas MH. Accessibility of substituted cysteines in TM2 and TM10 transmembrane segments in the equilibrative nucleoside transporter PfENT1. The Journal of Biological Chemistry. PMID 30541922 DOI: 10.1074/jbc.RA118.006547  0.48
2016 Van Voorhis WC, Adams JH, Adelfio R, Ahyong V, Akabas MH, Alano P, Alday A, Alemán Resto Y, Alsibaee A, Alzualde A, Andrews KT, Avery SV, Avery VM, Ayong L, Baker M, et al. Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond. Plos Pathogens. 12: e1005763. PMID 27467575 DOI: 10.1371/journal.ppat.1005763  0.32
2016 Arora A, Deniskin R, Sosa Y, Nishtala SN, Henrich PP, Kumar TR, Fidock DA, Akabas MH. Substrate and inhibitor specificity of the Plasmodium berghei Equilibrative Nucleoside Transporter Type 1 (PbENT1). Molecular Pharmacology. PMID 27048953 DOI: 10.1124/mol.115.101386  1
2016 Deniskin R, Frame IJ, Sosa Y, Akabas MH. Targeting the Plasmodium vivax equilibrative nucleoside transporter 1 (PvENT1) for antimalarial drug development. International Journal For Parasitology. Drugs and Drug Resistance. 6: 1-11. PMID 26862473 DOI: 10.1016/j.ijpddr.2015.11.003  0.92
2016 Deniskin R, Frame IJ, Sosa Y, Akabas MH. Targeting the Plasmodium vivax equilibrative nucleoside transporter 1 (PvENT1) for antimalarial drug development International Journal For Parasitology: Drugs and Drug Resistance. 6: 1-11. DOI: 10.1016/j.ijpddr.2015.11.003  1
2015 Akabas MH. Cysteine Modification: Probing Channel Structure, Function and Conformational Change. Advances in Experimental Medicine and Biology. 869: 25-54. PMID 26381939 DOI: 10.1007/978-1-4939-2845-3_3  1
2015 Frame IJ, Deniskin R, Rinderspacher A, Katz F, Deng SX, Moir RD, Adjalley SH, Coburn-Flynn O, Fidock DA, Willis IM, Landry DW, Akabas MH. Yeast-based high-throughput screen identifies Plasmodium falciparum equilibrative nucleoside transporter 1 inhibitors that kill malaria parasites. Acs Chemical Biology. 10: 775-83. PMID 25602169 DOI: 10.1021/cb500981y  1
2015 Frame IJ, Deniskin R, Arora A, Akabas MH. Purine import into malaria parasites as a target for antimalarial drug development. Annals of the New York Academy of Sciences. 1342: 19-28. PMID 25424653 DOI: 10.1111/nyas.12568  1
2014 Akabas MH, Brass LF. A closer look at attrition in MD-PhD programs. Academic Medicine : Journal of the Association of American Medical Colleges. 89: 958. PMID 24979155 DOI: 10.1097/ACM.0000000000000299  1
2013 Akabas MH. Using molecular dynamics to elucidate the structural basis for function in pLGICs. Proceedings of the National Academy of Sciences of the United States of America. 110: 16700-1. PMID 24096580 DOI: 10.1073/pnas.1316157110  1
2013 Brunner R, Ng CL, Aissaoui H, Akabas MH, Boss C, Brun R, Callaghan PS, Corminboeuf O, Fidock DA, Frame IJ, Heidmann B, Le Bihan A, Jenö P, Mattheis C, Moes S, et al. UV-triggered affinity capture identifies interactions between the Plasmodium falciparum multidrug resistance protein 1 (PfMDR1) and antimalarial agents in live parasitized cells. The Journal of Biological Chemistry. 288: 22576-83. PMID 23754276 DOI: 10.1074/jbc.M113.453159  1
2012 Akabas MH. Channels: Rotamers affect ion conductance. Nature Chemical Biology. 8: 953-4. PMID 23183578 DOI: 10.1038/nchembio.1115  1
2012 Bali M, Akabas MH. Gating-induced conformational rearrangement of the γ-aminobutyric acid type A receptor β-α subunit interface in the membrane-spanning domain. The Journal of Biological Chemistry. 287: 27762-70. PMID 22730325 DOI: 10.1074/jbc.M112.363341  1
2012 Frame IJ, Merino EF, Schramm VL, Cassera MB, Akabas MH. Malaria parasite type 4 equilibrative nucleoside transporters (ENT4) are purine transporters with distinct substrate specificity. The Biochemical Journal. 446: 179-90. PMID 22670848 DOI: 10.1042/BJ20112220  1
2012 Collins B, Kane EA, Reeves DC, Akabas MH, Blau J. Balance of activity between LN(v)s and glutamatergic dorsal clock neurons promotes robust circadian rhythms in Drosophila. Neuron. 74: 706-18. PMID 22632728 DOI: 10.1016/j.neuron.2012.02.034  1
2012 McKinnon NK, Bali M, Akabas MH. Length and amino acid sequence of peptides substituted for the 5-HT3A receptor M3M4 loop may affect channel expression and desensitization. Plos One. 7: e35563. PMID 22539982 DOI: 10.1371/journal.pone.0035563  1
2012 Collins B, Kane EA, Reeves DC, Akabas MH, Blau J. Balance of Activity between LN vs and Glutamatergic Dorsal Clock Neurons Promotes Robust Circadian Rhythms in Drosophila Neuron. 74: 1138. DOI: 10.1016/j.neuron.2012.06.007  1
2011 Akabas MH. Ion channels: Manipulating the munchies in mice. Nature Chemical Biology. 7: 759-60. PMID 22008994 DOI: 10.1038/nchembio.697  1
2011 McKinnon NK, Reeves DC, Akabas MH. 5-HT3 receptor ion size selectivity is a property of the transmembrane channel, not the cytoplasmic vestibule portals. The Journal of General Physiology. 138: 453-66. PMID 21948949 DOI: 10.1085/jgp.201110686  1
2011 Ekland EH, Akabas MH, Fidock DA. Taking Charge: Feeding Malaria via Anion Channels. Cell. 145: 645-7. PMID 21620131 DOI: 10.1016/j.cell.2011.05.012  1
2011 Parikh RB, Bali M, Akabas MH. Structure of the M2 transmembrane segment of GLIC, a prokaryotic Cys loop receptor homologue from Gloeobacter violaceus, probed by substituted cysteine accessibility. The Journal of Biological Chemistry. 286: 14098-109. PMID 21362624 DOI: 10.1074/jbc.M111.221895  1
2011 Brass LF, Andersen OS, Akabas MH. In reply Academic Medicine. 86: 277-278. DOI: 10.1097/ACM.0b013e3182092701  1
2010 Dahdal D, Reeves DC, Ruben M, Akabas MH, Blau J. Drosophila pacemaker neurons require g protein signaling and GABAergic inputs to generate twenty-four hour behavioral rhythms. Neuron. 68: 964-77. PMID 21145008 DOI: 10.1016/j.neuron.2010.11.017  1
2010 Riegelhaupt PM, Frame IJ, Akabas MH. Transmembrane segment 11 appears to line the purine permeation pathway of the Plasmodium falciparum equilibrative nucleoside transporter 1 (PfENT1). The Journal of Biological Chemistry. 285: 17001-10. PMID 20335165 DOI: 10.1074/jbc.M110.115758  1
2010 Brass LF, Akabas MH, Burnley LD, Engman DM, Wiley CA, Andersen OS. Are MD-PhD programs meeting their goals? An analysis of career choices made by graduates of 24 MD-PhD programs. Academic Medicine : Journal of the Association of American Medical Colleges. 85: 692-701. PMID 20186033 DOI: 10.1097/ACM.0b013e3181d3ca17  1
2010 Riegelhaupt PM, Cassera MB, Fröhlich RF, Hazleton KZ, Hefter JJ, Schramm VL, Akabas MH. Transport of purines and purine salvage pathway inhibitors by the Plasmodium falciparum equilibrative nucleoside transporter PfENT1. Molecular and Biochemical Parasitology. 169: 40-9. PMID 19818813 DOI: 10.1016/j.molbiopara.2009.10.001  1
2009 Nkrumah LJ, Riegelhaupt PM, Moura P, Johnson DJ, Patel J, Hayton K, Ferdig MT, Wellems TE, Akabas MH, Fidock DA. Probing the multifactorial basis of Plasmodium falciparum quinine resistance: evidence for a strain-specific contribution of the sodium-proton exchanger PfNHE. Molecular and Biochemical Parasitology. 165: 122-31. PMID 19428659 DOI: 10.1016/j.molbiopara.2009.01.011  1
2009 Bali M, Jansen M, Akabas MH. GABA-induced intersubunit conformational movement in the GABAA receptor alpha 1M1-beta 2M3 transmembrane subunit interface: experimental basis for homology modeling of an intravenous anesthetic binding site. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 3083-92. PMID 19279245 DOI: 10.1523/JNEUROSCI.6090-08.2009  1
2008 Cassera MB, Hazleton KZ, Riegelhaupt PM, Merino EF, Luo M, Akabas MH, Schramm VL. Erythrocytic adenosine monophosphate as an alternative purine source in Plasmodium falciparum. The Journal of Biological Chemistry. 283: 32889-99. PMID 18799466 DOI: 10.1074/jbc.M804497200  1
2008 Jansen M, Rabe H, Strehle A, Dieler S, Debus F, Dannhardt G, Akabas MH, Lüddens H. Synthesis of GABAA receptor agonists and evaluation of their alpha-subunit selectivity and orientation in the GABA binding site. Journal of Medicinal Chemistry. 51: 4430-48. PMID 18651727 DOI: 10.1021/jm701562x  1
2008 Zhao R, Qiu A, Tsai E, Jansen M, Akabas MH, Goldman ID. The proton-coupled folate transporter: impact on pemetrexed transport and on antifolates activities compared with the reduced folate carrier. Molecular Pharmacology. 74: 854-62. PMID 18524888 DOI: 10.1124/mol.108.045443  1
2008 Jansen M, Bali M, Akabas MH. Modular design of Cys-loop ligand-gated ion channels: functional 5-HT3 and GABA rho1 receptors lacking the large cytoplasmic M3M4 loop. The Journal of General Physiology. 131: 137-46. PMID 18227272 DOI: 10.1085/jgp.200709896  1
2007 Qiu A, Min SH, Jansen M, Malhotra U, Tsai E, Cabelof DC, Matherly LH, Zhao R, Akabas MH, Goldman ID. Rodent intestinal folate transporters (SLC46A1): secondary structure, functional properties, and response to dietary folate restriction. American Journal of Physiology. Cell Physiology. 293: C1669-78. PMID 17898134 DOI: 10.1152/ajpcell.00202.2007  1
2007 Rosen A, Bali M, Horenstein J, Akabas MH. Channel opening by anesthetics and GABA induces similar changes in the GABAA receptor M2 segment. Biophysical Journal. 92: 3130-9. PMID 17293408 DOI: 10.1529/biophysj.106.094490  1
2007 Bali M, Akabas MH. The location of a closed channel gate in the GABAA receptor channel. The Journal of General Physiology. 129: 145-59. PMID 17227918 DOI: 10.1085/jgp.200609639  1
2006 Qiu A, Jansen M, Sakaris A, Min SH, Chattopadhyay S, Tsai E, Sandoval C, Zhao R, Akabas MH, Goldman ID. Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption. Cell. 127: 917-28. PMID 17129779 DOI: 10.1016/j.cell.2006.09.041  1
2006 Reeves DC, Liebelt DA, Lakshmanan V, Roepe PD, Fidock DA, Akabas MH. Chloroquine-resistant isoforms of the Plasmodium falciparum chloroquine resistance transporter acidify lysosomal pH in HEK293 cells more than chloroquine-sensitive isoforms. Molecular and Biochemical Parasitology. 150: 288-99. PMID 17014918 DOI: 10.1016/j.molbiopara.2006.09.001  1
2006 Jansen M, Akabas MH. State-dependent cross-linking of the M2 and M3 segments: functional basis for the alignment of GABAA and acetylcholine receptor M3 segments. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 4492-9. PMID 16641228 DOI: 10.1523/JNEUROSCI.0224-06.2006  1
2006 Akabas MH. Watching single protons bind. Nature Chemical Biology. 2: 128-30. PMID 16485003 DOI: 10.1038/nchembio0306-128  1
2005 Reeves DC, Jansen M, Bali M, Lemster T, Akabas MH. A role for the beta 1-beta 2 loop in the gating of 5-HT3 receptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 9358-66. PMID 16221844 DOI: 10.1523/JNEUROSCI.1045-05.2005  1
2005 Hemmings HC, Akabas MH, Goldstein PA, Trudell JR, Orser BA, Harrison NL. Emerging molecular mechanisms of general anesthetic action. Trends in Pharmacological Sciences. 26: 503-10. PMID 16126282 DOI: 10.1016/j.tips.2005.08.006  1
2005 Bera AK, Akabas MH. Spontaneous thermal motion of the GABA(A) receptor M2 channel-lining segments. The Journal of Biological Chemistry. 280: 35506-12. PMID 16091360 DOI: 10.1074/jbc.M504645200  1
2005 Jung S, Akabas MH, Harris RA. Functional and structural analysis of the GABAA receptor alpha 1 subunit during channel gating and alcohol modulation. The Journal of Biological Chemistry. 280: 308-16. PMID 15522868 DOI: 10.1074/jbc.M409871200  1
2005 Horenstein J, Riegelhaupt P, Akabas MH. Differential protein mobility of the gamma-aminobutyric acid, type A, receptor alpha and beta subunit channel-lining segments. The Journal of Biological Chemistry. 280: 1573-81. PMID 15522864 DOI: 10.1074/jbc.M410881200  1
2005 Akabas MH, Bali M. GABAA receptor interactions with propofol: Binding site location and conformational changes International Congress Series. 1283: 3-8. DOI: 10.1016/j.ics.2005.07.014  1
2004 Akabas MH. GABAA receptor structure-function studies: a reexamination in light of new acetylcholine receptor structures. International Review of Neurobiology. 62: 1-43. PMID 15530567 DOI: 10.1016/S0074-7742(04)62001-0  1
2004 Akabas MH. Na+/Ca2+ exchange inhibitors: potential drugs to mitigate the severity of ischemic injury. Molecular Pharmacology. 66: 8-10. PMID 15213290 DOI: 10.1124/mol.104.000232.  1
2004 Bali M, Akabas MH. Defining the propofol binding site location on the GABAA receptor. Molecular Pharmacology. 65: 68-76. PMID 14722238 DOI: 10.1124/mol.65.1.68  1
2004 Goren EN, Reeves DC, Akabas MH. Loose protein packing around the extracellular half of the GABA(A) receptor beta1 subunit M2 channel-lining segment. The Journal of Biological Chemistry. 279: 11198-205. PMID 14715650 DOI: 10.1074/jbc.M314050200  1
2002 Bera AK, Chatav M, Akabas MH. GABA(A) receptor M2-M3 loop secondary structure and changes in accessibility during channel gating. The Journal of Biological Chemistry. 277: 43002-10. PMID 12226083 DOI: 10.1074/jbc.M206321200  1
2002 Williams DB, Akabas MH. Structural evidence that propofol stabilizes different GABA(A) receptor states at potentiating and activating concentrations. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 7417-24. PMID 12196563  1
2002 Akabas MH. Probing CFTR channel structure and function using the substituted-cysteine-accessibility method. Methods in Molecular Medicine. 70: 159-74. PMID 11917520 DOI: 10.1385/1-59259-187-6:159  1
2001 Williams DB, Akabas MH. Evidence for distinct conformations of the two alpha 1 subunits in diazepam-bound GABA(A) receptors. Neuropharmacology. 41: 539-45. PMID 11587708 DOI: 10.1016/S0028-3908(01)00099-5  1
2001 Reeves DC, Goren EN, Akabas MH, Lummis SC. Structural and electrostatic properties of the 5-HT3 receptor pore revealed by substituted cysteine accessibility mutagenesis. The Journal of Biological Chemistry. 276: 42035-42. PMID 11557761 DOI: 10.1074/jbc.M106066200  1
2001 Horenstein J, Wagner DA, Czajkowski C, Akabas MH. Protein mobility and GABA-induced conformational changes in GABA(A) receptor pore-lining M2 segment. Nature Neuroscience. 4: 477-85. PMID 11319555 DOI: 10.1038/87425  1
2000 Williams DB, Akabas MH. Benzodiazepines induce a conformational change in the region of the gamma-aminobutyric acid type A receptor alpha(1)-subunit M3 membrane-spanning segment. Molecular Pharmacology. 58: 1129-36. PMID 11040062  1
2000 Akabas MH. Cystic fibrosis transmembrane conductance regulator. Structure and function of an epithelial chloride channel. The Journal of Biological Chemistry. 275: 3729-32. PMID 10660517 DOI: 10.1074/jbc.275.6.3729  1
1999 Williams DB, Akabas MH. Gamma-aminobutyric acid increases the water accessibility of M3 membrane-spanning segment residues in gamma-aminobutyric acid type A receptors. Biophysical Journal. 77: 2563-74. PMID 10545357  1
1999 Guinamard R, Akabas MH. Arg352 is a major determinant of charge selectivity in the cystic fibrosis transmembrane conductance regulator chloride channel. Biochemistry. 38: 5528-37. PMID 10220340 DOI: 10.1021/bi990155n  1
1998 Akabas MH. Channel-lining residues in the M3 membrane-spanning segment of the cystic fibrosis transmembrane conductance regulator. Biochemistry. 37: 12233-40. PMID 9724537 DOI: 10.1021/bi980969o  1
1998 Karlin A, Akabas MH. Substituted-cysteine accessibility method. Methods in Enzymology. 293: 123-45. PMID 9711606 DOI: 10.1016/S0076-6879(98)93011-7  1
1998 Horenstein J, Akabas MH. Location of a high affinity Zn2+ binding site in the channel of alpha1beta1 gamma-aminobutyric acidA receptors. Molecular Pharmacology. 53: 870-7. PMID 9584213  1
1997 Akabas MH, Cheung M, Guinamard R. Probing the structural and functional domains of the CFTR chloride channel. Journal of Bioenergetics and Biomembranes. 29: 453-63. PMID 9511930 DOI: 10.1023/A:1022482923122  1
1997 Cheung M, Akabas MH. Locating the anion-selectivity filter of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel. The Journal of General Physiology. 109: 289-99. PMID 9089437 DOI: 10.1085/jgp.109.3.289  1
1996 Xu M, Akabas MH. Identification of channel-lining residues in the M2 membrane-spanning segment of the GABA(A) receptor alpha1 subunit. The Journal of General Physiology. 107: 195-205. PMID 8833341  1
1996 Cheung M, Akabas MH. Identification of cystic fibrosis transmembrane conductance regulator channel-lining residues in and flanking the M6 membrane-spanning segment. Biophysical Journal. 70: 2688-95. PMID 8744306 DOI: 10.1016/S0006-3495(96)79838-7  1
1996 Sun ZP, Akabas MH, Goulding EH, Karlin A, Siegelbaum SA. Exposure of residues in the cyclic nucleotide-gated channel pore: P region structure and function in gating. Neuron. 16: 141-9. PMID 8562078 DOI: 10.1016/S0896-6273(00)80031-8  1
1995 Karlin A, Akabas MH. Toward a structural basis for the function of nicotinic acetylcholine receptors and their cousins. Neuron. 15: 1231-44. PMID 8845149 DOI: 10.1016/0896-6273(95)90004-7  1
1995 Xu M, Covey DF, Akabas MH. Interaction of picrotoxin with GABAA receptor channel-lining residues probed in cysteine mutants. Biophysical Journal. 69: 1858-67. PMID 8580329 DOI: 10.1016/S0006-3495(95)80056-1  1
1995 Akabas MH, Karlin A. Identification of acetylcholine receptor channel-lining residues in the M1 segment of the alpha-subunit. Biochemistry. 34: 12496-500. PMID 7547996  1
1994 Akabas MH, Kaufmann C, Archdeacon P, Karlin A. Identification of acetylcholine receptor channel-lining residues in the entire M2 segment of the alpha subunit. Neuron. 13: 919-27. PMID 7524560 DOI: 10.1016/0896-6273(94)90257-7  1
1994 Karlin A, Akabas MH, Czajkowski C, Kaufmann C, Stauffer D, Xu M. Structures involved in binding, gating, and conduction in nicotinic acetylcholine receptors. Renal Physiology and Biochemistry. 17: 184-6. PMID 7518954 DOI: 10.1159/000173814  1
1994 Akabas MH, Kaufmann C, Cook TA, Archdeacon P. Amino acid residues lining the chloride channel of the cystic fibrosis transmembrane conductance regulator. The Journal of Biological Chemistry. 269: 14865-8. PMID 7515047  1
1993 Xu M, Akabas MH. Amino acids lining the channel of the gamma-aminobutyric acid type A receptor identified by cysteine substitution. The Journal of Biological Chemistry. 268: 21505-8. PMID 7691812  1
1992 Akabas MH, Stauffer DA, Xu M, Karlin A. Acetylcholine receptor channel structure probed in cysteine-substitution mutants. Science (New York, N.Y.). 258: 307-10. PMID 1384130  1
1991 Al-Awqati Q, Landry D, Akabas M, Redhead C, Edelman A, Edwards J. Purification of the epithelial C1 channel Advances in Experimental Medicine and Biology. 290: 235-240. PMID 1719761  1
1990 Akabas M, Dodd J, Al-Awqati Q. Identification of electrophysiologically distinct subpopulations of rat taste cells The Journal of Membrane Biology. 114: 71-78. PMID 2157018 DOI: 10.1007/BF01869386  1
1990 Akabas MH. Mechanisms of chemosensory transduction in taste cells. International Review of Neurobiology. 32: 241-79. PMID 1706688  1
1989 Cohen FS, Niles WD, Akabas MH. Fusion of phospholipid vesicles with a planar membrane depends on the membrane permeability of the solute used to create the osmotic pressure. The Journal of General Physiology. 93: 201-10. PMID 2539429  1
1989 Landry DW, Akabas MH, Redhead C, Edelman A, Cragoe EJ, Al-Awqati Q. Purification and reconstitution of chloride channels from kidney and trachea. Science (New York, N.Y.). 244: 1469-72. PMID 2472007  1
1988 Akabas MH, Dodd J, Al-Awqati Q. A bitter substance induces a rise in intracellular calcium in a subpopulation of rat taste cells. Science (New York, N.Y.). 242: 1047-50. PMID 3194756  1
1984 Akabas MH, Cohen FS, Finkelstein A. Separation of the osmotically driven fusion event from vesicle-planar membrane attachment in a model system for exocytosis. The Journal of Cell Biology. 98: 1063-71. PMID 6699082  1
1984 Cohen FS, Akabas MH, Zimmerberg J, Finkelstein A. Parameters affecting the fusion of unilamellar phospholipid vesicles with planar bilayer membranes. The Journal of Cell Biology. 98: 1054-62. PMID 6699081  1
1982 Cohen FS, Akabas MH, Finkelstein A. Osmotic swelling of phospholipid vesicles causes them to fuse with a planar phospholipid bilayer membrane. Science (New York, N.Y.). 217: 458-60. PMID 6283637  1
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