| Year |
Citation |
Score |
| 2024 |
Fallah S, Duncan D, Reichl KD, Smith MJ, Wang W, Porco JA, Brown LE, Whitesell L, Robbins N, Cowen LE. A chemical screen identifies structurally diverse metal chelators with activity against the fungal pathogen . Microbiology Spectrum. e0409523. PMID 38376363 DOI: 10.1128/spectrum.04095-23 |
0.542 |
|
| 2023 |
Millimaci AM, Trilles RV, McNeely JH, Brown LE, Beeler AB, Porco JA. Synthesis of Neocannabinoids Using Controlled Friedel-Crafts Reactions. The Journal of Organic Chemistry. PMID 37657122 DOI: 10.1021/acs.joc.3c01362 |
0.48 |
|
| 2023 |
Naineni SK, Cencic R, Robert F, Brown L, Haque M, Scott-Talib J, Senechal P, Schmeing TM, Porco J, Pelletier J. Exploring the Targeting Spectrum of Rocaglates Among eIF4A Homologs. Rna (New York, N.Y.). PMID 36882295 DOI: 10.1261/rna.079318.122 |
0.493 |
|
| 2023 |
Kavouris JA, McCall LI, Giardini MA, De Muylder G, Thomas D, Garcia-Pérez A, Cantizani J, Cotillo I, Fiandor JM, McKerrow JH, De Oliveira CI, Siqueira-Neto JL, González S, Brown LE, Schaus SE. Discovery of pyrazolopyrrolidinones as potent, broad-spectrum inhibitors of infection. Frontiers in Tropical Diseases. 3. PMID 36818551 DOI: 10.3389/fitd.2022.1011124 |
0.571 |
|
| 2022 |
Shaashua L, Ben-Shmuel A, Pevsner-Fischer M, Friedman G, Levi-Galibov O, Nandakumar S, Barki D, Nevo R, Brown LE, Zhang W, Stein Y, Lior C, Kim HS, Bojmar L, Jarnagin WR, et al. BRCA mutational status shapes the stromal microenvironment of pancreatic cancer linking clusterin expression in cancer associated fibroblasts with HSF1 signaling. Nature Communications. 13: 6513. PMID 36316305 DOI: 10.1038/s41467-022-34081-3 |
0.433 |
|
| 2022 |
Brown LE, Seitz S, Kondas AV, Marcyk PT, Filone CM, Hossain MM, Schaus SE, Olson VA, Connor JH. Identification of Small Molecules with Improved Potency against Orthopoxviruses from Vaccinia to Smallpox. Antimicrobial Agents and Chemotherapy. e0084122. PMID 36222522 DOI: 10.1128/aac.00841-22 |
0.588 |
|
| 2022 |
Lehman SL, Wechsler T, Schwartz K, Brown LE, Porco JA, Devine WG, Pelletier J, Shankavaram UT, Camphausen K, Tofilon PJ. Inhibition of the translation initiation factor eIF4A enhances tumor cell radiosensitivity. Molecular Cancer Therapeutics. PMID 35732578 DOI: 10.1158/1535-7163.MCT-22-0037 |
0.489 |
|
| 2022 |
Praditya DF, Klöhn M, Brüggemann Y, Brown LE, Porco JA, Zhang W, Kinast V, Kirschning A, Vondran FWR, Todt D, Steinmann E. Identification of structurally re-engineered rocaglates as inhibitors against hepatitis E virus replication. Antiviral Research. 105359. PMID 35728703 DOI: 10.1016/j.antiviral.2022.105359 |
0.521 |
|
| 2021 |
Xu W, Brown LE, Porco JA. Divergent, C-C Bond Forming Macrocyclizations Using Modular Sulfonylhydrazone and Derived Substrates. The Journal of Organic Chemistry. PMID 34730970 DOI: 10.1021/acs.joc.1c01848 |
0.474 |
|
| 2021 |
Chatterjee S, Yabaji SM, Rukhlenko OS, Bhattacharya B, Waligurski E, Vallavoju N, Ray S, Kholodenko BN, Brown LE, Beeler AB, Ivanov AR, Kobzik L, Porco JA, Kramnik I. Channeling macrophage polarization by rocaglates increases macrophage resistance to . Iscience. 24: 102845. PMID 34381970 DOI: 10.1016/j.isci.2021.102845 |
0.441 |
|
| 2020 |
Iyer KR, Camara K, Daniel-Ivad M, Trilles R, Pimentel-Elardo SM, Fossen JL, Marchillo K, Liu Z, Singh S, Muñoz JF, Kim SH, Porco JA, Cuomo CA, Williams NS, Ibrahim AS, ... ... Brown LE, et al. An oxindole efflux inhibitor potentiates azoles and impairs virulence in the fungal pathogen Candida auris. Nature Communications. 11: 6429. PMID 33353950 DOI: 10.1038/s41467-020-20183-3 |
0.493 |
|
| 2020 |
Levi-Galibov O, Lavon H, Wassermann-Dozorets R, Pevsner-Fischer M, Mayer S, Wershof E, Stein Y, Brown LE, Zhang W, Friedman G, Nevo R, Golani O, Katz LH, Yaeger R, Laish I, et al. Heat Shock Factor 1-dependent extracellular matrix remodeling mediates the transition from chronic intestinal inflammation to colon cancer. Nature Communications. 11: 6245. PMID 33288768 DOI: 10.1038/s41467-020-20054-x |
0.442 |
|
| 2020 |
Iyer KR, Whitesell L, Porco JA, Henkel T, Brown LE, Robbins N, Cowen LE. Translation Inhibition by Rocaglates Activates a Species-Specific Cell Death Program in the Emerging Fungal Pathogen Candida auris. Mbio. 11. PMID 32156828 DOI: 10.1128/Mbio.03329-19 |
0.588 |
|
| 2020 |
Chu J, Zhang W, Cencic R, O'Connor PBF, Robert F, Devine WG, Selznick A, Henkel T, Merrick WC, Brown LE, Baranov PV, Porco JA, Pelletier J. Rocaglates Induce Gain-of-Function Alterations to eIF4A and eIF4F. Cell Reports. PMID 32101697 DOI: 10.1016/J.Celrep.2020.02.002 |
0.549 |
|
| 2020 |
Lehman SL, Wechsler T, Schwartz KR, Wahba A, Brown LE, Porco JA, Pelletier J, Camphausen K, Tofilon PJ. Abstract 6507: Inhibition of the translation initiation factor eIF4A1 enhances tumor cell radiosensitivity Cancer Research. 80: 6507-6507. DOI: 10.1158/1538-7445.Am2020-6507 |
0.542 |
|
| 2019 |
Chan K, Robert F, Oertlin C, Kapeller-Libermann D, Avizonis D, Gutierrez J, Handly-Santana A, Doubrovin M, Park J, Schoepfer C, Da Silva B, Yao M, Gorton F, Shi J, Thomas CJ, ... Brown LE, et al. eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma. Nature Communications. 10: 5151. PMID 31723131 DOI: 10.1038/S41467-019-13086-5 |
0.54 |
|
| 2019 |
Chu J, Zhang W, Cencic R, Devine WG, Beglov D, Henkel T, Brown LE, Vajda S, Porco JA, Pelletier J. Amidino-Rocaglates: A Potent Class of eIF4A Inhibitors. Cell Chemical Biology. PMID 31519508 DOI: 10.1016/J.Chembiol.2019.08.008 |
0.575 |
|
| 2019 |
Huang D, LeBlanc E, Shekhar-Guturja T, Robbins N, Krysan D, Pizarro JC, Whitesell L, Cowen L, Brown LE. Design and synthesis of fungal-selective resorcylate aminopyrazole Hsp90 inhibitors. Journal of Medicinal Chemistry. PMID 31513387 DOI: 10.1021/Acs.Jmedchem.9B00826 |
0.364 |
|
| 2019 |
Zhang W, Chu J, Cyr AM, Yueh H, Brown LE, Wang TT, Pelletier J, Porco JA. Intercepted Retro-Nazarov Reaction: Syntheses of Amidino-Rocaglate Derivatives and Their Biological Evaluation as eIF4A Inhibitors. Journal of the American Chemical Society. PMID 31310112 DOI: 10.1021/Jacs.9B06446 |
0.602 |
|
| 2019 |
Zhang X, Bi C, Lu T, Zhang W, Yue T, Wang C, Tian T, Zhang X, Huang Y, Lunning M, Hao X, Brown LE, Devine WG, Vose J, Porco JA, et al. Targeting translation initiation by synthetic rocaglates for treating MYC-driven lymphomas. Leukemia. PMID 31171817 DOI: 10.1038/S41375-019-0503-Z |
0.58 |
|
| 2019 |
Chen CD, Zeldich E, Khodr C, Camara K, Tung TY, Lauder EC, Mullen P, Polanco TJ, Liu YY, Zeldich D, Xia W, Van Nostrand WE, Brown LE, Porco JA, Abraham CR. Small Molecule Amyloid-β Protein Precursor Processing Modulators Lower Amyloid-β Peptide Levels via cKit Signaling. Journal of Alzheimer's Disease : Jad. 67: 1089-1106. PMID 30776010 DOI: 10.3233/Jad-180923 |
0.53 |
|
| 2019 |
Itoua Maïga R, Cencic R, Chu J, Waller DD, Brown LE, Devine WG, Zhang W, Sebag M, Porco JA, Pelletier J. Oxo-aglaiastatin-Mediated Inhibition of Translation Initiation. Scientific Reports. 9: 1265. PMID 30718665 DOI: 10.1038/S41598-018-37666-5 |
0.595 |
|
| 2019 |
Whitesell L, Robbins N, Huang DS, McLellan CA, Shekhar-Guturja T, LeBlanc EV, Nation CS, Hui R, Hutchinson A, Collins C, Chatterjee S, Trilles R, Xie JL, Krysan DJ, Lindquist S, ... ... Brown LE, et al. Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus. Nature Communications. 10: 402. PMID 30679438 DOI: 10.1038/s41467-018-08248-w |
0.543 |
|
| 2019 |
Trilles R, Beglov D, Chen Q, He H, Wireman R, Reed A, Chennamadhavuni S, Panek JS, Brown LE, Vajda S, Porco JA, Kelley MR, Georgiadis MM. Discovery of macrocyclic inhibitors of Apurinic/apyrimidinic endonuclease 1. Journal of Medicinal Chemistry. PMID 30653918 DOI: 10.1021/Acs.Jmedchem.8B01529 |
0.575 |
|
| 2018 |
Kearney SE, Zahoránszky-Kőhalmi G, Brimacombe KR, Henderson MJ, Lynch C, Zhao T, Wan KK, Itkin Z, Dillon C, Shen M, Cheff DM, Lee TD, Bougie D, Cheng K, Coussens NP, ... ... Brown LE, et al. Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. Acs Central Science. 4: 1727-1741. PMID 30648156 DOI: 10.1021/Acscentsci.8B00747 |
0.575 |
|
| 2018 |
Zhang W, Liu S, Maiga RI, Pelletier J, Brown LE, Wang TT, Porco JA. Chemical Synthesis Enables Structural Reengineering of Aglaroxin C Leading to Inhibition Bias for HCV Infection. Journal of the American Chemical Society. PMID 30590924 DOI: 10.1021/Jacs.8B11477 |
0.575 |
|
| 2018 |
Nalli AD, Brown LE, Thomas CL, Sayers TJ, Porco JA, Henrich CJ. Sensitization of renal carcinoma cells to TRAIL-induced apoptosis by rocaglamide and analogs. Scientific Reports. 8: 17519. PMID 30504817 DOI: 10.1038/S41598-018-35908-0 |
0.536 |
|
| 2018 |
Chennamadhavuni S, Panek JS, Porco JA, Brown LE. Diastereodivergent synthesis of chiral tetrahydropyrrolodiazepinediones via a one-pot intramolecular aza-Michael/lactamization sequence. The Journal of Organic Chemistry. PMID 30458107 DOI: 10.1021/Acs.Joc.8B02724 |
0.565 |
|
| 2018 |
Yang X, Jounaidi Y, Dai JB, Marte-Oquendo F, Halpin ES, Brown LE, Trilles R, Xu W, Daigle R, Yu B, Schaus SE, Porco JA, Forman SA. High-throughput Screening in Larval Zebrafish Identifies Novel Potent Sedative-hypnotics. Anesthesiology. PMID 29894316 DOI: 10.1097/Aln.0000000000002281 |
0.676 |
|
| 2018 |
Langlais D, Cencic R, Moradin N, Kennedy JM, Ayi K, Brown LE, Crandall I, Tarry MJ, Schmeing M, Kain KC, Porco JA, Pelletier J, Gros P. Rocaglates as dual-targeting agents for experimental cerebral malaria. Proceedings of the National Academy of Sciences of the United States of America. PMID 29463745 DOI: 10.1073/Pnas.1713000115 |
0.544 |
|
| 2017 |
Porco J, Wang W, Clay A, Krishnan R, Lajkiewicz NJ, Brown LE, Sivaguru J. Total Syntheses of the Isomeric Aglain Natural Products Foveoglin A and Perviridisin B via Selective ESIPT Photocycloaddition. Angewandte Chemie (International Ed. in English). PMID 28950418 DOI: 10.1002/Anie.201707539 |
0.537 |
|
| 2017 |
Tardiff DF, Brown LE, Yan X, Trilles R, Jui NT, Barrasa MI, Caldwell KA, Caldwell GA, Schaus SE, Lindquist S. Dihydropyrimidine-thiones and clioquinol synergize to target β-amyloid cellular pathologies through a metal-dependent mechanism. Acs Chemical Neuroscience. PMID 28628299 DOI: 10.1021/Acschemneuro.7B00187 |
0.608 |
|
| 2017 |
Manier S, Huynh D, Shen YJ, Zhou J, Yusufzai T, Salem KZ, Ebright RY, Shi J, Park J, Glavey SV, Devine WG, Liu CJ, Leleu X, Quesnel B, Roche-Lestienne C, ... ... Brown LE, et al. Inhibiting the oncogenic translation program is an effective therapeutic strategy in multiple myeloma. Science Translational Medicine. 9. PMID 28490664 DOI: 10.1126/Scitranslmed.Aal2668 |
0.555 |
|
| 2016 |
Hayashi M, Brown LE, Porco JA. Asymmetric Dearomatization/Cyclization Enables Access to Polycyclic Chemotypes. European Journal of Organic Chemistry. 2016: 4800-4804. PMID 28082832 DOI: 10.1002/Ejoc.201601003 |
0.549 |
|
| 2016 |
Hayashi M, Brown LE, Porco JA. Asymmetric Dearomatization/Cyclization Enables Access to Polycyclic Chemotypes European Journal of Organic Chemistry. DOI: 10.1002/ejoc.201601003 |
0.502 |
|
| 2015 |
Liu S, Wang W, Brown LE, Qiu C, Lajkiewicz N, Zhao T, Zhou J, Porco JA, Wang TT. A Novel Class of Small Molecule Compounds that Inhibit Hepatitis C Virus Infection by Targeting the Prohibitin-CRaf Pathway. Ebiomedicine. 2: 1600-6. PMID 26870784 DOI: 10.1016/J.Ebiom.2015.09.018 |
0.545 |
|
| 2015 |
Liu S, Wang W, Brown LE, Qiu C, Lajkiewicz N, Zhao T, Zhou J, Porco JA, Wang TT. A Novel Class of Small Molecule Compounds that Inhibit Hepatitis C Virus Infection by Targeting the Prohibitin-CRaf Pathway Ebiomedicine. DOI: 10.1016/j.ebiom.2015.09.018 |
0.515 |
|
| 2012 |
Dower K, Filone CM, Hodges EN, Bjornson ZB, Rubins KH, Brown LE, Schaus S, Hensley LE, Connor JH. Identification of a pyridopyrimidinone inhibitor of orthopoxviruses from a diversity-oriented synthesis library. Journal of Virology. 86: 2632-40. PMID 22205744 DOI: 10.1128/Jvi.05416-11 |
0.628 |
|
| 2011 |
Brown LE, Dai P, Porco JA, Schaus SE. Gold catalyzed cyclization of alkyne-tethered dihydropyrimidones. Organic Letters. 13: 4228-31. PMID 21749159 DOI: 10.1021/Ol2015658 |
0.69 |
|
| 2011 |
Brown LE, Chih-Chien Cheng K, Wei WG, Yuan P, Dai P, Trilles R, Ni F, Yuan J, MacArthur R, Guha R, Johnson RL, Su XZ, Dominguez MM, Snyder JK, Beeler AB, et al. Discovery of new antimalarial chemotypes through chemical methodology and library development. Proceedings of the National Academy of Sciences of the United States of America. 108: 6775-80. PMID 21498685 DOI: 10.1073/Pnas.1017666108 |
0.701 |
|
| 2009 |
Brown LE, Landaverry YR, Davies JR, Milinkevich KA, Ast S, Carlson JS, Oliver AG, Konopelski JP. Progress toward the total synthesis of psymberin/irciniastatin A. The Journal of Organic Chemistry. 74: 5405-10. PMID 19572569 DOI: 10.1021/Jo9009003 |
0.711 |
|
| 2009 |
Chen W, Brown LE, Konopelski JP, Chen S. Intervalence transfer of ferrocene moieties adsorbed on electrode surfaces by a conjugated linkage Chemical Physics Letters. 471: 283-285. DOI: 10.1016/J.Cplett.2009.02.057 |
0.535 |
|
| 2009 |
Pradhan S, Brown LE, Konopelski JP, Chen S. Janus nanoparticles: Reaction dynamics and NOESY characterization Journal of Nanoparticle Research. 11: 1895-1903. DOI: 10.1007/S11051-008-9543-4 |
0.532 |
|
| 2008 |
Chen W, Chen S, Ding F, Wang H, Brown LE, Konopelski JP. Nanoparticle-mediated intervalence transfer. Journal of the American Chemical Society. 130: 12156-62. PMID 18710225 DOI: 10.1021/Ja803887B |
0.532 |
|
| 2008 |
Gerstenberger BS, Lin J, Mimieux YS, Brown LE, Oliver AG, Konopelski JP. Structural characterization of an enantiomerically pure amino acid imidazolide and direct formation of the beta-lactam nucleus from an alpha-amino acid. Organic Letters. 10: 369-72. PMID 18181633 DOI: 10.1021/Ol7025922 |
0.727 |
|
| 2008 |
Brown LE, Konopelski JP. Turning the corner: Recent advances in the synthesis of the welwitindolinones Organic Preparations and Procedures International. 40: 411-445. DOI: 10.1080/00304940809458104 |
0.587 |
|
| 2007 |
Xia J, Brown LE, Konopelski JP. Welwistatin support studies: expansion and limitation of aryllead(IV) coupling reactions. The Journal of Organic Chemistry. 72: 6885-90. PMID 17685656 DOI: 10.1021/Jo071156L |
0.71 |
|
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