Ole Isacson - Publications

Harvard Medical School, Boston, MA, United States 

261 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Brekk OR, Korecka JA, Crapart CC, Huebecker M, MacBain ZK, Rosenthal SA, Sena-Esteves M, Priestman DA, Platt FM, Isacson O, Hallett PJ. Upregulating β-hexosaminidase activity in rodents prevents α-synuclein lipid associations and protects dopaminergic neurons from α-synuclein-mediated neurotoxicity. Acta Neuropathologica Communications. 8: 127. PMID 32762772 DOI: 10.1186/s40478-020-01004-6  0.405
2020 Thomas R, Hallett PJ, Isacson O. Experimental studies of mitochondrial and lysosomal function in in vitro and in vivo models relevant to Parkinson's disease genetic risk. International Review of Neurobiology. 154: 279-302. PMID 32739007 DOI: 10.1016/bs.irn.2020.02.004  0.324
2020 Korecka JA, Thomas R, Hinrich AJ, Moskites AM, Macbain ZK, Hallett PJ, Isacson O, Hastings ML. Splice-Switching Antisense Oligonucleotides Reduce LRRK2 Kinase Activity in Human LRRK2 Transgenic Mice. Molecular Therapy. Nucleic Acids. 21: 623-635. PMID 32736291 DOI: 10.1016/j.omtn.2020.06.027  0.314
2020 Osborn TM, Hallett PJ, Schumacher JM, Isacson O. Advantages and Recent Developments of Autologous Cell Therapy for Parkinson's Disease Patients. Frontiers in Cellular Neuroscience. 14: 58. PMID 32317934 DOI: 10.3389/fncel.2020.00058  0.495
2019 Huebecker M, Moloney EB, van der Spoel AC, Priestman DA, Isacson O, Hallett PJ, Platt FM. Reduced sphingolipid hydrolase activities, substrate accumulation and ganglioside decline in Parkinson's disease. Molecular Neurodegeneration. 14: 40. PMID 31703585 DOI: 10.1186/s13024-019-0339-z  0.328
2019 Isacson O, Brekk OR, Hallett PJ. Novel Results and Concepts Emerging From Lipid Cell Biology Relevant to Degenerative Brain Aging and Disease. Frontiers in Neurology. 10: 1053. PMID 31649605 DOI: 10.3389/fneur.2019.01053  0.324
2019 Menon V, Thomas R, Elgueta C, Horl M, Osborn T, Hallett PJ, Bartos M, Isacson O, Pruszak J. Comprehensive cell surface antigen analysis identifies transferrin receptor protein-1 (CD71) as a negative selection marker for human neuronal cells. Stem Cells (Dayton, Ohio). PMID 31381839 DOI: 10.1002/Stem.3057  0.326
2019 Hallett PJ, Engelender S, Isacson O. Lipid and immune abnormalities causing age-dependent neurodegeneration and Parkinson's disease. Journal of Neuroinflammation. 16: 153. PMID 31331333 DOI: 10.1186/S12974-019-1532-2  0.351
2019 Korecka JA, Thomas R, Christensen DP, Hinrich AJ, Ferrari EJ, Levy SA, Hastings ML, Hallett PJ, Isacson O. Mitochondrial clearance and maturation of autophagosomes are compromised in LRRK2 G2019S familial Parkinson's disease patient fibroblasts. Human Molecular Genetics. PMID 31261377 DOI: 10.1093/hmg/ddz126  0.324
2019 Korecka JA, Talbot S, Osborn TM, de Leeuw SM, Levy SA, Ferrari EJ, Moskites A, Atkinson E, Jodelka FM, Hinrich AJ, Hastings ML, Woolf CJ, Hallett PJ, Isacson O. Neurite Collapse and Altered ER Ca Control in Human Parkinson Disease Patient iPSC-Derived Neurons with LRRK2 G2019S Mutation. Stem Cell Reports. 12: 29-41. PMID 30595548 DOI: 10.1016/J.Stemcr.2018.11.021  0.361
2018 Brekk OR, Moskites A, Isacson O, Hallett PJ. Lipid-dependent deposition of alpha-synuclein and Tau on neuronal Secretogranin II-positive vesicular membranes with age. Scientific Reports. 8: 15207. PMID 30315256 DOI: 10.1038/s41598-018-33474-z  0.324
2018 Moloney EB, Moskites A, Ferrari EJ, Isacson O, Hallett PJ. The glycoprotein GPNMB is selectively elevated in the substantia nigra of Parkinson's disease patients and increases after lysosomal stress. Neurobiology of Disease. PMID 30149180 DOI: 10.1016/j.nbd.2018.08.013  0.368
2018 Hallett PJ, Huebecker M, Brekk OR, Moloney EB, Rocha EM, Priestman DA, Platt FM, Isacson O. Glycosphingolipid levels and glucocerebrosidase activity are altered in normal aging of the mouse brain. Neurobiology of Aging. 67: 189-200. PMID 29735433 DOI: 10.1016/j.neurobiolaging.2018.02.028  0.345
2017 Osborn TM, Beagan J, Isacson O. Increased motor neuron resilience by small molecule compound that regulate IGF-II expression. Neurobiology of Disease. PMID 29113829 DOI: 10.1016/j.nbd.2017.11.002  0.372
2017 Klemann CJHM, Martens GJM, Sharma M, Martens MB, Isacson O, Gasser T, Visser JE, Poelmans G. Integrated molecular landscape of Parkinson's disease. Npj Parkinson's Disease. 3: 14. PMID 28649614 DOI: 10.1038/s41531-017-0015-3  0.366
2016 Engelender S, Isacson O. The Threshold Theory for Parkinson's Disease. Trends in Neurosciences. PMID 27894611 DOI: 10.1016/J.Tins.2016.10.008  0.389
2016 Kordower JH, Vinuela A, Chu Y, Isacson O, Redmond DE. Parkinsonian Monkeys With Prior Levodopa-Induced Dyskinesias Followed by Fetal Dopamine Precursor Grafts Do Not Display Graft-Induced Dyskinesias. The Journal of Comparative Neurology. PMID 27418401 DOI: 10.1002/Cne.24081  0.456
2016 Xiong N, Li N, Martin E, Yu J, Li J, Liu J, Lee DY, Isacson O, Vance J, Qing H, Wang T, Lin Z. hVMAT2: A Target of Individualized Medication for Parkinson's Disease. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. PMID 27137201 DOI: 10.1007/S13311-016-0435-5  0.364
2016 Wang X, Li N, Xiong N, You Q, Li J, Yu J, Qing H, Wang T, Cordell HJ, Isacson O, Vance JM, Martin ER, Zhao Y, Cohen BM, Buttner EA, et al. Genetic Variants of Microtubule Actin Cross-linking Factor 1 (MACF1) Confer Risk for Parkinson's Disease. Molecular Neurobiology. PMID 27021023 DOI: 10.1007/S12035-016-9861-Y  0.429
2016 Jeon J, Kim W, Jang J, Isacson O, Seo H. Gene therapy by proteasome activator, PA28γ, improves motor coordination and proteasome function in Huntington's disease YAC128 mice. Neuroscience. PMID 26944602 DOI: 10.1016/j.neuroscience.2016.02.054  0.375
2016 Mazzulli JR, Zunke F, Isacson O, Studer L, Krainc D. α-Synuclein-induced lysosomal dysfunction occurs through disruptions in protein trafficking in human midbrain synucleinopathy models. Proceedings of the National Academy of Sciences of the United States of America. PMID 26839413 DOI: 10.1073/Pnas.1520335113  0.377
2015 Korecka JA, Levy S, Isacson O. In vivo modeling of neuronal function, axonal impairment and connectivity in neurodegenerative and neuropsychiatric disorders using induced pluripotent stem cells. Molecular and Cellular Neurosciences. PMID 26691153 DOI: 10.1016/j.mcn.2015.12.004  0.411
2015 Smith GA, Jansson J, Rocha EM, Osborn T, Hallett PJ, Isacson O. Fibroblast Biomarkers of Sporadic Parkinson's Disease and LRRK2 Kinase Inhibition. Molecular Neurobiology. PMID 26399642 DOI: 10.1007/S12035-015-9435-4  0.69
2015 Rocha EM, Smith GA, Park E, Cao H, Brown E, Hayes MA, Beagan J, McLean JR, Izen SC, Perez-Torres E, Hallett PJ, Isacson O. Glucocerebrosidase gene therapy prevents α-synucleinopathy of midbrain dopamine neurons. Neurobiology of Disease. PMID 26392287 DOI: 10.1016/J.Nbd.2015.09.009  0.752
2015 Rocha EM, Smith GA, Park E, Cao H, Graham AR, Brown E, McLean JR, Hayes MA, Beagan J, Izen SC, Perez-Torres E, Hallett PJ, Isacson O. Chronic pharmacological glucocerebrosidase inhibition induces α-synuclein aggregation, microglial and complement activation and synaptic protein changes in mice. Antioxidants & Redox Signaling. PMID 26094487 DOI: 10.1089/Ars.2015.6307  0.7
2015 Isacson O. Lysosomes to combat Parkinson's disease. Nature Neuroscience. 18: 792-3. PMID 26007211 DOI: 10.1038/nn.4027  0.464
2015 Rocha EM, Smith GA, Park E, Cao H, Brown E, Hallett P, Isacson O. Progressive decline of glucocerebrosidase in aging and Parkinson's disease. Annals of Clinical and Translational Neurology. 2: 433-8. PMID 25909088 DOI: 10.1002/Acn3.177  0.708
2015 Isacson O. Sorting the wheat from the chaff in dopamine neuron-based cell therapies. Proceedings of the National Academy of Sciences of the United States of America. 112: 4512-3. PMID 25848026 DOI: 10.1073/pnas.1503859112  0.478
2015 Smith GA, Rocha EM, Rooney T, Barneoud P, McLean JR, Beagan J, Osborn T, Coimbra M, Luo Y, Hallett PJ, Isacson O. A Nurr1 agonist causes neuroprotection in a Parkinson's disease lesion model primed with the toll-like receptor 3 dsRNA inflammatory stimulant poly(I:C). Plos One. 10: e0121072. PMID 25815475 DOI: 10.1371/Journal.Pone.0121072  0.76
2015 Hallett PJ, Deleidi M, Astradsson A, Smith GA, Cooper O, Osborn TM, Sundberg M, Moore MA, Perez-Torres E, Brownell AL, Schumacher JM, Spealman RD, Isacson O. Successful function of autologous iPSC-derived dopamine neurons following transplantation in a non-human primate model of Parkinson's disease. Cell Stem Cell. 16: 269-74. PMID 25732245 DOI: 10.1016/J.Stem.2015.01.018  0.776
2014 Hallett PJ, Cooper O, Sadi D, Robertson H, Mendez I, Isacson O. Long-term health of dopaminergic neuron transplants in Parkinson's disease patients. Cell Reports. 7: 1755-61. PMID 24910427 DOI: 10.1016/J.Celrep.2014.05.027  0.491
2014 McLean JR, Smith GA, Rocha EM, Osborn TM, Dib S, Hayes MA, Beagan JA, Brown TB, Lawson TF, Hallett PJ, Robertson J, Isacson O. ALS-associated peripherin spliced transcripts form distinct protein inclusions that are neuroprotective against oxidative stress. Experimental Neurology. 261: 217-29. PMID 24907400 DOI: 10.1016/J.Expneurol.2014.05.024  0.683
2014 McLean JR, Smith GA, Rocha EM, Hayes MA, Beagan JA, Hallett PJ, Isacson O. Widespread neuron-specific transgene expression in brain and spinal cord following synapsin promoter-driven AAV9 neonatal intracerebroventricular injection. Neuroscience Letters. 576: 73-8. PMID 24882721 DOI: 10.1016/J.Neulet.2014.05.044  0.732
2014 Smith GA, Rocha EM, McLean JR, Hayes MA, Izen SC, Isacson O, Hallett PJ. Progressive axonal transport and synaptic protein changes correlate with behavioral and neuropathological abnormalities in the heterozygous Q175 KI mouse model of Huntington's disease. Human Molecular Genetics. 23: 4510-27. PMID 24728190 DOI: 10.1093/Hmg/Ddu166  0.712
2014 Zhang J, Saur T, Duke AN, Grant SG, Platt DM, Rowlett JK, Isacson O, Yao WD. Motor impairments, striatal degeneration, and altered dopamine-glutamate interplay in mice lacking PSD-95. Journal of Neurogenetics. 28: 98-111. PMID 24702501 DOI: 10.3109/01677063.2014.892486  0.335
2014 Sundberg M, Isacson O. Advances in stem-cell--generated transplantation therapy for Parkinson's disease. Expert Opinion On Biological Therapy. 14: 437-53. PMID 24437368 DOI: 10.1517/14712598.2014.876986  0.414
2014 Davies SE, Hallett PJ, Moens T, Smith G, Mangano E, Kim HT, Goldberg AL, Liu JL, Isacson O, Tofaris GK. Enhanced ubiquitin-dependent degradation by Nedd4 protects against α-synuclein accumulation and toxicity in animal models of Parkinson's disease. Neurobiology of Disease. 64: 79-87. PMID 24388974 DOI: 10.1016/J.Nbd.2013.12.011  0.75
2013 Sundberg M, Bogetofte H, Lawson T, Jansson J, Smith G, Astradsson A, Moore M, Osborn T, Cooper O, Spealman R, Hallett P, Isacson O. Improved cell therapy protocols for Parkinson's disease based on differentiation efficiency and safety of hESC-, hiPSC-, and non-human primate iPSC-derived dopaminergic neurons. Stem Cells (Dayton, Ohio). 31: 1548-62. PMID 23666606 DOI: 10.1002/Stem.1415  0.774
2012 Cooper O, Parmar M, Isacson O. Characterization and criteria of embryonic stem and induced pluripotent stem cells for a dopamine replacement therapy. Progress in Brain Research. 200: 265-76. PMID 23195423 DOI: 10.1016/B978-0-444-59575-1.00012-0  0.613
2012 Olanow CW, Isacson O. Stem cells for Parkinson's disease: advancing science but protecting patients. Movement Disorders : Official Journal of the Movement Disorder Society. 27: 1475-7. PMID 23032987 DOI: 10.1002/mds.25170  0.417
2012 Wray S, Self M, Lewis PA, Taanman JW, Ryan NS, Mahoney CJ, Liang Y, Devine MJ, Sheerin UM, Houlden H, Morris HR, Healy D, ... ... Isacson O, et al. Creation of an open-access, mutation-defined fibroblast resource for neurological disease research. Plos One. 7: e43099. PMID 22952635 DOI: 10.1371/Journal.Pone.0043099  0.313
2012 Smith GA, Isacson O, Dunnett SB. The search for genetic mouse models of prodromal Parkinson's disease. Experimental Neurology. 237: 267-73. PMID 22819262 DOI: 10.1016/J.Expneurol.2012.06.035  0.752
2012 Cooper O, Seo H, Andrabi S, Guardia-Laguarta C, Graziotto J, Sundberg M, McLean JR, Carrillo-Reid L, Xie Z, Osborn T, Hargus G, Deleidi M, Lawson T, Bogetofte H, Perez-Torres E, ... ... Isacson O, et al. Pharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson's disease. Science Translational Medicine. 4: 141ra90. PMID 22764206 DOI: 10.1126/Scitranslmed.3003985  0.351
2012 Hallett PJ, McLean JR, Kartunen A, Langston JW, Isacson O. α-Synuclein overexpressing transgenic mice show internal organ pathology and autonomic deficits. Neurobiology of Disease. 47: 258-67. PMID 22549133 DOI: 10.1016/j.nbd.2012.04.009  0.31
2012 Deleidi M, Isacson O. Viral and inflammatory triggers of neurodegenerative diseases. Science Translational Medicine. 4: 121ps3. PMID 22344685 DOI: 10.1126/scitranslmed.3003492  0.329
2012 Lindvall O, Barker RA, Brüstle O, Isacson O, Svendsen CN. Clinical translation of stem cells in neurodegenerative disorders. Cell Stem Cell. 10: 151-5. PMID 22305565 DOI: 10.1016/j.stem.2012.01.009  0.518
2012 Cooper O, Hallett P, Isacson O. Using stem cells and iPS cells to discover new treatments for Parkinson's disease. Parkinsonism & Related Disorders. 18: S14-6. PMID 22166414 DOI: 10.1016/S1353-8020(11)70007-4  0.43
2012 McLean JR, Hallett PJ, Cooper O, Stanley M, Isacson O. Transcript expression levels of full-length alpha-synuclein and its three alternatively spliced variants in Parkinson's disease brain regions and in a transgenic mouse model of alpha-synuclein overexpression. Molecular and Cellular Neurosciences. 49: 230-9. PMID 22155155 DOI: 10.1016/j.mcn.2011.11.006  0.344
2011 Deleidi M, Cooper O, Hargus G, Levy A, Isacson O. Oct4-induced reprogramming is required for adult brain neural stem cell differentiation into midbrain dopaminergic neurons. Plos One. 6: e19926. PMID 21655272 DOI: 10.1371/journal.pone.0019926  0.368
2011 Deleidi M, Hargus G, Hallett P, Osborn T, Isacson O. Development of histocompatible primate-induced pluripotent stem cells for neural transplantation. Stem Cells (Dayton, Ohio). 29: 1052-63. PMID 21608081 DOI: 10.1002/Stem.662  0.418
2011 Tsui A, Isacson O. Functions of the nigrostriatal dopaminergic synapse and the use of neurotransplantation in Parkinson's disease. Journal of Neurology. 258: 1393-405. PMID 21544566 DOI: 10.1007/s00415-011-6061-6  0.378
2010 Deleidi M, Hallett PJ, Koprich JB, Chung CY, Isacson O. The Toll-like receptor-3 agonist polyinosinic:polycytidylic acid triggers nigrostriatal dopaminergic degeneration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 16091-101. PMID 21123556 DOI: 10.1523/Jneurosci.2400-10.2010  0.629
2010 Hedlund E, Karlsson M, Osborn T, Ludwig W, Isacson O. Global gene expression profiling of somatic motor neuron populations with different vulnerability identify molecules and pathways of degeneration and protection. Brain : a Journal of Neurology. 133: 2313-30. PMID 20826431 DOI: 10.1093/brain/awq167  0.403
2010 Hargus G, Cooper O, Deleidi M, Levy A, Lee K, Marlow E, Yow A, Soldner F, Hockemeyer D, Hallett PJ, Osborn T, Jaenisch R, Isacson O. Differentiated Parkinson patient-derived induced pluripotent stem cells grow in the adult rodent brain and reduce motor asymmetry in Parkinsonian rats. Proceedings of the National Academy of Sciences of the United States of America. 107: 15921-6. PMID 20798034 DOI: 10.1073/Pnas.1010209107  0.527
2010 Cooper O, Hargus G, Deleidi M, Blak A, Osborn T, Marlow E, Lee K, Levy A, Perez-Torres E, Yow A, Isacson O. Differentiation of human ES and Parkinson's disease iPS cells into ventral midbrain dopaminergic neurons requires a high activity form of SHH, FGF8a and specific regionalization by retinoic acid. Molecular and Cellular Neurosciences. 45: 258-66. PMID 20603216 DOI: 10.1016/j.mcn.2010.06.017  0.469
2010 Chung CY, Licznerski P, Alavian KN, Simeone A, Lin Z, Martin E, Vance J, Isacson O. The transcription factor orthodenticle homeobox 2 influences axonal projections and vulnerability of midbrain dopaminergic neurons. Brain : a Journal of Neurology. 133: 2022-31. PMID 20573704 DOI: 10.1093/Brain/Awq142  0.611
2010 Lin Z, Zhao Y, Chung CY, Zhou Y, Xiong N, Glatt CE, Isacson O. High regulatability favors genetic selection in SLC18A2, a vesicular monoamine transporter essential for life. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 24: 2191-200. PMID 20181938 DOI: 10.1096/fj.09-140368  0.494
2009 Chung CY, Koprich JB, Hallett PJ, Isacson O. Functional enhancement and protection of dopaminergic terminals by RAB3B overexpression. Proceedings of the National Academy of Sciences of the United States of America. 106: 22474-9. PMID 20007772 DOI: 10.1073/Pnas.0912193106  0.623
2009 Isacson O. Cell therapy ahead for Parkinson's disease. Science (New York, N.Y.). 326: 1060. PMID 19965408 DOI: 10.1126/science.326.5956.1060-b  0.371
2009 Pruszak J, Just L, Isacson O, Nikkhah G. Isolation and culture of ventral mesencephalic precursor cells and dopaminergic neurons from rodent brains. Current Protocols in Stem Cell Biology. Unit 2D.5. PMID 19960452 DOI: 10.1002/9780470151808.Sc02D05S11  0.641
2009 Chung S, Leung A, Han BS, Chang MY, Moon JI, Kim CH, Hong S, Pruszak J, Isacson O, Kim KS. Wnt1-lmx1a forms a novel autoregulatory loop and controls midbrain dopaminergic differentiation synergistically with the SHH-FoxA2 pathway. Cell Stem Cell. 5: 646-58. PMID 19951692 DOI: 10.1016/j.stem.2009.09.015  0.399
2009 Hallett PJ, Cooper O, Isacson O. No evidence for disease-like processes in fetal transplants. Proceedings of the National Academy of Sciences of the United States of America. 106: E104; author reply E. PMID 19805203 DOI: 10.1073/pnas.0908169106  0.429
2009 Pruszak J, Isacson O. Molecular and cellular determinants for generating ES-cell derived dopamine neurons for cell therapy. Advances in Experimental Medicine and Biology. 651: 112-23. PMID 19731556 DOI: 10.1007/978-1-4419-0322-8_11  0.474
2009 Cooper O, Astradsson A, Hallett P, Robertson H, Mendez I, Isacson O. Lack of functional relevance of isolated cell damage in transplants of Parkinson's disease patients. Journal of Neurology. 256: 310-6. PMID 19711122 DOI: 10.1007/S00415-009-5242-Z  0.478
2009 Astradsson A, Jenkins BG, Choi JK, Hallett PJ, Levesque MA, McDowell JS, Brownell AL, Spealman RD, Isacson O. The blood-brain barrier is intact after levodopa-induced dyskinesias in parkinsonian primates--evidence from in vivo neuroimaging studies. Neurobiology of Disease. 35: 348-51. PMID 19501164 DOI: 10.1016/J.Nbd.2009.05.018  0.309
2009 Chung CY, Koprich JB, Siddiqi H, Isacson O. Dynamic changes in presynaptic and axonal transport proteins combined with striatal neuroinflammation precede dopaminergic neuronal loss in a rat model of AAV alpha-synucleinopathy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 3365-73. PMID 19295143 DOI: 10.1523/Jneurosci.5427-08.2009  0.595
2009 Soldner F, Hockemeyer D, Beard C, Gao Q, Bell GW, Cook EG, Hargus G, Blak A, Cooper O, Mitalipova M, Isacson O, Jaenisch R. Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors. Cell. 136: 964-77. PMID 19269371 DOI: 10.1016/J.Cell.2009.02.013  0.364
2009 Isacson O, Hallett P, Astradsson A, Cooper O, Robertson H, Mendez I. O.106 Post-mortem analyses of fetal transplants of dopamine neurons in Parkinson's disease patients reveal no or minimal pathology Parkinsonism & Related Disorders. 15: S28. DOI: 10.1016/S1353-8020(09)70121-X  0.455
2009 Pruszak J, Isacson O. Molecular and cellular determinants for generating ES-cell derived dopamine neurons for ceillherapy Advances in Experimental Medicine and Biology. 651: 112-123. DOI: 10.1007/978-1-4419-0322-8_11  0.317
2008 Isacson O, Kordower JH. Future of cell and gene therapies for Parkinson's disease. Annals of Neurology. 64: S122-38. PMID 19127583 DOI: 10.1002/Ana.21473  0.408
2008 Hedlund E, Isacson O. ALS model glia can mediate toxicity to motor neurons derived from human embryonic stem cells. Cell Stem Cell. 3: 575-6. PMID 19041769 DOI: 10.1016/j.stem.2008.11.004  0.353
2008 Vinuela A, Hallett PJ, Reske-Nielsen C, Patterson M, Sotnikova TD, Caron MG, Gainetdinov RR, Isacson O. Implanted reuptake-deficient or wild-type dopaminergic neurons improve ON L-dopa dyskinesias without OFF-dyskinesias in a rat model of Parkinson's disease. Brain : a Journal of Neurology. 131: 3361-79. PMID 18988638 DOI: 10.1093/brain/awn192  0.392
2008 Sanchez-Pernaute R, Lee H, Patterson M, Reske-Nielsen C, Yoshizaki T, Sonntag KC, Studer L, Isacson O. Parthenogenetic dopamine neurons from primate embryonic stem cells restore function in experimental Parkinson's disease. Brain : a Journal of Neurology. 131: 2127-39. PMID 18669499 DOI: 10.1093/Brain/Awn144  0.499
2008 Seo H, Kim W, Isacson O. Compensatory changes in the ubiquitin-proteasome system, brain-derived neurotrophic factor and mitochondrial complex II/III in YAC72 and R6/2 transgenic mice partially model Huntington's disease patients. Human Molecular Genetics. 17: 3144-53. PMID 18640989 DOI: 10.1093/hmg/ddn211  0.314
2008 de Chevigny A, Cooper O, Vinuela A, Reske-Nielsen C, Lagace DC, Eisch AJ, Isacson O. Fate mapping and lineage analyses demonstrate the production of a large number of striatal neuroblasts after transforming growth factor alpha and noggin striatal infusions into the dopamine-depleted striatum. Stem Cells (Dayton, Ohio). 26: 2349-60. PMID 18556510 DOI: 10.1634/stemcells.2008-0080  0.349
2008 Sanchez-Pernaute R, Wang JQ, Kuruppu D, Cao L, Tueckmantel W, Kozikowski A, Isacson O, Brownell AL. Enhanced binding of metabotropic glutamate receptor type 5 (mGluR5) PET tracers in the brain of parkinsonian primates. Neuroimage. 42: 248-51. PMID 18501638 DOI: 10.1016/J.Neuroimage.2008.04.170  0.348
2008 Viaro R, Sanchez-Pernaute R, Marti M, Trapella C, Isacson O, Morari M. Nociceptin/orphanin FQ receptor blockade attenuates MPTP-induced parkinsonism. Neurobiology of Disease. 30: 430-8. PMID 18413287 DOI: 10.1016/J.Nbd.2008.02.011  0.319
2008 Mendez I, Viñuela A, Astradsson A, Mukhida K, Hallett P, Robertson H, Tierney T, Holness R, Dagher A, Trojanowski JQ, Isacson O. Dopamine neurons implanted into people with Parkinson's disease survive without pathology for 14 years. Nature Medicine. 14: 507-9. PMID 18391961 DOI: 10.1038/Nm1752  0.497
2008 Wernig M, Zhao JP, Pruszak J, Hedlund E, Fu D, Soldner F, Broccoli V, Constantine-Paton M, Isacson O, Jaenisch R. Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. 105: 5856-61. PMID 18391196 DOI: 10.1073/Pnas.0801677105  0.503
2008 Hedlund E, Pruszak J, Lardaro T, Ludwig W, Viñuela A, Kim KS, Isacson O. Embryonic stem cell-derived Pitx3-enhanced green fluorescent protein midbrain dopamine neurons survive enrichment by fluorescence-activated cell sorting and function in an animal model of Parkinson's disease. Stem Cells (Dayton, Ohio). 26: 1526-36. PMID 18388307 DOI: 10.1634/Stemcells.2007-0996  0.42
2008 Astradsson A, Cooper O, Vinuela A, Isacson O. Recent advances in cell-based therapy for Parkinson disease. Neurosurgical Focus. 24: E6. PMID 18341409 DOI: 10.3171/FOC/2008/24/3-4/E5  0.421
2008 Koprich JB, Reske-Nielsen C, Mithal P, Isacson O. Neuroinflammation mediated by IL-1beta increases susceptibility of dopamine neurons to degeneration in an animal model of Parkinson's disease. Journal of Neuroinflammation. 5: 8. PMID 18304357 DOI: 10.1186/1742-2094-5-8  0.334
2008 Hong S, Kang UJ, Isacson O, Kim KS. Neural precursors derived from human embryonic stem cells maintain long-term proliferation without losing the potential to differentiate into all three neural lineages, including dopaminergic neurons. Journal of Neurochemistry. 104: 316-24. PMID 17944878 DOI: 10.1111/J.1471-4159.2007.04952.X  0.391
2008 Redmond DE, Vinuela A, Kordower JH, Isacson O. Influence of cell preparation and target location on the behavioral recovery after striatal transplantation of fetal dopaminergic neurons in a primate model of Parkinson's disease. Neurobiology of Disease. 29: 103-16. PMID 17920901 DOI: 10.1016/J.Nbd.2007.08.008  0.502
2008 Blak AA, Licznerski P, Isacson O. Studies to examine the neuroprotective effect of ALDH1a1 in midbrain dopamine neurons International Journal of Developmental Neuroscience. 26: 861-862. DOI: 10.1016/J.Ijdevneu.2008.09.111  0.436
2007 Hedlund E, Hefferan MP, Marsala M, Isacson O. Cell therapy and stem cells in animal models of motor neuron disorders. The European Journal of Neuroscience. 26: 1721-37. PMID 17897390 DOI: 10.1111/j.1460-9568.2007.05780.x  0.41
2007 Inoue H, Lin L, Lee X, Shao Z, Mendes S, Snodgrass-Belt P, Sweigard H, Engber T, Pepinsky B, Yang L, Beal MF, Mi S, Isacson O. Inhibition of the leucine-rich repeat protein LINGO-1 enhances survival, structure, and function of dopaminergic neurons in Parkinson's disease models. Proceedings of the National Academy of Sciences of the United States of America. 104: 14430-5. PMID 17726113 DOI: 10.1073/pnas.0700901104  0.389
2007 Chung CY, Koprich JB, Endo S, Isacson O. An endogenous serine/threonine protein phosphatase inhibitor, G-substrate, reduces vulnerability in models of Parkinson's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 8314-23. PMID 17670978 DOI: 10.1523/Jneurosci.1972-07.2007  0.586
2007 Brunlid G, Pruszak J, Holmes B, Isacson O, Sonntag KC. Immature and neurally differentiated mouse embryonic stem cells do not express a functional Fas/Fas ligand system. Stem Cells (Dayton, Ohio). 25: 2551-8. PMID 17615270 DOI: 10.1634/stemcells.2006-0745  0.356
2007 Sánchez-Pernaute R, Jenkins BG, Choi JK, Iris Chen YC, Isacson O. In vivo evidence of D3 dopamine receptor sensitization in parkinsonian primates and rodents with l-DOPA-induced dyskinesias. Neurobiology of Disease. 27: 220-7. PMID 17588764 DOI: 10.1016/J.Nbd.2007.04.016  0.304
2007 Seo H, Sonntag KC, Kim W, Cattaneo E, Isacson O. Proteasome activator enhances survival of Huntington's disease neuronal model cells. Plos One. 2: e238. PMID 17327906 DOI: 10.1371/Journal.Pone.0000238  0.313
2007 Hedlund E, Pruszak J, Ferree A, Viñuela A, Hong S, Isacson O, Kim KS. Selection of embryonic stem cell-derived enhanced green fluorescent protein-positive dopamine neurons using the tyrosine hydroxylase promoter is confounded by reporter gene expression in immature cell populations. Stem Cells (Dayton, Ohio). 25: 1126-35. PMID 17234989 DOI: 10.1634/stemcells.2006-0540  0.449
2007 Sonntag KC, Pruszak J, Yoshizaki T, van Arensbergen J, Sanchez-Pernaute R, Isacson O. Enhanced yield of neuroepithelial precursors and midbrain-like dopaminergic neurons from human embryonic stem cells using the bone morphogenic protein antagonist noggin. Stem Cells (Dayton, Ohio). 25: 411-8. PMID 17038668 DOI: 10.1634/stemcells.2006-0380  0.488
2006 Karki S, Pruszak J, Isacson O, Sonntag KC. ES cell-derived neuroepithelial cell cultures. Journal of Visualized Experiments : Jove. 118. PMID 18704173 DOI: 10.3791/118  0.303
2006 Ferrari D, Sanchez-Pernaute R, Lee H, Studer L, Isacson O. Transplanted dopamine neurons derived from primate ES cells preferentially innervate DARPP-32 striatal progenitors within the graft. The European Journal of Neuroscience. 24: 1885-96. PMID 17067292 DOI: 10.1111/J.1460-9568.2006.05093.X  0.507
2006 Isacson O. What are the long-term effects of neural grafting in patients with Huntington's disease? Nature Clinical Practice. Neurology. 2: 470-1. PMID 16932607 DOI: 10.1038/ncpneuro0264  0.327
2006 Kelly BB, Hedlund E, Kim C, Ishiguro H, Isacson O, Chikaraishi DM, Kim KS, Feng G. A tyrosine hydroxylase-yellow fluorescent protein knock-in reporter system labeling dopaminergic neurons reveals potential regulatory role for the first intron of the rodent tyrosine hydroxylase gene. Neuroscience. 142: 343-54. PMID 16876957 DOI: 10.1016/j.neuroscience.2006.06.032  0.407
2006 Lin L, Isacson O. Axonal growth regulation of fetal and embryonic stem cell-derived dopaminergic neurons by Netrin-1 and Slits. Stem Cells (Dayton, Ohio). 24: 2504-13. PMID 16840550 DOI: 10.1634/stemcells.2006-0119  0.358
2006 Chung S, Shin BS, Hedlund E, Pruszak J, Ferree A, Kang UJ, Isacson O, Kim KS. Genetic selection of sox1GFP-expressing neural precursors removes residual tumorigenic pluripotent stem cells and attenuates tumor formation after transplantation. Journal of Neurochemistry. 97: 1467-80. PMID 16696855 DOI: 10.1111/J.1471-4159.2006.03841.X  0.432
2006 Chung S, Shin BS, Hwang M, Lardaro T, Kang UJ, Isacson O, Kim KS. Neural precursors derived from embryonic stem cells, but not those from fetal ventral mesencephalon, maintain the potential to differentiate into dopaminergic neurons after expansion in vitro. Stem Cells (Dayton, Ohio). 24: 1583-93. PMID 16543488 DOI: 10.1634/Stemcells.2005-0558  0.389
2006 Kim DW, Chung S, Hwang M, Ferree A, Tsai HC, Park JJ, Chung S, Nam TS, Kang UJ, Isacson O, Kim KS. Stromal cell-derived inducing activity, Nurr1, and signaling molecules synergistically induce dopaminergic neurons from mouse embryonic stem cells. Stem Cells (Dayton, Ohio). 24: 557-67. PMID 16123386 DOI: 10.1634/Stemcells.2005-0233  0.471
2006 Lin L, Isacson O. Axonal growth regulation of fetal and ES-derived dopaminergic neurons by Netrin- 1 and Slits International Journal of Developmental Neuroscience. 24: 596. DOI: 10.1016/J.Ijdevneu.2006.09.295  0.363
2005 Sánchez-Pernaute R, Brownell AL, Jenkins BG, Isacson O. Insights into Parkinson's disease models and neurotoxicity using non-invasive imaging. Toxicology and Applied Pharmacology. 207: 251-6. PMID 15979668 DOI: 10.1016/j.taap.2005.02.039  0.376
2005 Sánchez-Pernaute R, Studer L, Ferrari D, Perrier A, Lee H, Viñuela A, Isacson O. Long-term survival of dopamine neurons derived from parthenogenetic primate embryonic stem cells (cyno-1) after transplantation. Stem Cells (Dayton, Ohio). 23: 914-22. PMID 15941857 DOI: 10.1634/Stemcells.2004-0172  0.491
2005 Chung CY, Seo H, Sonntag KC, Brooks A, Lin L, Isacson O. Cell type-specific gene expression of midbrain dopaminergic neurons reveals molecules involved in their vulnerability and protection. Human Molecular Genetics. 14: 1709-25. PMID 15888489 DOI: 10.1093/hmg/ddi178  0.602
2005 Mendez I, Sanchez-Pernaute R, Cooper O, Viñuela A, Ferrari D, Björklund L, Dagher A, Isacson O. Cell type analysis of functional fetal dopamine cell suspension transplants in the striatum and substantia nigra of patients with Parkinson's disease. Brain : a Journal of Neurology. 128: 1498-510. PMID 15872020 DOI: 10.1093/brain/awh510  0.474
2005 Seo H, Isacson O. Abnormal APP, cholinergic and cognitive function in Ts65Dn Down's model mice. Experimental Neurology. 193: 469-80. PMID 15869949 DOI: 10.1016/j.expneurol.2004.11.017  0.307
2005 Sonntag KC, Simantov R, Isacson O. Stem cells may reshape the prospect of Parkinson's disease therapy. Brain Research. Molecular Brain Research. 134: 34-51. PMID 15790528 DOI: 10.1016/j.molbrainres.2004.09.002  0.419
2005 Lin L, Rao Y, Isacson O. Netrin-1 and slit-2 regulate and direct neurite growth of ventral midbrain dopaminergic neurons. Molecular and Cellular Neurosciences. 28: 547-55. PMID 15737744 DOI: 10.1016/j.mcn.2004.11.009  0.357
2005 Sonntag KC, Simantov R, Björklund L, Cooper O, Pruszak J, Kowalke F, Gilmartin J, Ding J, Hu YP, Shen MM, Isacson O. Context-dependent neuronal differentiation and germ layer induction of Smad4-/- and Cripto-/- embryonic stem cells. Molecular and Cellular Neurosciences. 28: 417-29. PMID 15737733 DOI: 10.1016/j.mcn.2004.06.003  0.41
2005 Chung S, Hedlund E, Hwang M, Kim DW, Shin BS, Hwang DY, Kang UJ, Isacson O, Kim KS. The homeodomain transcription factor Pitx3 facilitates differentiation of mouse embryonic stem cells into AHD2-expressing dopaminergic neurons. Molecular and Cellular Neurosciences. 28: 241-52. PMID 15691706 DOI: 10.1016/J.Mcn.2004.09.008  0.472
2004 Jenkins BG, Sanchez-Pernaute R, Brownell AL, Chen YC, Isacson O. Mapping dopamine function in primates using pharmacologic magnetic resonance imaging. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 9553-60. PMID 15509742 DOI: 10.1523/JNEUROSCI.1558-04.2004  0.373
2004 Cooper O, Isacson O. Intrastriatal transforming growth factor alpha delivery to a model of Parkinson's disease induces proliferation and migration of endogenous adult neural progenitor cells without differentiation into dopaminergic neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 8924-31. PMID 15483111 DOI: 10.1523/JNEUROSCI.2344-04.2004  0.45
2004 Kakinohana O, Cizkova D, Tomori Z, Hedlund E, Marsala S, Isacson O, Marsala M. Region-specific cell grafting into cervical and lumbar spinal cord in rat: a qualitative and quantitative stereological study. Experimental Neurology. 190: 122-32. PMID 15473986 DOI: 10.1016/j.expneurol.2004.07.014  0.308
2004 Seo H, Sonntag KC, Isacson O. Generalized brain and skin proteasome inhibition in Huntington's disease. Annals of Neurology. 56: 319-28. PMID 15349858 DOI: 10.1002/ana.20207  0.405
2004 Sánchez-Pernaute R, Ferree A, Cooper O, Yu M, Brownell AL, Isacson O. Selective COX-2 inhibition prevents progressive dopamine neuron degeneration in a rat model of Parkinson's disease. Journal of Neuroinflammation. 1: 6. PMID 15285796 DOI: 10.1186/1742-2094-1-6  0.359
2004 Sonntag KC, Simantov R, Kim KS, Isacson O. Temporally induced Nurr1 can induce a non-neuronal dopaminergic cell type in embryonic stem cell differentiation. The European Journal of Neuroscience. 19: 1141-52. PMID 15016073 DOI: 10.1111/J.1460-9568.2004.03204.X  0.443
2003 Granholm AC, Sanders L, Seo H, Lin L, Ford K, Isacson O. Estrogen alters amyloid precursor protein as well as dendritic and cholinergic markers in a mouse model of Down syndrome. Hippocampus. 13: 905-14. PMID 14750653 DOI: 10.1002/hipo.10130  0.331
2003 Brownell AL, Canales K, Chen YI, Jenkins BG, Owen C, Livni E, Yu M, Cicchetti F, Sanchez-Pernaute R, Isacson O. Mapping of brain function after MPTP-induced neurotoxicity in a primate Parkinson's disease model. Neuroimage. 20: 1064-75. PMID 14568476 DOI: 10.1016/S1053-8119(03)00348-3  0.371
2003 Isacson O. The production and use of cells as therapeutic agents in neurodegenerative diseases. The Lancet. Neurology. 2: 417-24. PMID 12849120 DOI: 10.1016/S1474-4422(03)00437-X  0.361
2003 Kim KS, Kim CH, Hwang DY, Seo H, Chung S, Hong SJ, Lim JK, Anderson T, Isacson O. Orphan nuclear receptor Nurr1 directly transactivates the promoter activity of the tyrosine hydroxylase gene in a cell-specific manner. Journal of Neurochemistry. 85: 622-34. PMID 12694388 DOI: 10.1046/j.1471-4159.2003.01671.x  0.357
2003 Isacson O, Bjorklund LM, Schumacher JM. Toward full restoration of synaptic and terminal function of the dopaminergic system in Parkinson's disease by stem cells. Annals of Neurology. 53: S135-46; discussion . PMID 12666105 DOI: 10.1002/ana.10482  0.488
2003 Cicchetti F, Fodor W, Deacon TW, van Horne C, Rollins S, Burton W, Costantini LC, Isacson O. Immune parameters relevant to neural xenograft survival in the primate brain. Xenotransplantation. 10: 41-9. PMID 12535224 DOI: 10.1034/j.1399-3089.2003.01130.x  0.348
2003 McNaught KS, Belizaire R, Isacson O, Jenner P, Olanow CW. Altered proteasomal function in sporadic Parkinson's disease. Experimental Neurology. 179: 38-46. PMID 12504866 DOI: 10.1006/Exnr.2002.8050  0.402
2002 Chung S, Sonntag KC, Andersson T, Bjorklund LM, Park JJ, Kim DW, Kang UJ, Isacson O, Kim KS. Genetic engineering of mouse embryonic stem cells by Nurr1 enhances differentiation and maturation into dopaminergic neurons. The European Journal of Neuroscience. 16: 1829-38. PMID 12453046 DOI: 10.1046/J.1460-9568.2002.02255.X  0.459
2002 Björklund LM, Isacson O. Regulation of dopamine cell type and transmitter function in fetal and stem cell transplantation for Parkinson's disease. Progress in Brain Research. 138: 411-20. PMID 12432781 DOI: 10.1016/S0079-6123(02)38090-7  0.408
2002 Cicchetti F, Costantini L, Belizaire R, Burton W, Isacson O, Fodor W. Combined inhibition of apoptosis and complement improves neural graft survival of embryonic rat and porcine mesencephalon in the rat brain. Experimental Neurology. 177: 376-84. PMID 12429184 DOI: 10.1006/Exnr.2002.8007  0.385
2002 Sánchez-Pernaute R, Brownell AL, Isacson O. Functional imaging of the dopamine system: in vivo evaluation of dopamine deficiency and restoration. Neurotoxicology. 23: 469-78. PMID 12428719 DOI: 10.1016/S0161-813X(02)00064-5  0.383
2002 McNaught KS, Björklund LM, Belizaire R, Isacson O, Jenner P, Olanow CW. Proteasome inhibition causes nigral degeneration with inclusion bodies in rats. Neuroreport. 13: 1437-41. PMID 12167769 DOI: 10.1097/00001756-200208070-00018  0.408
2002 McNaught KS, Belizaire R, Jenner P, Olanow CW, Isacson O. Selective loss of 20S proteasome alpha-subunits in the substantia nigra pars compacta in Parkinson's disease. Neuroscience Letters. 326: 155-8. PMID 12095645 DOI: 10.1016/S0304-3940(02)00296-3  0.392
2002 Isacson O. Models of repair mechanisms for future treatment modalities of Parkinson's disease. Brain Research Bulletin. 57: 839-46. PMID 12031282 DOI: 10.1016/S0361-9230(01)00773-0  0.47
2002 Seo H, Hong SJ, Guo S, Kim HS, Kim CH, Hwang DY, Isacson O, Rosenthal A, Kim KS. A direct role of the homeodomain proteins Phox2a/2b in noradrenaline neurotransmitter identity determination. Journal of Neurochemistry. 80: 905-16. PMID 11948255 DOI: 10.1046/J.0022-3042.2002.00782.X  0.339
2002 Cicchetti F, Brownell AL, Williams K, Chen YI, Livni E, Isacson O. Neuroinflammation of the nigrostriatal pathway during progressive 6-OHDA dopamine degeneration in rats monitored by immunohistochemistry and PET imaging. The European Journal of Neuroscience. 15: 991-8. PMID 11918659 DOI: 10.1046/j.1460-9568.2002.01938.x  0.375
2002 Chung S, Andersson T, Sonntag KC, Björklund L, Isacson O, Kim KS. Analysis of different promoter systems for efficient transgene expression in mouse embryonic stem cell lines. Stem Cells (Dayton, Ohio). 20: 139-45. PMID 11897870 DOI: 10.1634/Stemcells.20-2-139  0.327
2002 Isacson O, Seo H, Lin L, Albeck D, Granholm AC. Alzheimer's disease and Down's syndrome: roles of APP, trophic factors and ACh. Trends in Neurosciences. 25: 79-84. PMID 11814559 DOI: 10.1016/S0166-2236(02)02037-4  0.315
2002 Bjorklund LM, Sánchez-Pernaute R, Chung S, Andersson T, Chen IY, McNaught KS, Brownell AL, Jenkins BG, Wahlestedt C, Kim KS, Isacson O. Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model. Proceedings of the National Academy of Sciences of the United States of America. 99: 2344-9. PMID 11782534 DOI: 10.1073/Pnas.022438099  0.51
2001 Moore AE, Cicchetti F, Hennen J, Isacson O. Parkinsonian motor deficits are reflected by proportional A9/A10 dopamine neuron degeneration in the rat. Experimental Neurology. 172: 363-76. PMID 11716560 DOI: 10.1006/exnr.2001.7823  0.377
2001 Hwang DY, Carlezon WA, Isacson O, Kim KS. A high-efficiency synthetic promoter that drives transgene expression selectively in noradrenergic neurons. Human Gene Therapy. 12: 1731-40. PMID 11560767 DOI: 10.1089/104303401750476230  0.362
2001 McNaught KS, Olanow CW, Halliwell B, Isacson O, Jenner P. Failure of the ubiquitin-proteasome system in Parkinson's disease. Nature Reviews. Neuroscience. 2: 589-94. PMID 11484002 DOI: 10.1038/35086067  0.355
2001 Browne SE, Lin L, Mattsson A, Georgievska B, Isacson O. Selective antibody-induced cholinergic cell and synapse loss produce sustained hippocampal and cortical hypometabolism with correlated cognitive deficits. Experimental Neurology. 170: 36-47. PMID 11421582 DOI: 10.1006/exnr.2001.7700  0.344
2001 Holm KH, Cicchetti F, Bjorklund L, Boonman Z, Tandon P, Costantini LC, Deacon TW, Huang X, Chen DF, Isacson O. Enhanced axonal growth from fetal human bcl-2 transgenic mouse dopamine neurons transplanted to the adult rat striatum. Neuroscience. 104: 397-405. PMID 11377843 DOI: 10.1016/S0306-4522(01)00098-7  0.483
2001 Isacson O, Bjorklund L, Pernaute RS. Parkinson's disease: interpretations of transplantation study are erroneous. Nature Neuroscience. 4: 553. PMID 11369929 DOI: 10.1038/88362  0.373
2001 Isacson O, Costantini L, Schumacher JM, Cicchetti F, Chung S, Kim K. Cell implantation therapies for Parkinson's disease using neural stem, transgenic or xenogeneic donor cells. Parkinsonism & Related Disorders. 7: 205-212. PMID 11331188 DOI: 10.1016/S1353-8020(00)00059-6  0.46
2001 Costantini LC, Cole D, Chaturvedi P, Isacson O. Immunophilin ligands can prevent progressive dopaminergic degeneration in animal models of Parkinson's disease. The European Journal of Neuroscience. 13: 1085-92. PMID 11285005 DOI: 10.1046/j.0953-816X.2001.01473.x  0.42
2000 Haque NS, Isacson O. Neurotrophic factors NGF and FGF-2 alter levels of huntingtin (IT15) in striatal neuronal cell cultures. Cell Transplantation. 9: 623-7. PMID 11144959 DOI: 10.1177/096368970000900507  0.42
2000 Freeman TB, Cicchetti F, Hauser RA, Deacon TW, Li XJ, Hersch SM, Nauert GM, Sanberg PR, Kordower JH, Saporta S, Isacson O. Transplanted fetal striatum in Huntington's disease: phenotypic development and lack of pathology. Proceedings of the National Academy of Sciences of the United States of America. 97: 13877-82. PMID 11106399 DOI: 10.1073/Pnas.97.25.13877  0.501
2000 Costantini LC, Isacson O. Neuroimmunophilin ligand enhances neurite outgrowth and effect of fetal dopamine transplants. Neuroscience. 100: 515-20. PMID 11098114 DOI: 10.1016/S0306-4522(00)00312-2  0.46
2000 Costantini LC, Isacson O. Immunophilin ligands and GDNF enhance neurite branching or elongation from developing dopamine neurons in culture. Experimental Neurology. 164: 60-70. PMID 10877916 DOI: 10.1006/exnr.2000.7417  0.43
2000 Fink JS, Schumacher JM, Ellias SL, Palmer EP, Saint-Hilaire M, Shannon K, Penn R, Starr P, VanHorne C, Kott HS, Dempsey PK, Fischman AJ, Raineri R, Manhart C, Dinsmore J, ... Isacson O, et al. Porcine xenografts in Parkinson's disease and Huntington's disease patients: preliminary results. Cell Transplantation. 9: 273-8. PMID 10811399 DOI: 10.1177/096368970000900212  0.494
2000 Schumacher JM, Ellias SA, Palmer EP, Kott HS, Dinsmore J, Dempsey PK, Fischman AJ, Thomas C, Feldman RG, Kassissieh S, Raineri R, Manhart C, Penney D, Fink JS, Isacson O. Transplantation of embryonic porcine mesencephalic tissue in patients with PD. Neurology. 54: 1042-50. PMID 10720272 DOI: 10.1212/Wnl.54.5.1042  0.361
1999 Chen YI, Brownell AL, Galpern W, Isacson O, Bogdanov M, Beal MF, Livni E, Rosen BR, Jenkins BG. Detection of dopaminergic cell loss and neural transplantation using pharmacological MRI, PET and behavioral assessment. Neuroreport. 10: 2881-6. PMID 10549790 DOI: 10.1097/00001756-199909290-00001  0.32
1999 Costantini LC, Jacoby DR, Wang S, Fraefel C, Breakefield XO, Isacson O. Gene transfer to the nigrostriatal system by hybrid herpes simplex virus/adeno-associated virus amplicon vectors. Human Gene Therapy. 10: 2481-94. PMID 10543613 DOI: 10.1089/10430349950016825  0.365
1999 Lin L, Georgievska B, Mattsson A, Isacson O. Cognitive changes and modified processing of amyloid precursor protein in the cortical and hippocampal system after cholinergic synapse loss and muscarinic receptor activation. Proceedings of the National Academy of Sciences of the United States of America. 96: 12108-13. PMID 10518584 DOI: 10.1073/pnas.96.21.12108  0.331
1999 Kordower JH, Isacson O, Emerich DF. Cellular delivery of trophic factors for the treatment of Huntington's disease: is neuroprotection possible? Experimental Neurology. 159: 4-20. PMID 10486171 DOI: 10.1006/Exnr.1999.7156  0.395
1999 Holm K, Isacson O. Factors intrinsic to the neuron can induce and maintain its ability to promote axonal outgrowth: a role for BCL2? Trends in Neurosciences. 22: 269-73. PMID 10354605 DOI: 10.1016/S0166-2236(98)01352-6  0.323
1999 Brownell AL, Jenkins BG, Isacson O. Dopamine imaging markers and predictive mathematical models for progressive degeneration in Parkinson's disease. Biomedicine & Pharmacotherapy = Biomã©Decine & Pharmacothã©Rapie. 53: 131-40. PMID 10349501 DOI: 10.1016/S0753-3322(99)80078-X  0.384
1999 Deacon T, Whatley B, LeBlanc C, Lin L, Isacson O. Pig fetal septal neurons implanted into the hippocampus of aged or cholinergic deafferented rats grow axons and form cross-species synapses in appropriate target regions. Cell Transplantation. 8: 111-29. PMID 10338280 DOI: 10.1177/096368979900800104  0.34
1999 Boonman Z, Isacson O. Apoptosis in neuronal development and transplantation: role of caspases and trophic factors. Experimental Neurology. 156: 1-15. PMID 10192773 DOI: 10.1006/exnr.1999.7056  0.469
1998 Brownell AL, Jenkins BG, Elmaleh DR, Deacon TW, Spealman RD, Isacson O. Combined PET/MRS brain studies show dynamic and long-term physiological changes in a primate model of Parkinson disease. Nature Medicine. 4: 1308-12. PMID 9809556 DOI: 10.1038/3300  0.409
1998 Costantini LC, Chaturvedi P, Armistead DM, McCaffrey PG, Deacon TW, Isacson O. A novel immunophilin ligand: distinct branching effects on dopaminergic neurons in culture and neurotrophic actions after oral administration in an animal model of Parkinson's disease. Neurobiology of Disease. 5: 97-106. PMID 9746907 DOI: 10.1006/nbdi.1998.0185  0.445
1998 Lin L, LeBlanc CJ, Deacon TW, Isacson O. Chronic cognitive deficits and amyloid precursor protein elevation after selective immunotoxin lesions of the basal forebrain cholinergic system. Neuroreport. 9: 547-52. PMID 9512404 DOI: 10.1097/00001756-199802160-00030  0.321
1998 Brownell AL, Livni E, Galpern W, Isacson O. In vivo PET imaging in rat of dopamine terminals reveals functional neural transplants. Annals of Neurology. 43: 387-90. PMID 9506557 DOI: 10.1002/ana.410430318  0.45
1998 Deacon T, Dinsmore J, Costantini LC, Ratliff J, Isacson O. Blastula-stage stem cells can differentiate into dopaminergic and serotonergic neurons after transplantation. Experimental Neurology. 149: 28-41. PMID 9454612 DOI: 10.1006/exnr.1997.6674  0.508
1997 Isacson O, Deacon T. Neural transplantation studies reveal the brain's capacity for continuous reconstruction. Trends in Neurosciences. 20: 477-82. PMID 9347616 DOI: 10.1016/S0166-2236(97)01081-3  0.374
1997 Chen YC, Galpern WR, Brownell AL, Matthews RT, Bogdanov M, Isacson O, Keltner JR, Beal MF, Rosen BR, Jenkins BG. Detection of dopaminergic neurotransmitter activity using pharmacologic MRI: correlation with PET, microdialysis, and behavioral data. Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. 38: 389-98. PMID 9339439 DOI: 10.1002/Mrm.1910380306  0.349
1997 Costantini LC, Lin L, Isacson O. Medial fetal ventral mesencephalon: a preferred source for dopamine neuron grafts. Neuroreport. 8: 2253-7. PMID 9243621 DOI: 10.1097/00001756-199707070-00032  0.52
1997 Haque NS, LeBlanc CJ, Isacson O. Differential dissection of the rat E16 ventral mesencephalon and survival and reinnervation of the 6-OHDA-lesioned striatum by a subset of aldehyde dehydrogenase-positive TH neurons. Cell Transplantation. 6: 239-48. PMID 9171157 DOI: 10.1016/S0963-6897(97)86921-7  0.504
1997 Schumacher JM, Isacson O. Neuronal xenotransplantation in Parkinson's disease. Nature Medicine. 3: 474-5. PMID 9142103 DOI: 10.1038/Nm0597-474C  0.436
1997 Haque NS, Borghesani P, Isacson O. Therapeutic strategies for Huntington's disease based on a molecular understanding of the disorder. Molecular Medicine Today. 3: 175-83. PMID 9134531 DOI: 10.1016/S1357-4310(97)01012-5  0.311
1997 Haque N, Isacson O. Antisense gene therapy for neurodegenerative disease? Experimental Neurology. 144: 139-46. PMID 9126163 DOI: 10.1006/exnr.1996.6400  0.335
1997 Deacon T, Schumacher J, Dinsmore J, Thomas C, Palmer P, Kott S, Edge A, Penney D, Kassissieh S, Dempsey P, Isacson O. Histological evidence of fetal pig neural cell survival after transplantation into a patient with Parkinson's disease. Nature Medicine. 3: 350-3. PMID 9055867 DOI: 10.1038/Nm0397-350  0.514
1996 Galpern WR, Matthews RT, Beal MF, Isacson O. NGF attenuates 3-nitrotyrosine formation in a 3-NP model of Huntington's disease. Neuroreport. 7: 2639-42. PMID 8981438 DOI: 10.1097/00001756-199611040-00046  0.335
1996 Isacson O, Deacon TW. Specific axon guidance factors persist in the adult brain as demonstrated by pig neuroblasts transplanted to the rat. Neuroscience. 75: 827-37. PMID 8951876 DOI: 10.1016/0306-4522(96)00305-3  0.393
1996 Galpern WR, Frim DM, Tatter SB, Altar CA, Beal MF, Isacson O. Cell-mediated delivery of brain-derived neurotrophic factor enhances dopamine levels in an MPP+ rat model of substantia nigra degeneration. Cell Transplantation. 5: 225-32. PMID 8689033 DOI: 10.1016/0963-6897(95)02030-6  0.659
1996 Dinsmore J, Ratliff J, Deacon T, Pakzaban P, Jacoby D, Galpern W, Isacson O. Embryonic stem cells differentiated in vitro as a novel source of cells for transplantation. Cell Transplantation. 5: 131-43. PMID 8689027 DOI: 10.1016/0963-6897(95)02040-3  0.375
1996 Galpern WR, Burns LH, Deacon TW, Dinsmore J, Isacson O. Xenotransplantation of porcine fetal ventral mesencephalon in a rat model of Parkinson's disease: functional recovery and graft morphology. Experimental Neurology. 140: 1-13. PMID 8682173 DOI: 10.1006/exnr.1996.0109  0.525
1996 Galpern WR, Frim DM, Tatter SB, Altar CA, Beal MF, Isacson O. Cell-Mediated Delivery of Brain-Derived Neurotrophic Factor Enhances Dopamine Levels in an Mpp+ Rat Model of Substantia Nigra Degeneration Cell Transplantation. 5: 225-232. DOI: 10.1177/096368979600500211  0.538
1996 Isacson O, Kordower JH. The neurobiological and clinical potential of neural cell transplantation: Special issue based on the meeting of the American Society for Neural Transplantation, 1995 Cell Transplantation. 5: 123-125. DOI: 10.1016/0963-6897(96)00059-0  0.304
1995 Isacson O, Frim DM, Galpern WR, Tatter SB, Breakefield XO, Schumacher JM. Cell-mediated delivery of neurotrophic factors and neuroprotection in the neostriatum and substantia nigra. Restorative Neurology and Neuroscience. 8: 59-61. PMID 21551807 DOI: 10.3233/Rnn-1995-81213  0.551
1995 Freeman TB, Sanberg PR, Isacson O. Development of the human striatum: implications for fetal striatal transplantation in the treatment of Huntington's disease. Cell Transplantation. 4: 539-45. PMID 8714776 DOI: 10.1016/0963-6897(95)00013-N  0.43
1995 Garcia AR, Deacon TW, Dinsmore J, Isacson O. Extensive axonal and glial fiber growth from fetal porcine cortical xenografts in the adult rat cortex. Cell Transplantation. 4: 515-27. PMID 8520835 DOI: 10.1016/0963-6897(95)00027-U  0.352
1995 Burns LH, Pakzaban P, Deacon TW, Brownell AL, Tatter SB, Jenkins BG, Isacson O. Selective putaminal excitotoxic lesions in non-human primates model the movement disorder of Huntington disease. Neuroscience. 64: 1007-17. PMID 7753372 DOI: 10.1016/0306-4522(94)00431-4  0.56
1995 Tatter SB, Galpern WR, Hoogeveen AT, Isacson O. Effects of striatal excitotoxicity on huntingtin-like immunoreactivity. Neuroreport. 6: 1125-9. PMID 7662892 DOI: 10.1097/00001756-199505300-00013  0.625
1995 Isacson O. Behavioral effects and gene delivery in a rat model of Parkinson's disease. Science (New York, N.Y.). 269: 856-7. PMID 7638605 DOI: 10.1126/Science.7638605  0.326
1995 Pakzaban P, Deacon TW, Burns LH, Dinsmore J, Isacson O. A novel mode of immunoprotection of neural xenotransplants: masking of donor major histocompatibility complex class I enhances transplant survival in the central nervous system. Neuroscience. 65: 983-96. PMID 7617173 DOI: 10.1016/0306-4522(94)00626-G  0.362
1995 Isacson O, Deacon TW, Pakzaban P, Galpern WR, Dinsmore J, Burns LH. Transplanted xenogeneic neural cells in neurodegenerative disease models exhibit remarkable axonal target specificity and distinct growth patterns of glial and axonal fibres. Nature Medicine. 1: 1189-94. PMID 7584993 DOI: 10.1038/nm1195-1189  0.418
1995 Tatter SB, Galpern WR, Isacson O. Neurotrophic Factor Protection against Excitotoxic Neuronal Death The Neuroscientist. 1: 286-297. DOI: 10.1177/107385849500100506  0.568
1995 Freeman TB, Sanberg PR, Isacson O. Article Commentary: Development of the Human Striatum: Implications for Fetal Striatal Transplantation in the Treatment of Huntington's Disease Cell Transplantation. 4: 539-545. DOI: 10.1177/096368979500400604  0.375
1994 Frim DM, Uhler TA, Galpern WR, Beal MF, Breakefield XO, Isacson O. Implanted fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevent 1-methyl-4-phenylpyridinium toxicity to dopaminergic neurons in the rat. Proceedings of the National Academy of Sciences of the United States of America. 91: 5104-8. PMID 8197193 DOI: 10.1073/Pnas.91.11.5104  0.474
1994 Frim DM, Wüllner U, Beal MF, Isacson O. Implanted NGF-producing fibroblasts induce catalase and modify ATP levels but do not affect glutamate receptor binding or NMDA receptor expression in the rat striatum. Experimental Neurology. 128: 172-80. PMID 8076661 DOI: 10.1006/Exnr.1994.1125  0.332
1994 Pakzaban P, Geller AI, Isacson O. Effect of exogenous nerve growth factor on neurotoxicity of and neuronal gene delivery by a herpes simplex amplicon vector in the rat brain. Human Gene Therapy. 5: 987-95. PMID 7948148 DOI: 10.1089/hum.1994.5.8-987  0.325
1994 Uhler TA, Frim DM, Pakzaban P, Isacson O. The effects of megadose methylprednisolone and U-78517F on toxicity mediated by glutamate receptors in the rat neostriatum. Neurosurgery. 34: 122-7; discussion 12. PMID 7907169 DOI: 10.1097/00006123-199401000-00018  0.321
1994 Pakzaban P, Isacson O. Neural xenotransplantation: reconstruction of neuronal circuitry across species barriers. Neuroscience. 62: 989-1001. PMID 7845600 DOI: 10.1016/0306-4522(94)90338-7  0.439
1994 Deacon TW, Pakzaban P, Burns LH, Dinsmore J, Isacson O. Cytoarchitectonic development, axon-glia relationships, and long distance axon growth of porcine striatal xenografts in rats. Experimental Neurology. 130: 151-67. PMID 7821391 DOI: 10.1006/exnr.1994.1194  0.431
1994 Andersen JK, Frim DM, Isacson O, Beal MF, Breakefield XO. Elevation of neuronal MAO-B activity in a transgenic mouse model does not increase sensitivity to the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Brain Research. 656: 108-14. PMID 7804823 DOI: 10.1016/0006-8993(94)91371-4  0.42
1994 Deacon TW, Pakzaban P, Isacson O. The lateral ganglionic eminence is the origin of cells committed to striatal phenotypes: neural transplantation and developmental evidence. Brain Research. 668: 211-9. PMID 7704606 DOI: 10.1016/0006-8993(94)90526-6  0.483
1993 Simpson JR, Isacson O. Mitochondrial impairment reduces the threshold for in vivo NMDA-mediated neuronal death in the striatum. Experimental Neurology. 121: 57-64. PMID 8495711 DOI: 10.1006/exnr.1993.1071  0.384
1993 Bossi SR, Simpson JR, Isacson O. Age dependence of striatal neuronal death caused by mitochondrial dysfunction. Neuroreport. 4: 73-6. PMID 8453041 DOI: 10.1097/00001756-199301000-00019  0.375
1993 Frim DM, Short MP, Rosenberg WS, Simpson J, Breakefield XO, Isacson O. Local protective effects of nerve growth factor-secreting fibroblasts against excitotoxic lesions in the rat striatum. Journal of Neurosurgery. 78: 267-73. PMID 8421209 DOI: 10.3171/Jns.1993.78.2.0267  0.437
1993 Yee WM, Frim DM, Isacson O. Relationships between stress protein induction and NMDA-mediated neuronal death in the entorhinal cortex. Experimental Brain Research. 94: 193-202. PMID 8395405 DOI: 10.1007/Bf00230287  0.326
1993 Andersen JK, Frim DM, Isacson O, Breakefield XO. Herpesvirus-mediated gene delivery into the rat brain: specificity and efficiency of the neuron-specific enolase promoter. Cellular and Molecular Neurobiology. 13: 503-15. PMID 8111822 DOI: 10.1007/Bf00711459  0.416
1993 Frim DM, Simpson J, Uhler TA, Short MP, Bossi SR, Breakefield XO, Isacson O. Striatal degeneration induced by mitochondrial blockade is prevented by biologically delivered NGF. Journal of Neuroscience Research. 35: 452-8. PMID 8103116 DOI: 10.1002/Jnr.490350413  0.405
1993 Frim DM, Uhler TA, Short MP, Ezzedine ZD, Klagsbrun M, Breakefield XO, Isacson O. Effects of biologically delivered NGF, BDNF and bFGF on striatal excitotoxic lesions. Neuroreport. 4: 367-70. PMID 8098961 DOI: 10.1097/00001756-199304000-00006  0.407
1993 Pakzaban P, Deacon TW, Burns LH, Isacson O. Increased proportion of acetylcholinesterase-rich zones and improved morphological integration in host striatum of fetal grafts derived from the lateral but not the medial ganglionic eminence. Experimental Brain Research. 97: 13-22. PMID 7907548 DOI: 10.1007/BF00228813  0.418
1993 Isacson O. On neuronal health. Trends in Neurosciences. 16: 306-8. PMID 7691004 DOI: 10.1016/0166-2236(93)90104-T  0.433
1993 Frim DM, Yee WM, Isacson O. NGF reduces striatal excitotoxic neuronal loss without affecting concurrent neuronal stress. Neuroreport. 4: 655-8. PMID 7688588 DOI: 10.1097/00001756-199306000-00013  0.398
1993 Frim DM, Short MP, Breakefield XO, Isacson O. Biological Gene-Product Delivery to the Brain: A Protocol for Retroviral Gene Transfer into Cultured Cells and Intracerebral Transplantation Neuroprotocols. 3: 63-68. DOI: 10.1006/Ncmn.1993.1038  0.317
1992 Isacson O, Peschanski M. Is there capacity for anatomical and functional repair in the adult somatosensory thalamus? Experimental Neurology. 115: 173-6. PMID 1728564 DOI: 10.1016/0014-4886(92)90244-K  0.405
1992 Hantraye P, Riche D, Maziere M, Isacson O. Intrastriatal transplantation of cross-species fetal striatal cells reduces abnormal movements in a primate model of Huntington disease. Proceedings of the National Academy of Sciences of the United States of America. 89: 4187-91. PMID 1533285 DOI: 10.1073/Pnas.89.9.4187  0.416
1992 Isacson O, Sofroniew MV. Neuronal loss or replacement in the injured adult cerebral neocortex induces extensive remodeling of intrinsic and afferent neural systems. Experimental Neurology. 117: 151-75. PMID 1379936 DOI: 10.1016/0014-4886(92)90123-8  0.425
1992 Schumacher JM, Hantraye P, Brownell AL, Riche D, Madras BK, Davenport PD, Maziere M, Elmaleh DR, Brownell GL, Isacson O. A primate model of Huntington's disease: functional neural transplantation and CT-guided stereotactic procedures. Cell Transplantation. 1: 313-22. PMID 1344304 DOI: 10.1177/096368979200100409  0.414
1992 Rosenberg WS, Breakefield XO, DeAntonio C, Isacson O. Authentic and artifactual detection of the E. coli lacZ gene product in the rat brain by histochemical methods. Brain Research. Molecular Brain Research. 16: 311-5. PMID 1337940 DOI: 10.1016/0169-328X(92)90240-C  0.304
1991 Schumacher JM, Short MP, Hyman BT, Breakefield XO, Isacson O. Intracerebral implantation of nerve growth factor-producing fibroblasts protects striatum against neurotoxic levels of excitatory amino acids. Neuroscience. 45: 561-70. PMID 1837849 DOI: 10.1016/0306-4522(91)90271-O  0.421
1991 Levisohn LF, Isacson O. Excitotoxic lesions of the rat entorhinal cortex. Effects of selective neuronal damage on acquisition and retention of a non-spatial reference memory task. Brain Research. 564: 230-44. PMID 1810624 DOI: 10.1016/0006-8993(91)91458-D  0.377
1990 O'Brien TS, Svendsen CN, Isacson O, Sofroniew MV. Loss of true blue labelling from the medial septum following transection of the fimbria-fornix: evidence for the death of cholinergic and non-cholinergic neurons. Brain Research. 508: 249-56. PMID 2306616 DOI: 10.1016/0006-8993(90)90403-X  0.425
1990 Sofroniew MV, Dunnett SB, Isacson O. Remodelling of intrinsic and afferent systems in neocortex with cortical transplants. Progress in Brain Research. 82: 313-20. PMID 2290944 DOI: 10.1016/S0079-6123(08)62618-7  0.589
1990 Isacson O, Hantraye P, Maziere M, Sofroniew MV, Riche D. Apomorphine-induced dyskinesias after excitotoxic caudate-putamen lesions and the effects of neural transplantation in non-human primates. Progress in Brain Research. 82: 523-33. PMID 2149770 DOI: 10.1016/S0079-6123(08)62643-6  0.42
1990 Hantraye P, Riche D, Maziere M, Isacson O. A primate model of Huntington's disease: behavioral and anatomical studies of unilateral excitotoxic lesions of the caudate-putamen in the baboon. Experimental Neurology. 108: 91-104. PMID 2139853 DOI: 10.1016/0014-4886(90)90014-J  0.4
1990 Sofroniew MV, Galletly NP, Isacson O, Svendsen CN. Survival of adult basal forebrain cholinergic neurons after loss of target neurons. Science (New York, N.Y.). 247: 338-42. PMID 1688664 DOI: 10.1126/Science.1688664  0.431
1989 Wictorin K, Simerly RB, Isacson O, Swanson LW, Björklund A. Connectivity of striatal grafts implanted into the ibotenic acid-lesioned striatum--III. Efferent projecting graft neurons and their relation to host afferents within the grafts. Neuroscience. 30: 313-30. PMID 2747920 DOI: 10.1016/0306-4522(89)90256-X  0.717
1989 Dusart I, Isacson O, Nothias F, Gumpel M, Peschanski M. Presence of Schwann cells in neurodegenerative lesions of the central nervous system. Neuroscience Letters. 105: 246-50. PMID 2594212 DOI: 10.1016/0304-3940(89)90628-9  0.404
1989 Isacson O, Riche D, Hantraye P, Sofroniew MV, Maziere M. A primate model of Huntington's disease: cross-species implantation of striatal precursor cells to the excitotoxically lesioned baboon caudate-putamen. Experimental Brain Research. 75: 213-20. PMID 2523313 DOI: 10.1007/BF00248544  0.474
1989 Dunnett S, Isacson O. Trophic mechanisms are not enough. Trends in Neurosciences. 12: 257. PMID 2475937 DOI: 10.1016/0166-2236(89)90024-6  0.393
1988 Dunnett SB, Isacson O, Sirinathsinghji DJ, Clarke DJ, Björklund A. Striatal grafts in rats with unilateral neostriatal lesions--III. Recovery from dopamine-dependent motor asymmetry and deficits in skilled paw reaching. Neuroscience. 24: 813-20. PMID 3380301 DOI: 10.1016/0306-4522(88)90069-3  0.575
1988 Sirinathsinghji DJ, Dunnett SB, Isacson O, Clarke DJ, Kendrick K, Björklund A. Striatal grafts in rats with unilateral neostriatal lesions--II. In vivo monitoring of GABA release in globus pallidus and substantia nigra. Neuroscience. 24: 803-11. PMID 3380300 DOI: 10.1016/0306-4522(88)90068-1  0.563
1988 Brundin P, Barbin G, Strecker RE, Isacson O, Prochiantz A, Björklund A. Survival and function of dissociated rat dopamine neurones grafted at different developmental stages or after being cultured in vitro. Brain Research. 467: 233-43. PMID 3378172 DOI: 10.1016/0165-3806(88)90027-2  0.629
1988 Gage FH, Brundin P, Strecker R, Dunnett SB, Isacson O, Bjorklund A. Intracerebral neuronal grafting in experimental animal models of age-related motor dysfunction. Annals of the New York Academy of Sciences. 515: 383-94. PMID 3284426 DOI: 10.1111/J.1749-6632.1988.Tb33014.X  0.723
1988 Björklund A, Brundin P, Isacson O. Neuronal replacement by intracerebral neural implants in animal models of neurodegenerative disease. Advances in Neurology. 47: 455-92. PMID 3278526  0.5
1988 Sofroniew MV, Isacson O. Distribution of degeneration of cholinergic neurons in the septum following axotomy in different portions of the fimbria-fornix: a correlation between degree of cell loss and proximity of neuronal somata to the lesion. Journal of Chemical Neuroanatomy. 1: 327-37. PMID 3270360  0.313
1988 Peschanski M, Rudin M, Isacson O, Delepierre M, Roques BP. Magnetic resonance imaging of intracerebral neural grafts. Progress in Brain Research. 78: 619-24. PMID 3247459 DOI: 10.1016/S0079-6123(08)60339-8  0.355
1988 Wictorin K, Isacson O, Fischer W, Nothias F, Peschanski M, Björklund A. Studies on host afferent inputs to fetal striatal transplants in the excitotoxically lesioned striatum. Progress in Brain Research. 78: 55-60. PMID 3247448 DOI: 10.1016/S0079-6123(08)60266-6  0.789
1988 Clarke DJ, Dunnett SB, Isacson O, Björklund A. Striatal grafts in the ibotenic acid-lesioned neostriatum: ultrastructural and immunocytochemical studies. Progress in Brain Research. 78: 47-53. PMID 3247443 DOI: 10.1016/S0079-6123(08)60265-4  0.591
1988 Fischer W, Wictorin K, Isacson O, Björklund A. Trophic effects on cholinergic striatal interneurons by submaxillary gland transplants. Progress in Brain Research. 78: 409-12. PMID 3247439 DOI: 10.1016/S0079-6123(08)60312-X  0.768
1988 Peschanski M, Isacson O. Fetal homotypic transplant in the excitotoxically neuron-depleted thalamus: light microscopy. The Journal of Comparative Neurology. 274: 449-63. PMID 3220970 DOI: 10.1002/cne.902740311  0.469
1988 Lams BE, Isacson O, Sofroniew MV. Loss of transmitter-associated enzyme staining following axotomy does not indicate death of brainstem cholinergic neurons. Brain Research. 475: 401-6. PMID 3214743 DOI: 10.1016/0006-8993(88)90635-X  0.395
1988 Dunnett SB, Isacson O, Sirinathsinghji DJ, Clarke DJ, Björklund A. Striatal grafts in the ibotenic acid-lesioned neostriatum: functional studies. Progress in Brain Research. 78: 39-45. PMID 3073422 DOI: 10.1016/S0079-6123(08)60264-2  0.585
1988 Isacson O, Wictorin K, Fischer W, Sofroniew MV, Björklund A. Fetal cortical cell suspension grafts to the excitotoxically lesioned neocortex: anatomical and neurochemical studies of trophic interactions. Progress in Brain Research. 78: 13-26. PMID 3073408 DOI: 10.1016/S0079-6123(08)60261-7  0.774
1988 Clarke DJ, Dunnett SB, Isacson O, Sirinathsinghji DJ, Björklund A. Striatal grafts in rats with unilateral neostriatal lesions--I. Ultrastructural evidence of afferent synaptic inputs from the host nigrostriatal pathway. Neuroscience. 24: 791-801. PMID 2898109 DOI: 10.1016/0306-4522(88)90067-X  0.593
1988 Wictorin K, Isacson O, Fischer W, Nothias F, Peschanski M, Björklund A. Connectivity of striatal grafts implanted into the ibotenic acid-lesioned striatum--I. Subcortical afferents. Neuroscience. 27: 547-62. PMID 2464147 DOI: 10.1016/0306-4522(88)90288-6  0.783
1988 Nothias F, Wictorin K, Isacson O, Björklund A, Peschanski M. Morphological alteration of thalamic afferents in the excitotoxically lesioned striatum. Brain Research. 461: 349-54. PMID 2460191 DOI: 10.1016/0006-8993(88)90266-1  0.699
1987 Isacson O, Fischer W, Wictorin K, Dawbarn D, Björklund A. Astroglial response in the excitotoxically lesioned neostriatum and its projection areas in the rat. Neuroscience. 20: 1043-56. PMID 3601061 DOI: 10.1016/0306-4522(87)90262-4  0.774
1987 Isacson O, Pritzel M, Dawbarn D, Brundin P, Kelly PA, Wiklund L, Emson PC, Gage FH, Dunnett SB, Björklund A. Striatal neural transplants in the ibotenic acid-lesioned rat neostriatum. Cellular and functional aspects. Annals of the New York Academy of Sciences. 495: 537-55. PMID 3474959 DOI: 10.1111/j.1749-6632.1987.tb23699.x  0.684
1987 Brundin P, Strecker RE, Lindvall O, Isacson O, Nilsson OG, Barbin G, Prochiantz A, Forni C, Nieoullon A, Widner H. Intracerebral grafting of dopamine neurons. Experimental basis for clinical trials in patients with Parkinson's disease. Annals of the New York Academy of Sciences. 495: 473-96. PMID 3474955 DOI: 10.1111/J.1749-6632.1987.Tb23695.X  0.753
1987 Isacson O, Dawbarn D, Brundin P, Gage FH, Emson PC, Björklund A. Neural grafting in a rat model of Huntington's disease: striosomal-like organization of striatal grafts as revealed by acetylcholinesterase histochemistry, immunocytochemistry and receptor autoradiography. Neuroscience. 22: 481-97. PMID 2823174 DOI: 10.1016/0306-4522(87)90348-4  0.672
1987 Björklund A, Lindvall O, Isacson O, Brundin P, Wictorin K, Strecker RE, Clarke DJ, Dunnett SB. Mechanisms of action of intracerebral neural implants: studies on nigral and striatal grafts to the lesioned striatum Trends in Neurosciences. 10: 509-516. DOI: 10.1016/0166-2236(87)90131-7  0.813
1986 Sofroniew MV, Isacson O, Björklund A. Cortical grafts prevent atrophy of cholinergic basal nucleus neurons induced by excitotoxic cortical damage. Brain Research. 378: 409-15. PMID 3730884 DOI: 10.1016/0006-8993(86)90947-9  0.47
1986 Sofroniew MV, Pearson RC, Isacson O, Björklund A. Experimental studies on the induction and prevention of retrograde degeneration of basal forebrain cholinergic neurons. Progress in Brain Research. 70: 363-89. PMID 3554356 DOI: 10.1016/S0079-6123(08)64316-2  0.414
1986 Brundin P, Isacson O, Gage FH, Prochiantz A, Björklund A. The rotating 6-hydroxydopamine-lesioned mouse as a model for assessing functional effects of neuronal grafting. Brain Research. 366: 346-9. PMID 3084035 DOI: 10.1016/0006-8993(86)91316-8  0.675
1986 Brundin P, Isacson O, Gage FH, Björklund A. Intrastriatal grafting of dopamine-containing neuronal cell suspensions: effects of mixing with target or non-target cells. Brain Research. 389: 77-84. PMID 3081240 DOI: 10.1016/0165-3806(86)90174-4  0.688
1986 Isacson O, Dunnett SB, Björklund A. Graft-induced behavioral recovery in an animal model of Huntington disease. Proceedings of the National Academy of Sciences of the United States of America. 83: 2728-32. PMID 2939457 DOI: 10.1073/Pnas.83.8.2728  0.586
1986 Dunnett SB, Whishaw IQ, Jones GH, Isacson O. Effects of dopamine-rich grafts on conditioned rotation in rats with unilateral 6-hydroxydopamine lesions. Neuroscience Letters. 68: 127-33. PMID 2873538 DOI: 10.1016/0304-3940(86)90242-9  0.554
1986 Pritzel M, Isacson O, Brundin P, Wiklund L, Björklund A. Afferent and efferent connections of striatal grafts implanted into the ibotenic acid lesioned neostriatum in adult rats. Experimental Brain Research. 65: 112-26. PMID 2433142 DOI: 10.1007/BF00243834  0.613
1986 Zetterström T, Brundin P, Gage FH, Sharp T, Isacson O, Dunnett SB, Ungerstedt U, Björklund A. In vivo measurement of spontaneous release and metabolism of dopamine from intrastriatal nigral grafts using intracerebral dialysis. Brain Research. 362: 344-9. PMID 2417666 DOI: 10.1016/0006-8993(86)90460-9  0.72
1985 Gage FH, Brundin P, Isacson O, Björklund A. Rat fetal brain tissue grafts survive and innervate host brain following five day pregraft tissue storage. Neuroscience Letters. 60: 133-7. PMID 4058805 DOI: 10.1016/0304-3940(85)90233-2  0.641
1985 Brundin P, Isacson O, Björklund A. Monitoring of cell viability in suspensions of embryonic CNS tissue and its use as a criterion for intracerebral graft survival. Brain Research. 331: 251-9. PMID 3986568 DOI: 10.1016/0006-8993(85)91550-1  0.62
1985 Brundin P, Barbin G, Isacson O, Mallat M, Chamak B, Prochiantz A, Gage FH, Björklund A. Survival of intracerebrally grafted rat dopamine neurons previously cultured in vitro. Neuroscience Letters. 61: 79-84. PMID 3935983 DOI: 10.1016/0304-3940(85)90404-5  0.634
1985 Emson PC, Dawbarn D, Rossor MN, Rehfeld JF, Brundin P, Isacson O, Björklund A. Cholecystokinin content in the basal ganglia in Huntington's disease. The expression of cholecystokinin immunoreactivity in striatal grafts to ibotenic acid-lesioned rat striatum. Annals of the New York Academy of Sciences. 448: 488-94. PMID 3161446 DOI: 10.1111/J.1749-6632.1985.Tb29942.X  0.59
1985 Isacson O, Brundin P, Gage FH, Björklund A. Neural grafting in a rat model of Huntington's disease: progressive neurochemical changes after neostriatal ibotenate lesions and striatal tissue grafting. Neuroscience. 16: 799-817. PMID 2936982 DOI: 10.1016/0306-4522(85)90095-8  0.663
1985 Brundin P, Isacson O, Gage FH. Intracerebral grafts of neuronal cell suspensions Fernstrom Foundation Series. 51-59.  0.359
1984 Isacson O, Brundin P, Kelly PA, Gage FH, Björklund A. Functional neuronal replacement by grafted striatal neurones in the ibotenic acid-lesioned rat striatum. Nature. 311: 458-60. PMID 6482962 DOI: 10.1038/311458a0  0.62
1983 Gage FH, Dunnett SB, Brundin P, Isacson O, Björklund A. Intracerebral grafting of embryonic neural cells into the adult host brain: an overview of the cell suspension method and its application. Developmental Neuroscience. 6: 137-51. PMID 6389079 DOI: 10.1159/000112341  0.702
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