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Joshua N. Leonard, Ph.D. - Publications

Affiliations: 
University of California, Berkeley, Berkeley, CA, United States 
Area:
viral gene delivery, stem cells
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38 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Cable J, Leonard JN, Lu TK, Xie Z, Chang MW, Fernández LÁ, Lora JM, Kaufman HL, Quintana FJ, Geiger R, F Lesser C, Lynch JP, Hava DL, Cornish VW, Lee GK, et al. Synthetic biology: at the crossroads of genetic engineering and human therapeutics-a Keystone Symposia report. Annals of the New York Academy of Sciences. PMID 34786712 DOI: 10.1111/nyas.14710  0.549
2020 Donahue PS, Draut JW, Muldoon JJ, Edelstein HI, Bagheri N, Leonard JN. The COMET toolkit for composing customizable genetic programs in mammalian cells. Nature Communications. 11: 779. PMID 32034124 DOI: 10.1038/S41467-019-14147-5  0.328
2018 Li K, Rodosthenous RS, Kashanchi F, Gingeras T, Gould SJ, Kuo LS, Kurre P, Lee H, Leonard JN, Liu H, Lombo TB, Momma S, Nolan JP, Ochocinska MJ, Pegtel DM, et al. Advances, challenges, and opportunities in extracellular RNA biology: insights from the NIH exRNA Strategic Workshop. Jci Insight. 3. PMID 29618663 DOI: 10.1172/Jci.Insight.98942  0.325
2018 Dolberg TB, Donahue PS, Leonard JN. Synthetic biology: Reframing cell therapy for cancer. Nature Chemical Biology. 14: 204-205. PMID 29443984 DOI: 10.1038/Nchembio.2573  0.354
2018 Hung ME, Lenzini SB, Stranford DM, Leonard JN. Enrichment of Extracellular Vesicle Subpopulations Via Affinity Chromatography. Methods in Molecular Biology (Clifton, N.J.). 1740: 109-124. PMID 29388139 DOI: 10.1007/978-1-4939-7652-2_9  0.317
2018 Younger AKD, Su PY, Shepard AJ, Udani SV, Cybulski TR, Tyo KEJ, Leonard JN. Development of novel metabolite-responsive transcription factors via transposon-mediated protein fusion. Protein Engineering, Design & Selection : Peds. PMID 29385546 DOI: 10.1093/Protein/Gzy001  0.303
2017 Muldoon JJ, Donahue PS, Dolberg TB, Leonard JN. Building with intent: technologies and principles for engineering mammalian cell-based therapies to sense and respond. Current Opinion in Biomedical Engineering. 4: 127-133. PMID 29450405 DOI: 10.1016/J.Cobme.2017.10.004  0.376
2017 Stranford DM, Leonard JN. Delivery of Biomolecules via Extracellular Vesicles: A Budding Therapeutic Strategy. Advances in Genetics. 98: 155-175. PMID 28942793 DOI: 10.1016/Bs.Adgen.2017.08.002  0.336
2017 Hartfield RM, Schwarz KA, Muldoon JJ, Bagheri N, Leonard JN. Multiplexing engineered receptors for multiparametric evaluation of environmental ligands. Acs Synthetic Biology. PMID 28771312 DOI: 10.1021/Acssynbio.6B00279  0.335
2017 Stranford D, Hung ME, Gargus E, Shah RN, Leonard JN. A systematic evaluation of factors affecting extracellular vesicle uptake by breast cancer cells. Tissue Engineering. Part A. PMID 28586292 DOI: 10.1089/Ten.Tea.2017.0158  0.303
2016 Schwarz KA, Daringer NM, Dolberg TB, Leonard JN. Rewiring human cellular input-output using modular extracellular sensors. Nature Chemical Biology. PMID 27941759 DOI: 10.1038/Nchembio.2253  0.353
2016 Younger AK, Dalvie NC, Rottinghaus AG, Leonard JN. Engineering modular biosensors to confer metabolite-responsive regulation of transcription. Acs Synthetic Biology. PMID 27744683 DOI: 10.1021/Acssynbio.6B00184  0.34
2016 Schwarz KA, Leonard JN. Engineering cell-based therapies to interface robustly with host physiology. Advanced Drug Delivery Reviews. PMID 27266446 DOI: 10.1016/J.Addr.2016.05.019  0.372
2016 Hung ME, Leonard JN. A platform for actively loading cargo RNA to elucidate limiting steps in EV-mediated delivery. Journal of Extracellular Vesicles. 5: 31027. PMID 27189348 DOI: 10.3402/Jev.V5.31027  0.355
2016 Hung ME, Leonard JN. 496. Elucidating Design Rules Governing Extracellular Vesicle-Mediated Therapeutic Protein Delivery Molecular Therapy. 24: S197. DOI: 10.1016/S1525-0016(16)33305-6  0.343
2015 Pitner RA, Scarpelli AH, Leonard JN. Regulation of Bacterial Gene Expression by Protease-Alleviated Spatial Sequestration (PASS). Acs Synthetic Biology. 4: 966-74. PMID 25822588 DOI: 10.1021/Sb500302Y  0.326
2015 Hung ME, Leonard JN. Stabilization of exosome-targeting peptides via engineered glycosylation. The Journal of Biological Chemistry. 290: 8166-72. PMID 25657008 DOI: 10.1074/Jbc.M114.621383  0.306
2015 György B, Hung ME, Breakefield XO, Leonard JN. Therapeutic applications of extracellular vesicles: clinical promise and open questions. Annual Review of Pharmacology and Toxicology. 55: 439-64. PMID 25292428 DOI: 10.1146/Annurev-Pharmtox-010814-124630  0.364
2014 Leonard JN. The rise of mammals. Acs Synthetic Biology. 3: 878-9. PMID 25524093 DOI: 10.1021/Sb5003554  0.335
2014 Dudek RM, Chuang Y, Leonard JN. Engineered cell-based therapies: a vanguard of design-driven medicine. Advances in Experimental Medicine and Biology. 844: 369-91. PMID 25480651 DOI: 10.1007/978-1-4939-2095-2_18  0.382
2014 Corey SJ, Kimmel M, Leonard JN. Systems hematology: an introduction. Advances in Experimental Medicine and Biology. 844: 3-10. PMID 25480634 DOI: 10.1007/978-1-4939-2095-2_1  0.333
2014 Daringer NM, Dudek RM, Schwarz KA, Leonard JN. Modular extracellular sensor architecture for engineering mammalian cell-based devices. Acs Synthetic Biology. 3: 892-902. PMID 24611683 DOI: 10.1021/Sb400128G  0.332
2014 Gower RM, Boehler RM, Azarin SM, Ricci CF, Leonard JN, Shea LD. Modulation of leukocyte infiltration and phenotype in microporous tissue engineering scaffolds via vector induced IL-10 expression. Biomaterials. 35: 2024-31. PMID 24309498 DOI: 10.1016/J.Biomaterials.2013.11.036  0.321
2014 Corey SJ, Kimmel M, Leonard JN. A systems biology approach to blood Advances in Experimental Medicine and Biology. 844. DOI: 10.1007/978-1-4939-2095_2  0.303
2013 Marcus ME, Leonard JN. FedExosomes: Engineering Therapeutic Biological Nanoparticles that Truly Deliver. Pharmaceuticals (Basel, Switzerland). 6: 659-80. PMID 23894228 DOI: 10.3390/Ph6050659  0.375
2011 Jelinek I, Leonard JN, Price GE, Brown KN, Meyer-Manlapat A, Goldsmith PK, Wang Y, Venzon D, Epstein SL, Segal DM. TLR3-specific double-stranded RNA oligonucleotide adjuvants induce dendritic cell cross-presentation, CTL responses, and antiviral protection. Journal of Immunology (Baltimore, Md. : 1950). 186: 2422-9. PMID 21242525 DOI: 10.4049/Jimmunol.1002845  0.303
2010 Samuel-Abraham S, Leonard JN. Staying on message: design principles for controlling nonspecific responses to siRNA. The Febs Journal. 277: 4828-36. PMID 21078117 DOI: 10.1111/J.1742-4658.2010.07905.X  0.39
2008 Leonard JN, Shah PS, Burnett JC, Schaffer DV. HIV evades RNA interference directed at TAR by an indirect compensatory mechanism. Cell Host & Microbe. 4: 484-94. PMID 18996348 DOI: 10.1016/J.Chom.2008.09.008  0.679
2008 Ricci C, Pastukh V, Leonard J, Turrens J, Wilson G, Schaffer D, Schaffer SW. Mitochondrial DNA damage triggers mitochondrial-superoxide generation and apoptosis. American Journal of Physiology. Cell Physiology. 294: C413-22. PMID 18077603 DOI: 10.1152/Ajpcell.00362.2007  0.397
2007 Ashton RS, Peltier J, Fasano CA, O'Neill A, Leonard J, Temple S, Schaffer DV, Kane RS. High-throughput screening of gene function in stem cells using clonal microarrays. Stem Cells (Dayton, Ohio). 25: 2928-35. PMID 17673524 DOI: 10.1634/Stemcells.2007-0468  0.662
2007 Leonard JN, Ferstl P, Delgado A, Schaffer DV. Enhanced preparation of adeno-associated viral vectors by using high hydrostatic pressure to selectively inactivate helper adenovirus. Biotechnology and Bioengineering. 97: 1170-9. PMID 17252611 DOI: 10.1002/Bit.21355  0.536
2006 Leonard JN, Schaffer DV. Antiviral RNAi therapy: emerging approaches for hitting a moving target. Gene Therapy. 13: 532-40. PMID 16177819 DOI: 10.1038/Sj.Gt.3302645  0.584
2005 Leonard JN, Schaffer DV. Computational design of antiviral RNA interference strategies that resist human immunodeficiency virus escape. Journal of Virology. 79: 1645-54. PMID 15650190 DOI: 10.1128/Jvi.79.3.1645-1654.2005  0.599
2005 Leonard JN, Schaffer DV. 1002. Therapeutic Design Principles for Achieving Long-Term Suppression of HIV-1 with RNA Interference Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.07.549  0.577
2005 Leonard JN, Schaffer DV, Ferstl P, Delgado A. 519. Selective Inactivation of Helper Adenovirus with High Hydrostatic Pressure for AAV-2 Vector Production Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.07.059  0.533
2005 Leonard JN, Ferstl P, Delgado A, Schaffer DV. Purification of Aav gene therapy vectors by selectively inactivating helper adenovirus using high hydrostatic pressure Aiche Annual Meeting, Conference Proceedings. 12143.  0.448
2005 Leonard JN, Schaffer DV. Computational design of RNA interference gene therapy strategies to treat HIV-1 infections and block viral escape Aiche Annual Meeting, Conference Proceedings. 8356-8357.  0.511
2004 Leonard JN, Schaffer DV. 547. Antiviral RNA Interference Strategies That Resist HIV Escape Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.463  0.583
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