John D. McCorvy, Ph.D. - Publications

Medicinal Chemistry and Molecular Pharmacology Purdue University, West Lafayette, IN, United States 
Dopamine and Serotonin Agonists

40 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Zhang G, McCorvy JD, Shen S, Cheng J, Roth BL, Kozikowski AP. Design of fluorinated cyclopropane derivatives of 2-phenylcyclopropylmethylamine leading to identification of a selective serotonin 2C (5-HT) receptor agonist without 5-HT agonism. European Journal of Medicinal Chemistry. 182: 111626. PMID 31445232 DOI: 10.1016/j.ejmech.2019.111626  0.52
2019 Martini ML, Ray C, Yu X, Liu J, Pogorelov V, Wetsel WC, Huang XP, McCorvy J, Caron MG, Jin J. Designing Functionally Selective Non-Catechol Dopamine D1 Receptor Agonists with Potent In Vivo Antiparkinsonian Activity. Acs Chemical Neuroscience. PMID 31387346 DOI: 10.1021/acschemneuro.9b00410  0.52
2019 Stauch B, Johansson LC, McCorvy JD, Patel N, Han GW, Huang XP, Gati C, Batyuk A, Slocum ST, Ishchenko A, Brehm W, White TA, Michaelian N, Madsen C, Zhu L, et al. Publisher Correction: Structural basis of ligand recognition at the human MT melatonin receptor. Nature. PMID 31048811 DOI: 10.1038/s41586-019-1209-0  0.52
2019 Stauch B, Johansson LC, McCorvy JD, Patel N, Han GW, Huang XP, Gati C, Batyuk A, Slocum ST, Ishchenko A, Brehm W, White TA, Michaelian N, Madsen C, Zhu L, et al. Structural basis of ligand recognition at the human MT melatonin receptor. Nature. PMID 31019306 DOI: 10.1038/s41586-019-1141-3  0.52
2019 Johansson LC, Stauch B, McCorvy JD, Han GW, Patel N, Huang XP, Batyuk A, Gati C, Slocum ST, Li C, Grandner JM, Hao S, Olsen RHJ, Tribo AR, Zaare S, et al. XFEL structures of the human MT melatonin receptor reveal the basis of subtype selectivity. Nature. PMID 31019305 DOI: 10.1038/s41586-019-1144-0  0.52
2019 Shen Y, McCorvy JD, Martini ML, Rodriguiz RM, Pogorelov VM, Ward KM, Wetsel WC, Liu J, Roth BL, Jin J. D2 Dopamine Receptor G protein-biased Partial Agonists Based on Cariprazine. Journal of Medicinal Chemistry. PMID 30964661 DOI: 10.1021/acs.jmedchem.9b00508  0.52
2019 Martini ML, Liu J, Ray C, Yu X, Huang XP, Urs A, Urs NM, McCorvy J, Caron MG, Roth BL, Jin J. Defining Structure-Functional Selectivity Relationships (SFSR) for a Class of Non-Catechol Dopamine D1 Receptor Agonists. Journal of Medicinal Chemistry. PMID 30875219 DOI: 10.1021/acs.jmedchem.9b00351  0.52
2018 McCorvy JD, Wacker D, Wang S, Agegnehu B, Liu J, Lansu K, Tribo AR, Olsen RHJ, Che T, Jin J, Roth BL. Structural determinants of 5-HT receptor activation and biased agonism. Nature Structural & Molecular Biology. PMID 30127358 DOI: 10.1038/s41594-018-0116-7  0.52
2018 Qin S, Meng M, Yang D, Bai W, Lu Y, Peng Y, Song G, Wu Y, Zhou Q, Zhao S, Huang X, McCorvy JD, Cai X, Dai A, Roth BL, et al. High-throughput identification of G protein-coupled receptor modulators through affinity mass spectrometry screening. Chemical Science. 9: 3192-3199. PMID 29732102 DOI: 10.1039/c7sc04698g  0.52
2018 Peng Y, McCorvy JD, Harpsøe K, Lansu K, Yuan S, Popov P, Qu L, Pu M, Che T, Nikolajsen LF, Huang XP, Wu Y, Shen L, Bjørn-Yoshimoto WE, Ding K, et al. 5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology. Cell. PMID 29398112 DOI: 10.1016/j.cell.2018.01.001  0.52
2018 Che T, Majumdar S, Zaidi SA, Ondachi P, McCorvy JD, Wang S, Mosier PD, Uprety R, Vardy E, Krumm BE, Han GW, Lee MY, Pardon E, Steyaert J, Huang XP, et al. Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor. Cell. PMID 29307491 DOI: 10.1016/j.cell.2017.12.011  0.52
2017 McCorvy JD, Butler KV, Kelly B, Rechsteiner K, Karpiak J, Betz RM, Kormos BL, Shoichet BK, Dror RO, Jin J, Roth BL. Structure-inspired design of β-arrestin-biased ligands for aminergic GPCRs. Nature Chemical Biology. PMID 29227473 DOI: 10.1038/nchembio.2527  0.52
2017 Chan JD, Cupit PM, Gunaratne GS, McCorvy JD, Yang Y, Stoltz K, Webb TR, Dosa PI, Roth BL, Abagyan R, Cunningham C, Marchant JS. The anthelmintic praziquantel is a human serotoninergic G-protein-coupled receptor ligand. Nature Communications. 8: 1910. PMID 29208933 DOI: 10.1038/s41467-017-02084-0  0.52
2017 Wang S, Wacker D, Levit A, Che T, Betz RM, McCorvy JD, Venkatakrishnan AJ, Huang XP, Dror RO, Shoichet BK, Roth BL. D4 dopamine receptor high-resolution structures enable the discovery of selective agonists. Science (New York, N.Y.). 358: 381-386. PMID 29051383 DOI: 10.1126/science.aan5468  0.52
2017 Zhang G, Cheng J, McCorvy JD, Lorello PJ, Caldarone BJ, Roth BL, Kozikowski AP. Discovery of N-Substituted 2-Phenylcyclopropylmethylamines as Functionally Selective Serotonin 2C (5-HT2C) Receptor Agonists for Potential Use as Antipsychotic Medications. Journal of Medicinal Chemistry. PMID 28657744 DOI: 10.1021/acs.jmedchem.7b00584  0.52
2017 Brandt SD, Kavanagh PV, Twamley B, Westphal F, Elliott SP, Wallach J, Stratford A, Klein LM, McCorvy JD, Nichols DE, Halberstadt AL. Return of the lysergamides. Part IV: Analytical and pharmacological characterization of lysergic acid morpholide (LSM-775). Drug Testing and Analysis. PMID 28585392 DOI: 10.1002/dta.2222  0.8
2017 Hoehn RD, Nichols DE, McCorvy JD, Neven H, Kais S. Experimental evaluation of the generalized vibrational theory of G protein-coupled receptor activation. Proceedings of the National Academy of Sciences of the United States of America. PMID 28500275 DOI: 10.1073/pnas.1618422114  0.8
2017 Lansu K, Karpiak J, Liu J, Huang XP, McCorvy JD, Kroeze WK, Che T, Nagase H, Carroll FI, Jin J, Shoichet BK, Roth BL. In silico design of novel probes for the atypical opioid receptor MRGPRX2. Nature Chemical Biology. PMID 28288109 DOI: 10.1038/nchembio.2334  0.52
2017 Wacker D, Wang S, McCorvy JD, Betz RM, Venkatakrishnan AJ, Levit A, Lansu K, Schools ZL, Che T, Nichols DE, Shoichet BK, Dror RO, Roth BL. Crystal Structure of an LSD-Bound Human Serotonin Receptor. Cell. 168: 377-389.e12. PMID 28129538 DOI: 10.1016/j.cell.2016.12.033  0.8
2016 Urs NM, Gee SM, Pack TF, McCorvy JD, Evron T, Snyder JC, Yang X, Rodriguiz RM, Borrelli E, Wetsel WC, Jin J, Roth BL, O'Donnell P, Caron MG. Distinct cortical and striatal actions of a β-arrestin-biased dopamine D2 receptor ligand reveal unique antipsychotic-like properties. Proceedings of the National Academy of Sciences of the United States of America. PMID 27911814 DOI: 10.1073/pnas.1614347113  0.52
2016 McCorvy JD, Olsen RH, Roth BL. Psilocybin for depression and anxiety associated with life-threatening illnesses. Journal of Psychopharmacology (Oxford, England). 30: 1209-1210. PMID 27909171 DOI: 10.1177/0269881116675771  0.52
2016 Chen X, McCorvy JD, Fischer MG, Butler KV, Shen Y, Roth BL, Jin J. Discovery of G Protein-biased D2 Dopamine Receptor Partial Agonists. Journal of Medicinal Chemistry. PMID 27805392 DOI: 10.1021/acs.jmedchem.6b01208  0.52
2016 Cheng J, McCorvy JD, Giguère PM, Zhu H, Kenakin T, Roth BL, Kozikowski AP. Design and Discovery of Functionally Selective Serotonin 2C (5-HT2C) Receptor Agonists. Journal of Medicinal Chemistry. PMID 27726356 DOI: 10.1021/acs.jmedchem.6b01194  0.52
2016 Manglik A, Lin H, Aryal DK, McCorvy JD, Dengler D, Corder G, Levit A, Kling RC, Bernat V, Hübner H, Huang XP, Sassano MF, Giguère PM, Löber S, Da Duan, et al. Structure-based discovery of opioid analgesics with reduced side effects. Nature. 1-6. PMID 27533032 DOI: 10.1038/nature19112  0.52
2016 Chan JD, McCorvy JD, Acharya S, Johns ME, Day TA, Roth BL, Marchant JS. A Miniaturized Screen of a Schistosoma mansoni Serotonergic G Protein-Coupled Receptor Identifies Novel Classes of Parasite-Selective Inhibitors. Plos Pathogens. 12: e1005651. PMID 27187180 DOI: 10.1371/journal.ppat.1005651  0.52
2016 Farrell MS, McCorvy JD, Huang XP, Urban DJ, White KL, Giguere PM, Doak AK, Bernstein AI, Stout KA, Park SM, Rodriguiz RM, Gray BW, Hyatt WS, Norwood AP, Webster KA, et al. In Vitro and In Vivo Characterization of the Alkaloid Nuciferine. Plos One. 11: e0150602. PMID 26963248 DOI: 10.1371/journal.pone.0150602  0.8
2015 Cheng J, Giguère PM, Schmerberg CM, Pogorelov VM, Rodriguiz RM, Huang XP, Zhu H, McCorvy JD, Wetsel WC, Roth BL, Kozikowski AP. Further Advances in Optimizing (2-Phenylcyclopropyl)methylamines as Novel Serotonin 2C Agonists: Effects on Hyperlocomotion, Prepulse Inhibition, and Cognition Models. Journal of Medicinal Chemistry. PMID 26704965 DOI: 10.1021/acs.jmedchem.5b01153  0.8
2015 Kroeze WK, Sassano MF, Huang XP, Lansu K, McCorvy JD, Giguère PM, Sciaky N, Roth BL. PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome. Nature Structural & Molecular Biology. 22: 362-9. PMID 25895059 DOI: 10.1038/nsmb.3014  0.8
2015 McCorvy JD, Roth BL. Structure and function of serotonin G protein-coupled receptors. Pharmacology & Therapeutics. 150: 129-42. PMID 25601315 DOI: 10.1016/j.pharmthera.2015.01.009  0.8
2015 Hansen M, Jacobsen SE, Plunkett S, Liebscher GE, McCorvy JD, Bräuner-Osborne H, Kristensen JL. Synthesis and pharmacological evaluation of N-benzyl substituted 4-bromo-2,5-dimethoxyphenethylamines as 5-HT2A/2C partial agonists. Bioorganic & Medicinal Chemistry. 23: 3933-7. PMID 25583099 DOI: 10.1016/j.bmc.2014.12.011  0.8
2013 Wacker D, Wang C, Katritch V, Han GW, Huang XP, Vardy E, McCorvy JD, Jiang Y, Chu M, Siu FY, Liu W, Xu HE, Cherezov V, Roth BL, Stevens RC. Structural features for functional selectivity at serotonin receptors. Science (New York, N.Y.). 340: 615-9. PMID 23519215 DOI: 10.1126/science.1232808  0.8
2013 Wang C, Jiang Y, Ma J, Wu H, Wacker D, Katritch V, Han GW, Liu W, Huang XP, Vardy E, McCorvy JD, Gao X, Zhou XE, Melcher K, Zhang C, et al. Structural basis for molecular recognition at serotonin receptors. Science (New York, N.Y.). 340: 610-4. PMID 23519210 DOI: 10.1126/science.1232807  0.8
2013 Juncosa JI, Hansen M, Bonner LA, Cueva JP, Maglathlin R, McCorvy JD, Marona-Lewicka D, Lill MA, Nichols DE. Extensive rigid analogue design maps the binding conformation of potent N-benzylphenethylamine 5-HT2A serotonin receptor agonist ligands. Acs Chemical Neuroscience. 4: 96-109. PMID 23336049 DOI: 10.1021/cn3000668  0.8
2012 Pigott A, Frescas S, McCorvy JD, Huang XP, Roth BL, Nichols DE. trans-2-(2,5-Dimethoxy-4-iodophenyl)cyclopropylamine and trans-2-(2,5-dimethoxy-4-bromophenyl)cyclopropylamine as potent agonists for the 5-HT(2) receptor family. Beilstein Journal of Organic Chemistry. 8: 1705-9. PMID 23209503 DOI: 10.3762/bjoc.8.194  0.8
2012 Clark AH, McCorvy JD, Conley JM, Williams WK, Bekkam M, Watts VJ, Nichols DE. Identification of a 2-phenyl-substituted octahydrobenzo[f]quinoline as a dopamine D₃ receptor-selective full agonist ligand. Bioorganic & Medicinal Chemistry. 20: 6366-74. PMID 23018094 DOI: 10.1016/j.bmc.2012.08.058  0.8
2012 McCorvy JD, Watts VJ, Nichols DE. Comparison of the D₁ dopamine full agonists, dihydrexidine and doxanthrine, in the 6-OHDA rat model of Parkinson's disease. Psychopharmacology. 222: 81-7. PMID 22222862 DOI: 10.1007/s00213-011-2625-5  0.8
2011 Clark AH, McCorvy JD, Watts VJ, Nichols DE. Assessment of dopamine D₁ receptor affinity and efficacy of three tetracyclic conformationally-restricted analogs of SKF38393. Bioorganic & Medicinal Chemistry. 19: 5420-31. PMID 21862338 DOI: 10.1016/j.bmc.2011.07.057  0.8
2011 McCorvy JD, Harland AA, Maglathlin R, Nichols DE. A 5-HT(2C) receptor antagonist potentiates a low dose amphetamine-induced conditioned place preference. Neuroscience Letters. 505: 10-3. PMID 21827831 DOI: 10.1016/j.neulet.2011.07.036  0.8
2011 Clark LH, Cueva JP, McCorvy JD, Harland AA, Watts VJ, Nichols DE. C-Ring expanded analogs of doxanthrine: Conformation plays a critical role Arkivoc. 2010: 125-138.  0.8
2009 Przybyla JA, Cueva JP, Chemel BR, Hsu KJ, Riese DJ, McCorvy JD, Chester JA, Nichols DE, Watts VJ. Comparison of the enantiomers of (+/-)-doxanthrine, a high efficacy full dopamine D(1) receptor agonist, and a reversal of enantioselectivity at D(1) versus alpha(2C) adrenergic receptors. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 19: 138-46. PMID 19028082 DOI: 10.1016/j.euroneuro.2008.10.002  0.8
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