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Ronald W. Irwin, Ph.D. - Publications

Affiliations: 
Molecular Pharmacology and Toxicology University of Southern California, Los Angeles, CA, United States 
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41 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Wang JY, Trivedi AM, Carrillo NR, Yang J, Schneider A, Giulivi C, Adams P, Tassone F, Kim K, Rivera SM, Lubarr N, Wu CY, Irwin RW, Brinton RD, Olichney JM, et al. Open-Label Allopregnanolone Treatment of Men with Fragile X-Associated Tremor/Ataxia Syndrome. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. PMID 28707277 DOI: 10.1007/S13311-017-0555-6  0.523
2017 Irwin RW, Hernandez G, Solinsky CM, Lopez CM, Kono N, Mack WJ, Schneider LS, Diaz Brinton R. [P4-020]: CLINICAL TRIAL RECRUITMENT FRAMEWORK FOR EARLY ALZHEIMER's DISEASE Alzheimer's & Dementia. 13: P1262-P1262. DOI: 10.1016/J.Jalz.2017.06.1884  0.423
2016 Irwin RW, Solinsky CM, Rodgers KE, Bauer G, Rogawski MA, Brinton RD. P1-072: Comparative Pharmacokinetic Assessment of Allopregnanolone to Develop a Regenerative Therapeutic for Mild Cognitive Impairment and Early Alzheimer’s Disease Alzheimer's & Dementia. 12: P430-P430. DOI: 10.1016/J.Jalz.2016.06.820  0.577
2016 Brinton RD, Swanson HM, Irwin RW. P4-026: Allopregnanolone Promotes Cholesterol and Amyloid-Beta Clearance Mechanisms: Assessment of a Regenerative Therapeutic for Alzheimer’s Disease Alzheimer's & Dementia. 12: P1024-P1025. DOI: 10.1016/J.Jalz.2016.06.2115  0.566
2015 Irwin RW, Solinsky CM, Loya CM, Salituro FG, Rodgers KE, Bauer G, Rogawski MA, Brinton RD. Allopregnanolone preclinical acute pharmacokinetic and pharmacodynamic studies to predict tolerability and efficacy for Alzheimer's disease. Plos One. 10: e0128313. PMID 26039057 DOI: 10.1371/Journal.Pone.0128313  0.571
2015 Irwin RW, Kim K, Green CE, Solinsky CM, Bauer G, Rogawski MA, Rodgers KE, Brinton RD. P1-303: Allopregnanolone chronic exposure using regenerative treatment regimen: Preclinical ind enabling toxicology indicating safety Alzheimer's & Dementia. 11: P472-P473. DOI: 10.1016/J.Jalz.2015.06.518  0.505
2014 Irwin RW, Solinsky CM, Brinton RD. Frontiers in therapeutic development of allopregnanolone for Alzheimer's disease and other neurological disorders. Frontiers in Cellular Neuroscience. 8: 203. PMID 25126056 DOI: 10.3389/Fncel.2014.00203  0.639
2014 Irwin RW, Brinton RD. Allopregnanolone as regenerative therapeutic for Alzheimer's disease: translational development and clinical promise. Progress in Neurobiology. 113: 40-55. PMID 24044981 DOI: 10.1016/J.Pneurobio.2013.08.004  0.642
2013 Irwin R, Chen S, To J, Zhu M, Yao J, Rodgers K, Bolger M, Brinton R. P4-016: Allopregnanolone as a regenerative therapeutic for Alzheimer's disease, 2: Bridging subcutaneous to intravenous formulations for clinical trials Alzheimer's & Dementia. 9: P710-P711. DOI: 10.1016/J.Jalz.2013.05.1404  0.664
2013 Yao J, Chen S, Wong K, Irwin R, Brinton R. P4-013: Allopregnanolone as a regenerative therapeutic for Alzheimer's disease, 3: Evidence for potentiation of brain mitochondrial function Alzheimer's & Dementia. 9: P709-P710. DOI: 10.1016/J.Jalz.2013.05.1401  0.718
2013 Brinton R, Irwin R, Mack W, Rodgers K, Bauer G, Rogawski M, Schneider L. P4-012: Allopregnanolone as a regenerative therapeutic for Alzheimer's disease, 1: From discovery to phase I multiple-ascending-dose clinical trial Alzheimer's & Dementia. 9: P709-P709. DOI: 10.1016/J.Jalz.2013.05.1400  0.582
2012 Wang JM, Hou X, Adeosun S, Hill R, Henry S, Paul I, Irwin RW, Ou XM, Bigler S, Stockmeier C, Brinton RD, Gomez-Sanchez E. A dominant negative ERβ splice variant determines the effectiveness of early or late estrogen therapy after ovariectomy in rats. Plos One. 7: e33493. PMID 22428062 DOI: 10.1371/Journal.Pone.0033493  0.515
2012 Irwin RW, Yao J, To J, Hamilton RT, Cadenas E, Brinton RD. Selective oestrogen receptor modulators differentially potentiate brain mitochondrial function. Journal of Neuroendocrinology. 24: 236-48. PMID 22070562 DOI: 10.1111/J.1365-2826.2011.02251.X  0.648
2012 Singh C, Liu L, Wang JM, Irwin RW, Yao J, Chen S, Henry S, Thompson RF, Brinton RD. Allopregnanolone restores hippocampal-dependent learning and memory and neural progenitor survival in aging 3xTgAD and nonTg mice. Neurobiology of Aging. 33: 1493-506. PMID 21803451 DOI: 10.1016/J.Neurobiolaging.2011.06.008  0.743
2012 Yao J, Irwin R, Chen S, Hamilton R, Cadenas E, Brinton RD. Ovarian hormone loss induces bioenergetic deficits and mitochondrial β-amyloid. Neurobiology of Aging. 33: 1507-21. PMID 21514693 DOI: 10.1016/J.Neurobiolaging.2011.03.001  0.696
2012 Adeosun S, Hou X, Zheng B, Paul I, Irwin R, Brinton R, Wang J. Motor deficits in mouse models of Alzheimer's disease Alzheimers & Dementia. 8. DOI: 10.1016/J.Jalz.2012.05.1813  0.57
2012 Irwin R, Chen S, Zhu M, Hernandez E, Rodgers K, Wang J, Bolger M, Brinton R. P2-393: Allopregnanolone as a regenerative therapeutic for Alzheimer's: Formulation development for clinical trials Alzheimer's & Dementia. 8: P400-P400. DOI: 10.1016/J.Jalz.2012.05.1103  0.587
2012 Zhu M, Irwin R, Chen S, Brinton R. P2-386: Allopregnanolone as a regenerative drug candidate in a female mouse model of Alzheimer's disease Alzheimer's & Dementia. 8: P398-P398. DOI: 10.1016/J.Jalz.2012.05.1096  0.599
2011 Irwin RW, Wang JM, Chen S, Brinton RD. Neuroregenerative mechanisms of allopregnanolone in Alzheimer's disease. Frontiers in Endocrinology. 2: 117. PMID 22654847 DOI: 10.3389/Fendo.2011.00117  0.627
2011 Chen S, Wang JM, Irwin RW, Yao J, Liu L, Brinton RD. Allopregnanolone promotes regeneration and reduces β-amyloid burden in a preclinical model of Alzheimer's disease. Plos One. 6: e24293. PMID 21918687 DOI: 10.1371/Journal.Pone.0024293  0.753
2011 Irwin RW, Yao J, Ahmed SS, Hamilton RT, Cadenas E, Brinton RD. Medroxyprogesterone acetate antagonizes estrogen up-regulation of brain mitochondrial function. Endocrinology. 152: 556-67. PMID 21159850 DOI: 10.1210/En.2010-1061  0.655
2011 Yao J, Chen S, Irwin R, Mao Z, Cadenas E, Brinton R. P3-476: Preclinical efficacy of 2-Deoxyglucose to sustain mitochondrial metabolic function and delay progression of Alzheimer's pathology Alzheimer's & Dementia. 7: S667-S668. DOI: 10.1016/J.Jalz.2011.05.1921  0.694
2010 Wang JM, Singh C, Liu L, Irwin RW, Chen S, Chung EJ, Thompson RF, Brinton RD. Allopregnanolone reverses neurogenic and cognitive deficits in mouse model of Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 107: 6498-503. PMID 20231471 DOI: 10.1073/Pnas.1001422107  0.716
2010 Wang M, Singh C, Liu L, Irwin RW, Chen S, Chung EJ, Thompson RF, Brinton RD. Allopregnanolone reverses neurogenic and cognitive deficits in mouse model of Alzheimer's disease (Proceedings of the National Academy of Sciences of the United States of America (2010) 107, 14, (6498-6503) DOI: 10.1073/pnas. 1001422107) Proceedings of the National Academy of Sciences of the United States of America. 107: 11145. DOI: 10.1073/pnas.1006236107  0.522
2010 Irwin RW, Singh C, Liu L, Wang J, Yao J, Chen S, Henry S, Thompson RF, Brinton RD. P3-369: Allopregnanolone promotes neurogenesis, restores cognitive function and reduces Alzheimer's pathology in adult triple transgenic Alzheimer's mice: Preclinical development and formulation Alzheimer's & Dementia. 6: S560-S560. DOI: 10.1016/J.Jalz.2010.05.1911  0.764
2010 Yao J, Irwin R, Chen S, Brinton RD. P3-365: Deficits in mitochondrial bioenergetics and mitochondrial beta-amyloid deposition in brain are associated with reproductive senescence and loss of ovarian hormones: Prevention by estradiol Alzheimer's & Dementia. 6: S559-S559. DOI: 10.1016/J.Jalz.2010.05.1907  0.667
2009 Yao J, Irwin RW, Zhao L, Nilsen J, Hamilton RT, Brinton RD. Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 106: 14670-5. PMID 19667196 DOI: 10.1073/Pnas.0903563106  0.766
2008 Irwin RW, Yao J, Hamilton RT, Cadenas E, Brinton RD, Nilsen J. Progesterone and estrogen regulate oxidative metabolism in brain mitochondria. Endocrinology. 149: 3167-75. PMID 18292191 DOI: 10.1210/En.2007-1227  0.739
2008 Wang JM, Liu L, Irwin RW, Chen S, Brinton RD. Regenerative potential of allopregnanolone. Brain Research Reviews. 57: 398-409. PMID 17931704 DOI: 10.1016/J.Brainresrev.2007.08.010  0.743
2007 Wang JM, Irwin RW, Liu L, Chen S, Brinton RD. Regeneration in a degenerating brain: potential of allopregnanolone as a neuroregenerative agent. Current Alzheimer Research. 4: 510-7. PMID 18220513 DOI: 10.2174/156720507783018262  0.745
2007 Nilsen J, Irwin RW, Gallaher TK, Brinton RD. Estradiol in vivo regulation of brain mitochondrial proteome. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 14069-77. PMID 18094246 DOI: 10.1523/Jneurosci.4391-07.2007  0.705
2007 Wang JM, Liu L, Irwin RW, Chen S, Chung EJ, Seligman E, Brinton RD. P-076: Estrogen receptor-selective ligands regulate ApoE expression and neurogenesis in 3xTgAD mouse hippocampus Alzheimer's & Dementia. 3: S123-S123. DOI: 10.1016/J.Jalz.2007.04.329  0.679
2007 Nilsen J, Irwin RW, Yao J, Brinton RD. P-073: Prevention of Alzheimer's pathology: Estrogen targeting of mitochondrial function Alzheimer's & Dementia. 3: S122-S122. DOI: 10.1016/J.Jalz.2007.04.326  0.763
2007 Wang JM, Singh C, Irwin RW, Liu L, Chen S, Thompson RF, Brinton RD. O2-04-07: Allopregnanolone reverses the neurogenic and cognitive deficits of triple transgenic Alzheimer mice Alzheimer's & Dementia. 3: S194-S194. DOI: 10.1016/J.Jalz.2007.04.302  0.689
2006 Nilsen J, Chen S, Irwin RW, Iwamoto S, Brinton RD. Estrogen protects neuronal cells from amyloid beta-induced apoptosis via regulation of mitochondrial proteins and function. Bmc Neuroscience. 7: 74. PMID 17083736 DOI: 10.1186/1471-2202-7-74  0.696
2006 Wang JM, Irwin RW, Brinton RD. Activation of estrogen receptor alpha increases and estrogen receptor beta decreases apolipoprotein E expression in hippocampus in vitro and in vivo. Proceedings of the National Academy of Sciences of the United States of America. 103: 16983-8. PMID 17077142 DOI: 10.1073/Pnas.0608128103  0.574
2006 Desai MK, Irwin RW, Prajapati M, Pathak KV, McGilvrey M, Pirrotte P, Brinton RD. P2-129: ALLOPREGNANOLONE RESTORES COGNITIVE FUNCTION IN APOE4+ FEMALES AND MALES AND PROMOTES METABOLISM OF FUELS REQUIRED FOR ATP GENERATION Alzheimer's & Dementia. 14: P717-P718. DOI: 10.1016/J.Jalz.2018.06.815  0.542
2006 Hernandez GD, Lopez C, Desai MK, Kono N, Irwin RW, Rodgers KE, Mack WJ, Rogawski MA, Schneider LS, Brinton RD. P1-053: PHARMACOKINETICS AND SAFETY PROFILE OF INTRAVENOUS ADMINISTRATION OF ALLOPREGNANOLONE IN PATIENTS WITH EARLY ALZHEIMER'S DISEASE Alzheimer's & Dementia. 14: P288-P288. DOI: 10.1016/J.Jalz.2018.06.055  0.598
2006 Nilsen J, Irwin RW, Brinton RD. P4-390: Brain mitochondria as therapeutic target for the prevention of Alzheimers pathology Alzheimer's & Dementia. 2: S632-S633. DOI: 10.1016/J.Jalz.2006.05.2131  0.728
2006 Brinton RD, Wang JM, Irwin R, Liu L, Chen S, Wu T. P4-350: Promotion of neurogenesis in the triple transgenic Alzheimer's mouse dentate gyrus and subventricular zone by the neurosteroid allopregnanolone Alzheimer's & Dementia. 2: S620-S620. DOI: 10.1016/J.Jalz.2006.05.2091  0.763
2005 Nilsen J, Irwin RW, Masri R, Diaz Brinton R. [P-200]: Estrogen regulation of mitochondrial function: Target for therapeutics to prevent Alzheimer's disease Alzheimer's & Dementia. 1: S71-S72. DOI: 10.1016/J.Jalz.2005.06.258  0.695
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