David Lodge - Publications

University of Bristol, Bristol, England, United Kingdom 

127 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Kang H, Park P, Han M, Tidball P, Georgiou J, Bortolotto ZA, Lodge D, Kaang BK, Collingridge GL. (2,6)- and (2,6)-hydroxynorketamine inhibit the induction of NMDA receptor-dependent LTP at hippocampal CA1 synapses in mice. Brain and Neuroscience Advances. 4: 2398212820957847. PMID 33088919 DOI: 10.1177/2398212820957847  0.84
2019 Wallach J, Colestock T, Agramunt J, Claydon MDB, Dybek M, Filemban N, Chatha M, Halberstadt AL, Brandt SD, Lodge D, Bortolotto ZA, Adejare A. Pharmacological characterizations of the legal high fluorolintane and isomers. European Journal of Pharmacology. 172427. PMID 31152702 DOI: 10.1016/j.ejphar.2019.172427  0.84
2018 Lodge D, Watkins JC, Bortolotto ZA, Jane DE, Volianskis A. The 1980s: D-AP5, LTP and a Decade of NMDA Receptor Discoveries. Neurochemical Research. PMID 30284673 DOI: 10.1007/s11064-018-2640-6  0.84
2018 Ingram R, Kang H, Lightman S, Jane DE, Bortolotto ZA, Collingridge GL, Lodge D, Volianskis A. Some distorted thoughts about ketamine as a psychedelic and a novel hypothesis based on NMDA receptor-mediated synaptic plasticity. Neuropharmacology. PMID 29885421 DOI: 10.1016/j.neuropharm.2018.06.008  0.84
2016 Collingridge GL, Lee Y, Bortolotto ZA, Kang H, Lodge D. Antidepressant Actions of Ketamine Versus Hydroxynorketamine. Biological Psychiatry. PMID 27817845 DOI: 10.1016/j.biopsych.2016.06.029  0.84
2016 Collingridge GL, Lodge D, Mayer M, Turrigiano G, Frenguelli BG. Ionotropic glutamate receptors: still exciting after all these years. Neuropharmacology. PMID 27659748 DOI: 10.1016/j.neuropharm.2016.09.019  0.84
2016 Kang H, Park P, Bortolotto ZA, Brandt SD, Colestock T, Wallach J, Collingridge GL, Lodge D. Ephenidine: A new psychoactive agent with ketamine-like NMDA receptor antagonist properties. Neuropharmacology. PMID 27520396 DOI: 10.1016/j.neuropharm.2016.08.004  0.84
2016 Wallach J, Kang H, Colestock T, Morris H, Bortolotto ZA, Collingridge GL, Lodge D, Halberstadt AL, Brandt SD, Adejare A. Pharmacological Investigations of the Dissociative 'Legal Highs' Diphenidine, Methoxphenidine and Analogues. Plos One. 11: e0157021. PMID 27314670 DOI: 10.1371/journal.pone.0157021  0.84
2016 Wood CM, Nicolas CS, Choi SL, Roman E, Nylander I, Fernandez-Teruel A, Kiianmaa K, Bienkowski P, de Jong TR, Colombo G, Chastagnier D, Wafford KA, Collingridge GL, Wildt SJ, Conway-Campbell BL, ... ... Lodge D, et al. Prevalence and influence of cys407* Grm2 mutation in Hannover-derived Wistar rats: mGlu2 receptor loss links to alcohol intake, risk taking and emotional behaviour. Neuropharmacology. PMID 26987983 DOI: 10.1016/j.neuropharm.2016.03.020  0.84
2015 Lodge D, Mercier MS. Ketamine and phencyclidine: the good, the bad and the unexpected. British Journal of Pharmacology. 172: 4254-76. PMID 26075331 DOI: 10.1111/bph.13222  0.84
2015 Wallis JL, Irvine MW, Jane DE, Lodge D, Collingridge GL, Bortolotto ZA. An interchangeable role for kainate and metabotropic glutamate receptors in the induction of rat hippocampal mossy fiber long-term potentiation in vivo. Hippocampus. PMID 25821051 DOI: 10.1002/hipo.22460  0.84
2015 Wallach J, Kavanagh PV, McLaughlin G, Morris N, Power JD, Elliott SP, Mercier MS, Lodge D, Morris H, Dempster NM, Brandt SD. Preparation and characterization of the 'research chemical' diphenidine, its pyrrolidine analogue, and their 2,2-diphenylethyl isomers. Drug Testing and Analysis. 7: 358-67. PMID 25044512 DOI: 10.1002/dta.1689  0.84
2014 Mercier MS, Lodge D. Group III metabotropic glutamate receptors: pharmacology, physiology and therapeutic potential. Neurochemical Research. 39: 1876-94. PMID 25146900 DOI: 10.1007/s11064-014-1415-y  0.84
2013 Lodge D, Tidball P, Mercier MS, Lucas SJ, Hanna L, Ceolin L, Kritikos M, Fitzjohn SM, Sherwood JL, Bannister N, Volianskis A, Jane DE, Bortolotto ZA, Collingridge GL. Antagonists reversibly reverse chemical LTD induced by group I, group II and group III metabotropic glutamate receptors. Neuropharmacology. 74: 135-46. PMID 23542080 DOI: 10.1016/j.neuropharm.2013.03.011  0.84
2013 Crabtree JW, Lodge D, Bashir ZI, Isaac JT. GABAA , NMDA and mGlu2 receptors tonically regulate inhibition and excitation in the thalamic reticular nucleus. The European Journal of Neuroscience. 37: 850-9. PMID 23294136 DOI: 10.1111/ejn.12098  0.84
2013 Mercier MS, Lodge D, Fang G, Nicolas CS, Collett VJ, Jane DE, Collingridge GL, Bortolotto ZA. Characterisation of an mGlu8 receptor-selective agonist and antagonist in the lateral and medial perforant path inputs to the dentate gyrus. Neuropharmacology. 67: 294-303. PMID 23220400 DOI: 10.1016/j.neuropharm.2012.11.020  0.84
2013 Collingridge GL, Volianskis A, Bannister N, France G, Hanna L, Mercier M, Tidball P, Fang G, Irvine MW, Costa BM, Monaghan DT, Bortolotto ZA, Molnár E, Lodge D, Jane DE. The NMDA receptor as a target for cognitive enhancement. Neuropharmacology. 64: 13-26. PMID 22796429 DOI: 10.1016/j.neuropharm.2012.06.051  0.84
2013 Sanger H, Hanna L, Colvin EM, Grubisha O, Ursu D, Heinz BA, Findlay JD, Vivier RG, Sher E, Lodge D, Monn JA, Broad LM. Pharmacological profiling of native group II metabotropic glutamate receptors in primary cortical neuronal cultures using a FLIPR. Neuropharmacology. 66: 264-73. PMID 22659090 DOI: 10.1016/j.neuropharm.2012.05.023  0.84
2013 Lucas SJ, Bortolotto ZA, Collingridge GL, Lodge D. Selective activation of either mGlu2 or mGlu3 receptors can induce LTD in the amygdala. Neuropharmacology. 66: 196-201. PMID 22531751 DOI: 10.1016/j.neuropharm.2012.04.006  0.84
2013 Hanna L, Ceolin L, Lucas S, Monn J, Johnson B, Collingridge G, Bortolotto Z, Lodge D. Differentiating the roles of mGlu2 and mGlu3 receptors using LY541850, an mGlu2 agonist/mGlu3 antagonist. Neuropharmacology. 66: 114-21. PMID 22445601 DOI: 10.1016/j.neuropharm.2012.02.023  0.84
2012 Sherwood JL, Amici M, Dargan SL, Culley GR, Fitzjohn SM, Jane DE, Collingridge GL, Lodge D, Bortolotto ZA. Differences in kainate receptor involvement in hippocampal mossy fibre long-term potentiation depending on slice orientation. Neurochemistry International. 61: 482-9. PMID 22564530 DOI: 10.1016/j.neuint.2012.04.021  0.84
2012 Ceolin L, Bortolotto ZA, Bannister N, Collingridge GL, Lodge D, Volianskis A. A novel anti-epileptic agent, perampanel, selectively inhibits AMPA receptor-mediated synaptic transmission in the hippocampus. Neurochemistry International. 61: 517-22. PMID 22433907 DOI: 10.1016/j.neuint.2012.02.035  0.84
2012 Lodge D. Translational models of schizophrenia. Neuropharmacology. 62: 1163. PMID 21843536 DOI: 10.1016/j.neuropharm.2011.08.001  0.84
2012 Lodge D, Jones M, Fletcher E. Non-competitive antagonists of N-methyl-D-aspartate The Nmda Receptor. DOI: 10.1093/acprof:oso/9780192625021.003.0003  0.84
2011 Ceolin L, Kantamneni S, Barker GR, Hanna L, Murray L, Warburton EC, Robinson ES, Monn JA, Fitzjohn SM, Collingridge GL, Bortolotto ZA, Lodge D. Study of novel selective mGlu2 agonist in the temporo-ammonic input to CA1 neurons reveals reduced mGlu2 receptor expression in a Wistar substrain with an anxiety-like phenotype. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 6721-31. PMID 21543601 DOI: 10.1523/JNEUROSCI.0418-11.2011  0.84
2010 Huang LT, Sherwood JL, Sun YJ, Lodge D, Wang Y. Activation of presynaptic alpha7 nicotinic receptors evokes an excitatory response in hippocampal CA3 neurones in anaesthetized rats: an in vivo iontophoretic study. British Journal of Pharmacology. 159: 554-65. PMID 20105181 DOI: 10.1111/j.1476-5381.2009.00529.x  0.84
2009 Nisticò R, Dargan S, Fitzjohn SM, Lodge D, Jane DE, Collingridge GL, Bortolotto ZA. GLUK1 receptor antagonists and hippocampal mossy fiber function. International Review of Neurobiology. 85: 13-27. PMID 19607958 DOI: 10.1016/S0074-7742(09)85002-2  0.84
2009 Jane DE, Lodge D, Collingridge GL. Kainate receptors: pharmacology, function and therapeutic potential. Neuropharmacology. 56: 90-113. PMID 18793656 DOI: 10.1016/j.neuropharm.2008.08.023  0.84
2009 Dargan SL, Clarke VR, Alushin GM, Sherwood JL, Nisticò R, Bortolotto ZA, Ogden AM, Bleakman D, Doherty AJ, Lodge D, Mayer ML, Fitzjohn SM, Jane DE, Collingridge GL. ACET is a highly potent and specific kainate receptor antagonist: characterisation and effects on hippocampal mossy fibre function. Neuropharmacology. 56: 121-30. PMID 18789344 DOI: 10.1016/j.neuropharm.2008.08.016  0.84
2009 Lodge D. The history of the pharmacology and cloning of ionotropic glutamate receptors and the development of idiosyncratic nomenclature. Neuropharmacology. 56: 6-21. PMID 18765242 DOI: 10.1016/j.neuropharm.2008.08.006  0.84
2007 Bartlett TE, Bannister NJ, Collett VJ, Dargan SL, Massey PV, Bortolotto ZA, Fitzjohn SM, Bashir ZI, Collingridge GL, Lodge D. Differential roles of NR2A and NR2B-containing NMDA receptors in LTP and LTD in the CA1 region of two-week old rat hippocampus. Neuropharmacology. 52: 60-70. PMID 16904707 DOI: 10.1016/j.neuropharm.2006.07.013  0.84
2006 Wang Y, Sherwood JL, Lodge D. The alpha4beta2 nicotinic acetylcholine receptor agonist TC-2559 impairs long-term potentiation in the dentate gyrus in vivo. Neuroscience Letters. 406: 183-8. PMID 16935422 DOI: 10.1016/j.neulet.2006.06.075  0.84
2006 Wang Y, Sherwood JL, Miles CP, Whiffin G, Lodge D. TC-2559 excites dopaminergic neurones in the ventral tegmental area by stimulating alpha4beta2-like nicotinic acetylcholine receptors in anaesthetised rats. British Journal of Pharmacology. 147: 379-90. PMID 16402043 DOI: 10.1038/sj.bjp.0706621  0.84
2006 Takeuchi K, Kohn TJ, Honigschmidt NA, Rocco VP, Spinazze PG, Hemrick-Luecke SK, Thompson LK, Evans DC, Rasmussen K, Koger D, Lodge D, Martin LJ, Shaw J, Threlkeld PG, Wong DT. Advances toward new antidepressants beyond SSRIs: 1-aryloxy-3-piperidinylpropan-2-ols with dual 5-HT1A receptor antagonism/SSRI activities. Part 5. Bioorganic & Medicinal Chemistry Letters. 16: 2347-51. PMID 16298130 DOI: 10.1016/j.bmcl.2005.11.007  0.84
2005 Lee DH, Singh JP, Lodge D. Experiments with nitric oxide synthase inhibitors in spinal nerve ligated rats provide no evidence of a role for nitric oxide in neuropathic mechanical allodynia. Neuroscience Letters. 385: 179-83. PMID 15964141 DOI: 10.1016/j.neulet.2005.05.036  0.84
2004 Smolders I, Lindekens H, Clinckers R, Meurs A, O'Neill MJ, Lodge D, Ebinger G, Michotte Y. In vivo modulation of extracellular hippocampal glutamate and GABA levels and limbic seizures by group I and II metabotropic glutamate receptor ligands. Journal of Neurochemistry. 88: 1068-77. PMID 15009663 DOI: 10.1046/j.1471-4159.2003.02251.x  0.84
2003 Lee DH, Iyengar S, Lodge D. The role of uninjured nerve in spinal nerve ligated rats points to an improved animal model of neuropathic pain. European Journal of Pain (London, England). 7: 473-9. PMID 12935800 DOI: 10.1016/S1090-3801(03)00019-3  0.84
2003 Lauri SE, Bortolotto ZA, Nistico R, Bleakman D, Ornstein PL, Lodge D, Isaac JT, Collingridge GL. A role for Ca2+ stores in kainate receptor-dependent synaptic facilitation and LTP at mossy fiber synapses in the hippocampus. Neuron. 39: 327-41. PMID 12873388 DOI: 10.1016/S0896-6273(03)00369-6  0.84
2003 Murray TK, Whalley K, Robinson CS, Ward MA, Hicks CA, Lodge D, Vandergriff JL, Baumbarger P, Siuda E, Gates M, Ogden AM, Skolnick P, Zimmerman DM, Nisenbaum ES, Bleakman D, et al. LY503430, a novel alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor potentiator with functional, neuroprotective and neurotrophic effects in rodent models of Parkinson's disease. The Journal of Pharmacology and Experimental Therapeutics. 306: 752-62. PMID 12730350 DOI: 10.1124/jpet.103.049445  0.84
2002 Smolders I, Bortolotto ZA, Clarke VR, Warre R, Khan GM, O'Neill MJ, Ornstein PL, Bleakman D, Ogden A, Weiss B, Stables JP, Ho KH, Ebinger G, Collingridge GL, Lodge D, et al. Antagonists of GLU(K5)-containing kainate receptors prevent pilocarpine-induced limbic seizures. Nature Neuroscience. 5: 796-804. PMID 12080343 DOI: 10.1038/nn880  0.84
2002 Sharpe EF, Kingston AE, Lodge D, Monn JA, Headley PM. Systemic pre-treatment with a group II mGlu agonist, LY379268, reduces hyperalgesia in vivo. British Journal of Pharmacology. 135: 1255-62. PMID 11877334 DOI: 10.1038/sj.bjp.0704583  0.84
2001 Lauri SE, Bortolotto ZA, Bleakman D, Ornstein PL, Lodge D, Isaac JT, Collingridge GL. A critical role of a facilitatory presynaptic kainate receptor in mossy fiber LTP. Neuron. 32: 697-709. PMID 11719209 DOI: 10.1016/S0896-6273(01)00511-6  0.84
2001 Vandergriff J, Huff K, Bond A, Lodge D. Potentiation of responses to AMPA on central neurones by LY392098 and LY404187 in vivo. Neuropharmacology. 40: 1003-9. PMID 11406191 DOI: 10.1016/S0028-3908(01)00031-4  0.84
2001 Lodge D. Neuronal nicotinic receptors: no smoke without fire! Trends in Neurosciences. 24: 132-3. PMID 11294134 DOI: 10.1016/S0166-2236(00)01741-0  0.84
2001 Lee DH, Katner J, Iyengar S, Lodge D. The effect of lumbar sympathectomy on increased tactile sensitivity in spinal nerve ligated rats. Neuroscience Letters. 298: 99-102. PMID 11163287 DOI: 10.1016/S0304-3940(00)01726-2  0.84
2000 Doherty AJ, Palmer MJ, Bortolotto ZA, Hargreaves A, Kingston AE, Ornstein PL, Schoepp DD, Lodge D, Collingridge GL. A novel, competitive mGlu(5) receptor antagonist (LY344545) blocks DHPG-induced potentiation of NMDA responses but not the induction of LTP in rat hippocampal slices. British Journal of Pharmacology. 131: 239-44. PMID 10991916 DOI: 10.1038/sj.bjp.0703574  0.84
2000 Bond A, Jones NM, Hicks CA, Whiffin GM, Ward MA, O'Neill MF, Kingston AE, Monn JA, Ornstein PL, Schoepp DD, Lodge D, O'Neill MJ. Neuroprotective effects of LY379268, a selective mGlu2/3 receptor agonist: investigations into possible mechanism of action in vivo. The Journal of Pharmacology and Experimental Therapeutics. 294: 800-9. PMID 10945827  0.84
2000 O'Neill MJ, Murray TK, McCarty DR, Hicks CA, Dell CP, Patrick KE, Ward MA, Osborne DJ, Wiernicki TR, Roman CR, Lodge D, Fleisch JH, Singh J. ARL 17477, a selective nitric oxide synthase inhibitor, with neuroprotective effects in animal models of global and focal cerebral ischaemia. Brain Research. 871: 234-44. PMID 10899290 DOI: 10.1016/S0006-8993(00)02471-9  0.84
2000 O'Neill MJ, Bogaert L, Hicks CA, Bond A, Ward MA, Ebinger G, Ornstein PL, Michotte Y, Lodge D. LY377770, a novel iGlu5 kainate receptor antagonist with neuroprotective effects in global and focal cerebral ischaemia. Neuropharmacology. 39: 1575-88. PMID 10854902 DOI: 10.1016/S0028-3908(99)00250-6  0.84
1999 Kingston AE, O'Neill MJ, Bond A, Bruno V, Battaglia G, Nicoletti F, Harris JR, Clark BP, Monn JA, Lodge D, Schoepp DD. Neuroprotective actions of novel and potent ligands of group I and group II metabotropic glutamate receptors. Annals of the New York Academy of Sciences. 890: 438-49. PMID 10668448 DOI: 10.1111/j.1749-6632.1999.tb08022.x  0.84
1999 Bortolotto ZA, Clarke VR, Delany CM, Parry MC, Smolders I, Vignes M, Ho KH, Miu P, Brinton BT, Fantaske R, Ogden A, Gates M, Ornstein PL, Lodge D, Bleakman D, et al. Kainate receptors are involved in synaptic plasticity. Nature. 402: 297-301. PMID 10580501 DOI: 10.1038/46290  0.84
1999 Lam AG, Monn JA, Schoepp DD, Lodge D, McCulloch J. Group II selective metabotropic glutamate receptor agonists and local cerebral glucose use in the rat. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 19: 1083-91. PMID 10532632 DOI: 10.1097/00004647-199910000-00004  0.84
1999 Fitzjohn SM, Kingston AE, Lodge D, Collingridge GL. DHPG-induced LTD in area CA1 of juvenile rat hippocampus; characterisation and sensitivity to novel mGlu receptor antagonists. Neuropharmacology. 38: 1577-83. PMID 10530819 DOI: 10.1016/S0028-3908(99)00123-9  0.84
1999 Cushing A, Price-Jones MJ, Graves R, Harris AJ, Hughes KT, Bleakman D, Lodge D. Measurement of calcium flux through ionotropic glutamate receptors using Cytostar-T scintillating microplates. Journal of Neuroscience Methods. 90: 33-6. PMID 10517271 DOI: 10.1016/S0165-0270(99)00058-8  0.84
1999 Bond A, Ragumoorthy N, Monn JA, Hicks CA, Ward MA, Lodge D, O'Neill MJ. LY379268, a potent and selective Group II metabotropic glutamate receptor agonist, is neuroprotective in gerbil global, but not focal, cerebral ischaemia. Neuroscience Letters. 273: 191-4. PMID 10515191 DOI: 10.1016/S0304-3940(99)00663-1  0.84
1999 Bond A, Lodge D, Hicks CA, Ward MA, O'Neill MJ. NMDA receptor antagonism, but not AMPA receptor antagonism attenuates induced ischaemic tolerance in the gerbil hippocampus. European Journal of Pharmacology. 380: 91-9. PMID 10513567 DOI: 10.1016/S0014-2999(99)00523-3  0.84
1999 Anderson BA, Harn NK, Hansen MM, Harkness AR, Lodge D, Leander JD. Synthesis and anticonvulsant activity of 3-aryl-5H-2,3-benzodiazephine AMPA antagonists. Bioorganic & Medicinal Chemistry Letters. 9: 1953-6. PMID 10450961 DOI: 10.1016/S0960-894X(99)00315-7  0.84
1998 Fitzjohn SM, Bortolotto ZA, Palmer MJ, Doherty AJ, Ornstein PL, Schoepp DD, Kingston AE, Lodge D, Collingridge GL. The potent mGlu receptor antagonist LY341495 identifies roles for both cloned and novel mGlu receptors in hippocampal synaptic plasticity. Neuropharmacology. 37: 1445-58. PMID 9886667 DOI: 10.1016/S0028-3908(98)00145-2  0.84
1998 Ornstein PL, Arnold MB, Lunn WH, Heinz LJ, Leander JD, Lodge D, Schoepp DD. Heteroatom-substitution as a strategy for increasing the potency of competitive NMDA antagonists. Bioorganic & Medicinal Chemistry Letters. 8: 389-94. PMID 9871691 DOI: 10.1016/S0960-894X(98)00038-9  0.84
1998 Procter MJ, Houghton AK, Faber ES, Chizh BA, Ornstein PL, Lodge D, Headley PM. Actions of kainate and AMPA selective glutamate receptor ligands on nociceptive processing in the spinal cord. Neuropharmacology. 37: 1287-97. PMID 9849666 DOI: 10.1016/S0028-3908(98)00136-1  0.84
1998 Vignes M, Clarke VR, Parry MJ, Bleakman D, Lodge D, Ornstein PL, Collingridge GL. The GluR5 subtype of kainate receptor regulates excitatory synaptic transmission in areas CA1 and CA3 of the rat hippocampus. Neuropharmacology. 37: 1269-77. PMID 9849664 DOI: 10.1016/S0028-3908(98)00148-8  0.84
1998 O'Neill MJ, Bond A, Ornstein PL, Ward MA, Hicks CA, Hoo K, Bleakman D, Lodge D. Decahydroisoquinolines: novel competitive AMPA/kainate antagonists with neuroprotective effects in global cerebral ischaemia. Neuropharmacology. 37: 1211-22. PMID 9849659 DOI: 10.1016/S0028-3908(98)00134-8  0.84
1998 Bleakman D, Lodge D. Neuropharmacology of AMPA and kainate receptors. Neuropharmacology. 37: 1187-204. PMID 9849657 DOI: 10.1016/S0028-3908(98)00139-7  0.84
1998 Lam AG, Soriano MA, Monn JA, Schoepp DD, Lodge D, McCulloch J. Effects of the selective metabotropic glutamate agonist LY354740 in a rat model of permanent ischaemia. Neuroscience Letters. 254: 121-3. PMID 9779935 DOI: 10.1016/S0304-3940(98)00651-X  0.84
1998 Kingston AE, Lowndes J, Evans N, Clark B, Tomlinson R, Burnett JP, Mayne NG, Cockerham SL, Lodge D. Sulphur-containing amino acids are agonists for group 1 metabotropic receptors expressed in clonal RGT cell lines. Neuropharmacology. 37: 277-87. PMID 9681926 DOI: 10.1016/S0028-3908(98)00018-5  0.84
1998 Pinto A, Gillard S, Moss F, Whyte K, Brust P, Williams M, Stauderman K, Harpold M, Lang B, Newsom-Davis J, Bleakman D, Lodge D, Boot J. Human autoantibodies specific for the alpha1A calcium channel subunit reduce both P-type and Q-type calcium currents in cerebellar neurons. Proceedings of the National Academy of Sciences of the United States of America. 95: 8328-33. PMID 9653186 DOI: 10.1073/pnas.95.14.8328  0.84
1998 Bond A, O'Neill MJ, Hicks CA, Monn JA, Lodge D. Neuroprotective effects of a systemically active group II metabotropic glutamate receptor agonist LY354740 in a gerbil model of global ischaemia. Neuroreport. 9: 1191-3. PMID 9601692  0.84
1998 Collingridge GL, Lodge D. 7th Neuropharmacology Conference: Editorial Neuropharmacology. 37: 1185. DOI: 10.1016/S0028-3908(98)00169-5  0.84
1997 Vignes M, Bleakman D, Lodge D, Collingridge GL. The synaptic activation of the GluR5 subtype of kainate receptor in area CA3 of the rat hippocampus. Neuropharmacology. 36: 1477-81. PMID 9517417 DOI: 10.1016/S0028-3908(97)00158-5  0.84
1997 Clarke VR, Ballyk BA, Hoo KH, Mandelzys A, Pellizzari A, Bath CP, Thomas J, Sharpe EF, Davies CH, Ornstein PL, Schoepp DD, Kamboj RK, Collingridge GL, Lodge D, Bleakman D. A hippocampal GluR5 kainate receptor regulating inhibitory synaptic transmission. Nature. 389: 599-603. PMID 9335499 DOI: 10.1038/39315  0.84
1997 Gillard SE, Volsen SG, Smith W, Beattie RE, Bleakman D, Lodge D. Identification of pore-forming subunit of P-type calcium channels: an antisense study on rat cerebellar Purkinje cells in culture. Neuropharmacology. 36: 405-9. PMID 9175621 DOI: 10.1016/S0028-3908(97)00046-4  0.84
1997 Bond A, Monn JA, Lodge D. A novel orally active group 2 metabotropic glutamate receptor agonist: LY354740. Neuroreport. 8: 1463-6. PMID 9172154  0.84
1997 Willis CL, Wacker DA, Bartlett RD, Bleakman D, Lodge D, Chamberlin AR, Bridges RJ. Irreversible inhibition of high-affinity [3H]kainate binding by a novel photoactivatable analogue: (2'S,3'S,4'R)-2'-carboxy-4'-(2-diazo-1-oxo-3, 3,3-trifluoropropyl)-3'-pyrrolidinyl acetate. Journal of Neurochemistry. 68: 1503-10. PMID 9084420 DOI: 10.1046/j.1471-4159.1997.68041503.x  0.84
1997 Gill R, Lodge D. Pharmacology of AMPA antagonists and their role in neuroprotection. International Review of Neurobiology. 40: 197-232. PMID 8989622  0.84
1997 Bleisch TJ, Ornstein PL, Allen NK, Wright RA, Lodge D, Schoepp DD. Structure-activity studies of aryl-spaced decahydroisoquinoline-3-carboxylic acid AMPA receptor antagonists Bioorganic and Medicinal Chemistry Letters. 7: 1161-1166. DOI: 10.1016/S0960-894X(97)00185-6  0.84
1996 Bleakman D, Ballyk BA, Schoepp DD, Palmer AJ, Bath CP, Sharpe EF, Woolley ML, Bufton HR, Kamboj RK, Tarnawa I, Lodge D. Activity of 2,3-benzodiazepines at native rat and recombinant human glutamate receptors in vitro: stereospecificity and selectivity profiles. Neuropharmacology. 35: 1689-702. PMID 9076748 DOI: 10.1016/S0028-3908(96)00156-6  0.84
1996 Lodge D, Bond A, O'Neill MJ, Hicks CA, Jones MG. Stereoselective effects-of 2,3-benzodiazepines in vivo: electrophysiology and neuroprotection studies. Neuropharmacology. 35: 1681-8. PMID 9076747 DOI: 10.1016/S0028-3908(96)00155-4  0.84
1996 Nooney JM, Lodge D. The use of invertebrate peptide toxins to establish Ca2+ channel identity of CA3-CA1 neurotransmission in rat hippocampal slices. European Journal of Pharmacology. 306: 41-50. PMID 8813613 DOI: 10.1016/0014-2999(96)00195-1  0.84
1996 Fletcher EJ, Lodge D. New developments in the molecular pharmacology of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate and kainate receptors. Pharmacology & Therapeutics. 70: 65-89. PMID 8804111 DOI: 10.1016/0163-7258(96)00014-9  0.84
1996 Fitzjohn SM, Irving AJ, Palmer MJ, Harvey J, Lodge D, Collingridge GL. Activation of group I mGluRs potentiates NMDA responses in rat hippocampal slices. Neuroscience Letters. 203: 211-3. PMID 8742030 DOI: 10.1016/0304-3940(96)12301-6  0.84
1996 Monn JA, Valli MJ, Johnson BG, Salhoff CR, Wright RA, Howe T, Bond A, Lodge D, Spangle LA, Paschal JW, Campbell JB, Griffey K, Tizzano JP, Schoepp DD. Synthesis of the four isomers of 4-aminopyrrolidine-2,4-dicarboxylate: identification of a potent, highly selective, and systemically-active agonist for metabotropic glutamate receptors negatively coupled to adenylate cyclase. Journal of Medicinal Chemistry. 39: 2990-3000. PMID 8709133 DOI: 10.1021/jm9601765  0.84
1996 Day NC, Shaw PJ, McCormack AL, Craig PJ, Smith W, Beattie R, Williams TL, Ellis SB, Ince PG, Harpold MM, Lodge D, Volsen SG. Distribution of alpha 1A, alpha 1B and alpha 1E voltage-dependent calcium channel subunits in the human hippocampus and parahippocampal gyrus. Neuroscience. 71: 1013-24. PMID 8684604 DOI: 10.1016/0306-4522(95)00514-5  0.84
1996 Ornstein PL, Arnold MB, Allen NK, Bleisch T, Borromeo PS, Lugar CW, Leander JD, Lodge D, Schoepp DD. Structure-activity studies of 6-substituted decahydroisoquinoline-3-carboxylic acid AMPA receptor antagonists. 2. Effects of distal acid bioisosteric substitution, absolute stereochemical preferences, and in vivo activity. Journal of Medicinal Chemistry. 39: 2232-44. PMID 8667366 DOI: 10.1021/jm950913h  0.84
1996 Ornstein PL, Arnold MB, Allen NK, Bleisch T, Borromeo PS, Lugar CW, Leander JD, Lodge D, Schoepp DD. Structure-activity studies of 6-(tetrazolylalkyl)-substituted decahydroisoquinoline-3-carboxylic acid AMPA receptor antagonists. 1. Effects of stereochemistry, chain length, and chain substitution. Journal of Medicinal Chemistry. 39: 2219-31. PMID 8667365 DOI: 10.1021/jm950912p  0.84
1996 Lodge D, Bond A. Spinal glutamate receptors Pharmacochemistry Library. 24: 241-252. DOI: 10.1016/S0165-7208(96)80020-1  0.84
1996 Fitzjohn SM, Lodge D, Collingridge GL. Long-term depression of synaptic transmission induced by group in metabotropic glutamate receptor activation in the CA1 of young rat hippocampus Journal of Physiology Paris. 90: 410-4111.  0.84
1996 Gill R, Lodge D. Pharmacology of AMPA antagonists and their role in neurophotection International Review of Neurobiology. 197-232.  0.84
1995 Volsen SG, Day NC, McCormack AL, Smith W, Craig PJ, Beattie R, Ince PG, Shaw PJ, Ellis SB, Gillespie A. The expression of neuronal voltage-dependent calcium channels in human cerebellum. Brain Research. Molecular Brain Research. 34: 271-82. PMID 8750830 DOI: 10.1016/0169-328X(95)00234-J  0.84
1995 Schoepp DD, Lodge D, Bleakman D, Leander JD, Tizzano JP, Wright RA, Palmer AJ, Salhoff CR, Ornstein PL. In vitro and in vivo antagonism of AMPA receptor activation by (3S, 4aR, 6R, 8aR)-6-[2-(1(2)H-tetrazole-5-yl) ethyl] decahydroisoquinoline-3-carboxylic acid. Neuropharmacology. 34: 1159-68. PMID 8532186 DOI: 10.1016/0028-3908(95)00099-R  0.84
1995 Kingston AE, Burnett JP, Mayne NG, Lodge D. Pharmacological analysis of 4-carboxyphenylglycine derivatives: comparison of effects on mGluR1 alpha and mGluR5a subtypes. Neuropharmacology. 34: 887-94. PMID 8532170 DOI: 10.1016/0028-3908(95)00069-I  0.84
1995 Bond A, Lodge D. Pharmacology of metabotropic glutamate receptor-mediated enhancement of responses to excitatory and inhibitory amino acids on rat spinal neurones in vivo. Neuropharmacology. 34: 1015-23. PMID 8532150 DOI: 10.1016/0028-3908(95)00046-9  0.84
1995 Ornstein PL, Arnold MB, Allen NK, Leander JD, Tizzano JP, Lodge D, Schoepp DD. (3SR,4aRS,6SR,8aRS)-6-(1H-tetrazol-5-yl)decahydroisoquinoline-3-carboxylic acid, a novel, competitive, systemically active NMDA and AMPA receptor antagonist. Journal of Medicinal Chemistry. 38: 4885-90. PMID 8523401  0.84
1995 Collingridge G, Lodge D. Editorial Neuropharmacology. 34: v.  0.84
1994 Gill R, Lodge D. The neuroprotective effects of the decahydroisoquinoline, LY 215490; a novel AMPA antagonist in focal ischaemia. Neuropharmacology. 33: 1529-36. PMID 7760975 DOI: 10.1016/0028-3908(94)90126-0  0.84
1993 Ornstein PL, Arnold MB, Augenstein NK, Lodge D, Leander JD, Schoepp DD. (3SR,4aRS,6RS,8aRS)-6-[2-(1H-tetrazol-5-yl)ethyl]decahydroisoquinoline-3 - carboxylic acid: a structurally novel, systemically active, competitive AMPA receptor antagonist. Journal of Medicinal Chemistry. 36: 2046-8. PMID 8393116  0.84
1993 Parsons CG, Gruner R, Rozental J, Millar J, Lodge D. Patch clamp studies on the kinetics and selectivity of N-methyl-D-aspartate receptor antagonism by memantine (1-amino-3,5-dimethyladamantan). Neuropharmacology. 32: 1337-50. PMID 8152525 DOI: 10.1016/0028-3908(93)90029-3  0.84
1993 Bowman D, Alexander S, Lodge D. Pharmacological characterisation of the calcium channels coupled to the plateau phase of KCl-induced intracellular free Ca2+ elevation in chicken and rat synaptosomes. Neuropharmacology. 32: 1195-202. PMID 8107973 DOI: 10.1016/0028-3908(93)90013-S  0.84
1993 Palmer AJ, Lodge D. Cyclothiazide reverses AMPA receptor antagonism of the 2,3-benzodiazepine, GYKI 53655. European Journal of Pharmacology. 244: 193-4. PMID 7679352 DOI: 10.1016/0922-4106(93)90027-7  0.84
1993 Ornstein PL, Arnold MB, Augenstein NK, Deeter JB, Leander JD, Lodge D, Calligaro DO, Schoepp DD. Unusual stereochemical preferences of decahydroisoquinoline-3-cargoxylic acid competitive NMDA antagonists Bioorganic and Medicinal Chemistry Letters. 3: 2067-2072. DOI: 10.1016/S0960-894X(01)81017-9  0.84
1993 Monn JA, Valli MJ, 1 RA, Schoepp DD, Leander JD, Lodge D. Synthesis and pharmacological characterization of l-trans-4-tetrazolylproline (ly300020): A novel systemically-active ampa receptor agonist Bioorganic and Medicinal Chemistry Letters. 3: 95-98. DOI: 10.1016/S0960-894X(00)80099-2  0.84
1993 Ornstein PL, Arnold MB, Evrard D, Leander JD, Lodge D, Schoepp DD. Tetrazole amino acids as competitive NMDA antagonists Bioorganic and Medicinal Chemistry Letters. 3: 43-48. DOI: 10.1016/S0960-894X(00)80089-X  0.84
1993 Lodge D, Bond A. Pharmacology of ionotropic and metabotropic glutamate receptors European Neuropsychopharmacology. 3: 181-182. DOI: 10.1016/0924-977X(93)90013-C  0.84
1992 Leander JD, Parli CJ, Potts B, Lodge D. Relation of plasma and brain concentrations of the anticonvulsant ameltolide to its pharmacologic effects. Epilepsia. 33: 696-704. PMID 1628587 DOI: 10.1111/j.1528-1157.1992.tb02350.x  0.84
1992 Ornstein PL, Schoepp DD, Arnold MB, Augenstein NK, Lodge D, Millar JD, Chambers J, Campbell J, Paschal JW, Zimmerman DM. 6-substituted decahydroisoquinoline-3-carboxylic acids as potent and selective conformationally constrained NMDA receptor antagonists. Journal of Medicinal Chemistry. 35: 3547-60. PMID 1404235  0.84
1992 Ornstein PL, Schoepp DD, Arnold MB, Jones ND, Deeter JB, Lodge D, Leander JD. NMDA antagonist activity of (+/-)-(2SR,4RS)-4-(1H-tetrazol-5-ylmethyl)piperidine-2-carboxylic acid resides with the (-)-2R,4S-isomer. Journal of Medicinal Chemistry. 35: 3111-5. PMID 1387167  0.84
1992 Zeman S, Lodge D. Pharmacological characterization of non-NMDA subtypes of glutamate receptor in the neonatal rat hemisected spinal cord in vitro. British Journal of Pharmacology. 106: 367-72. PMID 1382781  0.84
1992 McQuaid LA, Smith EC, South KK, Mitch CH, Schoepp DD, True RA, Calligaro DO, O'Malley PJ, Lodge D, Ornstein PL. Synthesis and excitatory amino acid pharmacology of a series of heterocyclic-fused quinoxalinones and quinazolinones. Journal of Medicinal Chemistry. 35: 3319-24. PMID 1382133  0.84
1992 Palmer AJ, Zeman S, Lodge D. Methohexitone antagonises kainate and epileptiform activity in rat neocortical slices. European Journal of Pharmacology. 221: 205-9. PMID 1330621 DOI: 10.1016/0014-2999(92)90702-6  0.84
1992 McQuaid LA, Smith EC, Lodge D, Pralong E, Wikel JH, Calligaro DO, O'Malley PJ. 3-Phenyl-4-hydroxyquinolin-2(1H)-ones: potent and selective antagonists at the strychnine-insensitive glycine site on the N-methyl-D-aspartate receptor complex. Journal of Medicinal Chemistry. 35: 3423-5. PMID 1326635  0.84
1991 Ornstein PL, Schoepp DD, Arnold MB, Leander JD, Lodge D, Paschal JW, Elzey T. 4-(Tetrazolylalkyl)piperidine-2-carboxylic acids. Potent and selective N-methyl-D-aspartic acid receptor antagonists with a short duration of action. Journal of Medicinal Chemistry. 34: 90-7. PMID 1825117  0.84
1991 Schoepp DD, Smith CL, Lodge D, Millar JD, Leander JD, Sacaan AI, Lunn WH. D,L-(tetrazol-5-yl) glycine: a novel and highly potent NMDA receptor agonist. European Journal of Pharmacology. 203: 237-43. PMID 1686860 DOI: 10.1016/0014-2999(91)90719-7  0.84
1990 Lodge D, Johnson KM. Noncompetitive excitatory amino acid receptor antagonists. Trends in Pharmacological Sciences. 11: 81-6. PMID 2156365 DOI: 10.1016/0165-6147(90)90323-Z  0.84
1990 Ornstein PL, Schoepp DD, Leander JD, Wong T, Zimmerman DM, Lodge D. LY233053: a structurally novel, potent and selective competitive N-methyl-D-aspartate receptor antagonist. Progress in Clinical and Biological Research. 361: 429-33. PMID 2149764  0.84
1990 Schoepp DD, Ornstein PL, Leander JD, Lodge D, Salhoff CR, Zeman S, Zimmerman DM. Pharmacological characterization of LY233053: a structurally novel tetrazole-substituted competitive N-methyl-D-aspartic acid antagonist with a short duration of action. The Journal of Pharmacology and Experimental Therapeutics. 255: 1301-8. PMID 2148188  0.84
1990 Beart PM, Lodge D. Chronic administration of MK-801 and the NMDA receptor: further evidence for reduced sensitivity of the primary acceptor site from studies with the cortical wedge preparation. The Journal of Pharmacy and Pharmacology. 42: 354-5. PMID 1976785  0.84
1989 Fletcher EJ, Drew C, Lodge D, O'Shaughnessy CT. Efflux of rubidium in rat cortical synaptosomes is blocked by sigma and dextromethorphan binding site ligands. Neuropharmacology. 28: 661-6. PMID 2548109 DOI: 10.1016/0028-3908(89)90148-2  0.84
1988 Lodge D, Davies SN, Jones MG, Millar J, Manallack DT, Ornstein PL, Verberne AJ, Young N, Beart PM. A comparison between the in vivo and in vitro activity of five potent and competitive NMDA antagonists. British Journal of Pharmacology. 95: 957-65. PMID 2905186  0.84
1988 Church J, Zeman S, Lodge D. The neuroprotective action of ketamine and MK-801 after transient cerebral ischemia in rats. Anesthesiology. 69: 702-9. PMID 2847595  0.84
1985 Spence I, Drew C, Johnston GA, Lodge D. Acute effects of lead at central synapses in vitro. Brain Research. 333: 103-9. PMID 2986766 DOI: 10.1016/0006-8993(85)90129-5  0.84
1979 Curtis DR, Lodge D, McLennan H. The excitation and depression of spinal neurones by ibotenic acid. The Journal of Physiology. 291: 19-28. PMID 480204  0.84
1979 McLennan H, Lodge D. The antagonism of amino acid-induced excitation of spinal neurones in the cat. Brain Research. 169: 83-90. PMID 222399 DOI: 10.1016/0006-8993(79)90375-5  0.84
1977 Martin MR, Lodge D, Headley PM, Biscoe TJ. Pharmacological studies of facial motoneurones in the rat. European Journal of Pharmacology. 42: 291-8. PMID 856610  0.84
1977 Martin MR, Lodge D. Morphology of the facial nucleus of the rat. Brain Research. 123: 1-12. PMID 843907 DOI: 10.1016/0006-8993(77)90639-4  0.84
1977 Craig CR, Curtis DR, Lodge D. Dual effects of hemicholinium-3 at central cholinergic synapses. The Journal of Physiology. 264: 367-77. PMID 190385  0.84
1977 Martin MR, Lodge D, Max Headley P, Biscoe TJ. Pharmacological studies on facial motoneurones in the rat European Journal of Pharmacology. 42: 298. DOI: 10.1016/0014-2999(77)90296-5  0.84
1976 Biscoe TJ, Headley PM, Lodge D, Martin MR, Watkins JC. The sensitivity of rat spinal interneurones and renshaw cells to L-glutamate and L-aspartate. Experimental Brain Research. 26: 547-51. PMID 1010006 DOI: 10.1007/BF00238827  0.84
1976 Lodge D, Johnston GA, Stephenson AL. The uptake of GABA and beta-alanine in slices of cat and rat CNS tissue: regional differences in susceptibility to inhibitors. Journal of Neurochemistry. 27: 1569-70. PMID 1003233  0.84
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