Guojun Ma, Ph.D. - Related publications

Johns Hopkins University, Baltimore, MD 
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50 most relevant papers in past 60 days:
Year Citation  Score
2021 Lee SB, Park A, Ma CT, Kim YH, Yang HO. 3'-O-Acetyl-24-Epi-7,8-Didehydrocimigenol-3-O-β-D-Xylopryranoside Decreases Amyloid Beta Production in Amyloid Precursor Protein-Transfected HeLa Cells. Biomolecules & Therapeutics. PMID 33619237 DOI: 10.4062/biomolther.2020.195   
2021 Zimmer JA, Shcherbinin S, Devous MD, Bragg SM, Selzler KJ, Wessels AM, Shering C, Mullen J, Landry J, Andersen SW, Downing AM, Fleisher AS, Svaldi DO, Sims JR. Lanabecestat: Neuroimaging results in early symptomatic Alzheimer's disease. Alzheimer's & Dementia (New York, N. Y.). 7: e12123. PMID 33614894 DOI: 10.1002/trc2.12123   
2021 Zheng X, Lin W, Jiang Y, Lu K, Wei W, Huo Q, Cui S, Yang X, Li M, Xu N, Tang C, Song JX. Electroacupuncture ameliorates beta-amyloid pathology and cognitive impairment in Alzheimer disease via a novel mechanism involving activation of TFEB (transcription factor EB). Autophagy. 1-15. PMID 33622188 DOI: 10.1080/15548627.2021.1886720   
2021 Jiang N, Cupolillo D, Grosjean N, Muller E, Deforges S, Mulle C, Amédée T. Impaired plasticity of intrinsic excitability in the dentate gyrus alters spike transfer in a mouse model of Alzheimer's disease. Neurobiology of Disease. 105345. PMID 33766653 DOI: 10.1016/j.nbd.2021.105345   
2021 Jang M, Choi SH, Choi JH, Oh J, Lee RM, Lee NE, Cho YJ, Rhim H, Kim HC, Cho IH, Nah SY. Ginseng gintonin attenuates the disruptions of brain microvascular permeability and microvascular endothelium junctional proteins in an APPswe/PSEN-1 double-transgenic mouse model of Αlzheimer's disease. Experimental and Therapeutic Medicine. 21: 310. PMID 33717253 DOI: 10.3892/etm.2021.9741   
2021 Locci A, Orellana H, Rodriguez G, Gottliebson M, McClarty B, Dominguez S, Keszycki R, Dong H. Comparison of memory, affective behavior, and neuropathology in APP knock-in mice to 5xFAD and APP/PS1 mice. Behavioural Brain Research. 113192. PMID 33607163 DOI: 10.1016/j.bbr.2021.113192   
2021 Jiang H, Niu F, Zheng Y, Xu Y. CART mitigates oxidative stress and DNA damage in memory deficits of APP/PS1 mice via upregulating β‑amyloid metabolism‑associated enzymes. Molecular Medicine Reports. 23: 1-12. PMID 33604684 DOI: 10.3892/mmr.2021.11919   
2021 Brown A, Török M. Functional amyloids in the human body. Bioorganic & Medicinal Chemistry Letters. 127914. PMID 33691165 DOI: 10.1016/j.bmcl.2021.127914   
2021 Abbaszadeh M, Sahin M, Ozgun A, Oncu G, Garipcan B, Saybasili H. A Transient Survival Model of Alteration of Electrophysiological Properties Due to Amyloid-Beta Toxicity Based on SH-SY5Y Cell Line. Current Alzheimer Research. PMID 33583383 DOI: 10.2174/1567205018666210212155750   
2021 Cai T, Tomita T. Sequential conformational changes in transmembrane domains of presenilin 1 in Aβ42 downregulation. Journal of Biochemistry. PMID 33739423 DOI: 10.1093/jb/mvab033   
2021 Zhang X, Zhang CM, Prokopenko D, Liang Y, Zhen SY, Weigle IQ, Han W, Aryal M, Tanzi RE, Sisodia SS. An APP ectodomain mutation outside of the Aβ domain promotes Aβ production in vitro and deposition in vivo. The Journal of Experimental Medicine. 218. PMID 33822840 DOI: 10.1084/jem.20210313   
2021 Reddy AP, Sawant N, Morton H, Kshirsagar S, Bunquin LE, Yin X, Reddy PH. Selective Serotonin Reuptake Inhibitor Citalopram Ameliorates Cognitive Decline and Protects Against Amyloid Beta-induced Mitochondrial Dynamics, Biogenesis, Autopahgy, Mitophagy and Synaptic Toxicities in a Mouse Model of Alzheimer's Disease. Human Molecular Genetics. PMID 33791799 DOI: 10.1093/hmg/ddab091   
2021 Qu Y, Wang W, Chen T, Yang Y, Zhang Y, Wang D. The neuroprotection of deproteinized calf blood extractives injection against Alzheimer's disease via regulation of Nrf-2 signaling. Aging. 13. PMID 33819182 DOI: 10.18632/aging.202776   
2021 Qiao A, Li J, Hu Y, Wang J, Zhao Z. Reduction BACE1 expression via suppressing NF-κB mediated signaling by Tamibarotene in a mouse model of Alzheimer's disease. Ibro Neuroscience Reports. 10: 153-160. PMID 33842919 DOI: 10.1016/j.ibneur.2021.02.004   
2021 Miranda A, Montiel E, Ulrich H, Paz C. Selective Secretase Targeting for Alzheimer's Disease Therapy. Journal of Alzheimer's Disease : Jad. PMID 33749645 DOI: 10.3233/JAD-201027   
2021 Ulm BS, Borchelt DR, Moore BD. Remodeling Alzheimer-amyloidosis models by seeding. Molecular Neurodegeneration. 16: 8. PMID 33588898 DOI: 10.1186/s13024-021-00429-4   
2021 Park SE, Kim HS, Kwon SJ, Kim MJ, Choi SJ, Oh SY, Ryu GH, Jeon HB, Na DL, Chang JW. Exposure of Mesenchymal Stem Cells to an Alzheimer's Disease Environment Enhances Therapeutic Effects. Stem Cells International. 2021: 6660186. PMID 33815510 DOI: 10.1155/2021/6660186   
2021 Yoo JY, Kim HB, Baik TK, Lee JH, Woo RS. Neuregulin 1/ErbB4/Akt signaling attenuates cytotoxicity mediated by the APP-CT31 fragment of amyloid precursor protein. Experimental and Molecular Pathology. 104622. PMID 33684392 DOI: 10.1016/j.yexmp.2021.104622   
2021 Yoon JH, Lee N, Youn K, Jo MR, Kim HR, Lee DS, Ho CT, Jun M. Dieckol Ameliorates Aβ Production via PI3K/Akt/GSK-3β Regulated APP Processing in SweAPP N2a Cell. Marine Drugs. 19. PMID 33804171 DOI: 10.3390/md19030152   
2021 Lu MH, Ji WL, Chen H, Sun YY, Zhao XY, Wang F, Shi Y, Hu YN, Liu BX, Wu JW, Xu DE, Zheng JW, Liu CF, Ma QH. Intranasal Transplantation of Human Neural Stem Cells Ameliorates Alzheimer's Disease-Like Pathology in a Mouse Model. Frontiers in Aging Neuroscience. 13: 650103. PMID 33776747 DOI: 10.3389/fnagi.2021.650103   
2021 Lau JKY, Tian M, Shen Y, Lau SF, Fu WY, Fu AKY, Ip NY. Melanocortin receptor activation alleviates amyloid pathology and glial reactivity in an Alzheimer's disease transgenic mouse model. Scientific Reports. 11: 4359. PMID 33623128 DOI: 10.1038/s41598-021-83932-4   
2021 Koriyama Y, Hori A, Ito H, Yonezawa S, Baba Y, Tanimoto N, Ueno T, Yamamoto S, Yamamoto T, Asada N, Morimoto K, Einaru S, Sakai K, Kanazu T, Matsuda A, et al. Discovery of Atabecestat (JNJ-54861911): A Thiazine-Based β-Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor Advanced to the Phase 2b/3 EARLY Clinical Trial. Journal of Medicinal Chemistry. 64: 1873-1888. PMID 33588527 DOI: 10.1021/acs.jmedchem.0c01917   
2021 Zhang X, Li J, Ma L, Xu H, Cao Y, Liang W, Ma J, Wang ZP, Li Y. BMP4 overexpression induces the upregulation of APP/Tau and memory deficits in Alzheimer's disease. Cell Death Discovery. 7: 51. PMID 33723239 DOI: 10.1038/s41420-021-00435-x   
2021 Choi J, Chung C, Woo H. Diet-Related Mobile Apps to Promote Healthy Eating and Proper Nutrition: A Content Analysis and Quality Assessment. International Journal of Environmental Research and Public Health. 18. PMID 33800531 DOI: 10.3390/ijerph18073496   
2021 Deng Z, Wang J, Xiao Y, Li F, Niu L, Liu X, Meng L, Zheng H. Ultrasound-mediated augmented exosome release from astrocytes alleviates amyloid-β-induced neurotoxicity. Theranostics. 11: 4351-4362. PMID 33754065 DOI: 10.7150/thno.52436   
2021 Khan A, Das S, Sergi C. Therapeutic Potential of Neu1 in Alzheimer's Disease Via the Immune System. American Journal of Alzheimer's Disease and Other Dementias. 36: 1533317521996147. PMID 33719595 DOI: 10.1177/1533317521996147   
2021 Tosh JL, Rhymes ER, Mumford P, Whittaker HT, Pulford LJ, Noy SJ, Cleverley K, , Walker MC, Tybulewicz VLJ, Wykes RC, Fisher EMC, Wiseman FK. Genetic dissection of down syndrome-associated alterations in APP/amyloid-β biology using mouse models. Scientific Reports. 11: 5736. PMID 33707583 DOI: 10.1038/s41598-021-85062-3   
2021 Wang NY, Li JN, Liu WL, Huang Q, Li WX, Tan YH, Liu F, Song ZH, Wang MY, Xie N, Mao RR, Gan P, Ding YQ, Zhang Z, Shan BC, et al. Ferulic Acid Ameliorates Alzheimer's Disease-like Pathology and Repairs Cognitive Decline by Preventing Capillary Hypofunction in APP/PS1 Mice. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. PMID 33786807 DOI: 10.1007/s13311-021-01024-7   
2021 Geisler SM, Benedetti A, Schöpf CL, Schwarzer C, Stefanova N, Schwartz A, Obermair GJ. Phenotypic Characterization and Brain Structure Analysis of Calcium Channel Subunit αδ-2 Mutant (Ducky) and αδ Double Knockout Mice. Frontiers in Synaptic Neuroscience. 13: 634412. PMID 33679366 DOI: 10.3389/fnsyn.2021.634412   
2021 Shin JH, Hwang YS, Jung BK, Seo SH, Ham DW, Shin EH. Reduction of Amyloid Burden by Proliferated Homeostatic Microglia in -Infected Alzheimer's Disease Model Mice. International Journal of Molecular Sciences. 22. PMID 33803262 DOI: 10.3390/ijms22052764   
2021 Huang X, Yang J, Huang X, Zhang Z, Liu J, Zou L, Yang X. Tetramethylpyrazine Improves Cognitive Impairment and Modifies the Hippocampal Proteome in Two Mouse Models of Alzheimer's Disease. Frontiers in Cell and Developmental Biology. 9: 632843. PMID 33791294 DOI: 10.3389/fcell.2021.632843   
2021 Ackley SF, Zimmerman SC, Brenowitz WD, Tchetgen Tchetgen EJ, Gold AL, Manly JJ, Mayeda ER, Filshtein TJ, Power MC, Elahi FM, Brickman AM, Glymour MM. Effect of reductions in amyloid levels on cognitive change in randomized trials: instrumental variable meta-analysis. Bmj (Clinical Research Ed.). 372: n156. PMID 33632704 DOI: 10.1136/bmj.n156   
2021 Leinenga G, Koh WK, Götz J. A comparative study of the effects of Aducanumab and scanning ultrasound on amyloid plaques and behavior in the APP23 mouse model of Alzheimer disease. Alzheimer's Research & Therapy. 13: 76. PMID 33836798 DOI: 10.1186/s13195-021-00809-4   
2021 Al-Thani HF, Ahmad MN, Younes S, Zayed H. Genetic Variants Associated With Alzheimer Disease in the 22 Arab Countries: A Systematic Review. Alzheimer Disease and Associated Disorders. PMID 33769987 DOI: 10.1097/WAD.0000000000000447   
2021 Paulus A, Engdahl A, Yang Y, Boza-Serrano A, Bachiller S, Torres-Garcia L, Svanbergsson A, Garcia MG, Gouras GK, Li JY, Deierborg T, Klementieva O. Amyloid Structural Changes Studied by Infrared Microspectroscopy in Bigenic Cellular Models of Alzheimer's Disease. International Journal of Molecular Sciences. 22. PMID 33810433 DOI: 10.3390/ijms22073430   
2021 Zhu ZY, Liu YD, Gong Y, Jin W, Topchiy E, Turdi S, Gao YF, Culver B, Wang SY, Ge W, Zha WL, Ren J, Pei ZH, Qin X. Mitochondrial aldehyde dehydrogenase (ALDH2) rescues cardiac contractile dysfunction in an APP/PS1 murine model of Alzheimer's disease via inhibition of ACSL4-dependent ferroptosis. Acta Pharmacologica Sinica. PMID 33767380 DOI: 10.1038/s41401-021-00635-2   
2021 Roberts C, Kaplow J, Giroux M, Krause S, Kanekiyo M. Amyloid and APOE Status of Screened Subjects in the Elenbecestat MissionAD Phase 3 Program. The Journal of Prevention of Alzheimer's Disease. 8: 218-223. PMID 33569570 DOI: 10.14283/jpad.2021.4   
2021 Illouz T, Nicola R, Ben-Shushan L, Madar R, Biragyn A, Okun E. Maternal antibodies facilitate Amyloid-β clearance by activating Fc-receptor-Syk-mediated phagocytosis. Communications Biology. 4: 329. PMID 33712740 DOI: 10.1038/s42003-021-01851-6   
2021 Ashford MT, Veitch DP, Neuhaus J, Nosheny RL, Tosun D, Weiner MW. The search for a convenient procedure to detect one of the earliest signs of Alzheimer's disease: A systematic review of the prediction of brain amyloid status. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 33583100 DOI: 10.1002/alz.12253   
2021 Wu T, Chen L, Zhou L, Xu J, Guo K. Platelets transport β-amyloid from the peripheral blood into the brain by destroying the blood-brain barrier to accelerate the process of Alzheimer's disease in mouse models. Aging. 13. PMID 33668038 DOI: 10.18632/aging.202662   
2021 Xu L, Pan CL, Wu XH, Song JJ, Meng P, Li L, Wang L, Zhang Z, Zhang ZY. Inhibition of Smad3 in macrophages promotes Aβ efflux from the brain and thereby ameliorates Alzheimer's pathology. Brain, Behavior, and Immunity. PMID 33737172 DOI: 10.1016/j.bbi.2021.03.013   
2021 Müller L, Power Guerra N, Stenzel J, Rühlmann C, Lindner T, Krause BJ, Vollmar B, Teipel S, Kuhla A. Long-Term Caloric Restriction Attenuates β-Amyloid Neuropathology and Is Accompanied by Autophagy in APPswe/PS1delta9 Mice. Nutrients. 13. PMID 33803798 DOI: 10.3390/nu13030985   
2021 Su X, Tang Z, Lu Z, Liu Y, He W, Jiang J, Zhang Y, Wu H. Oral Treponema denticola Infection Induces Aβ and Aβ Accumulation in the Hippocampus of C57BL/6 Mice. Journal of Molecular Neuroscience : Mn. PMID 33763842 DOI: 10.1007/s12031-021-01827-5   
2021 Yanagisawa D, Ibrahim NF, Taguchi H, Morikawa S, Tomiyama T, Tooyama I. Fluorine-19 Magnetic Resonance Imaging for Detection of Amyloid β Oligomers Using a Keto Form of Curcumin Derivative in a Mouse Model of Alzheimer's Disease. Molecules (Basel, Switzerland). 26. PMID 33806326 DOI: 10.3390/molecules26051362   
2021 Xian-Hui D, Dong-Xue M, Tian-Ci Z, Xiao-Ping H, Li-Jun X, Ya-Lei L, Hao L, Wei-Juan G. The Effect of TCM-Induced HAMP on Key Enzymes in the Hydrolysis of AD Model Cells. Neurochemical Research. PMID 33683629 DOI: 10.1007/s11064-021-03235-y   
2021 Jang BG, Lee J, Choi B, Koh YH, Kim MJ. Unexpected beta-amyloid production by middle doses of resveratrol through stabilization of APP protein and AMPK-mediated inhibition of trypsin-like proteasome activity in a cell model of Alzheimer's disease. Food and Chemical Toxicology : An International Journal Published For the British Industrial Biological Research Association. 112185. PMID 33845068 DOI: 10.1016/j.fct.2021.112185   
2021 Wang J, Liu B, Xu Y, Yang M, Wang C, Song M, Liu J, Wang W, You J, Sun F, Wang D, Liu D, Yan H. Activation of CREB-mediated autophagy by thioperamide ameliorates β-amyloid pathology and cognition in Alzheimer's disease. Aging Cell. e13333. PMID 33682314 DOI: 10.1111/acel.13333   
2021 Lee JH, Ahn NH, Choi SB, Kwon Y, Yang SH. Natural Products Targeting Amyloid Beta in Alzheimer's Disease. International Journal of Molecular Sciences. 22. PMID 33652858 DOI: 10.3390/ijms22052341   
2021 Delgado A, Cholevas C, Theoharides TC. Neuroinflammation in Alzheimer's disease and beneficial action of luteolin. Biofactors (Oxford, England). PMID 33615581 DOI: 10.1002/biof.1714   
2021 Kundu P, Torres ERS, Stagaman K, Kasschau K, Okhovat M, Holden S, Ward S, Nevonen KA, Davis BA, Saito T, Saido TC, Carbone L, Sharpton TJ, Raber J. Integrated analysis of behavioral, epigenetic, and gut microbiome analyses in App, App, and wild type mice. Scientific Reports. 11: 4678. PMID 33633159 DOI: 10.1038/s41598-021-83851-4