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Victor R. DeFilippis, Ph.D. - Publications

Affiliations: 
University of California, Irvine, Irvine, CA 
Area:
molecular clock evolution, evolution of introns
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56 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Weber WC, Labriola CS, Kreklywich CN, Ray K, Haese NN, Andoh TF, Denton M, Medica S, Streblow MM, Smith PP, Mizuno N, Frias N, Fisher MB, Barber-Axthelm AM, Chun K, ... ... DeFilippis V, et al. Mayaro virus pathogenesis and immunity in rhesus macaques. Plos Neglected Tropical Diseases. 17: e0011742. PMID 37983245 DOI: 10.1371/journal.pntd.0011742  0.39
2021 Pham AH, Mitchell J, Botto S, Pryke KM, DeFilippis VR, Hancock MH. Human cytomegalovirus blocks canonical TGFβ signaling during lytic infection to limit induction of type I interferons. Plos Pathogens. 17: e1009380. PMID 34411201 DOI: 10.1371/journal.ppat.1009380  0.37
2021 Haese NN, May NA, Taft-Benz S, Moukha-Chafiq O, Madadi N, Zhang S, Karyakarte SD, Rodzinak KJ, Nguyen TH, Denton M, Streblow AD, Towers NA, Rasmussen L, Bostwick RJ, Maddry JA, ... ... DeFilippis V, et al. Identification of Quinolinones as Antivirals Against Venezuelan Equine Encephalitis Virus. Antimicrobial Agents and Chemotherapy. AAC0024421. PMID 34152810 DOI: 10.1128/AAC.00244-21  0.314
2021 Powers JM, Haese NN, Denton M, Ando T, Kreklywich C, Bonin K, Streblow CE, Kreklywich N, Smith P, Broeckel R, DeFilippis V, Morrison TE, Heise MT, Streblow DN. Non-replicating adenovirus based Mayaro virus vaccine elicits protective immune responses and cross protects against other alphaviruses. Plos Neglected Tropical Diseases. 15: e0009308. PMID 33793555 DOI: 10.1371/journal.pntd.0009308  0.31
2020 Abraham J, Botto S, Mizuno N, Pryke K, Gall B, Boehm D, Sali TM, Jin H, Nilsen A, Gough M, Baird J, Chakhtoura M, Subra C, Trautmann L, Haddad EK, ... DeFilippis VR, et al. Characterization of a Novel Compound That Stimulates STING-Mediated Innate Immune Activity in an Allele-Specific Manner. Frontiers in Immunology. 11: 1430. PMID 32733475 DOI: 10.3389/Fimmu.2020.01430  0.46
2020 Murphy Schafer AR, Smith JL, Pryke KM, DeFilippis VR, Hirsch AJ. The E3 Ubiquitin Ligase SIAH1 Targets MyD88 for Proteasomal Degradation During Dengue Virus Infection. Frontiers in Microbiology. 11: 24. PMID 32117091 DOI: 10.3389/Fmicb.2020.00024  0.473
2020 Karaba AH, Figueroa A, Massaccesi G, Botto S, DeFilippis VR, Cox AL. Herpes simplex virus type 1 inflammasome activation in proinflammatory human macrophages is dependent on NLRP3, ASC, and caspase-1. Plos One. 15: e0229570. PMID 32101570 DOI: 10.1371/Journal.Pone.0229570  0.402
2019 Broeckel RM, Haese N, Ando T, Dmitriev I, Kreklywich CN, Powers J, Denton M, Smith P, Morrison TE, Heise M, DeFilippis V, Messaoudi I, Curiel DT, Streblow DN. Vaccine-Induced Skewing of T Cell Responses Protects Against Chikungunya Virus Disease. Frontiers in Immunology. 10: 2563. PMID 31736977 DOI: 10.3389/Fimmu.2019.02563  0.326
2019 DeFilippis VR. Chikungunya Virus Vaccines: Platforms, Progress, and Challenges. Current Topics in Microbiology and Immunology. PMID 31338593 DOI: 10.1007/82_2019_175  0.398
2019 Nguyen TH, Haese NN, Madadi N, Sarkar S, Bonin K, Streblow C, Taft-Benz S, Tower NA, Rasmussen L, Bostwick R, Augelli-Szafran CE, Suto MJ, Morrision TE, DeFilippis V, Heise M, et al. Studies on Dibenzylamines as Inhibitors of Venezuelan Equine Encephalitis Virus (VEEV). Acs Infectious Diseases. PMID 31257853 DOI: 10.1021/Acsinfecdis.9B00035  0.408
2019 Zhang X, Liu B, Tang L, Su Q, Hwang N, Sehgal M, Cheng J, Ma J, Zhang X, Tan Y, Zhou Y, Duan Z, DeFilippis VR, Viswanathan U, Kulp J, et al. Discovery and Mechanistic Study of a Novel Human STING Agonist. Acs Infectious Diseases. PMID 31060350 DOI: 10.1021/Acsinfecdis.9B00010  0.496
2019 Broeckel R, Sarkar S, May NA, Totonchy J, Kreklywich CN, Smith P, Graves L, DeFilippis VR, Heise MT, Morrison TE, Moorman N, Streblow DN. Src Family Kinase Inhibitors Block Translation of Alphavirus Subgenomic mRNAs. Antimicrobial Agents and Chemotherapy. 63. PMID 30917980 DOI: 10.1128/Aac.02325-18  0.428
2019 Botto S, Abraham J, Mizuno N, Pryke K, Gall B, Landais I, Streblow DN, Fruh KJ, DeFilippis VR. Human Cytomegalovirus Immediate Early 86-kDa Protein Blocks Transcription and Induces Degradation of the Immature Interleukin-1β Protein during Virion-Mediated Activation of the AIM2 Inflammasome. Mbio. 10. PMID 30755509 DOI: 10.1128/Mbio.02510-18  0.457
2018 Hirsch AJ, Roberts VHJ, Grigsby PL, Haese N, Schabel MC, Wang X, Lo JO, Liu Z, Kroenke CD, Smith JL, Kelleher M, Broeckel R, Kreklywich CN, Parkins CJ, Denton M, ... ... DeFilippis V, et al. Zika virus infection in pregnant rhesus macaques causes placental dysfunction and immunopathology. Nature Communications. 9: 263. PMID 29343712 DOI: 10.1038/S41467-017-02499-9  0.36
2017 Gall B, Pryke K, Abraham J, Mizuno N, Botto S, Sali TM, Broeckel R, Haese N, Nilson A, Placzek A, Morrison T, Heise M, Streblow D, DeFilippis V. Emerging Alphaviruses are Sensitive to Cellular States Induced by a Novel Small Molecule Agonist of the STING Pathway. Journal of Virology. PMID 29263267 DOI: 10.1128/Jvi.01913-17  0.518
2017 Gall BJ, DeFilippis VR. High-Throughput Screening for Identification of Novel Innate Immune Activators. Methods in Molecular Biology (Clifton, N.J.). 1656: 183-193. PMID 28808971 DOI: 10.1007/978-1-4939-7237-1_12  0.376
2017 Pryke KM, Abraham J, Sali TM, Gall BJ, Archer I, Liu A, Bambina S, Baird J, Gough M, Chakhtoura M, Haddad EK, Kirby IT, Nilsen A, Streblow DN, Hirsch AJ, ... ... DeFilippis VR, et al. A Novel Agonist of the TRIF Pathway Induces a Cellular State Refractory to Replication of Zika, Chikungunya, and Dengue Viruses. Mbio. 8. PMID 28465426 DOI: 10.1128/Mbio.00452-17  0.514
2017 Hirsch AJ, Smith JL, Haese NN, Broeckel RM, Parkins CJ, Kreklywich C, DeFilippis VR, Denton M, Smith PP, Messer WB, Colgin LM, Ducore RM, Grigsby PL, Hennebold JD, Swanson T, et al. Correction: Zika Virus infection of rhesus macaques leads to viral persistence in multiple tissues. Plos Pathogens. 13: e1006317. PMID 28380070 DOI: 10.1371/Journal.Ppat.1006317  0.42
2017 Hirsch AJ, Smith JL, Haese NN, Broeckel RM, Parkins CJ, Kreklywich C, DeFilippis VR, Denton M, Smith PP, Messer WB, Colgin LM, Ducore RM, Grigsby PL, Hennebold JD, Swanson T, et al. Zika Virus infection of rhesus macaques leads to viral persistence in multiple tissues. Plos Pathogens. 13: e1006219. PMID 28278237 DOI: 10.1371/Journal.Ppat.1006219  0.44
2016 Greene TT, Tokuyama M, Knudsen GM, Kunz M, Lin J, Greninger AL, DeFilippis VR, DeRisi JL, Raulet DH, Coscoy L. A Herpesviral induction of RAE-1 NKG2D ligand expression occurs through release of HDAC mediated repression. Elife. 5. PMID 27874833 DOI: 10.7554/Elife.14749  0.413
2016 Uhrlaub JL, Pulko V, DeFilippis VR, Broeckel R, Streblow DN, Coleman GD, Park BS, Lindo JF, Vickers I, Anzinger JJ, Nikolich-Žugich J. Dysregulated TGF-β Production Underlies the Age-Related Vulnerability to Chikungunya Virus. Plos Pathogens. 12: e1005891. PMID 27736984 DOI: 10.1371/Journal.Ppat.1005891  0.377
2015 Sali TM, Pryke KM, Abraham J, Liu A, Archer I, Broeckel R, Staverosky JA, Smith JL, Al-Shammari A, Amsler L, Sheridan K, Nilsen A, Streblow DN, DeFilippis VR. Characterization of a Novel Human-Specific STING Agonist that Elicits Antiviral Activity Against Emerging Alphaviruses. Plos Pathogens. 11: e1005324. PMID 26646986 DOI: 10.1371/Journal.Ppat.1005324  0.505
2015 Whitmer T, Malouli D, Uebelhoer LS, DeFilippis VR, Früh K, Verweij MC. The ORF61 Protein Encoded by Simian Varicella Virus and Varicella-Zoster Virus Inhibits NF-κB Signaling by Interfering with IκBα Degradation. Journal of Virology. 89: 8687-700. PMID 26085158 DOI: 10.1128/Jvi.01149-15  0.49
2015 Chiang C, Beljanski V, Yin K, Olagnier D, Ben Yebdri F, Steel C, Goulet ML, DeFilippis VR, Streblow DN, Haddad EK, Trautmann L, Ross T, Lin R, Hiscott J. Sequence-Specific Modifications Enhance the Broad-Spectrum Antiviral Response Activated by RIG-I Agonists. Journal of Virology. 89: 8011-25. PMID 26018150 DOI: 10.1128/Jvi.00845-15  0.482
2015 Verweij MC, Wellish M, Whitmer T, Malouli D, Lapel M, Jonjić S, Haas JG, DeFilippis VR, Mahalingam R, Früh K. Varicella Viruses Inhibit Interferon-Stimulated JAK-STAT Signaling through Multiple Mechanisms. Plos Pathogens. 11: e1004901. PMID 25973608 DOI: 10.1371/Journal.Ppat.1004901  0.516
2015 Landais I, Pelton C, Streblow D, DeFilippis V, McWeeney S, Nelson JA. Human Cytomegalovirus miR-UL112-3p Targets TLR2 and Modulates the TLR2/IRAK1/NFκB Signaling Pathway. Plos Pathogens. 11: e1004881. PMID 25955717 DOI: 10.1371/Journal.Ppat.1004881  0.334
2014 Malouli D, Hansen SG, Nakayasu ES, Marshall EE, Hughes CM, Ventura AB, Gilbride RM, Lewis MS, Xu G, Kreklywich C, Whizin N, Fischer M, Legasse AW, Viswanathan K, Siess D, ... ... DeFilippis VR, et al. Cytomegalovirus pp65 limits dissemination but is dispensable for persistence. The Journal of Clinical Investigation. 124: 1928-44. PMID 24691437 DOI: 10.1172/Jci67420  0.478
2013 Amsler L, Malouli D, DeFilippis V. The inflammasome as a target of modulation by DNA viruses. Future Virology. 8: 357-370. PMID 24955107 DOI: 10.2217/Fvl.13.22  0.441
2013 Amsler L, Verweij MC, DeFilippis VR. The tiers and dimensions of evasion of the type I interferon response by human cytomegalovirus. Journal of Molecular Biology. 425: 4857-71. PMID 24013068 DOI: 10.1016/J.Jmb.2013.08.023  0.535
2013 Messaoudi I, Vomaske J, Totonchy T, Kreklywich CN, Haberthur K, Springgay L, Brien JD, Diamond MS, Defilippis VR, Streblow DN. Chikungunya virus infection results in higher and persistent viral replication in aged rhesus macaques due to defects in anti-viral immunity. Plos Neglected Tropical Diseases. 7: e2343. PMID 23936572 DOI: 10.1371/Journal.Pntd.0002343  0.482
2012 Pissani F, Malherbe DC, Robins H, DeFilippis VR, Park B, Sellhorn G, Stamatatos L, Overbaugh J, Haigwood NL. Motif-optimized subtype A HIV envelope-based DNA vaccines rapidly elicit neutralizing antibodies when delivered sequentially. Vaccine. 30: 5519-26. PMID 22749601 DOI: 10.1016/J.Vaccine.2012.06.042  0.354
2012 Robinson BA, O'Connor MA, Li H, Engelmann F, Poland B, Grant R, DeFilippis V, Estep RD, Axthelm MK, Messaoudi I, Wong SW. Viral interferon regulatory factors are critical for delay of the host immune response against rhesus macaque rhadinovirus infection. Journal of Virology. 86: 2769-79. PMID 22171275 DOI: 10.1128/Jvi.05657-11  0.522
2011 Wahl-Jensen V, Kurz S, Feldmann F, Buehler LK, Kindrachuk J, DeFilippis V, da Silva Correia J, Früh K, Kuhn JH, Burton DR, Feldmann H. Ebola virion attachment and entry into human macrophages profoundly effects early cellular gene expression. Plos Neglected Tropical Diseases. 5: e1359. PMID 22028943 DOI: 10.1371/Journal.Pntd.0001359  0.488
2011 White LK, Sali T, Alvarado D, Gatti E, Pierre P, Streblow D, Defilippis VR. Chikungunya virus induces IPS-1-dependent innate immune activation and protein kinase R-independent translational shutoff. Journal of Virology. 85: 606-20. PMID 20962078 DOI: 10.1128/Jvi.00767-10  0.529
2011 Botto S, Streblow DN, DeFilippis V, White L, Kreklywich CN, Smith PP, Caposio P. IL-6 in human cytomegalovirus secretome promotes angiogenesis and survival of endothelial cells through the stimulation of survivin. Blood. 117: 352-61. PMID 20930069 DOI: 10.1182/Blood-2010-06-291245  0.337
2010 Viswanathan K, Früh K, DeFilippis V. Viral hijacking of the host ubiquitin system to evade interferon responses. Current Opinion in Microbiology. 13: 517-23. PMID 20699190 DOI: 10.1016/J.Mib.2010.05.012  0.448
2010 DeFilippis VR, Sali T, Alvarado D, White L, Bresnahan W, Früh KJ. Activation of the interferon response by human cytomegalovirus occurs via cytoplasmic double-stranded DNA but not glycoprotein B. Journal of Virology. 84: 8913-25. PMID 20573816 DOI: 10.1128/Jvi.00169-10  0.486
2010 DeFilippis VR, Alvarado D, Sali T, Rothenburg S, Früh K. Human cytomegalovirus induces the interferon response via the DNA sensor ZBP1. Journal of Virology. 84: 585-98. PMID 19846511 DOI: 10.1128/Jvi.01748-09  0.453
2009 Vomaske J, Melnychuk RM, Smith PP, Powell J, Hall L, DeFilippis V, Früh K, Smit M, Schlaepfer DD, Nelson JA, Streblow DN. Differential ligand binding to a human cytomegalovirus chemokine receptor determines cell type-specific motility. Plos Pathogens. 5: e1000304. PMID 19229316 DOI: 10.1371/Journal.Ppat.1000304  0.321
2008 Powers C, DeFilippis V, Malouli D, Früh K. Cytomegalovirus immune evasion. Current Topics in Microbiology and Immunology. 325: 333-359. PMID 18637515 DOI: 10.1007/978-3-540-77349-8_19  0.424
2008 Streblow DN, Kreklywich CN, Andoh T, Moses AV, Dumortier J, Smith PP, Defilippis V, Fruh K, Nelson JA, Orloff SL. The Role of Angiogenic and Wound Repair Factors During CMV‐Accelerated Transplant Vascular Sclerosis in Rat Cardiac Transplants American Journal of Transplantation. 8: 277-287. PMID 18093265 DOI: 10.1111/J.1600-6143.2007.02062.X  0.384
2007 DeFilippis VR. Induction and evasion of the type I interferon response by cytomegaloviruses. Advances in Experimental Medicine and Biology. 598: 309-24. PMID 17892221 DOI: 10.1007/978-0-387-71767-8_22  0.447
2007 Medigeshi GR, Lancaster AM, Hirsch AJ, Briese T, Lipkin WI, Defilippis V, Früh K, Mason PW, Nikolich-Zugich J, Nelson JA. West Nile virus infection activates the unfolded protein response, leading to CHOP induction and apoptosis. Journal of Virology. 81: 10849-60. PMID 17686866 DOI: 10.1128/Jvi.01151-07  0.469
2007 Streblow DN, van Cleef KW, Kreklywich CN, Meyer C, Smith P, Defilippis V, Grey F, Früh K, Searles R, Bruggeman C, Vink C, Nelson JA, Orloff SL. Rat cytomegalovirus gene expression in cardiac allograft recipients is tissue specific and does not parallel the profiles detected in vitro. Journal of Virology. 81: 3816-26. PMID 17251289 DOI: 10.1128/Jvi.02425-06  0.396
2007 Rose PP, Carroll JM, Carroll PA, DeFilippis VR, Lagunoff M, Moses AV, Roberts CT, Früh K. The insulin receptor is essential for virus-induced tumorigenesis of Kaposi's sarcoma. Oncogene. 26: 1995-2005. PMID 17001305 DOI: 10.1038/Sj.Onc.1210006  0.341
2006 DeFilippis VR, Robinson B, Keck TM, Hansen SG, Nelson JA, Früh KJ. Interferon regulatory factor 3 is necessary for induction of antiviral genes during human cytomegalovirus infection. Journal of Virology. 80: 1032-7. PMID 16379004 DOI: 10.1128/Jvi.80.2.1032-1037.2006  0.47
2006 DeFilippis V, Früh K. Host cell targets for antiviral therapy: an update Future Virology. 1: 509-518. DOI: 10.2217/17460794.1.4.509  0.45
2005 Hirsch AJ, Medigeshi GR, Meyers HL, DeFilippis V, Früh K, Briese T, Lipkin WI, Nelson JA. The Src family kinase c-Yes is required for maturation of West Nile virus particles. Journal of Virology. 79: 11943-51. PMID 16140770 DOI: 10.1128/Jvi.79.18.11943-11951.2005  0.477
2005 DeFilippis V, Früh K. Rhesus cytomegalovirus particles prevent activation of interferon regulatory factor 3. Journal of Virology. 79: 6419-6431. PMID 15858025 DOI: 10.1128/Jvi.79.10.6419-6431.2005  0.555
2004 Rue CA, Jarvis MA, Knoche AJ, Meyers HL, DeFilippis VR, Hansen SG, Wagner M, Früh K, Anders DG, Wong SW, Barry PA, Nelson JA. A cyclooxygenase-2 homologue encoded by rhesus cytomegalovirus is a determinant for endothelial cell tropism. Journal of Virology. 78: 12529-36. PMID 15507640 DOI: 10.1128/Jvi.78.22.12529-12536.2004  0.49
2004 McAllister SC, Hansen SG, Ruhl RA, Raggo CM, DeFilippis VR, Greenspan D, Früh K, Moses AV. Kaposi sarcoma-associated herpesvirus (KSHV) induces heme oxygenase-1 expression and activity in KSHV-infected endothelial cells. Blood. 103: 3465-73. PMID 14726403 DOI: 10.1182/Blood-2003-08-2781  0.421
2003 DeFilippis V, Raggo C, Moses A, Früh K. Functional genomics in virology and antiviral drug discovery. Trends in Biotechnology. 21: 452-457. PMID 14512232 DOI: 10.1016/S0167-7799(03)00207-5  0.395
2002 DeFilippis VR, Ayala FJ, Villarreal LP. Evidence of diversifying selection in human papillomavirus type 16 E6 but not E7 oncogenes. Journal of Molecular Evolution. 55: 491-9. PMID 12355268 DOI: 10.1007/S00239-002-2344-Y  0.43
2001 DeFilippis V. Lateral Gene Transfer or Viral Colonization? Science. 293: 1048a-1048. DOI: 10.1126/Science.293.5532.1048A  0.34
2000 Villarreal LP, DeFilippis VR. A hypothesis for DNA viruses as the origin of eukaryotic replication proteins. Journal of Virology. 74: 7079-84. PMID 10888648 DOI: 10.1128/Jvi.74.15.7079-7084.2000  0.337
2000 Villarreal LP, Defilippis VR, Gottlieb KA. Acute and persistent viral life strategies and their relationship to emerging diseases. Virology. 272: 1-6. PMID 10873743 DOI: 10.1006/Viro.2000.0381  0.451
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