Senthilkumar S. Karuppagounder, Ph.D. - Publications

2002-2004 Biomedical sciences Jadavpur University, Kolkata, West Bengal, India 
 2004-2006 Cell Biology & Physiology Indian inst. of Chemical Engineering 
 2006-2009 Pharmacal Science Auburn University, Auburn, AL, United States 
 2009- Neurology Johns Hopkins University School of Medicine, Baltimore, MD, United States 
Parkinson's Disease, Neurodegeneration, Synaptic Transmission, hippocampal glutamatergic system, AMPA and NMDA channels

38 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Pirooznia SK, Yuan C, Khan MR, Karuppagounder SS, Wang L, Xiong Y, Kang SU, Lee Y, Dawson VL, Dawson TM. PARIS induced defects in mitochondrial biogenesis drive dopamine neuron loss under conditions of parkin or PINK1 deficiency. Molecular Neurodegeneration. 15: 17. PMID 32138754 DOI: 10.1186/s13024-020-00363-x  1
2019 Brahmachari S, Lee S, Kim S, Yuan C, Karuppagounder SS, Ge P, Shi R, Kim EJ, Liu A, Kim D, Quintin S, Jiang H, Kumar M, Yun SP, Kam TI, et al. Parkin interacting substrate zinc finger protein 746 is a pathological mediator in Parkinson's disease. Brain : a Journal of Neurology. PMID 31237944 DOI: 10.1093/brain/awz172  1
2018 Xue Y, Zhan X, Sun S, Karuppagounder SS, Xia S, Dawson VL, Dawson TM, Laterra J, Zhang J, Ying M. Synthetic mRNAs Drive Highly Efficient iPS Cell Differentiation to Dopaminergic Neurons. Stem Cells Translational Medicine. PMID 30387318 DOI: 10.1002/sctm.18-0036  1
2018 Kam TI, Mao X, Park H, Chou SC, Karuppagounder SS, Umanah GE, Yun SP, Brahmachari S, Panicker N, Chen R, Andrabi SA, Qi C, Poirier GG, Pletnikova O, Troncoso JC, et al. Poly(ADP-ribose) drives pathologic α-synuclein neurodegeneration in Parkinson's disease. Science (New York, N.Y.). 362. PMID 30385548 DOI: 10.1126/science.aat8407  1
2018 Yun SP, Kam TI, Panicker N, Kim S, Oh Y, Park JS, Kwon SH, Park YJ, Karuppagounder SS, Park H, Kim S, Oh N, Kim NA, Lee S, Brahmachari S, et al. Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson's disease. Nature Medicine. PMID 29892066 DOI: 10.1038/s41591-018-0051-5  1
2018 Xiong Y, Neifert S, Karuppagounder SS, Liu Q, Stankowski JN, Lee BD, Ko HS, Lee Y, Grima JC, Mao X, Jiang H, Kang SU, Swing DA, Iacovitti L, Tessarollo L, et al. Robust kinase- and age-dependent dopaminergic and norepinephrine neurodegeneration in LRRK2 G2019S transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. PMID 29386392 DOI: 10.1073/pnas.1712648115  1
2018 Kim S, Yun SP, Lee S, Umanah GE, Bandaru VVR, Yin X, Rhee P, Karuppagounder SS, Kwon SH, Lee H, Mao X, Kim D, Pandey A, Lee G, Dawson VL, et al. GBA1 deficiency negatively affects physiological α-synuclein tetramers and related multimers. Proceedings of the National Academy of Sciences of the United States of America. PMID 29311330 DOI: 10.1073/pnas.1700465115  1
2018 Yun SP, Kim D, Kim S, Kim S, Karuppagounder SS, Kwon SH, Lee S, Kam TI, Lee S, Ham S, Park JH, Dawson VL, Dawson TM, Lee Y, Ko HS. α-Synuclein accumulation and GBA deficiency due to L444P GBA mutation contributes to MPTP-induced parkinsonism. Molecular Neurodegeneration. 13: 1. PMID 29310663 DOI: 10.1186/s13024-017-0233-5  1
2017 Brahmachari S, Karuppagounder SS, Ge P, Lee S, Dawson VL, Dawson TM, Ko HS. c-Abl and Parkinson's Disease: Mechanisms and Therapeutic Potential. Journal of Parkinson's Disease. 7: 589-601. PMID 29103051 DOI: 10.3233/JPD-171191  1
2017 Xiong Y, Neifert S, Karuppagounder SS, Stankowski JN, Lee BD, Grima JC, Chen G, Ko HS, Lee Y, Swing D, Tessarollo L, Dawson TM, Dawson VL. Overexpression of Parkinson's Disease-Associated Mutation LRRK2 G2019S in Mouse Forebrain Induces Behavioral Deficits and α-Synuclein Pathology. Eneuro. 4. PMID 28321439 DOI: 10.1523/ENEURO.0004-17.2017  1
2017 Pignatelli M, Umanah GK, Ribeiro SP, Chen R, Karuppagounder SS, Yau HJ, Eacker S, Dawson VL, Dawson TM, Bonci A. Synaptic Plasticity onto Dopamine Neurons Shapes Fear Learning. Neuron. 93: 425-440. PMID 28103482 DOI: 10.1016/j.neuron.2016.12.030  1
2016 Mao X, Ou MT, Karuppagounder SS, Kam TI, Yin X, Xiong Y, Ge P, Umanah GE, Brahmachari S, Shin JH, Kang HC, Zhang J, Xu J, Chen R, Park H, et al. Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3. Science (New York, N.Y.). 353. PMID 27708076 DOI: 10.1126/science.aah3374  1
2016 Jiang H, Kang SU, Zhang S, Karuppagounder S, Xu J, Lee YK, Kang BG, Lee Y, Zhang J, Pletnikova O, Troncoso JC, Pirooznia S, Andrabi SA, Dawson VL, Dawson TM. Adult Conditional Knockout of PGC-1α Leads to Loss of Dopamine Neurons. Eneuro. 3. PMID 27622213 DOI: 10.1523/ENEURO.0183-16.2016  1
2016 Brahmachari S, Ge P, Lee SH, Kim D, Karuppagounder SS, Kumar M, Mao X, Lee Y, Pletnikova O, Troncoso JC, Dawson VL, Dawson TM, Ko HS. Activation of tyrosine kinase c-Abl contributes to α-synuclein-induced neurodegeneration. The Journal of Clinical Investigation. PMID 27348587 DOI: 10.1172/JCI85456  1
2016 Thrash-Williams B, Karuppagounder SS, Bhattacharya D, Ahuja M, Suppiramaniam V, Dhanasekaran M. Methamphetamine-induced dopaminergic toxicity prevented owing to the neuroprotective effects of salicylic acid. Life Sciences. PMID 26926078 DOI: 10.1016/j.lfs.2016.02.072  1
2016 Karuppagounder SS, Xiong Y, Lee Y, Lawless MC, Kim D, Nordquist E, Martin I, Ge P, Brahmachari S, Jhaldiyal A, Kumar M, Andrabi SA, Dawson TM, Dawson VL. LRRK2 G2019S Transgenic Mice Display Increased Susceptibility to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-Mediated Neurotoxicity. Journal of Chemical Neuroanatomy. PMID 26808467 DOI: 10.1016/j.jchemneu.2016.01.007  1
2015 Lee Y, Karuppagounder SS, Shin JH, Lee YI, Ko HS, Swing D, Jiang H, Kang SU, Lee BD, Kang HC, Kim D, Tessarollo L, Dawson VL, Dawson TM. Corrigendum: Parthanatos mediates AIMP2-activated age-dependent dopaminergic neuronal loss. Nature Neuroscience. 18: 1861. PMID 26605883 DOI: 10.1038/nn1215-1861a  1
2014 Lu W, Karuppagounder SS, Springer DA, Allen MD, Zheng L, Chao B, Zhang Y, Dawson VL, Dawson TM, Lenardo M. Genetic deficiency of the mitochondrial protein PGAM5 causes a Parkinson's-like movement disorder. Nature Communications. 5: 4930. PMID 25222142 DOI: 10.1038/ncomms5930  1
2014 Andrabi SA, Umanah GK, Chang C, Stevens DA, Karuppagounder SS, Gagné JP, Poirier GG, Dawson VL, Dawson TM. Poly(ADP-ribose) polymerase-dependent energy depletion occurs through inhibition of glycolysis. Proceedings of the National Academy of Sciences of the United States of America. 111: 10209-14. PMID 24987120 DOI: 10.1073/pnas.1405158111  1
2014 Sagal J, Zhan X, Xu J, Tilghman J, Karuppagounder SS, Chen L, Dawson VL, Dawson TM, Laterra J, Ying M. Proneural transcription factor Atoh1 drives highly efficient differentiation of human pluripotent stem cells into dopaminergic neurons. Stem Cells Translational Medicine. 3: 888-98. PMID 24904172 DOI: 10.5966/sctm.2013-0213  1
2014 Karuppagounder SS, Brahmachari S, Lee Y, Dawson VL, Dawson TM, Ko HS. The c-Abl inhibitor, nilotinib, protects dopaminergic neurons in a preclinical animal model of Parkinson's disease. Scientific Reports. 4: 4874. PMID 24786396 DOI: 10.1038/srep04874  1
2014 Xiao J, Li Y, Prandovszky E, Karuppagounder SS, Talbot CC, Dawson VL, Dawson TM, Yolken RH. MicroRNA-132 dysregulation in Toxoplasma gondii infection has implications for dopamine signaling pathway. Neuroscience. 268: 128-38. PMID 24657774 DOI: 10.1016/j.neuroscience.2014.03.015  1
2014 Karuppagounder SS, Bhattacharya D, Ahuja M, Suppiramaniam V, Deruiter J, Clark R, Dhanasekaran M. Elucidating the neurotoxic effects of MDMA and its analogs. Life Sciences. 101: 37-42. PMID 24560859 DOI: 10.1016/j.lfs.2014.02.010  1
2013 Lee Y, Karuppagounder SS, Shin JH, Lee YI, Ko HS, Swing D, Jiang H, Kang SU, Lee BD, Kang HC, Kim D, Tessarollo L, Dawson VL, Dawson TM. Parthanatos mediates AIMP2-activated age-dependent dopaminergic neuronal loss. Nature Neuroscience. 16: 1392-400. PMID 23974709 DOI: 10.1038/nn.3500  1
2013 Thrash-Williams B, Ahuja M, Karuppagounder SS, Uthayathas S, Suppiramaniam V, Dhanasekaran M. Assessment of therapeutic potential of amantadine in methamphetamine induced neurotoxicity. Neurochemical Research. 38: 2084-94. PMID 23918203 DOI: 10.1007/s11064-013-1117-x  1
2013 Uthayathas S, Parameshwaran K, Karuppagounder SS, Ahuja M, Dhanasekaran M, Suppiramaniam V. Selective inhibition of phosphodiesterase 5 enhances glutamatergic synaptic plasticity and memory in mice. Synapse (New York, N.Y.). 67: 741-7. PMID 23620198 DOI: 10.1002/syn.21676  1
2013 Vandiver MS, Paul BD, Xu R, Karuppagounder S, Rao F, Snowman AM, Ko HS, Lee YI, Dawson VL, Dawson TM, Sen N, Snyder SH. Sulfhydration mediates neuroprotective actions of parkin. Nature Communications. 4: 1626. PMID 23535647 DOI: 10.1038/ncomms2623  1
2012 Karuppagounder SS, Ahuja M, Buabeid M, Parameshwaran K, Abdel-Rehman E, Suppiramaniam V, Dhanasekaran M. Investigate the chronic neurotoxic effects of diquat. Neurochemical Research. 37: 1102-11. PMID 22331545 DOI: 10.1007/s11064-012-0715-3  1
2012 Parameshwaran K, Buabeid MA, Karuppagounder SS, Uthayathas S, Thiruchelvam K, Shonesy B, Dityatev A, Escobar MC, Dhanasekaran M, Suppiramaniam V. Developmental nicotine exposure induced alterations in behavior and glutamate receptor function in hippocampus. Cellular and Molecular Life Sciences : Cmls. 69: 829-41. PMID 22033836 DOI: 10.1007/s00018-011-0805-4  1
2012 Shonesy BC, Thiruchelvam K, Parameshwaran K, Rahman EA, Karuppagounder SS, Huggins KW, Pinkert CA, Amin R, Dhanasekaran M, Suppiramaniam V. Central insulin resistance and synaptic dysfunction in intracerebroventricular-streptozotocin injected rodents. Neurobiology of Aging. 33: 430.e5-18. PMID 21256630 DOI: 10.1016/j.neurobiolaging.2010.12.002  1
2010 Ko HS, Lee Y, Shin JH, Karuppagounder SS, Gadad BS, Koleske AJ, Pletnikova O, Troncoso JC, Dawson VL, Dawson TM. Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function. Proceedings of the National Academy of Sciences of the United States of America. 107: 16691-6. PMID 20823226 DOI: 10.1073/pnas.1006083107  1
2010 Thrash B, Karuppagounder SS, Uthayathas S, Suppiramaniam V, Dhanasekaran M. Neurotoxic effects of methamphetamine. Neurochemical Research. 35: 171-9. PMID 19697126 DOI: 10.1007/s11064-009-0042-5  1
2008 Dhanasekaran M, Karuppagounder SS, Uthayathas S, Wold LE, Parameshwaran K, Jayachandra Babu R, Suppiramaniam V, Brown-Borg H. Effect of dopaminergic neurotoxin MPTP/MPP+ on coenzyme Q content. Life Sciences. 83: 92-5. PMID 18565546 DOI: 10.1016/j.lfs.2008.04.016  1
2008 Dhanasekaran M, Albano CB, Pellet L, Karuppagounder SS, Uthayathas S, Suppiramaniam V, Brown-Borg H, Ebadi M. Role of lipoamide dehydrogenase and metallothionein on 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine-induced neurotoxicity. Neurochemical Research. 33: 980-4. PMID 17768676 DOI: 10.1007/s11064-007-9468-9  1
2007 Thrash B, Uthayathas S, Karuppagounder SS, Suppiramaniam V, Dhanasekaran M. Paraquat and maneb induced neurotoxicity. Proceedings of the Western Pharmacology Society. 50: 31-42. PMID 18605226  1
2007 Uthayathas S, Karuppagounder SS, Tamer SI, Parameshwaran K, Degim T, Suppiramaniam V, Dhanasekaran M. Evaluation of neuroprotective and anti-fatigue effects of sildenafil. Life Sciences. 81: 988-92. PMID 17825848 DOI: 10.1016/j.lfs.2007.07.018  1
2007 Uthayathas S, Karuppagounder SS, Thrash BM, Parameshwaran K, Suppiramaniam V, Dhanasekaran M. Versatile effects of sildenafil: recent pharmacological applications. Pharmacological Reports : Pr. 59: 150-63. PMID 17556793  1
2006 Dhanasekaran M, Uthayathas S, Karuppagounder SS, Parameshwaran K, Suppiramaniam V, Ebadi M, Brown-Borg HM. Ebselen effects on MPTP-induced neurotoxicity. Brain Research. 1118: 251-4. PMID 16956591 DOI: 10.1016/j.brainres.2006.08.020  1
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