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Joseph W. Lewcock, Ph.D. - Publications

Affiliations: 
Johns Hopkins University, Baltimore, MD 
Area:
Olfaction
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28/53 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Andreone BJ, Przybyla L, Llapashtica C, Rana A, Davis SS, van Lengerich B, Lin K, Shi J, Mei Y, Astarita G, Di Paolo G, Sandmann T, Monroe KM, Lewcock JW. Alzheimer's-associated PLCγ2 is a signaling node required for both TREM2 function and the inflammatory response in human microglia. Nature Neuroscience. PMID 32514138 DOI: 10.1038/S41593-020-0650-6  0.375
2019 Nugent AA, Lin K, van Lengerich B, Lianoglou S, Przybyla L, Davis SS, Llapashtica C, Wang J, Kim DJ, Xia D, Lucas A, Baskaran S, Haddick PCG, Lenser M, Earr TK, ... ... Lewcock JW, et al. TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge. Neuron. PMID 31902528 DOI: 10.1016/J.Neuron.2019.12.007  0.32
2019 Andreone BJ, Larhammar M, Lewcock JW. Cell Death and Neurodegeneration. Cold Spring Harbor Perspectives in Biology. PMID 31451511 DOI: 10.1101/Cshperspect.A036434  0.393
2019 Fang MY, Markmiller S, Vu AQ, Javaherian A, Dowdle WE, Jolivet P, Bushway PJ, Castello NA, Baral A, Chan MY, Linsley JW, Linsley D, Mercola M, Finkbeiner S, Lecuyer E, ... Lewcock JW, et al. Small-Molecule Modulation of TDP-43 Recruitment to Stress Granules Prevents Persistent TDP-43 Accumulation in ALS/FTD. Neuron. PMID 31272829 DOI: 10.1016/J.Neuron.2019.05.048  0.303
2019 Bonanomi D, Valenza F, Chivatakarn O, Sternfeld MJ, Driscoll SP, Aslanian A, Lettieri K, Gullo M, Badaloni A, Lewcock JW, Hunter T, Pfaff SL. p190RhoGAP Filters Competing Signals to Resolve Axon Guidance Conflicts. Neuron. PMID 30902550 DOI: 10.1016/J.Neuron.2019.02.034  0.368
2018 Newton K, Dugger DL, Sengupta-Ghosh A, Ferrando RE, Chu F, Tao J, Lam W, Haller S, Chan S, Sa S, Dunlap D, Eastham-Anderson J, Ngu H, Hung J, French DM, ... ... Lewcock JW, et al. Ubiquitin ligase COP1 coordinates transcriptional programs that control cell type specification in the developing mouse brain. Proceedings of the National Academy of Sciences of the United States of America. PMID 30322923 DOI: 10.1073/Pnas.1805033115  0.35
2018 Siu M, Sengupta Ghosh A, Lewcock JW. Dual Leucine Zipper Kinase Inhibitors for the Treatment of Neurodegeneration. Journal of Medicinal Chemistry. PMID 29863360 DOI: 10.1021/Acs.Jmedchem.8B00370  0.412
2017 Larhammar M, Huntwork-Rodriguez S, Rudhard Y, Sengupta-Ghosh A, Lewcock JW. The Ste20 family kinases MAP4K4, MINK1 and TNIK, converge to regulate stress induced JNK signaling in neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28993483 DOI: 10.1523/Jneurosci.0905-17.2017  0.438
2017 Patel S, Meilandt WJ, Erickson RI, Chen J, Deshmukh G, Estrada AA, Fuji RN, Gibbons P, Gustafson A, Harris SF, Imperio J, Liu W, Liu X, Liu Y, Lyssikatos JP, ... ... Lewcock JW, et al. Selective Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12) with Activity in a Model of Alzheimer's Disease. Journal of Medicinal Chemistry. PMID 28929759 DOI: 10.1021/Acs.Jmedchem.7B00843  0.366
2017 Le Pichon CE, Meilandt WJ, Dominguez S, Solanoy H, Lin H, Ngu H, Gogineni A, Sengupta Ghosh A, Jiang Z, Lee SH, Maloney J, Gandham VD, Pozniak CD, Wang B, Lee S, ... ... Lewcock JW, et al. Loss of dual leucine zipper kinase signaling is protective in animal models of neurodegenerative disease. Science Translational Medicine. 9. PMID 28814543 DOI: 10.1126/Scitranslmed.Aag0394  0.429
2017 Larhammar M, Huntwork-Rodriguez S, Jiang Z, Solanoy H, Sengupta Ghosh A, Wang B, Kaminker JS, Huang K, Eastham-Anderson J, Siu M, Modrusan Z, Farley MM, Tessier-Lavigne M, Lewcock JW, Watkins TA. Dual leucine zipper kinase-dependent PERK activation contributes to neuronal degeneration following insult. Elife. 6. PMID 28440222 DOI: 10.7554/Elife.20725  0.397
2017 Larhammar M, Huntwork-Rodriguez S, Jiang Z, Solanoy H, Ghosh AS, Wang B, Kaminker JS, Huang K, Eastham-Anderson J, Siu M, Modrusan Z, Farley MM, Tessier-Lavigne M, Lewcock JW, Watkins TA. Author response: Dual leucine zipper kinase-dependent PERK activation contributes to neuronal degeneration following insult Elife. DOI: 10.7554/Elife.20725.038  0.368
2015 Patel S, Harris SF, Gibbons P, Deshmukh G, Gustafson A, Kellar T, Lin H, Liu X, Liu Y, Liu Y, Ma C, Scearce-Levie K, Ghosh AS, Shin YG, Solanoy H, ... ... Lewcock JW, et al. Scaffold-Hopping and Structure-Based Discovery of Potent, Selective, And Brain Penetrant N-(1H-Pyrazol-3-yl)pyridin-2-amine Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12). Journal of Medicinal Chemistry. PMID 26431428 DOI: 10.1021/Acs.Jmedchem.5B01072  0.313
2015 Rudhard Y, Sengupta Ghosh A, Lippert B, Böcker A, Pedaran M, Krämer J, Ngu H, Foreman O, Liu Y, Lewcock JW. Identification of 12/15-lipoxygenase as a regulator of axon degeneration through high-content screening. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 2927-41. PMID 25698732 DOI: 10.1523/Jneurosci.2936-14.2015  0.414
2015 Patel S, Cohen F, Dean BJ, De La Torre K, Deshmukh G, Estrada AA, Ghosh AS, Gibbons P, Gustafson A, Huestis MP, Le Pichon CE, Lin H, Liu W, Liu X, Liu Y, ... ... Lewcock JW, et al. Discovery of dual leucine zipper kinase (DLK, MAP3K12) inhibitors with activity in neurodegeneration models. Journal of Medicinal Chemistry. 58: 401-18. PMID 25341110 DOI: 10.1021/Jm5013984  0.372
2013 Lobsiger CS, Boillée S, Pozniak C, Khan AM, McAlonis-Downes M, Lewcock JW, Cleveland DW. C1q induction and global complement pathway activation do not contribute to ALS toxicity in mutant SOD1 mice. Proceedings of the National Academy of Sciences of the United States of America. 110: E4385-92. PMID 24170856 DOI: 10.1073/Pnas.1318309110  0.359
2013 Pozniak CD, Sengupta Ghosh A, Gogineni A, Hanson JE, Lee SH, Larson JL, Solanoy H, Bustos D, Li H, Ngu H, Jubb AM, Ayalon G, Wu J, Scearce-Levie K, Zhou Q, ... ... Lewcock JW, et al. Dual leucine zipper kinase is required for excitotoxicity-induced neuronal degeneration. The Journal of Experimental Medicine. 210: 2553-67. PMID 24166713 DOI: 10.1084/Jem.20122832  0.413
2013 Huntwork-Rodriguez S, Wang B, Watkins T, Ghosh AS, Pozniak CD, Bustos D, Newton K, Kirkpatrick DS, Lewcock JW. JNK-mediated phosphorylation of DLK suppresses its ubiquitination to promote neuronal apoptosis. The Journal of Cell Biology. 202: 747-63. PMID 23979718 DOI: 10.1083/Jcb.201303066  0.434
2013 Watkins TA, Wang B, Huntwork-Rodriguez S, Yang J, Jiang Z, Eastham-Anderson J, Modrusan Z, Kaminker JS, Tessier-Lavigne M, Lewcock JW. DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury. Proceedings of the National Academy of Sciences of the United States of America. 110: 4039-44. PMID 23431164 DOI: 10.1073/Pnas.1211074110  0.332
2012 Chen M, Maloney JA, Kallop DY, Atwal JK, Tam SJ, Baer K, Kissel H, Kaminker JS, Lewcock JW, Weimer RM, Watts RJ. Spatially coordinated kinase signaling regulates local axon degeneration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 13439-53. PMID 23015435 DOI: 10.1523/Jneurosci.2039-12.2012  0.375
2011 Ghosh AS, Wang B, Pozniak CD, Chen M, Watts RJ, Lewcock JW. DLK induces developmental neuronal degeneration via selective regulation of proapoptotic JNK activity. The Journal of Cell Biology. 194: 751-64. PMID 21893599 DOI: 10.1083/Jcb.201103153  0.447
2011 Bai G, Chivatakarn O, Bonanomi D, Lettieri K, Franco L, Xia C, Stein E, Ma L, Lewcock JW, Pfaff SL. Presenilin-dependent receptor processing is required for axon guidance. Cell. 144: 106-18. PMID 21215373 DOI: 10.1016/J.Cell.2010.11.053  0.431
2007 Lewcock JW, Genoud N, Lettieri K, Pfaff SL. The ubiquitin ligase Phr1 regulates axon outgrowth through modulation of microtubule dynamics. Neuron. 56: 604-20. PMID 18031680 DOI: 10.1016/J.Neuron.2007.09.009  0.376
2006 Shirasaki R, Lewcock JW, Lettieri K, Pfaff SL. FGF as a target-derived chemoattractant for developing motor axons genetically programmed by the LIM code. Neuron. 50: 841-53. PMID 16772167 DOI: 10.1016/J.Neuron.2006.04.030  0.376
2004 Wang SS, Lewcock JW, Feinstein P, Mombaerts P, Reed RR. Genetic disruptions of O/E2 and O/E3 genes reveal involvement in olfactory receptor neuron projection. Development (Cambridge, England). 131: 1377-88. PMID 14993187 DOI: 10.1242/Dev.01009  0.545
2004 Lewcock JW, Reed RR. A feedback mechanism regulates monoallelic odorant receptor expression. Proceedings of the National Academy of Sciences of the United States of America. 101: 1069-74. PMID 14732684 DOI: 10.1073/Pnas.0307986100  0.576
2003 Lewcock JW, Reed RR. Neuroscience. ORs rule the roost in the olfactory system. Science (New York, N.Y.). 302: 2078-9. PMID 14684811 DOI: 10.1126/Science.1093397  0.557
2001 Lewcock JW, Reed RR. Sweet successes. Neuron. 31: 515-7. PMID 11545710 DOI: 10.1016/S0896-6273(01)00404-4  0.501
Low-probability matches (unlikely to be authored by this person)
2005 Myers CP, Lewcock JW, Hanson MG, Gosgnach S, Aimone JB, Gage FH, Lee KF, Landmesser LT, Pfaff SL. Cholinergic input is required during embryonic development to mediate proper assembly of spinal locomotor circuits. Neuron. 46: 37-49. PMID 15820692 DOI: 10.1016/J.Neuron.2005.02.022  0.297
2024 Miyamoto T, Kim C, Chow J, Dugas JC, DeGroot J, Bagdasarian AL, Thottumkara AP, Larhammar M, Calvert ME, Fox BM, Lewcock JW, Kane LA. SARM1 is responsible for calpain-dependent dendrite degeneration in mouse hippocampal neurons. The Journal of Biological Chemistry. 105630. PMID 38199568 DOI: 10.1016/j.jbc.2024.105630  0.297
2012 Mintzer R, Ramaswamy S, Shah K, Hannoush RN, Pozniak CD, Cohen F, Zhao X, Plise E, Lewcock JW, Heise CE. A whole cell assay to measure caspase-6 activity by detecting cleavage of lamin A/C. Plos One. 7: e30376. PMID 22253931 DOI: 10.1371/Journal.Pone.0030376  0.297
2012 Stanger K, Steffek M, Zhou L, Pozniak CD, Quan C, Franke Y, Tom J, Tam C, Krylova I, Elliott JM, Lewcock JW, Zhang Y, Murray J, Hannoush RN. Allosteric peptides bind a caspase zymogen and mediate caspase tetramerization. Nature Chemical Biology. 8: 655-60. PMID 22683611 DOI: 10.1038/Nchembio.967  0.296
2012 Heise CE, Murray J, Augustyn KE, Bravo B, Chugha P, Cohen F, Giannetti AM, Gibbons P, Hannoush RN, Hearn BR, Jaishankar P, Ly CQ, Shah K, Stanger K, Steffek M, ... ... Lewcock JW, et al. Mechanistic and structural understanding of uncompetitive inhibitors of caspase-6. Plos One. 7: e50864. PMID 23227217 DOI: 10.1371/Journal.Pone.0050864  0.283
2013 Boxer AL, Gold M, Huey E, Hu WT, Rosen H, Kramer J, Gao FB, Burton EA, Chow T, Kao A, Leavitt BR, Lamb B, Grether M, Knopman D, Cairns NJ, ... ... Lewcock J, et al. The advantages of frontotemporal degeneration drug development (part 2 of frontotemporal degeneration: the next therapeutic frontier). Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 9: 189-98. PMID 23062850 DOI: 10.1016/J.Jalz.2012.03.003  0.263
2020 Scearce-Levie K, Sanchez PE, Lewcock JW. Leveraging preclinical models for the development of Alzheimer disease therapeutics. Nature Reviews. Drug Discovery. 19: 447-462. PMID 32612262 DOI: 10.1038/S41573-020-0065-9  0.259
2019 Naguib A, Sandmann T, Yi F, Watts RJ, Lewcock JW, Dowdle WE. SUPT4H1 Depletion Leads to a Global Reduction in RNA. Cell Reports. 26: 45-53.e4. PMID 30605685 DOI: 10.1016/J.Celrep.2018.12.004  0.25
2021 Logan T, Simon MJ, Rana A, Cherf GM, Srivastava A, Davis SS, Low RLY, Chiu CL, Fang M, Huang F, Bhalla A, Llapashtica C, Prorok R, Pizzo ME, Calvert MEK, ... ... Lewcock JW, et al. Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic. Cell. PMID 34450028 DOI: 10.1016/j.cell.2021.08.002  0.222
2013 Stanger K, Steffek M, Zhou L, Pozniak CD, Quan C, Franke Y, Tom J, Tam C, Elliott JM, Lewcock JW, Zhang Y, Murray J, Hannoush RN. Erratum: Corrigendum: Allosteric peptides bind a caspase zymogen and mediate caspase tetramerization Nature Chemical Biology. 9: 466-466. DOI: 10.1038/Nchembio-0613-466B  0.213
2023 Monroe KM, Lewcock JW. Cleaning crew: Soluble TREM2 mops up complement. Immunity. 56: 1701-1703. PMID 37557076 DOI: 10.1016/j.immuni.2023.07.012  0.186
2021 Bosch-Queralt M, Cantuti-Castelvetri L, Damkou A, Schifferer M, Schlepckow K, Alexopoulos I, Lütjohann D, Klose C, Vaculčiaková L, Masuda T, Prinz M, Monroe KM, Di Paolo G, Lewcock JW, Haass C, et al. Diet-dependent regulation of TGFβ impairs reparative innate immune responses after demyelination. Nature Metabolism. 3: 211-227. PMID 33619376 DOI: 10.1038/s42255-021-00341-7  0.184
2023 Wang X, Bondar VV, Davis OB, Maloney MT, Agam M, Chin MY, Cheuk-Nga Ho A, Ghosh R, Leto DE, Joy D, Calvert MEK, Lewcock JW, Di Paolo G, Thorne RG, Sweeney ZK, et al. Rab12 is a regulator of LRRK2 and its activation by damaged lysosomes. Elife. 12. PMID 37874617 DOI: 10.7554/eLife.87255  0.176
2020 Schlepckow K, Monroe KM, Kleinberger G, Cantuti-Castelvetri L, Parhizkar S, Xia D, Willem M, Werner G, Pettkus N, Brunner B, Sülzen A, Nuscher B, Hampel H, Xiang X, Feederle R, ... ... Lewcock JW, et al. Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk region. Embo Molecular Medicine. e11227. PMID 32154671 DOI: 10.15252/Emmm.201911227  0.175
2022 Reifschneider A, Robinson S, van Lengerich B, Gnörich J, Logan T, Heindl S, Vogt MA, Weidinger E, Riedl L, Wind K, Zatcepin A, Pesämaa I, Haberl S, Nuscher B, Kleinberger G, ... ... Lewcock JW, et al. Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency. The Embo Journal. e109108. PMID 35019161 DOI: 10.15252/embj.2021109108  0.173
2020 Lewcock JW, Schlepckow K, Di Paolo G, Tahirovic S, Monroe KM, Haass C. Emerging Microglia Biology Defines Novel Therapeutic Approaches for Alzheimer's Disease. Neuron. PMID 33096024 DOI: 10.1016/j.neuron.2020.09.029  0.163
2022 Xia D, Lianoglou S, Sandmann T, Calvert M, Suh JH, Thomsen E, Dugas J, Pizzo ME, DeVos SL, Earr TK, Lin CC, Davis S, Ha C, Leung AW, Nguyen H, ... ... Lewcock JW, et al. Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia. Molecular Neurodegeneration. 17: 41. PMID 35690868 DOI: 10.1186/s13024-022-00547-7  0.159
2023 van Lengerich B, Zhan L, Xia D, Chan D, Joy D, Park JI, Tatarakis D, Calvert M, Hummel S, Lianoglou S, Pizzo ME, Prorok R, Thomsen E, Bartos LM, Beumers P, ... ... Lewcock JW, et al. A TREM2-activating antibody with a blood-brain barrier transport vehicle enhances microglial metabolism in Alzheimer's disease models. Nature Neuroscience. PMID 36635496 DOI: 10.1038/s41593-022-01240-0  0.15
2023 Iwatsubo T, Irizarry MC, Lewcock JW, Carrillo MC. Alzheimer's Targeted Treatments: Focus on Amyloid and Inflammation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 43: 7894-7898. PMID 37968119 DOI: 10.1523/JNEUROSCI.1576-23.2023  0.127
2022 Arguello A, Mahon CS, Calvert MEK, Chan D, Dugas JC, Pizzo ME, Thomsen ER, Chau R, Damo LA, Duque J, Fang M, Giese T, Kim DJ, Liang N, Nguyen HN, ... ... Lewcock JW, et al. Molecular architecture determines brain delivery of a transferrin receptor-targeted lysosomal enzyme. The Journal of Experimental Medicine. 219. PMID 35226042 DOI: 10.1084/jem.20211057  0.122
2023 Chew KS, Wells RC, Moshkforoush A, Chan D, Lechtenberg KJ, Tran HL, Chow J, Kim DJ, Robles-Colmenares Y, Srivastava DB, Tong RK, Tong M, Xa K, Yang A, Zhou Y, ... ... Lewcock JW, et al. CD98hc is a target for brain delivery of biotherapeutics. Nature Communications. 14: 5053. PMID 37598178 DOI: 10.1038/s41467-023-40681-4  0.103
2023 Bosch-Queralt M, Cantuti-Castelvetri L, Damkou A, Schifferer M, Schlepckow K, Alexopoulos I, Lütjohann D, Klose C, Vaculčiaková L, Masuda T, Prinz M, Monroe KM, Di Paolo G, Lewcock JW, Haass C, et al. Author Correction: Diet-dependent regulation of TGFβ impairs reparative innate immune responses after demyelination. Nature Metabolism. PMID 36823473 DOI: 10.1038/s42255-023-00750-w  0.077
2023 Chew KS, Wells RC, Moshkforoush A, Chan D, Lechtenberg KJ, Tran HL, Chow J, Kim DJ, Robles-Colmenares Y, Srivastava DB, Tong RK, Tong M, Xa K, Yang A, Zhou Y, ... ... Lewcock JW, et al. Author Correction: CD98hc is a target for brain delivery of biotherapeutics. Nature Communications. 14: 5516. PMID 37679403 DOI: 10.1038/s41467-023-41355-x  0.07
2023 Benatar M, Ostrow LW, Lewcock JW, Bennett F, Shefner J, Bowser R, Larkin P, Bruijn L, Wuu J. Biomarker Qualification for Neurofilament Light Chain in Amyotrophic Lateral Sclerosis: Theory and Practice. Annals of Neurology. 95: 211-216. PMID 38110839 DOI: 10.1002/ana.26860  0.057
2011 Sweeney ZK, Lewcock JW. ACS chemical neuroscience spotlight on CEP-1347. Acs Chemical Neuroscience. 2: 3-4. PMID 22778853 DOI: 10.1021/cn1000793  0.035
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