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Tarek A. Leil, Ph.D. - Publications

Affiliations: 
University of California, Los Angeles, Los Angeles, CA 
Area:
GABA-A receptor proteins
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4/33 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Cai W, Leil TA, Gibiansky L, Krishna M, Zhang H, Gu H, Sun H, Throup J, Banerjee S, Girgis I. Modeling and Simulation of the Pharmacokinetics and Target Engagement of an Antagonist Monoclonal Antibody to Interferon-γ-Induced Protein 10, BMS-986184, in Healthy Participants to Guide Therapeutic Dosing. Clinical Pharmacology in Drug Development. PMID 32068354 DOI: 10.1002/Cpdd.784  0.305
2007 Chen ZW, Chang CS, Leil TA, Olsen RW. C-terminal modification is required for GABARAP-mediated GABA(A) receptor trafficking. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 6655-63. PMID 17581952 DOI: 10.1523/Jneurosci.0919-07.2007  0.513
2005 Chen ZW, Chang CS, Leil TA, Olcese R, Olsen RW. GABAA receptor-associated protein regulates GABAA receptor cell-surface number in Xenopus laevis oocytes. Molecular Pharmacology. 68: 152-9. PMID 15814572 DOI: 10.1124/Mol.104.009878  0.508
2004 Leil TA, Chen ZW, Chang CS, Olsen RW. GABAA receptor-associated protein traffics GABAA receptors to the plasma membrane in neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 11429-38. PMID 15601949 DOI: 10.1523/Jneurosci.3355-04.2004  0.512
Low-probability matches (unlikely to be authored by this person)
2015 Leil TA, Ermakov S. Editorial: The emerging discipline of quantitative systems pharmacology. Frontiers in Pharmacology. 6: 129. PMID 26175687 DOI: 10.3389/Fphar.2015.00129  0.298
2017 Cheng Y, Thalhauser CJ, Smithline S, Pagidala J, Miladinov M, Vezina HE, Gupta M, Leil TA, Schmidt BJ. QSP Toolbox: Computational Implementation of Integrated Workflow Components for Deploying Multi-Scale Mechanistic Models. The Aaps Journal. PMID 28540623 DOI: 10.1208/S12248-017-0100-X  0.288
2014 Ermakov S, Forster P, Pagidala J, Miladinov M, Wang A, Baillie R, Bartlett D, Reed M, Leil TA. Virtual Systems Pharmacology (ViSP) software for simulation from mechanistic systems-level models. Frontiers in Pharmacology. 5: 232. PMID 25374542 DOI: 10.3389/Fphar.2014.00232  0.274
2019 Hamuro L, Tirucherai GS, Crawford SM, Nayeem A, Pillutla RC, DeSilva BS, Leil TA, Thalhauser CJ. Evaluating a Multiscale Mechanistic Model of the Immune System to Predict Human Immunogenicity for a Biotherapeutic in Phase 1. The Aaps Journal. 21: 94. PMID 31342199 DOI: 10.1208/S12248-019-0361-7  0.268
2013 Leil TA, Zee P, Suryawanshi S, Male C, Portman R. Quantitative Extrapolation: An Approach to Validation of Adult Drug Efficacy in Pediatric Subjects. Therapeutic Innovation & Regulatory Science. 47: 557-565. PMID 30235580 DOI: 10.1177/2168479013500286  0.266
2010 Leil TA, Feng Y, Zhang L, Paccaly A, Mohan P, Pfister M. Quantification of apixaban's therapeutic utility in prevention of venous thromboembolism: selection of phase III trial dose. Clinical Pharmacology and Therapeutics. 88: 375-82. PMID 20686477 DOI: 10.1038/Clpt.2010.106  0.263
2003 Leil TA, Ossadtchi A, Nichols TE, Leahy RM, Smith DJ. Genes regulated by learning in the hippocampus. Journal of Neuroscience Research. 71: 763-8. PMID 12605401 DOI: 10.1002/Jnr.10541  0.258
2014 Leil TA, Bertz R. Quantitative Systems Pharmacology can reduce attrition and improve productivity in pharmaceutical research and development. Frontiers in Pharmacology. 5: 247. PMID 25426074 DOI: 10.3389/Fphar.2014.00247  0.252
2009 Schild-Hay LJ, Leil TA, Divi RL, Olivero OA, Weston A, Poirier MC. Tamoxifen induces expression of immune response-related genes in cultured normal human mammary epithelial cells. Cancer Research. 69: 1150-5. PMID 19155303 DOI: 10.1158/0008-5472.Can-08-2806  0.25
2007 Leil TA, Endo C, Adjei AA, Dy GK, Salavaggione OE, Reid JR, Ames MM, Adjei AA. Identification and characterization of genetic variation in the folylpolyglutamate synthase gene. Cancer Research. 67: 8772-82. PMID 17875718 DOI: 10.1158/0008-5472.Can-07-0156  0.245
2014 Lu Y, Griffen SC, Boulton DW, Leil TA. Use of systems pharmacology modeling to elucidate the operating characteristics of SGLT1 and SGLT2 in renal glucose reabsorption in humans. Frontiers in Pharmacology. 5: 274. PMID 25540623 DOI: 10.3389/Fphar.2014.00274  0.242
2002 Leil TA, Ossadtchi A, Cortes JS, Leahy RM, Smith DJ. Finding new candidate genes for learning and memory. Journal of Neuroscience Research. 68: 127-37. PMID 11948658 DOI: 10.1002/Jnr.10184  0.241
2020 Leil T, Lu Y, Bouillon-Pichault M, Wong R, Nowak M. Model-Based Meta-analysis Compares DAS28 Rheumatoid Arthritis Treatment Effects and Suggests an Expedited Trial Design for Early Clinical Development. Clinical Pharmacology and Therapeutics. PMID 32860421 DOI: 10.1002/Cpt.2023  0.241
2019 Cheng L, Wei G, Leil T. Review of quantitative systems pharmacological modeling in thrombosis Communications in Information and Systems. 19: 219-240. DOI: 10.4310/Cis.2019.V19.N3.A1  0.238
2007 Raetz EA, Cairo MS, Borowitz MJ, Blaney SM, Krailo MD, Leil TA, Goldenberg DM, Wegener WA, Carroll WL, Adamson PC. Chemoimmunotherapy reinduction with epratuzumab in children with ALL with marrow relapse: A Children's Oncology Group (COG) pilot study (ADVL04P2) Journal of Clinical Oncology. 25: 9513-9513. DOI: 10.1200/Jco.2007.25.18_Suppl.9513  0.238
2003 Smith DJ, Leil TA, Liu X. Neurotrophin-4 is required for tolerance to morphine in the mouse. Neuroscience Letters. 340: 103-6. PMID 12668247 DOI: 10.1016/S0304-3940(03)00084-3  0.226
2002 Shai SY, Harpf AE, Babbitt CJ, Jordan MC, Fishbein MC, Chen J, Omura M, Leil TA, Becker KD, Jiang M, Smith DJ, Cherry SR, Loftus JC, Ross RS. Cardiac myocyte-specific excision of the beta1 integrin gene results in myocardial fibrosis and cardiac failure. Circulation Research. 90: 458-64. PMID 11884376 DOI: 10.1161/Hh0402.105790  0.218
2007 Van Gijssel HE, Leil TA, Weinberg WC, Divi RL, Olivero OA, Poirier MC. Cisplatin-DNA damage in p21WAF1/Cip1 deficient mouse keratinocytes exposed to cisplatin Mutagenesis. 22: 49-54. PMID 17158520 DOI: 10.1093/Mutage/Gel050  0.212
2008 Raetz EA, Cairo MS, Borowitz MJ, Blaney SM, Krailo MD, Leil TA, Reid JM, Goldenberg DM, Wegener WA, Carroll WL, Adamson PC. Chemoimmunotherapy reinduction with epratuzumab in children with acute lymphoblastic leukemia in marrow relapse: a Children's Oncology Group Pilot Study. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 26: 3756-62. PMID 18669463 DOI: 10.1200/Jco.2007.15.3528  0.207
2019 Schmidt BJ, Bee C, Han M, Jing Y, Cheng Y, Tenney DJ, Leil TA. Antibodies to modulate surface receptor systems are often bivalent and must compete in a two-dimensional cell contact region. Cpt: Pharmacometrics & Systems Pharmacology. PMID 31529681 DOI: 10.1002/psp4.12468  0.195
2015 Tang W, Leil TA, Johnsson E, Boulton DW, LaCreta F. Comparison of the pharmacokinetics and pharmacodynamics of dapagliflozin in patients with type 1 versus type 2 diabetes mellitus. Diabetes, Obesity & Metabolism. PMID 26510924 DOI: 10.1111/Dom.12594  0.193
2022 Cheng Y, Straube R, Alnaif AE, Huang L, Leil TA, Schmidt BJ. Virtual Populations for Quantitative Systems Pharmacology Models. Methods in Molecular Biology (Clifton, N.J.). 2486: 129-179. PMID 35437722 DOI: 10.1007/978-1-0716-2265-0_8  0.185
2019 Kierzek AM, Hickling TP, Figueroa I, Kalvass JC, Nijsen M, Mohan K, Veldman GM, Yamada A, Sayama H, Yokoo S, Gulati A, Dhanikula RS, Gokemeijer J, Leil TA, Thalhauser CJ, et al. A Quantitative Systems Pharmacology Consortium Approach to Managing Immunogenicity of Therapeutic Proteins. Cpt: Pharmacometrics & Systems Pharmacology. PMID 31529677 DOI: 10.1002/psp4.12465  0.156
2019 Cheng L, Wei GW, Leil T. Review of quantitative systems pharmacological modeling in thrombosis. Communications in Information and Systems. 19: 219-240. PMID 34045928 DOI: 10.4310/cis.2019.v19.n3.a1  0.137
2024 Zou P, Zahir H, Duggal A, Pandya G, Jin J, Leil TA. Pharmacokinetics, Pharmacodynamics, and Safety of Edoxaban in Pediatric Subjects: A Phase I Single-Dose Study. Clinical Pharmacology and Therapeutics. PMID 38369608 DOI: 10.1002/cpt.3196  0.114
2014 Leil TA, Kasichayanula S, Boulton DW, LaCreta F. Evaluation of 4β-Hydroxycholesterol as a Clinical Biomarker of CYP3A4 Drug Interactions Using a Bayesian Mechanism-Based Pharmacometric Model. Cpt: Pharmacometrics & Systems Pharmacology. 3: e120. PMID 24964282 DOI: 10.1038/psp.2014.18  0.104
2018 Cirincione B, Kowalski K, Nielsen J, Roy A, Thanneer N, Byon W, Boyd R, Wang X, Leil T, LaCreta F, Ueno T, Oishi M, Frost C. Population Pharmacokinetics of Apixaban in Subjects with Non-valvular Atrial Fibrillation. Cpt: Pharmacometrics & Systems Pharmacology. PMID 30259707 DOI: 10.1002/psp4.12347  0.093
2014 Leil TA, Frost C, Wang X, Pfister M, LaCreta F. Model-based exposure-response analysis of apixaban to quantify bleeding risk in special populations of subjects undergoing orthopedic surgery. Cpt: Pharmacometrics & Systems Pharmacology. 3: e136. PMID 25229619 DOI: 10.1038/psp.2014.34  0.076
2014 Leil TA. A bayesian perspective on estimation of variability and uncertainty in mechanism-based models. Cpt: Pharmacometrics & Systems Pharmacology. 3: e121. PMID 24964283 DOI: 10.1038/psp.2014.19  0.062
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