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Timothy J. Jarome, Ph.D. - Publications

Affiliations: 
2013-2017 Neurobiology University of Alabama, Birmingham, Birmingham, AL, United States 
 2018- Animal and Poultry Science Virginia Polytechnic Institute and State University, Blacksburg, VA, United States 
Area:
Epigenetics of memory, memory storage and retrieval
Website:
https://www.apsc.vt.edu/OurPeople/Faculty/Timothy-Jarome.html
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63 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Navabpour S, Patrick MB, Omar NA, Kincaid SE, Bae Y, Abraham J, McGrew J, Musaus M, Ray WK, Helm RF, Jarome TJ. Indirectly acquired fear memories have distinct, sex-specific molecular signatures from directly acquired fear memories. Plos One. 19: e0315564. PMID 39715176 DOI: 10.1371/journal.pone.0315564  0.794
2024 Preveza NJ, Setenet G, Gwin P, Bae Y, Patrick MB, Cummings A, Abraham JR, Ray WK, Helm RF, Jarome TJ. Decreases in K63 Polyubiquitination in the Hippocampus Promote the Formation of Contextual Fear Memories in Both Males and Females. Hippocampus. 35: e23650. PMID 39610227 DOI: 10.1002/hipo.23650  0.757
2024 Uh K, Monarch K, Reese ED, Rodriguez K, Yoon J, Spate LD, Samuel MS, Koh S, Chen PR, Jarome TJ, Allen TA, Prather RS, Lee K. Impaired Skeletal Development by Disruption of Presenilin-1 in Pigs and Generation of Novel Pig Models for Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. PMID 39177593 DOI: 10.3233/JAD-231297  0.594
2024 Patrick MB, Preveza NJ, Kincaid SE, Setenet G, Abraham JR, Cummings A, Banani S, Ray WK, Helm RF, Trask S, Jarome TJ. Dysregulation of baseline and learning-dependent protein degradation in the aged hippocampus. Brain Research Bulletin. 111015. PMID 38879089 DOI: 10.1016/j.brainresbull.2024.111015  0.825
2024 Navabpour S, Farrell K, Kincaid SE, Omar N, Musaus M, Lin Y, Xie H, Jarome TJ. Monoubiquitination of histone H2B is a crucial regulator of the transcriptome during memory formation. Learning & Memory (Cold Spring Harbor, N.Y.). 31. PMID 38580378 DOI: 10.1101/lm.053912.123  0.812
2023 Farrell K, Auerbach A, Musaus M, Navabpour S, Liu C, Lin Y, Xie H, Jarome TJ. Phosphorylation of RPT6 controls its ability to bind DNA and regulate gene expression in the hippocampus of male rats during memory formation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 38124005 DOI: 10.1523/JNEUROSCI.1453-23.2023  0.791
2023 Farrell K, Auerbach A, Liu C, Martin K, Pareno M, Ray WK, Helm RF, Biase F, Jarome TJ. Sex-differences in proteasome-dependent K48-polyubiquitin signaling in the amygdala are developmentally regulated in rats. Biology of Sex Differences. 14: 80. PMID 37950270 DOI: 10.1186/s13293-023-00566-z  0.771
2023 Swilley C, Lin Y, Zheng Y, Xu X, Liu M, Jarome T, Hodes GE, Xie H. Sex linked behavioral and hippocampal transcriptomic changes in mice with cell-type specific loss. Frontiers in Neuroscience. 17: 1240209. PMID 37928724 DOI: 10.3389/fnins.2023.1240209  0.692
2023 McFadden T, Carucci I, Farrell K, Fletchall E, Jarome TJ. Hypothalamic DNA 5-hydroxymethylation levels are altered by diet-induced weight gain during the development of obesity in a sex-specific manner. Brain Research. 1817: 148478. PMID 37422205 DOI: 10.1016/j.brainres.2023.148478  0.599
2023 Patrick MB, Omar N, Werner CT, Mitra S, Jarome TJ. The ubiquitin-proteasome system and learning-dependent synaptic plasticity - a 10 year update. Neuroscience and Biobehavioral Reviews. 105280. PMID 37315660 DOI: 10.1016/j.neubiorev.2023.105280  0.749
2023 Farrell K, Musaus M, Auerbach A, Navabpour S, Ray WK, Helm RF, Jarome TJ. Proteasome-independent K63 polyubiquitination selectively regulates ATP levels and proteasome activity during fear memory formation in the female amygdala. Molecular Psychiatry. PMID 37198264 DOI: 10.1038/s41380-023-02112-0  0.762
2023 McFadden T, Gaito N, Carucci I, Fletchall E, Farrell K, Jarome TJ. Controlling hypothalamic DNA methylation at the Pomc promoter does not regulate weight gain during the development of obesity. Plos One. 18: e0284286. PMID 37036864 DOI: 10.1371/journal.pone.0284286  0.597
2023 Farrell K, McFadden T, Jarome TJ. Neuronal and astrocytic protein degradation are critical for fear memory formation. Learning & Memory (Cold Spring Harbor, N.Y.). 30: 70-73. PMID 36921984 DOI: 10.1101/lm.053716.122  0.779
2022 Farrell K, Auerbach A, Musaus M, Jarome TJ. The epigenetic role of proteasome subunit RPT6 during memory formation in female rats. Learning & Memory (Cold Spring Harbor, N.Y.). 29: 256-264. PMID 36206393 DOI: 10.1101/lm.053498.121  0.794
2022 Gustin A, Navabpour S, Farrell K, Martin K, DuVall J, Keith Ray W, Helm RF, Jarome TJ. Protein SUMOylation is a sex-specific regulator of fear memory formation in the amygdala. Behavioural Brain Research. 430: 113928. PMID 35597476 DOI: 10.1016/j.bbr.2022.113928  0.802
2022 McFadden T, Farrell K, Martin K, Musaus M, Jarome TJ. Short-term exposure to an obesogenic diet causes dynamic dysregulation of proteasome-mediated protein degradation in the hypothalamus of female rats. Nutritional Neuroscience. 1-13. PMID 35282800 DOI: 10.1080/1028415X.2022.2046965  0.625
2021 Maity S, Farrell K, Navabpour S, Narayanan SN, Jarome TJ. Epigenetic Mechanisms in Memory and Cognitive Decline Associated with Aging and Alzheimer's Disease. International Journal of Molecular Sciences. 22. PMID 34830163 DOI: 10.3390/ijms222212280  0.767
2021 Farrell K, Musaus M, Navabpour S, Martin K, Ray WK, Helm RF, Jarome TJ. Proteomic Analysis Reveals Sex-Specific Protein Degradation Targets in the Amygdala During Fear Memory Formation. Frontiers in Molecular Neuroscience. 14: 716284. PMID 34658783 DOI: 10.3389/fnmol.2021.716284  0.736
2021 Musaus M, Farrell K, Navabpour S, Ray WK, Helm RF, Jarome TJ. Sex-Specific Linear Polyubiquitination Is a Critical Regulator of Contextual Fear Memory Formation. Frontiers in Behavioral Neuroscience. 15: 709392. PMID 34305548 DOI: 10.3389/fnbeh.2021.709392  0.822
2021 Martin K, Musaus M, Navabpour S, Gustin A, Ray WK, Helm RF, Jarome TJ. Females, but not males, require protein degradation in the hippocampus for contextual fear memory formation. Learning & Memory (Cold Spring Harbor, N.Y.). 28: 248-253. PMID 34266989 DOI: 10.1101/lm.053429.121  0.789
2021 Jarome TJ, Perez GA, Webb WM, Hatch KM, Navabpour S, Musaus M, Farrell K, Hauser RM, McFadden T, Martin K, Butler AA, Wang J, Lubin FD. Ubiquitination of Histone H2B by Proteasome Subunit RPT6 Controls Histone Methylation Chromatin Dynamics During Memory Formation. Biological Psychiatry. PMID 33934885 DOI: 10.1016/j.biopsych.2020.12.029  0.807
2021 Jarome TJ, Kwapis JL. Special Issue "Molecular Mechanisms of Memory Formation and Modification". International Journal of Molecular Sciences. 22. PMID 33923416 DOI: 10.3390/ijms22084113  0.858
2021 Farrell K, Jarome TJ. Is PROTAC technology really a game changer for central nervous system drug discovery? Expert Opinion On Drug Discovery. 1-8. PMID 33870803 DOI: 10.1080/17460441.2021.1915979  0.6
2021 Devulapalli R, Jones N, Farrell K, Musaus M, Kugler H, McFadden T, Orsi SA, Martin K, Nelsen J, Navabpour S, O'Donnell M, McCoig E, Jarome TJ. Males and females differ in the regulation and engagement of, but not requirement for, protein degradation in the amygdala during fear memory formation. Neurobiology of Learning and Memory. 107404. PMID 33609735 DOI: 10.1016/j.nlm.2021.107404  0.791
2020 Navabpour S, Rogers J, McFadden T, Jarome TJ. DNA Double-Strand Breaks Are a Critical Regulator of Fear Memory Reconsolidation. International Journal of Molecular Sciences. 21. PMID 33256213 DOI: 10.3390/ijms21238995  0.806
2020 Musaus M, Navabpour S, Jarome TJ. The diversity of linkage-specific polyubiquitin chains and their role in synaptic plasticity and memory formation. Neurobiology of Learning and Memory. 174: 107286. PMID 32745599 DOI: 10.1016/j.nlm.2020.107286  0.721
2020 McFadden T, Musaus M, Nelsen JL, Martin K, Jones N, Smith P, Kugler H, Jarome TJ. Dysregulation of protein degradation in the hippocampus is associated with impaired spatial memory during the development of obesity'. Behavioural Brain Research. 112787. PMID 32603798 DOI: 10.1016/j.bbr.2020.112787  0.776
2019 Navabpour S, Kwapis JL, Jarome TJ. A neuroscientist's guide to transgenic mice and other genetic tools. Neuroscience and Biobehavioral Reviews. 108: 732-748. PMID 31843544 DOI: 10.1016/j.neubiorev.2019.12.013  0.745
2019 Devulapalli RK, Nelsen JL, Orsi SA, McFadden T, Navabpour S, Jones N, Martin K, O'Donnell M, McCoig EL, Jarome TJ. Males and Females Differ in the Subcellular and Brain Region Dependent Regulation of Proteasome Activity by CaMKII and Protein Kinase a. Neuroscience. PMID 31449987 DOI: 10.1016/j.neuroscience.2019.08.031  0.666
2019 Butler AA, Sanchez RG, Jarome TJ, Webb WM, Lubin FD. O-GlcNAc and EZH2-mediated epigenetic regulation of gene expression during consolidation of fear memories. Learning & Memory (Cold Spring Harbor, N.Y.). 26: 373-379. PMID 31416910 DOI: 10.1101/Lm.049023.118  0.855
2019 McFadden T, Devulapalli RK, Jarome TJ. Quantifying Subcellular Ubiquitin-proteasome Activity in the Rodent Brain. Journal of Visualized Experiments : Jove. PMID 31180360 DOI: 10.3791/59695  0.729
2019 Ferrara NC, Jarome TJ, Cullen PK, Orsi SA, Kwapis JL, Trask S, Pullins SE, Helmstetter FJ. GluR2 endocytosis-dependent protein degradation in the amygdala mediates memory updating. Scientific Reports. 9: 5180. PMID 30914678 DOI: 10.1038/S41598-019-41526-1  0.859
2018 Orsi SA, Devulapalli RK, Nelsen JL, McFadden T, Surineni R, Jarome TJ. Distinct subcellular changes in proteasome activity and linkage-specific protein polyubiquitination in the amygdala during the consolidation and reconsolidation of a fear memory. Neurobiology of Learning and Memory. 157: 1-11. PMID 30458285 DOI: 10.1016/j.nlm.2018.11.012  0.8
2018 Jarome TJ, Perez GA, Hauser RM, Hatch KM, Lubin FD. EZH2 Methyltransferase Activity Controls Pten Expression and mTOR Signaling During Fear Memory Reconsolidation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 30030400 DOI: 10.1523/Jneurosci.0538-18.2018  0.875
2018 Jarome TJ, Devulapalli RK. The Ubiquitin-Proteasome System and Memory: Moving Beyond Protein Degradation. The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. 1073858418762317. PMID 29529924 DOI: 10.1177/1073858418762317  0.809
2017 Webb WM, Sanchez RG, Perez G, Butler AA, Hauser RM, Rich MC, O'Bierne AL, Jarome TJ, Lubin FD. Dynamic association of epigenetic H3K4me3 and DNA 5hmC marks in the dorsal hippocampus and anterior cingulate cortex following reactivation of a fear memory. Neurobiology of Learning and Memory. PMID 28232238 DOI: 10.1016/J.Nlm.2017.02.010  0.837
2017 Kwapis JL, Jarome TJ, Ferrara NC, Helmstetter FJ. Updating Procedures can Reorganize the Neural Circuit Supporting a Fear Memory. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 28139682 DOI: 10.1038/Npp.2017.23  0.872
2016 Jarome TJ, Ferrara NC, Kwapis JL, Helmstetter FJ. CaMKII regulates proteasome phosphorylation and activity and promotes memory destabilization following retrieval. Neurobiology of Learning and Memory. PMID 26779588 DOI: 10.1016/J.Nlm.2016.01.001  0.885
2015 Maity S, Jarome TJ, Blair J, Lubin FD, Nguyen PV. Norepinephrine goes nuclear: Epigenetic modifications during long-lasting synaptic potentiation triggered by activation of beta-adrenergic receptors. The Journal of Physiology. PMID 26574176 DOI: 10.1113/Jp271432  0.754
2015 Jarome TJ, Butler AA, Nichols JN, Pacheco NL, Lubin FD. NF-κB mediates Gadd45β expression and DNA demethylation in the hippocampus during fear memory formation. Frontiers in Molecular Neuroscience. 8: 54. PMID 26441517 DOI: 10.3389/Fnmol.2015.00054  0.86
2015 Kwapis JL, Jarome TJ, Lee JL, Helmstetter FJ. The retrosplenial cortex is involved in the formation of memory for context and trace fear conditioning. Neurobiology of Learning and Memory. 123: 110-6. PMID 26079095 DOI: 10.1016/J.Nlm.2015.06.007  0.887
2015 Jarome TJ, Ferrara NC, Kwapis JL, Helmstetter FJ. Contextual Information Drives the Reconsolidation-Dependent Updating of Retrieved Fear Memories. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 40: 3044-52. PMID 26062788 DOI: 10.1038/Npp.2015.161  0.875
2015 Jarome TJ, Ferrara NC, Kwapis JL, Helmstetter FJ. Contextual Information Drives the Reconsolidation-Dependent Updating of Retrieved Fear Memories Neuropsychopharmacology. DOI: 10.1038/npp.2015.161  0.865
2015 Kwapis JL, Jarome TJ, Lee JL, Helmstetter FJ. The retrosplenial cortex is involved in the formation of memory for context and trace fear conditioning Neurobiology of Learning and Memory. 123: 110-116. DOI: 10.1016/j.nlm.2015.06.007  0.868
2014 Kwapis JL, Jarome TJ, Helmstetter FJ. The role of the medial prefrontal cortex in trace fear extinction. Learning & Memory (Cold Spring Harbor, N.Y.). 22: 39-46. PMID 25512576 DOI: 10.1101/Lm.036517.114  0.812
2014 Jarome TJ, Thomas JS, Lubin FD. The epigenetic basis of memory formation and storage. Progress in Molecular Biology and Translational Science. 128: 1-27. PMID 25410539 DOI: 10.1016/B978-0-12-800977-2.00001-2  0.864
2014 Jarome TJ, Lubin FD. Epigenetic mechanisms of memory formation and reconsolidation. Neurobiology of Learning and Memory. 115: 116-27. PMID 25130533 DOI: 10.1016/J.Nlm.2014.08.002  0.865
2014 Jarome TJ, Helmstetter FJ. Protein degradation and protein synthesis in long-term memory formation. Frontiers in Molecular Neuroscience. 7: 61. PMID 25018696 DOI: 10.3389/Fnmol.2014.00061  0.835
2014 Gupta-Agarwal S, Jarome TJ, Fernandez J, Lubin FD. NMDA receptor- and ERK-dependent histone methylation changes in the lateral amygdala bidirectionally regulate fear memory formation. Learning & Memory (Cold Spring Harbor, N.Y.). 21: 351-62. PMID 24939839 DOI: 10.1101/Lm.035105.114  0.854
2014 Jarome TJ, Kwapis JL, Hallengren JJ, Wilson SM, Helmstetter FJ. The ubiquitin-specific protease 14 (USP14) is a critical regulator of long-term memory formation. Learning & Memory (Cold Spring Harbor, N.Y.). 21: 9-13. PMID 24344179 DOI: 10.1101/Lm.032771.113  0.873
2014 Kwapis JL, Jarome TJ, Lee JL, Gilmartin MR, Helmstetter FJ. Extinguishing trace fear engages the retrosplenial cortex rather than the amygdala. Neurobiology of Learning and Memory. 113: 41-54. PMID 24055593 DOI: 10.1016/J.Nlm.2013.09.007  0.814
2013 Reis DS, Jarome TJ, Helmstetter FJ. Memory formation for trace fear conditioning requires ubiquitin-proteasome mediated protein degradation in the prefrontal cortex. Frontiers in Behavioral Neuroscience. 7: 150. PMID 24167477 DOI: 10.3389/Fnbeh.2013.00150  0.87
2013 Jarome TJ, Kwapis JL, Ruenzel WL, Helmstetter FJ. CaMKII, but not protein kinase A, regulates Rpt6 phosphorylation and proteasome activity during the formation of long-term memories. Frontiers in Behavioral Neuroscience. 7: 115. PMID 24009566 DOI: 10.3389/Fnbeh.2013.00115  0.865
2013 Jarome TJ, Lubin FD. Histone lysine methylation: critical regulator of memory and behavior. Reviews in the Neurosciences. 24: 375-87. PMID 23729618 DOI: 10.1515/Revneuro-2013-0008  0.79
2013 Jarome TJ, Helmstetter FJ. The ubiquitin-proteasome system as a critical regulator of synaptic plasticity and long-term memory formation. Neurobiology of Learning and Memory. 105: 107-16. PMID 23623827 DOI: 10.1016/J.Nlm.2013.03.009  0.873
2012 Jarome TJ, Kwapis JL, Werner CT, Parsons RG, Gafford GM, Helmstetter FJ. The timing of multiple retrieval events can alter GluR1 phosphorylation and the requirement for protein synthesis in fear memory reconsolidation. Learning & Memory (Cold Spring Harbor, N.Y.). 19: 300-6. PMID 22723052 DOI: 10.1101/Lm.024901.111  0.87
2012 Kwapis JL, Jarome TJ, Gilmartin MR, Helmstetter FJ. Intra-amygdala infusion of the protein kinase Mzeta inhibitor ZIP disrupts foreground context fear memory. Neurobiology of Learning and Memory. 98: 148-53. PMID 22659643 DOI: 10.1016/J.Nlm.2012.05.003  0.861
2011 Kwapis JL, Jarome TJ, Schiff JC, Helmstetter FJ. Memory consolidation in both trace and delay fear conditioning is disrupted by intra-amygdala infusion of the protein synthesis inhibitor anisomycin. Learning & Memory (Cold Spring Harbor, N.Y.). 18: 728-32. PMID 22028394 DOI: 10.1101/Lm.023945.111  0.864
2011 Jarome TJ, Werner CT, Kwapis JL, Helmstetter FJ. Activity dependent protein degradation is critical for the formation and stability of fear memory in the amygdala. Plos One. 6: e24349. PMID 21961035 DOI: 10.1371/Journal.Pone.0024349  0.883
2010 Lonergan ME, Gafford GM, Jarome TJ, Helmstetter FJ. Time-dependent expression of Arc and zif268 after acquisition of fear conditioning. Neural Plasticity. 2010: 139891. PMID 20592749 DOI: 10.1155/2010/139891  0.85
2010 Jarome TJ, Kwapis JL, Nye SH, Helmstetter FJ. Introgression of Brown Norway chromosome 1 onto the fawn hooded hypertensive background rescues long-term fear memory deficits. Behavior Genetics. 40: 85-92. PMID 19757016 DOI: 10.1007/s10519-009-9297-5  0.843
2009 Lee T, Jarome T, Li SJ, Kim JJ, Helmstetter FJ. Chronic stress selectively reduces hippocampal volume in rats: a longitudinal magnetic resonance imaging study. Neuroreport. 20: 1554-8. PMID 19858767 DOI: 10.1097/Wnr.0B013E328332Bb09  0.76
2009 Kwapis JL, Jarome TJ, Lonergan ME, Helmstetter FJ. Protein kinase Mzeta maintains fear memory in the amygdala but not in the hippocampus. Behavioral Neuroscience. 123: 844-50. PMID 19634944 DOI: 10.1037/A0016343  0.878
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