Chad A. Dickey - Publications

University of South Florida, Tampa, FL, United States 
Alzheimer's disease

111 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Webster JM, Darling AL, Sanders TA, Blazier DM, Vidal-Aguiar Y, Beaulieu-Abdelahad D, Plemmons DG, Hill SE, Uversky VN, Bickford PC, Dickey CA, Blair LJ. Hsp22 with an N-Terminal Domain Truncation Mediates a Reduction in Tau Protein Levels. International Journal of Molecular Sciences. 21. PMID 32751642 DOI: 10.3390/ijms21155442  0.52
2019 Hill SE, Kwon MS, Martin MD, Suntharalingam A, Hazel A, Dickey CA, Gumbart JC, Lieberman RL. Stable calcium-free myocilin olfactomedin domain variants reveal challenges in differentiating between benign and glaucoma-causing mutations. The Journal of Biological Chemistry. PMID 31270212 DOI: 10.1074/jbc.RA119.009419  0.4
2019 Sandusky-Beltran LA, Kovalenko A, Ma C, Calahatian JIT, Placides DS, Watler MD, Hunt JB, Darling AL, Baker JD, Blair LJ, Martin MD, Fontaine SN, Dickey CA, Lussier AL, Weeber EJ, et al. Spermidine/spermine-N-acetyltransferase ablation impacts tauopathy-induced polyamine stress response. Alzheimer's Research & Therapy. 11: 58. PMID 31253191 DOI: 10.1186/s13195-019-0507-y  0.56
2019 Criado-Marrero M, Gebru NT, Gould LA, Smith TM, Kim S, Blackburn RJ, Dickey CA, Blair LJ. Early Life Stress and High FKBP5 Interact to Increase Anxiety-Like Symptoms through Altered AKT Signaling in the Dorsal Hippocampus. International Journal of Molecular Sciences. 20. PMID 31167373 DOI: 10.3390/ijms20112738  0.52
2019 Blair LJ, Criado-Marrero M, Zheng D, Wang X, Kamath S, Nordhues BA, Weeber EJ, Dickey CA. The Disease-Associated Chaperone FKBP51 Impairs Cognitive Function by Accelerating AMPA Receptor Recycling. Eneuro. 6. PMID 30963102 DOI: 10.1523/ENEURO.0242-18.2019  0.52
2019 Darling AL, Breydo L, Rivas EG, Gebru NT, Zheng D, Baker JD, Blair LJ, Dickey CA, Koren J, Uversky VN. Repeated repeat problems: Combinatorial effect of C9orf72-derived dipeptide repeat proteins. International Journal of Biological Macromolecules. PMID 30639592 DOI: 10.1016/j.ijbiomac.2019.01.035  1
2018 Oroz J, Chang BJ, Wysoczanski P, Lee CT, Pérez-Lara Á, Chakraborty P, Hofele RV, Baker JD, Blair LJ, Biernat J, Urlaub H, Mandelkow E, Dickey CA, Zweckstetter M. Structure and pro-toxic mechanism of the human Hsp90/PPIase/Tau complex. Nature Communications. 9: 4532. PMID 30382094 DOI: 10.1038/s41467-018-06880-0  0.52
2018 Sabbagh JJ, Cordova RA, Zheng D, Criado-Marrero M, Lemus A, Li P, Baker JD, Nordhues BA, Darling AL, Martinez-Licha C, Rutz DA, Patel S, Buchner J, Leahy JW, Koren J, ... Dickey CA, et al. Targeting the FKBP51/GR/Hsp90 complex to identify functionally relevant treatments for depression and PTSD. Acs Chemical Biology. PMID 29893552 DOI: 10.1021/acschembio.8b00454  1
2018 Mok SA, Condello C, Freilich R, Gillies A, Arhar T, Oroz J, Kadavath H, Julien O, Assimon VA, Rauch JN, Dunyak BM, Lee J, Tsai FTF, Wilson MR, Zweckstetter M, ... Dickey CA, et al. Mapping interactions with the chaperone network reveals factors that protect against tau aggregation. Nature Structural & Molecular Biology. 25: 384-393. PMID 29728653 DOI: 10.1038/s41594-018-0057-1  0.64
2018 Huard DJ, Crowley VM, Du Y, Cordova RA, Sun Z, Tomlin MO, Dickey CA, Koren J, Blair L, Fu H, Blagg BSJ, Lieberman RL. Trifunctional high-throughput screen identifies promising scaffold to inhibit Grp94 and treat myocilin-associated glaucoma. Acs Chemical Biology. PMID 29402077 DOI: 10.1021/acschembio.7b01083  1
2017 Stothert AR, Suntharalingam A, Tang X, Crowley VM, Mishra SJ, Webster JM, Nordhues BA, Huard DJE, Passaglia CL, Lieberman RL, Blagg BSJ, Blair LJ, Koren J, Dickey CA. Isoform-selective Hsp90 inhibition rescues model of hereditary open-angle glaucoma. Scientific Reports. 7: 17951. PMID 29263415 DOI: 10.1038/s41598-017-18344-4  1
2017 Shelton LB, Baker JD, Zheng D, Sullivan LE, Solanki PK, Webster JM, Sun Z, Sabbagh JJ, Nordhues BA, Koren J, Ghosh S, Blagg BSJ, Blair LJ, Dickey CA. Hsp90 activator Aha1 drives production of pathological tau aggregates. Proceedings of the National Academy of Sciences of the United States of America. PMID 28827321 DOI: 10.1073/pnas.1707039114  1
2017 Baker JD, Shelton LB, Zheng D, Favretto F, Nordhues BA, Darling A, Sullivan LE, Sun Z, Solanki PK, Martin MD, Suntharalingam A, Sabbagh JJ, Becker S, Mandelkow E, Uversky VN, ... ... Dickey CA, et al. Human cyclophilin 40 unravels neurotoxic amyloids. Plos Biology. 15: e2001336. PMID 28654636 DOI: 10.1371/journal.pbio.2001336  1
2016 Young ZT, Rauch JN, Assimon VA, Jinwal UK, Ahn M, Li X, Dunyak BM, Ahmad A, Carlson GA, Srinivasan SR, Zuiderweg ER, Dickey CA, Gestwicki JE. Stabilizing the Hsp70-Tau Complex Promotes Turnover in Models of Tauopathy. Cell Chemical Biology. PMID 27499529 DOI: 10.1016/j.chembiol.2016.04.014  1
2016 Ouimet CM, Shao H, Rauch JN, Dawod M, Nordhues BA, Dickey CA, Gestwicki JE, Kennedy RT. Protein Cross-linking Capillary Electrophoresis (PXCE) for Protein-Protein Interaction Analysis. Analytical Chemistry. PMID 27434096 DOI: 10.1021/acs.analchem.6b02126  0.64
2016 Zheng D, Sabbagh JJ, Blair LJ, Darling AL, Wen X, Dickey CA. MicroRNA-511 binds to FKBP5 mRNA, which encodes a chaperone protein, and regulates neuronal differentiation. The Journal of Biological Chemistry. PMID 27334923 DOI: 10.1074/jbc.M116.727941  1
2016 Fontaine SN, Zheng D, Sabbagh JJ, Martin MD, Chaput D, Darling A, Trotter JH, Stothert AR, Nordhues BA, Lussier A, Baker J, Shelton L, Kahn M, Blair LJ, Stevens SM, ... Dickey CA, et al. DnaJ/Hsc70 chaperone complexes control the extracellular release of neurodegenerative-associated proteins. The Embo Journal. PMID 27261198 DOI: 10.15252/embj.201593489  1
2016 Martin MD, Baker JD, Suntharalingam A, Nordhues BA, Shelton LB, Zheng D, Sabbagh JJ, Haystead TA, Gestwicki JE, Dickey CA. Inhibition of Both Hsp70 Activity and Tau Aggregation In Vitro Best Predicts Tau Lowering Activity of Small Molecules. Acs Chemical Biology. PMID 27177119 DOI: 10.1021/acschembio.6b00223  1
2016 Fontaine SN, Martin MD, Dickey CA. Neurodegeneration and the Heat Shock Protein 70 Machinery: Implications for Therapeutic Development. Current Topics in Medicinal Chemistry. PMID 27072702  0.4
2016 Crowley VM, Khandelwal A, Mishra S, Stothert AR, Huard DJ, Zhao J, Muth A, Duerfeldt AS, Kizziah JL, Lieberman RL, Dickey CA, Blagg BS. Development of Glucose Regulated Protein 94-Selective Inhibitors based on the BnIm and Radamide Scaffold. Journal of Medicinal Chemistry. PMID 27003516 DOI: 10.1021/acs.jmedchem.6b00085  1
2016 Zhang YJ, Gendron TF, Grima JC, Sasaguri H, Jansen-West K, Xu YF, Katzman RB, Gass J, Murray ME, Shinohara M, Lin WL, Garrett A, Stankowski JN, Daughrity L, Tong J, ... ... Dickey CA, et al. C9ORF72 poly(GA) aggregates sequester and impair HR23 and nucleocytoplasmic transport proteins. Nature Neuroscience. PMID 26998601 DOI: 10.1038/nn.4272  1
2016 Sabbagh JJ, Dickey CA. The Metamorphic Nature of the Tau Protein: Dynamic Flexibility Comes at a Cost. Frontiers in Neuroscience. 10: 3. PMID 26834532 DOI: 10.3389/fnins.2016.00003  1
2016 Sabbagh JJ, Fontaine SN, Shelton LB, Blair LJ, Hunt JB, Zhang B, Lee DC, Lloyd JD, Dickey CA. Non-contact rotational head injury produces transient cognitive deficits but lasting neuropathological changes. Journal of Neurotrauma. PMID 26739819 DOI: 10.1089/neu.2015.4288  0.52
2015 Hunt JB, Nash KR, Placides D, Moran P, Selenica ML, Abuqalbeen F, Ratnasamy K, Slouha N, Rodriguez-Ospina S, Savlia M, Ranaweera Y, Reid P, Dickey CA, Uricia R, Yang CG, et al. Sustained Arginase 1 Expression Modulates Pathological Tau Deposits in a Mouse Model of Tauopathy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 14842-60. PMID 26538654 DOI: 10.1523/JNEUROSCI.3959-14.2015  0.56
2015 Lindberg I, Shorter J, Wiseman RL, Chiti F, Dickey CA, McLean PJ. Chaperones in Neurodegeneration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 13853-9. PMID 26468185 DOI: 10.1523/JNEUROSCI.2600-15.2015  1
2015 Stothert AR, Fontaine SN, Sabbagh JJ, Dickey CA. Targeting the ER-autophagy system in the trabecular meshwork to treat glaucoma. Experimental Eye Research. PMID 26302411 DOI: 10.1016/j.exer.2015.08.017  1
2015 Fontaine SN, Martin MD, Akoury E, Assimon VA, Borysov S, Nordhues BA, Sabbagh JJ, Cockman M, Gestwicki JE, Zweckstetter M, Dickey CA. The active Hsc70/tau complex can be exploited to enhance tau turnover without damaging microtubule dynamics. Human Molecular Genetics. 24: 3971-81. PMID 25882706 DOI: 10.1093/hmg/ddv135  1
2015 Fontaine SN, Rauch JN, Nordhues BA, Assimon VA, Stothert AR, Jinwal UK, Sabbagh JJ, Chang L, Stevens SM, Zuiderweg ER, Gestwicki JE, Dickey CA. Isoform-selective Genetic Inhibition of Constitutive Cytosolic Hsp70 Activity Promotes Client Tau Degradation Using an Altered Co-chaperone Complement. The Journal of Biological Chemistry. 290: 13115-27. PMID 25864199 DOI: 10.1074/jbc.M115.637595  1
2015 Blair LJ, Frauen HD, Zhang B, Nordhues BA, Bijan S, Lin YC, Zamudio F, Hernandez LD, Sabbagh JJ, Selenica ML, Dickey CA. Tau depletion prevents progressive blood-brain barrier damage in a mouse model of tauopathy. Acta Neuropathologica Communications. 3: 8. PMID 25775028 DOI: 10.1186/s40478-015-0186-2  0.52
2015 Fontaine SN, Sabbagh JJ, Baker J, Martinez-Licha CR, Darling A, Dickey CA. Cellular factors modulating the mechanism of tau protein aggregation. Cellular and Molecular Life Sciences : Cmls. 72: 1863-79. PMID 25666877 DOI: 10.1007/s00018-015-1839-9  1
2015 Blair LJ, Baker JD, Sabbagh JJ, Dickey CA. The emerging role of peptidyl-prolyl isomerase chaperones in tau oligomerization, amyloid processing, and Alzheimer's disease. Journal of Neurochemistry. 133: 1-13. PMID 25628064 DOI: 10.1111/jnc.13033  1
2015 Martin MD, Calcul L, Smith C, Jinwal UK, Fontaine SN, Darling A, Seeley K, Wojtas L, Narayan M, Gestwicki JE, Smith GR, Reitz AB, Baker BJ, Dickey CA. Synthesis, stereochemical analysis, and derivatization of myricanol provide new probes that promote autophagic tau clearance. Acs Chemical Biology. 10: 1099-109. PMID 25588114 DOI: 10.1021/cb501013w  1
2014 Sabbagh JJ, O'Leary JC, Blair LJ, Klengel T, Nordhues BA, Fontaine SN, Binder EB, Dickey CA. Age-associated epigenetic upregulation of the FKBP5 gene selectively impairs stress resiliency. Plos One. 9: e107241. PMID 25191701 DOI: 10.1371/journal.pone.0107241  1
2014 Selenica ML, Davtyan H, Housley SB, Blair LJ, Gillies A, Nordhues BA, Zhang B, Liu J, Gestwicki JE, Lee DC, Gordon MN, Morgan D, Dickey CA. Epitope analysis following active immunization with tau proteins reveals immunogens implicated in tau pathogenesis. Journal of Neuroinflammation. 11: 152. PMID 25183004 DOI: 10.1186/s12974-014-0152-0  1
2014 Blair LJ, Sabbagh JJ, Dickey CA. Targeting Hsp90 and its co-chaperones to treat Alzheimer's disease. Expert Opinion On Therapeutic Targets. 18: 1219-32. PMID 25069659 DOI: 10.1517/14728222.2014.943185  1
2014 Stothert AR, Suntharalingam A, Huard DJ, Fontaine SN, Crowley VM, Mishra S, Blagg BS, Lieberman RL, Dickey CA. Exploiting the interaction between Grp94 and aggregated myocilin to treat glaucoma. Human Molecular Genetics. 23: 6470-80. PMID 25027323 DOI: 10.1093/hmg/ddu367  0.44
2014 Karagöz GE, Duarte AM, Akoury E, Ippel H, Biernat J, Morán Luengo T, Radli M, Didenko T, Nordhues BA, Veprintsev DB, Dickey CA, Mandelkow E, Zweckstetter M, Boelens R, Madl T, et al. Hsp90-Tau complex reveals molecular basis for specificity in chaperone action. Cell. 156: 963-74. PMID 24581495 DOI: 10.1016/j.cell.2014.01.037  1
2014 Orwig SD, Chi PV, Du Y, Hill SE, Cavitt MA, Suntharalingam A, Turnage KC, Dickey CA, France S, Fu H, Lieberman RL. Ligands for glaucoma-associated myocilin discovered by a generic binding assay. Acs Chemical Biology. 9: 517-25. PMID 24279319 DOI: 10.1021/cb4007776  1
2013 Blair LJ, Zhang B, Dickey CA. Potential synergy between tau aggregation inhibitors and tau chaperone modulators. Alzheimer's Research & Therapy. 5: 41. PMID 24041111 DOI: 10.1186/alzrt207  1
2013 O'Leary JC, Zhang B, Koren J, Blair L, Dickey CA. The role of FKBP5 in mood disorders: action of FKBP5 on steroid hormone receptors leads to questions about its evolutionary importance. Cns & Neurological Disorders Drug Targets. 12: 1157-62. PMID 24040820  1
2013 Blair LJ, Nordhues BA, Hill SE, Scaglione KM, O'Leary JC, Fontaine SN, Breydo L, Zhang B, Li P, Wang L, Cotman C, Paulson HL, Muschol M, Uversky VN, Klengel T, ... ... Dickey CA, et al. Accelerated neurodegeneration through chaperone-mediated oligomerization of tau. The Journal of Clinical Investigation. 123: 4158-69. PMID 23999428 DOI: 10.1172/JCI69003  1
2013 Smith MC, Scaglione KM, Assimon VA, Patury S, Thompson AD, Dickey CA, Southworth DR, Paulson HL, Gestwicki JE, Zuiderweg ER. The E3 ubiquitin ligase CHIP and the molecular chaperone Hsc70 form a dynamic, tethered complex. Biochemistry. 52: 5354-64. PMID 23865999 DOI: 10.1021/bi4009209  1
2013 Jinwal UK, Koren J, Dickey CA. Reconstructing the Hsp90/Tau Machine. Current Enzyme Inhibition. 9: 41-45. PMID 23798910 DOI: 10.2174/1573408011309010006  1
2013 Abisambra JF, Jinwal UK, Blair LJ, O'Leary JC, Li Q, Brady S, Wang L, Guidi CE, Zhang B, Nordhues BA, Cockman M, Suntharalingham A, Li P, Jin Y, Atkins CA, ... Dickey CA, et al. Tau accumulation activates the unfolded protein response by impairing endoplasmic reticulum-associated degradation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 9498-507. PMID 23719816 DOI: 10.1523/JNEUROSCI.5397-12.2013  1
2013 Abisambra J, Jinwal UK, Miyata Y, Rogers J, Blair L, Li X, Seguin SP, Wang L, Jin Y, Bacon J, Brady S, Cockman M, Guidi C, Zhang J, Koren J, ... ... Dickey CA, et al. Allosteric heat shock protein 70 inhibitors rapidly rescue synaptic plasticity deficits by reducing aberrant tau. Biological Psychiatry. 74: 367-74. PMID 23607970 DOI: 10.1016/j.biopsych.2013.02.027  1
2013 Lee DC, Ruiz CR, Lebson L, Selenica ML, Rizer J, Hunt JB, Rojiani R, Reid P, Kammath S, Nash K, Dickey CA, Gordon M, Morgan D. Aging enhances classical activation but mitigates alternative activation in the central nervous system. Neurobiology of Aging. 34: 1610-20. PMID 23481567 DOI: 10.1016/j.neurobiolaging.2012.12.014  1
2013 Miyata Y, Li X, Lee HF, Jinwal UK, Srinivasan SR, Seguin SP, Young ZT, Brodsky JL, Dickey CA, Sun D, Gestwicki JE. Synthesis and initial evaluation of YM-08, a blood-brain barrier permeable derivative of the heat shock protein 70 (Hsp70) inhibitor MKT-077, which reduces tau levels. Acs Chemical Neuroscience. 4: 930-9. PMID 23472668 DOI: 10.1021/cn300210g  1
2013 Braswell K, Dickey CA, Jinwal UK. A commentary on: Modulating molecular chaperones improves sensory fiber recovery and mitochondrial function in diabetic peripheral neuropathy. Experimental Neurology. 241: 122-4. PMID 23298520 DOI: 10.1016/j.expneurol.2012.12.016  1
2013 Chiosis G, Dickey CA, Johnson JL. A global view of Hsp90 functions. Nature Structural & Molecular Biology. 20: 1-4. PMID 23288357 DOI: 10.1038/nsmb.2481  1
2013 Jinwal UK, Akoury E, Abisambra JF, O'Leary JC, Thompson AD, Blair LJ, Jin Y, Bacon J, Nordhues BA, Cockman M, Zhang J, Li P, Zhang B, Borysov S, Uversky VN, ... ... Dickey CA, et al. Imbalance of Hsp70 family variants fosters tau accumulation. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 27: 1450-9. PMID 23271055 DOI: 10.1096/fj.12-220889  1
2013 Selenica ML, Brownlow M, Jimenez JP, Lee DC, Pena G, Dickey CA, Gordon MN, Morgan D. Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy. Neuro-Degenerative Diseases. 11: 165-81. PMID 22796753 DOI: 10.1159/000337230  1
2012 Miyata Y, Rauch JN, Jinwal UK, Thompson AD, Srinivasan S, Dickey CA, Gestwicki JE. Cysteine reactivity distinguishes redox sensing by the heat-inducible and constitutive forms of heat shock protein 70. Chemistry & Biology. 19: 1391-9. PMID 23177194 DOI: 10.1016/j.chembiol.2012.07.026  1
2012 Suntharalingam A, Abisambra JF, O'Leary JC, Koren J, Zhang B, Joe MK, Blair LJ, Hill SE, Jinwal UK, Cockman M, Duerfeldt AS, Tomarev S, Blagg BS, Lieberman RL, Dickey CA. Glucose-regulated protein 94 triage of mutant myocilin through endoplasmic reticulum-associated degradation subverts a more efficient autophagic clearance mechanism. The Journal of Biological Chemistry. 287: 40661-9. PMID 23035116 DOI: 10.1074/jbc.M112.384800  1
2012 Calcul L, Zhang B, Jinwal UK, Dickey CA, Baker BJ. Natural products as a rich source of tau-targeting drugs for Alzheimer's disease. Future Medicinal Chemistry. 4: 1751-61. PMID 22924511 DOI: 10.4155/fmc.12.124  1
2012 Thompson AD, Scaglione KM, Prensner J, Gillies AT, Chinnaiyan A, Paulson HL, Jinwal UK, Dickey CA, Gestwicki JE. Analysis of the tau-associated proteome reveals that exchange of Hsp70 for Hsp90 is involved in tau degradation. Acs Chemical Biology. 7: 1677-86. PMID 22769591 DOI: 10.1021/cb3002599  1
2012 Jinwal UK, Abisambra JF, Zhang J, Dharia S, O'Leary JC, Patel T, Braswell K, Jani T, Gestwicki JE, Dickey CA. Cdc37/Hsp90 protein complex disruption triggers an autophagic clearance cascade for TDP-43 protein. The Journal of Biological Chemistry. 287: 24814-20. PMID 22674575 DOI: 10.1074/jbc.M112.367268  1
2012 Koren J, Miyata Y, Kiray J, O'Leary JC, Nguyen L, Guo J, Blair LJ, Li X, Li X, Jinwal UK, Cheng JQ, Gestwicki JE, Dickey CA. Rhodacyanine derivative selectively targets cancer cells and overcomes tamoxifen resistance. Plos One. 7: e35566. PMID 22563386 DOI: 10.1371/journal.pone.0035566  1
2012 Congdon EE, Wu JW, Myeku N, Figueroa YH, Herman M, Marinec PS, Gestwicki JE, Dickey CA, Yu WH, Duff KE. Methylthioninium chloride (methylene blue) induces autophagy and attenuates tauopathy in vitro and in vivo. Autophagy. 8: 609-22. PMID 22361619 DOI: 10.4161/auto.19048  1
2012 Abisambra JF, Jinwal UK, Suntharalingam A, Arulselvam K, Brady S, Cockman M, Jin Y, Zhang B, Dickey CA. DnaJA1 antagonizes constitutive Hsp70-mediated stabilization of tau. Journal of Molecular Biology. 421: 653-61. PMID 22343013 DOI: 10.1016/j.jmb.2012.02.003  1
2011 Abisambra JF, Jinwal UK, Jones JR, Blair LJ, Koren J, Dickey CA. Exploiting the diversity of the heat-shock protein family for primary and secondary tauopathy therapeutics. Current Neuropharmacology. 9: 623-31. PMID 22654720 DOI: 10.2174/157015911798376226  1
2011 Daily JL, Nash K, Jinwal U, Golde T, Rogers J, Peters MM, Burdine RD, Dickey C, Banko JL, Weeber EJ. Adeno-associated virus-mediated rescue of the cognitive defects in a mouse model for Angelman syndrome. Plos One. 6: e27221. PMID 22174738 DOI: 10.1371/journal.pone.0027221  1
2011 Trotter JH, Klein M, Jinwal UK, Abisambra JF, Dickey CA, Tharkur J, Masiulis I, Ding J, Locke KG, Rickman CB, Birch DG, Weeber EJ, Herz J. ApoER2 function in the establishment and maintenance of retinal synaptic connectivity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 14413-23. PMID 21976526 DOI: 10.1523/JNEUROSCI.3135-11.2011  1
2011 Voss K, Koren J, Dickey CA. The earliest tau dysfunction in Alzheimer's disease? Tau phosphorylated at s422 as a toxic seed. The American Journal of Pathology. 179: 2148-51. PMID 21964186 DOI: 10.1016/j.ajpath.2011.08.020  1
2011 O'Leary JC, Dharia S, Blair LJ, Brady S, Johnson AG, Peters M, Cheung-Flynn J, Cox MB, de Erausquin G, Weeber EJ, Jinwal UK, Dickey CA. A new anti-depressive strategy for the elderly: ablation of FKBP5/FKBP51. Plos One. 6: e24840. PMID 21935478 DOI: 10.1371/journal.pone.0024840  1
2011 Storer CL, Dickey CA, Galigniana MD, Rein T, Cox MB. FKBP51 and FKBP52 in signaling and disease. Trends in Endocrinology and Metabolism: Tem. 22: 481-90. PMID 21889356 DOI: 10.1016/j.tem.2011.08.001  1
2011 Miyata Y, Koren J, Kiray J, Dickey CA, Gestwicki JE. Molecular chaperones and regulation of tau quality control: strategies for drug discovery in tauopathies. Future Medicinal Chemistry. 3: 1523-37. PMID 21882945 DOI: 10.4155/fmc.11.88  1
2011 Rousaki A, Miyata Y, Jinwal UK, Dickey CA, Gestwicki JE, Zuiderweg ER. Allosteric drugs: the interaction of antitumor compound MKT-077 with human Hsp70 chaperones. Journal of Molecular Biology. 411: 614-32. PMID 21708173 DOI: 10.1016/j.jmb.2011.06.003  1
2011 O'Leary JC, Koren J, Dickey CA. Neuronal life span versus health span: principles of natural selection at work in the degenerating brain. Journal of Molecular Neuroscience : Mn. 45: 467-72. PMID 21559875 DOI: 10.1007/s12031-011-9540-4  1
2011 Koren J, Jinwal UK, Davey Z, Kiray J, Arulselvam K, Dickey CA. Bending tau into shape: the emerging role of peptidyl-prolyl isomerases in tauopathies. Molecular Neurobiology. 44: 65-70. PMID 21523562 DOI: 10.1007/s12035-011-8182-4  1
2011 Jinwal UK, Trotter JH, Abisambra JF, Koren J, Lawson LY, Vestal GD, O'Leary JC, Johnson AG, Jin Y, Jones JR, Li Q, Weeber EJ, Dickey CA. The Hsp90 kinase co-chaperone Cdc37 regulates tau stability and phosphorylation dynamics. The Journal of Biological Chemistry. 286: 16976-83. PMID 21367866 DOI: 10.1074/jbc.M110.182493  1
2011 Jones JR, Lebar MD, Jinwal UK, Abisambra JF, Koren J, Blair L, O'Leary JC, Davey Z, Trotter J, Johnson AG, Weeber E, Eckman CB, Baker BJ, Dickey CA. The diarylheptanoid (+)-aR,11S-myricanol and two flavones from bayberry (Myrica cerifera) destabilize the microtubule-associated protein tau. Journal of Natural Products. 74: 38-44. PMID 21141876 DOI: 10.1021/np100572z  1
2011 Evans CG, Jinwal UK, Makley LN, Dickey CA, Gestwicki JE. Identification of dihydropyridines that reduce cellular tau levels. Chemical Communications (Cambridge, England). 47: 529-31. PMID 21082080 DOI: 10.1039/c0cc02253e  1
2011 Jinwal UK, Dickey CA. Cell-based assays for regulators of tau biology. Methods in Molecular Biology (Clifton, N.J.). 670: 93-108. PMID 20967586 DOI: 10.1007/978-1-60761-744-0_8  1
2010 Abisambra JF, Blair LJ, Hill SE, Jones JR, Kraft C, Rogers J, Koren J, Jinwal UK, Lawson L, Johnson AG, Wilcock D, O'Leary JC, Jansen-West K, Muschol M, Golde TE, ... ... Dickey CA, et al. Phosphorylation dynamics regulate Hsp27-mediated rescue of neuronal plasticity deficits in tau transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 15374-82. PMID 21084594 DOI: 10.1523/JNEUROSCI.3155-10.2010  1
2010 O'Leary JC, Li Q, Marinec P, Blair LJ, Congdon EE, Johnson AG, Jinwal UK, Koren J, Jones JR, Kraft C, Peters M, Abisambra JF, Duff KE, Weeber EJ, Gestwicki JE, ... Dickey CA, et al. Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden. Molecular Neurodegeneration. 5: 45. PMID 21040568 DOI: 10.1186/1750-1326-5-45  1
2010 Carty N, Lee D, Dickey C, Ceballos-Diaz C, Jansen-West K, Golde TE, Gordon MN, Morgan D, Nash K. Convection-enhanced delivery and systemic mannitol increase gene product distribution of AAV vectors 5, 8, and 9 and increase gene product in the adult mouse brain. Journal of Neuroscience Methods. 194: 144-53. PMID 20951738 DOI: 10.1016/j.jneumeth.2010.10.010  1
2010 Lee DC, Rizer J, Selenica ML, Reid P, Kraft C, Johnson A, Blair L, Gordon MN, Dickey CA, Morgan D. LPS- induced inflammation exacerbates phospho-tau pathology in rTg4510 mice. Journal of Neuroinflammation. 7: 56. PMID 20846376 DOI: 10.1186/1742-2094-7-56  1
2010 Lebson L, Nash K, Kamath S, Herber D, Carty N, Lee DC, Li Q, Szekeres K, Jinwal U, Koren J, Dickey CA, Gottschall PE, Morgan D, Gordon MN. Trafficking CD11b-positive blood cells deliver therapeutic genes to the brain of amyloid-depositing transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 9651-8. PMID 20660248 DOI: 10.1523/JNEUROSCI.0329-10.2010  1
2010 Jinwal UK, Koren J, O'Leary JC, Jones JR, Abisambra JF, Dickey CA. Hsp70 ATPase Modulators as Therapeutics for Alzheimer's and other Neurodegenerative Diseases. Molecular and Cellular Pharmacology. 2: 43-46. PMID 20523917 DOI: 10.4255/mcpharmacol.10.06  1
2010 Jinwal UK, O'Leary JC, Borysov SI, Jones JR, Li Q, Koren J, Abisambra JF, Vestal GD, Lawson LY, Johnson AG, Blair LJ, Jin Y, Miyata Y, Gestwicki JE, Dickey CA. Hsc70 rapidly engages tau after microtubule destabilization. The Journal of Biological Chemistry. 285: 16798-805. PMID 20308058 DOI: 10.1074/jbc.M110.113753  1
2010 Jinwal UK, Koren J, Borysov SI, Schmid AB, Abisambra JF, Blair LJ, Johnson AG, Jones JR, Shults CL, O'Leary JC, Jin Y, Buchner J, Cox MB, Dickey CA. The Hsp90 cochaperone, FKBP51, increases Tau stability and polymerizes microtubules. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 591-9. PMID 20071522 DOI: 10.1523/JNEUROSCI.4815-09.2010  1
2010 Azorsa DO, Robeson RH, Frost D, Meec hoovet B, Brautigam GR, Dickey C, Beaudry C, Basu GD, Holz DR, Hernandez JA, Bisanz KM, Gwinn L, Grover A, Rogers J, Reiman EM, et al. High-content siRNA screening of the kinome identifies kinases involved in Alzheimer's disease-related tau hyperphosphorylation. Bmc Genomics. 11: 25. PMID 20067632 DOI: 10.1186/1471-2164-11-25  1
2010 Koren J, Jinwal UK, Jin Y, O'Leary J, Jones JR, Johnson AG, Blair LJ, Abisambra JF, Chang L, Miyata Y, Cheng AM, Guo J, Cheng JQ, Gestwicki JE, Dickey CA. Facilitating Akt clearance via manipulation of Hsp70 activity and levels. The Journal of Biological Chemistry. 285: 2498-505. PMID 19889640 DOI: 10.1074/jbc.M109.057208  1
2009 Jinwal UK, Miyata Y, Koren J, Jones JR, Trotter JH, Chang L, O'Leary J, Morgan D, Lee DC, Shults CL, Rousaki A, Weeber EJ, Zuiderweg ER, Gestwicki JE, Dickey CA. Chemical manipulation of hsp70 ATPase activity regulates tau stability. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 12079-88. PMID 19793966 DOI: 10.1523/JNEUROSCI.3345-09.2009  1
2009 Koren J, Jinwal UK, Lee DC, Jones JR, Shults CL, Johnson AG, Anderson LJ, Dickey CA. Chaperone signalling complexes in Alzheimer's disease. Journal of Cellular and Molecular Medicine. 13: 619-30. PMID 19449461 DOI: 10.1111/j.1582-4934.2008.00557.x  1
2009 Dickey C, Kraft C, Jinwal U, Koren J, Johnson A, Anderson L, Lebson L, Lee D, Dickson D, de Silva R, Binder LI, Morgan D, Lewis J. Aging analysis reveals slowed tau turnover and enhanced stress response in a mouse model of tauopathy. The American Journal of Pathology. 174: 228-38. PMID 19074615 DOI: 10.2353/ajpath.2009.080764  1
2008 Dickey CA, Koren J, Zhang YJ, Xu YF, Jinwal UK, Birnbaum MJ, Monks B, Sun M, Cheng JQ, Patterson C, Bailey RM, Dunmore J, Soresh S, Leon C, Morgan D, et al. Akt and CHIP coregulate tau degradation through coordinated interactions. Proceedings of the National Academy of Sciences of the United States of America. 105: 3622-7. PMID 18292230 DOI: 10.1073/pnas.0709180105  1
2007 Dickey CA, Petrucelli L. Commentary on "Cytoskeletal modulators and pleiotropic strategies for Alzheimer drug discovery." The last stand: the dichotomy of chaperone function in Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 3: 3-6. PMID 19595909 DOI: 10.1016/j.jalz.2006.09.001  1
2007 Zhang YJ, Xu YF, Dickey CA, Buratti E, Baralle F, Bailey R, Pickering-Brown S, Dickson D, Petrucelli L. Progranulin mediates caspase-dependent cleavage of TAR DNA binding protein-43. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 10530-4. PMID 17898224 DOI: 10.1523/JNEUROSCI.3421-07.2007  1
2007 Dickey CA, Kamal A, Lundgren K, Klosak N, Bailey RM, Dunmore J, Ash P, Shoraka S, Zlatkovic J, Eckman CB, Patterson C, Dickson DW, Nahman NS, Hutton M, Burrows F, et al. The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins. The Journal of Clinical Investigation. 117: 648-58. PMID 17304350 DOI: 10.1172/JCI29715  1
2007 Dickey CA, Patterson C, Dickson D, Petrucelli L. Brain CHIP: removing the culprits in neurodegenerative disease. Trends in Molecular Medicine. 13: 32-8. PMID 17127096 DOI: 10.1016/j.molmed.2006.11.003  1
2007 Karlnoski R, Wilcock D, Dickey C, Ronan V, Gordon MN, Zhang W, Morgan D, Taglialatela G. Up-regulation of Bcl-2 in APP transgenic mice is associated with neuroprotection Neurobiology of Disease. 25: 179-188. PMID 17067805 DOI: 10.1016/j.nbd.2006.09.007  1
2006 Dickey CA, Petrucelli L. Current strategies for the treatment of Alzheimer's disease and other tauopathies. Expert Opinion On Therapeutic Targets. 10: 665-76. PMID 16981824 DOI: 10.1517/14728222.10.5.665  1
2006 Dickey CA, Ash P, Klosak N, Lee WC, Petrucelli L, Hutton M, Eckman CB. Pharmacologic reductions of total tau levels; implications for the role of microtubule dynamics in regulating tau expression. Molecular Neurodegeneration. 1: 6. PMID 16930453 DOI: 10.1186/1750-1326-1-6  1
2006 Baker M, Mackenzie IR, Pickering-Brown SM, Gass J, Rademakers R, Lindholm C, Snowden J, Adamson J, Sadovnick AD, Rollinson S, Cannon A, Dwosh E, Neary D, Melquist S, Richardson A, ... ... Dickey CA, et al. Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17. Nature. 442: 916-9. PMID 16862116 DOI: 10.1038/nature05016  1
2006 Dickey CA, Yue M, Lin WL, Dickson DW, Dunmore JH, Lee WC, Zehr C, West G, Cao S, Clark AM, Caldwell GA, Caldwell KA, Eckman C, Patterson C, Hutton M, et al. Deletion of the ubiquitin ligase CHIP leads to the accumulation, but not the aggregation, of both endogenous phospho- and caspase-3-cleaved tau species. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 6985-96. PMID 16807328 DOI: 10.1523/JNEUROSCI.0746-06.2006  1
2006 Lee WC, Tsoi YK, Dickey CA, Delucia MW, Dickson DW, Eckman CB. Suppression of galactosylceramidase (GALC) expression in the twitcher mouse model of globoid cell leukodystrophy (GLD) is caused by nonsense-mediated mRNA decay (NMD). Neurobiology of Disease. 23: 273-80. PMID 16759875 DOI: 10.1016/j.nbd.2006.03.005  1
2006 Dickey CA, Dunmore J, Lu B, Wang JW, Lee WC, Kamal A, Burrows F, Eckman C, Hutton M, Petrucelli L. HSP induction mediates selective clearance of tau phosphorylated at proline-directed Ser/Thr sites but not KXGS (MARK) sites. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 20: 753-5. PMID 16464956 DOI: 10.1096/fj.05-5343fje  1
2005 Lee WC, Courtenay A, Troendle FJ, Stallings-Mann ML, Dickey CA, DeLucia MW, Dickson DW, Eckman CB. Enzyme replacement therapy results in substantial improvements in early clinical phenotype in a mouse model of globoid cell leukodystrophy. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 19: 1549-51. PMID 15987783 DOI: 10.1096/fj.05-3826fje  1
2005 Dickey CA, Eriksen J, Kamal A, Burrows F, Kasibhatla S, Eckman CB, Hutton M, Petrucelli L. Development of a high throughput drug screening assay for the detection of changes in tau levels -- proof of concept with HSP90 inhibitors. Current Alzheimer Research. 2: 231-8. PMID 15974923 DOI: 10.2174/1567205053585927  1
2005 Dickey CA, Gordon MN, Wilcock DM, Herber DL, Freeman MJ, Morgan D. Dysregulation of Na+/K+ ATPase by amyloid in APP+PS1 transgenic mice. Bmc Neuroscience. 6: 7. PMID 15689237 DOI: 10.1186/1471-2202-6-7  1
2004 Dickey CA, De Mesquita DD, Morgan D, Pennypacker KR. Induction of memory-associated immediate early genes by nerve growth factor in rat primary cortical neurons and differentiated mouse Neuro2A cells. Neuroscience Letters. 366: 10-4. PMID 15265580 DOI: 10.1016/j.neulet.2004.04.089  1
2004 Garcia MF, Gordon MN, Hutton M, Lewis J, McGowan E, Dickey CA, Morgan D, Arendash GW. The retinal degeneration (rd) gene seriously impairs spatial cognitive performance in normal and Alzheimer's transgenic mice. Neuroreport. 15: 73-7. PMID 15106834 DOI: 10.1097/00001756-200401190-00015  1
2004 Dickey CA, Gordon MN, Mason JE, Wilson NJ, Diamond DM, Guzowski JF, Morgan D. Amyloid suppresses induction of genes critical for memory consolidation in APP + PS1 transgenic mice. Journal of Neurochemistry. 88: 434-42. PMID 14690531  1
2003 Dickey CA, Loring JF, Montgomery J, Gordon MN, Eastman PS, Morgan D. Selectively reduced expression of synaptic plasticity-related genes in amyloid precursor protein + presenilin-1 transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 5219-26. PMID 12832546  1
2003 Austin L, Arendash GW, Gordon MN, Diamond DM, DiCarlo G, Dickey C, Ugen K, Morgan D. Short-term beta-amyloid vaccinations do not improve cognitive performance in cognitively impaired APP + PS1 mice. Behavioral Neuroscience. 117: 478-84. PMID 12802876 DOI: 10.1037/0735-7044.117.3.478  1
2001 Wilcock DM, Gordon MN, Ugen KE, Gottschall PE, DiCarlo G, Dickey C, Boyett KW, Jantzen PT, Connor KE, Melachrino J, Hardy J, Morgan D. Number of Abeta inoculations in APP+PS1 transgenic mice influences antibody titers, microglial activation, and congophilic plaque levels. Dna and Cell Biology. 20: 731-6. PMID 11788051 DOI: 10.1089/10445490152717596  1
2001 Dickey CA, Morgan DG, Kudchodkar S, Weiner DB, Bai Y, Cao C, Gordon MN, Ugen KE. Duration and specificity of humoral immune responses in mice vaccinated with the Alzheimer's disease-associated beta-amyloid 1-42 peptide. Dna and Cell Biology. 20: 723-9. PMID 11788050 DOI: 10.1089/10445490152717587  1
2000 Morgan D, Diamond DM, Gottschall PE, Ugen KE, Dickey C, Hardy J, Duff K, Jantzen P, DiCarlo G, Wilcock D, Connor K, Hatcher J, Hope C, Gordon M, Arendash GW. A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease. Nature. 408: 982-5. PMID 11140686 DOI: 10.1038/35050116  1
2000 Dickey C, Ziegner U, Agadjanyan MG, Srikantan V, Refaeli Y, Prabhu A, Sato A, Williams WV, Weiner DB, Ugen KE. Murine monoclonal antibodies biologically active against the amino region of HIV-1 gp120: isolation and characterization. Dna and Cell Biology. 19: 243-52. PMID 10798448 DOI: 10.1089/104454900314519  1
2000 Viveros M, Dickey C, Cotropia JP, Gevorkian G, Larralde C, Broliden K, Levi M, Burgess A, Cao C, Weiner DB, Agadjanyan MG, Ugen KE. Characterization of a novel human immunodeficiency virus type 1 neutralizable epitope within the immunodominant region of gp41. Virology. 270: 135-45. PMID 10772986 DOI: 10.1006/viro.2000.0269  1
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