Elena Pasquale - Publications

Affiliations: 
The Burnham Institute, Taplow, England, United Kingdom 
Area:
Eph Receptors

33/226 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Stupack J, Xiong XP, Jiang LL, Zhang T, Zhou L, Campos A, Ranscht B, Mobley W, Pasquale EB, Xu H, Huang TY. Soluble SORLA enhances neurite outgrowth and regeneration through activation of the EGF Receptor/ERK signaling axis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 32601248 DOI: 10.1523/Jneurosci.0723-20.2020  0.581
2019 Pasquale EB. Eph receptors and ephrins engage in cellular cannibalism. The Journal of Cell Biology. 218: 3168-3170. PMID 31537710 DOI: 10.1083/jcb.201908074  0.345
2016 Pasquale EB. Exosomes expand the sphere of influence of Eph receptors and ephrins. The Journal of Cell Biology. PMID 27354377 DOI: 10.1083/jcb.201606074  0.323
2015 Barquilla A, Pasquale EB. Eph receptors and ephrins: therapeutic opportunities. Annual Review of Pharmacology and Toxicology. 55: 465-87. PMID 25292427 DOI: 10.1146/annurev-pharmtox-011112-140226  0.317
2013 Falivelli G, Lisabeth EM, Rubio de la Torre E, Perez-Tenorio G, Tosato G, Salvucci O, Pasquale EB. Attenuation of eph receptor kinase activation in cancer cells by coexpressed ephrin ligands. Plos One. 8: e81445. PMID 24348920 DOI: 10.1371/journal.pone.0081445  0.3
2013 Lisabeth EM, Falivelli G, Pasquale EB. Eph receptor signaling and ephrins. Cold Spring Harbor Perspectives in Biology. 5. PMID 24003208 DOI: 10.1101/cshperspect.a009159  0.348
2012 Noberini R, Koolpe M, Lamberto I, Pasquale EB. Inhibition of Eph receptor-ephrin ligand interaction by tea polyphenols. Pharmacological Research : the Official Journal of the Italian Pharmacological Society. 66: 363-73. PMID 22750215 DOI: 10.1016/j.phrs.2012.05.010  0.333
2012 Noberini R, Rubio de la Torre E, Pasquale EB. Profiling Eph receptor expression in cells and tissues: a targeted mass spectrometry approach. Cell Adhesion & Migration. 6: 102-12. PMID 22568954 DOI: 10.4161/cam.19620  0.325
2012 Noberini R, Lamberto I, Pasquale EB. Targeting Eph receptors with peptides and small molecules: progress and challenges. Seminars in Cell & Developmental Biology. 23: 51-7. PMID 22044885 DOI: 10.1016/j.semcdb.2011.10.023  0.321
2011 Noberini R, De SK, Zhang Z, Wu B, Raveendra-Panickar D, Chen V, Vazquez J, Qin H, Song J, Cosford ND, Pellecchia M, Pasquale EB. A disalicylic acid-furanyl derivative inhibits ephrin binding to a subset of Eph receptors. Chemical Biology & Drug Design. 78: 667-78. PMID 21791013 DOI: 10.1111/j.1747-0285.2011.01199.x  0.32
2009 Pasquale EB. Journal club. A biologist is gratified to find reconciliation for a conflicted receptor. Nature. 461: 149. PMID 19741666 DOI: 10.1038/461149e  0.305
2008 Noberini R, Koolpe M, Peddibhotla S, Dahl R, Su Y, Cosford ND, Roth GP, Pasquale EB. Small molecules can selectively inhibit ephrin binding to the EphA4 and EphA2 receptors. The Journal of Biological Chemistry. 283: 29461-72. PMID 18728010 DOI: 10.1074/Jbc.M804103200  0.312
2005 Pasquale EB. Eph receptor signalling casts a wide net on cell behaviour. Nature Reviews. Molecular Cell Biology. 6: 462-75. PMID 15928710 DOI: 10.1038/nrm1662  0.319
2004 Noren NK, Pasquale EB. Eph receptor-ephrin bidirectional signals that target Ras and Rho proteins. Cellular Signalling. 16: 655-66. PMID 15093606 DOI: 10.1016/J.Cellsig.2003.10.006  0.331
2003 Murai KK, Nguyen LN, Koolpe M, McLennan R, Krull CE, Pasquale EB. Targeting the EphA4 receptor in the nervous system with biologically active peptides. Molecular and Cellular Neurosciences. 24: 1000-11. PMID 14697664 DOI: 10.1016/J.Mcn.2003.08.006  0.575
2003 Murai KK, Pasquale EB. 'Eph'ective signaling: forward, reverse and crosstalk. Journal of Cell Science. 116: 2823-32. PMID 12808016 DOI: 10.1242/Jcs.00625  0.359
2003 Murai KK, Nguyen LN, Irie F, Yamaguchi Y, Pasquale EB. Control of hippocampal dendritic spine morphology through ephrin-A3/EphA4 signaling. Nature Neuroscience. 6: 153-60. PMID 12496762 DOI: 10.1038/Nn994  0.553
2002 Murai KK, Pasquale EB. Can Eph receptors stimulate the mind? Neuron. 33: 159-62. PMID 11804564 DOI: 10.1016/S0896-6273(02)00565-2  0.374
1999 Kalo MS, Pasquale EB. Signal transfer by Eph receptors. Cell and Tissue Research. 298: 1-9. PMID 10555534 DOI: 10.1007/PL00008807  0.338
1999 Kalo MS, Pasquale EB. Signal transfer by eph receptors Cell and Tissue Research. 298: 1-9. PMID 10502115  0.338
1999 Rogers JH, Ciossek T, Menzel P, Pasquale EB. Eph receptors and ephrins demarcate cerebellar lobules before and during their formation. Mechanisms of Development. 87: 119-28. PMID 10495276 DOI: 10.1016/S0925-4773(99)00154-9  0.301
1997 Zisch AH, Pasquale EB. The Eph family: a multitude of receptors that mediate cell recognition signals. Cell and Tissue Research. 290: 217-26. PMID 9321683  0.362
1997 Brückner K, Pasquale EB, Klein R. Tyrosine phosphorylation of transmembrane ligands for Eph receptors. Science (New York, N.Y.). 275: 1640-3. PMID 9054357  0.301
1995 Brambilla R, Schnapp A, Casagranda F, Labrador JP, Bergemann AD, Flanagan JG, Pasquale EB, Klein R. Membrane-bound LERK2 ligand can signal through three different Eph-related receptor tyrosine kinases. The Embo Journal. 14: 3116-26. PMID 7621826 DOI: 10.1002/J.1460-2075.1995.Tb07314.X  0.373
1986 Karpen JW, Sachs AB, Pasquale EB, Hess GP. Spectrophotometric detection of monovalent cation flux in cells: fluorescence microscope measurement of acetylcholine receptor-mediated ion flux in PC-12 cells. Analytical Biochemistry. 157: 353-9. PMID 3777439 DOI: 10.1016/0003-2697(86)90637-8  0.73
1986 Pasquale EB, Udgaonkar JB, Hess GP. Single-channel current recordings of acetylcholine receptors in electroplax isolated from the Electrophorus electricus Main and Sachs' electric organs. The Journal of Membrane Biology. 93: 195-204. PMID 2433452 DOI: 10.1007/Bf01870811  0.69
1985 Cash DJ, Aoshima H, Pasquale EB, Hess GP. Acetylcholine-receptor-mediated ion fluxes in Electrophorus electricus and Torpedo california membrane vesicles. Reviews of Physiology, Biochemistry and Pharmacology. 102: 73-117. PMID 2412273 DOI: 10.1007/Bfb0034085  0.753
1983 Pasquale EB, Takeyasu K, Udgaonkar JB, Cash DJ, Severski MC, Hess GP. Acetylcholine receptor: evidence for a regulatory binding site in investigations of suberyldicholine-induced transmembrane ion flux in Electrophorus electricus membrane vesicles. Biochemistry. 22: 5967-73. PMID 6661420 DOI: 10.1021/Bi00294A041  0.751
1983 Sachs AB, Leprince P, Karpen JW, Pasquale EB, Abood LG, Hess GP. Phencyclidine inhibition of the acetylcholine receptor: measurement of cation flux in a sympathetic neuronal cell line using 22Na+ and spectroscopic detection of Cs+. Archives of Biochemistry and Biophysics. 225: 500-4. PMID 6625597 DOI: 10.1016/0003-9861(83)90059-0  0.727
1983 Karpen JW, Sachs AB, Cash DJ, Pasquale EB, Hess GP. Direct spectrophotometric detection of cation flux in membrane vesicles: stopped-flow measurements of acetylcholine-receptor-mediated ion flux. Analytical Biochemistry. 135: 83-94. PMID 6230951 DOI: 10.1016/0003-2697(83)90734-0  0.74
1982 Hess GP, Pasquale EB, Walker JW, McNamee MG. Comparison of acetylcholine receptor-controlled cation flux in membrane vesicles from Torpedo californica and Electrophorus electricus: chemical kinetic measurements in the millisecond region. Proceedings of the National Academy of Sciences of the United States of America. 79: 963-7. PMID 6951180 DOI: 10.1073/Pnas.79.4.963  0.741
1982 Hess GP, Pasquale EB, Karpen JW, Sachs AB, Takeyasu K, Cash DJ. Acetylcholine receptor-controlled ion translocation. A comparison of the effects of suberyldicholine, carbamoylcholine, and acetylcholine. Biochemical and Biophysical Research Communications. 107: 1583-8. PMID 6291537 DOI: 10.1016/S0006-291X(82)80181-2  0.761
1981 Walker JW, McNamee MG, Pasquale E, Cash DJ, Hess GP. Acetylcholine receptor inactivation in Torpedo californica electroplax membrane vesicles. Detection of two processes in the millisecond and second time regions. Biochemical and Biophysical Research Communications. 100: 86-90. PMID 7259763 DOI: 10.1016/S0006-291X(81)80066-6  0.758
Low-probability matches (unlikely to be authored by this person)
2006 Yang NY, Pasquale EB, Owen LB, Ethell IM. The EphB4 receptor-tyrosine kinase promotes the migration of melanoma cells through Rho-mediated actin cytoskeleton reorganization. The Journal of Biological Chemistry. 281: 32574-86. PMID 16950769 DOI: 10.1074/Jbc.M604338200  0.294
2015 Singh DR, Cao Q, King C, Salotto M, Ahmed F, Zhou XY, Pasquale EB, Hristova K. Unliganded EphA3 dimerization promoted by the SAM domain. The Biochemical Journal. 471: 101-9. PMID 26232493 DOI: 10.1042/Bj20150433  0.291
2004 Murai KK, Pasquale EB. Eph receptors, ephrins, and synaptic function. The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. 10: 304-14. PMID 15271258 DOI: 10.1177/1073858403262221  0.29
2018 Singh DR, Kanvinde P, King C, Pasquale EB, Hristova K. The EphA2 receptor is activated through induction of distinct, ligand-dependent oligomeric structures. Communications Biology. 1: 15. PMID 30271902 DOI: 10.1038/s42003-018-0017-7  0.289
2015 Riedl SJ, Pasquale EB. Targeting the Eph System with Peptides and Peptide Conjugates. Current Drug Targets. 16: 1031-47. PMID 26212263  0.287
1993 Patstone G, Pasquale EB, Maher PA. Different members of the fibroblast growth factor receptor family are specific to distinct cell types in the developing chicken embryo. Developmental Biology. 155: 107-23. PMID 8416827 DOI: 10.1006/dbio.1993.1011  0.285
2005 Koolpe M, Burgess R, Dail M, Pasquale EB. EphB receptor-binding peptides identified by phage display enable design of an antagonist with ephrin-like affinity. The Journal of Biological Chemistry. 280: 17301-11. PMID 15722342 DOI: 10.1074/jbc.M500363200  0.283
1991 Sajjadi FG, Pasquale EB, Subramani S. Identification of a new eph-related receptor tyrosine kinase gene from mouse and chicken that is developmentally regulated and encodes at least two forms of the receptor. The New Biologist. 3: 769-78. PMID 1657122  0.282
2011 Cesa R, Premoselli F, Renna A, Ethell IM, Pasquale EB, Strata P. Eph receptors are involved in the activity-dependent synaptic wiring in the mouse cerebellar cortex. Plos One. 6: e19160. PMID 21559471 DOI: 10.1371/Journal.Pone.0019160  0.281
2009 Noren NK, Yang NY, Silldorff M, Mutyala R, Pasquale EB. Ephrin-independent regulation of cell substrate adhesion by the EphB4 receptor. The Biochemical Journal. 422: 433-42. PMID 19552627 DOI: 10.1042/Bj20090014  0.278
2008 Pasquale EB. Eph-ephrin bidirectional signaling in physiology and disease. Cell. 133: 38-52. PMID 18394988 DOI: 10.1016/j.cell.2008.03.011  0.278
2006 Ogawa K, Wada H, Okada N, Harada I, Nakajima T, Pasquale EB, Tsuyama S. EphB2 and ephrin-B1 expressed in the adult kidney regulate the cytoarchitecture of medullary tubule cells through Rho family GTPases. Journal of Cell Science. 119: 559-70. PMID 16443753 DOI: 10.1242/jcs.02777  0.278
2016 Singh DR, Ahmed F, Paul MD, Gedam M, Pasquale EB, Hristova K. The SAM domain inhibits EphA2 interactions in the plasma membrane. Biochimica Et Biophysica Acta. PMID 27776928 DOI: 10.1016/J.Bbamcr.2016.10.011  0.275
2007 Chrencik JE, Brooun A, Recht MI, Nicola G, Davis LK, Abagyan R, Widmer H, Pasquale EB, Kuhn P. Three-dimensional structure of the EphB2 receptor in complex with an antagonistic peptide reveals a novel mode of inhibition. The Journal of Biological Chemistry. 282: 36505-13. PMID 17897949 DOI: 10.1074/Jbc.M706340200  0.272
2012 Tognolini M, Incerti M, Hassan-Mohamed I, Giorgio C, Russo S, Bruni R, Lelli B, Bracci L, Noberini R, Pasquale EB, Barocelli E, Vicini P, Mor M, Lodola A. Structure-activity relationships and mechanism of action of Eph-ephrin antagonists: interaction of cholanic acid with the EphA2 receptor. Chemmedchem. 7: 1071-83. PMID 22529030 DOI: 10.1002/cmdc.201200102  0.271
1998 Connor RJ, Menzel P, Pasquale EB. Expression and tyrosine phosphorylation of Eph receptors suggest multiple mechanisms in patterning of the visual system. Developmental Biology. 193: 21-35. PMID 9466885 DOI: 10.1006/dbio.1997.8786  0.27
2008 Qin H, Shi J, Noberini R, Pasquale EB, Song J. Crystal structure and NMR binding reveal that two small molecule antagonists target the high affinity ephrin-binding channel of the EphA4 receptor. The Journal of Biological Chemistry. 283: 29473-84. PMID 18708347 DOI: 10.1074/jbc.M804114200  0.269
2004 Yamaguchi Y, Pasquale EB. Eph receptors in the adult brain. Current Opinion in Neurobiology. 14: 288-96. PMID 15194108 DOI: 10.1016/j.conb.2004.04.003  0.269
2001 Yu HH, Zisch AH, Dodelet VC, Pasquale EB. Multiple signaling interactions of Abl and Arg kinases with the EphB2 receptor. Oncogene. 20: 3995-4006. PMID 11494128 DOI: 10.1038/sj.onc.1204524  0.267
2006 Chrencik JE, Brooun A, Recht MI, Kraus ML, Koolpe M, Kolatkar AR, Bruce RH, Martiny-Baron G, Widmer H, Pasquale EB, Kuhn P. Structure and thermodynamic characterization of the EphB4/Ephrin-B2 antagonist peptide complex reveals the determinants for receptor specificity. Structure (London, England : 1993). 14: 321-30. PMID 16472751 DOI: 10.1016/j.str.2005.11.011  0.266
2022 Wirth D, Paul MD, Pasquale EB, Hristova K. Direct quantification of ligand-induced lipid and protein microdomains with distinctive signaling properties. Chemsystemschem. 4. PMID 36337751 DOI: 10.1002/syst.202200011  0.263
2001 Ethell IM, Irie F, Kalo MS, Couchman JR, Pasquale EB, Yamaguchi Y. EphB/syndecan-2 signaling in dendritic spine morphogenesis. Neuron. 31: 1001-13. PMID 11580899 DOI: 10.1016/S0896-6273(01)00440-8  0.262
2002 Koolpe M, Dail M, Pasquale EB. An ephrin mimetic peptide that selectively targets the EphA2 receptor. The Journal of Biological Chemistry. 277: 46974-9. PMID 12351647 DOI: 10.1074/jbc.M208495200  0.26
2013 Huan X, Shi J, Lim L, Mitra S, Zhu W, Qin H, Pasquale EB, Song J. Unique structure and dynamics of the EphA5 ligand binding domain mediate its binding specificity as revealed by X-ray crystallography, NMR and MD simulations. Plos One. 8: e74040. PMID 24086308 DOI: 10.1371/Journal.Pone.0074040  0.26
2011 Ishii M, Mueller I, Nakajima T, Pasquale EB, Ogawa K. EphB signaling inhibits gap junctional intercellular communication and synchronized contraction in cultured cardiomyocytes. Basic Research in Cardiology. 106: 1057-68. PMID 21892745 DOI: 10.1007/s00395-011-0219-3  0.258
2015 Truini A, Piroso S, Pasquale E, Notartomaso S, Di Stefano G, Lattanzi R, Battaglia G, Nicoletti F, Cruccu G. N-acetyl-cysteine, a drug that enhances the endogenous activation of group-II metabotropic glutamate receptors, inhibits nociceptive transmission in humans. Molecular Pain. 11: 14. PMID 25889381 DOI: 10.1186/S12990-015-0009-2  0.257
2005 Irie F, Okuno M, Pasquale EB, Yamaguchi Y. EphrinB-EphB signalling regulates clathrin-mediated endocytosis through tyrosine phosphorylation of synaptojanin 1. Nature Cell Biology. 7: 501-9. PMID 15821731 DOI: 10.1038/ncb1252  0.256
2005 Murai KK, Pasquale EB. New exchanges in eph-dependent growth cone dynamics. Neuron. 46: 161-3. PMID 15848793 DOI: 10.1016/J.Neuron.2005.04.004  0.255
1999 Dodelet VC, Pazzagli C, Zisch AH, Hauser CA, Pasquale EB. A novel signaling intermediate, SHEP1, directly couples Eph receptors to R-Ras and Rap1A. The Journal of Biological Chemistry. 274: 31941-6. PMID 10542222 DOI: 10.1074/jbc.274.45.31941  0.254
2019 Pan Y, Lu S, Lei L, Lamberto I, Wang Y, Pasquale EB, Wang Y. A genetically encoded FRET biosensor for visualizing EphA4 activity in different compartments of the plasma membrane. Acs Sensors. PMID 30608127 DOI: 10.1021/Acssensors.8B00465  0.251
2013 Duggineni S, Mitra S, Lamberto I, Han X, Xu Y, An J, Pasquale EB, Huang Z. Design and Synthesis of Potent Bivalent Peptide Agonists Targeting the EphA2 Receptor. Acs Medicinal Chemistry Letters. 4. PMID 24167659 DOI: 10.1021/Ml3004523  0.247
2012 Lamberto I, Qin H, Noberini R, Premkumar L, Bourgin C, Riedl SJ, Song J, Pasquale EB. Distinctive binding of three antagonistic peptides to the ephrin-binding pocket of the EphA4 receptor. The Biochemical Journal. 445: 47-56. PMID 22489865 DOI: 10.1042/BJ20120408  0.244
2010 Mitra S, Duggineni S, Koolpe M, Zhu X, Huang Z, Pasquale EB. Structure-activity relationship analysis of peptides targeting the EphA2 receptor. Biochemistry. 49: 6687-95. PMID 20677833 DOI: 10.1021/Bi1006223  0.244
2020 Karl K, Paul MD, Pasquale EB, Hristova K. Ligand bias in receptor tyrosine kinase signaling. The Journal of Biological Chemistry. 295: 18494-18507. PMID 33453850 DOI: 10.1074/jbc.REV120.015190  0.244
2020 Karl K, Paul MD, Pasquale EB, Hristova K. Ligand bias in receptor tyrosine kinase signaling. The Journal of Biological Chemistry. PMID 33122191 DOI: 10.1074/jbc.REV120.015190  0.244
2007 Richter M, Murai KK, Bourgin C, Pak DT, Pasquale EB. The EphA4 receptor regulates neuronal morphology through SPAR-mediated inactivation of Rap GTPases. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 14205-15. PMID 18094260 DOI: 10.1523/Jneurosci.2746-07.2007  0.241
2015 Forse GJ, Uson ML, Nasertorabi F, Kolatkar A, Lamberto I, Pasquale EB, Kuhn P. Distinctive Structure of the EphA3/Ephrin-A5 Complex Reveals a Dual Mode of Eph Receptor Interaction for Ephrin-A5. Plos One. 10: e0127081. PMID 25993310 DOI: 10.1371/journal.pone.0127081  0.241
1992 Pasquale EB, Deerinck TJ, Singer SJ, Ellisman MH. Cek5, a membrane receptor-type tyrosine kinase, is in neurons of the embryonic and postnatal avian brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 12: 3956-67. PMID 1403093 DOI: 10.1523/Jneurosci.12-10-03956.1992  0.241
2014 Lamberto I, Lechtenberg BC, Olson EJ, Mace PD, Dawson PE, Riedl SJ, Pasquale EB. Development and structural analysis of a nanomolar cyclic peptide antagonist for the EphA4 receptor. Acs Chemical Biology. 9: 2787-95. PMID 25268696 DOI: 10.1021/Cb500677X  0.24
2012 Lisabeth EM, Fernandez C, Pasquale EB. Cancer somatic mutations disrupt functions of the EphA3 receptor tyrosine kinase through multiple mechanisms. Biochemistry. 51: 1464-75. PMID 22242939 DOI: 10.1021/bi2014079  0.24
2019 Gomez-Soler M, Petersen Gehring M, Lechtenberg BC, Zapata-Mercado E, Hristova K, Pasquale EB. Engineering Nanomolar Peptide LigandsThat Differentially Modulate EphA2 Receptor Signaling. The Journal of Biological Chemistry. PMID 31015204 DOI: 10.2210/Pdb6Nkp/Pdb  0.24
2007 Noren NK, Pasquale EB. Paradoxes of the EphB4 receptor in cancer. Cancer Research. 67: 3994-7. PMID 17483308 DOI: 10.1158/0008-5472.Can-07-0525  0.237
2013 Jellinghaus S, Poitz DM, Ende G, Augstein A, Weinert S, Stütz B, Braun-Dullaeus RC, Pasquale EB, Strasser RH. Ephrin-A1/EphA4-mediated adhesion of monocytes to endothelial cells. Biochimica Et Biophysica Acta. 1833: 2201-11. PMID 23707953 DOI: 10.1016/j.bbamcr.2013.05.017  0.236
2009 Noberini R, Pasquale EB. Proliferation and tumor suppression: not mutually exclusive for Eph receptors. Cancer Cell. 16: 452-4. PMID 19962662 DOI: 10.1016/j.ccr.2009.11.008  0.236
2004 Zisch AH, Zeisberger SM, Ehrbar M, Djonov V, Weber CC, Ziemiecki A, Pasquale EB, Hubbell JA. Engineered fibrin matrices for functional display of cell membrane-bound growth factor-like activities: study of angiogenic signaling by ephrin-B2. Biomaterials. 25: 3245-57. PMID 14980419 DOI: 10.1016/J.Biomaterials.2003.10.015  0.234
1999 Kalo MS, Pasquale EB. Multiple in vivo tyrosine phosphorylation sites in EphB receptors. Biochemistry. 38: 14396-408. PMID 10572014 DOI: 10.1021/bi991628t  0.233
1997 Pasquale EB. The Eph family of receptors. Current Opinion in Cell Biology. 9: 608-15. PMID 9330863  0.232
1996 Soans C, Holash JA, Pavlova Y, Pasquale EB. Developmental expression and distinctive tyrosine phosphorylation of the Eph-related receptor tyrosine kinase Cek9. The Journal of Cell Biology. 135: 781-95. PMID 8909550  0.231
1996 Magal E, Holash JA, Toso RJ, Chang D, Lindberg RA, Pasquale EB. B61, a ligand for the Eck receptor protein-tyrosine kinase, exhibits neurotrophic activity in cultures of rat spinal cord neurons. Journal of Neuroscience Research. 43: 735-44. PMID 8984203 DOI: 10.1002/(SICI)1097-4547(19960315)43:6<735::AID-JNR10>3.0.CO;2-X  0.231
2011 Noberini R, Mitra S, Salvucci O, Valencia F, Duggineni S, Prigozhina N, Wei K, Tosato G, Huang Z, Pasquale EB. PEGylation potentiates the effectiveness of an antagonistic peptide that targets the EphB4 receptor with nanomolar affinity. Plos One. 6: e28611. PMID 22194865 DOI: 10.1371/Journal.Pone.0028611  0.228
2010 Murai KK, Pasquale EB. Restraining stem cell niche plasticity: a new talent of Eph receptors. Cell Stem Cell. 7: 647-8. PMID 21112558 DOI: 10.1016/J.Stem.2010.11.023  0.227
2023 Pasquale EB. Eph receptors and ephrins in cancer progression. Nature Reviews. Cancer. PMID 37996538 DOI: 10.1038/s41568-023-00634-x  0.227
2006 Noren NK, Foos G, Hauser CA, Pasquale EB. The EphB4 receptor suppresses breast cancer cell tumorigenicity through an Abl-Crk pathway. Nature Cell Biology. 8: 815-25. PMID 16862147 DOI: 10.1038/Ncb1438  0.226
2022 Zapata-Mercado E, Biener G, McKenzie DM, Wimley WC, Pasquale EB, Raicu V, Hristova K. The efficacy of receptor tyrosine kinase EphA2 autophosphorylation increases with EphA2 oligomer size. The Journal of Biological Chemistry. 102370. PMID 35970390 DOI: 10.1016/j.jbc.2022.102370  0.226
2000 Zisch AH, Pazzagli C, Freeman AL, Schneller M, Hadman M, Smith JW, Ruoslahti E, Pasquale EB. Replacing two conserved tyrosines of the EphB2 receptor with glutamic acid prevents binding of SH2 domains without abrogating kinase activity and biological responses. Oncogene. 19: 177-87. PMID 10644995 DOI: 10.1038/Sj.Onc.1203304  0.224
2018 Singh DR, Kanvinde P, King C, Pasquale EB, Hristova K. Erratum: Author Correction: The EphA2 receptor is activated through induction of distinct, ligand-dependent oligomeric structures. Communications Biology. 1: 40. PMID 30273417 DOI: 10.1038/s42003-018-0044-4  0.224
1997 Holash JA, Soans C, Chong LD, Shao H, Dixit VM, Pasquale EB. Reciprocal expression of the Eph receptor Cek5 and its ligand(s) in the early retina. Developmental Biology. 182: 256-69. PMID 9070326 DOI: 10.1006/Dbio.1996.8496  0.223
2011 Yang NY, Fernandez C, Richter M, Xiao Z, Valencia F, Tice DA, Pasquale EB. Crosstalk of the EphA2 receptor with a serine/threonine phosphatase suppresses the Akt-mTORC1 pathway in cancer cells. Cellular Signalling. 23: 201-12. PMID 20837138 DOI: 10.1016/j.cellsig.2010.09.004  0.221
2000 Dodelet VC, Pasquale EB. Eph receptors and ephrin ligands: embryogenesis to tumorigenesis. Oncogene. 19: 5614-9. PMID 11114742 DOI: 10.1038/sj.onc.1203856  0.221
2015 Singh DR, Ahmed F, King C, Gupta N, Salotto M, Pasquale EB, Hristova K. EphA2 unliganded dimers suppress EphA2 pro-tumorigenic signaling. The Journal of Biological Chemistry. PMID 26363067 DOI: 10.1074/Jbc.M115.676866  0.216
2008 Irie F, Okuno M, Matsumoto K, Pasquale EB, Yamaguchi Y. Heparan sulfate regulates ephrin-A3/EphA receptor signaling. Proceedings of the National Academy of Sciences of the United States of America. 105: 12307-12. PMID 18715996 DOI: 10.1073/pnas.0801302105  0.215
2011 Ogawa K, Takemoto N, Ishii M, Pasquale EB, Nakajima T. Complementary expression and repulsive signaling suggest that EphB receptors and ephrin-B ligands control cell positioning in the gastric epithelium. Histochemistry and Cell Biology. 136: 617-36. PMID 21959989 DOI: 10.1007/s00418-011-0867-2  0.215
2022 Gomez-Soler M, Gehring MP, Lechtenberg BC, Zapata-Mercado E, Ruelos A, Matsumoto MW, Hristova K, Pasquale EB. Ligands with different dimeric configurations potently activate the EphA2 receptor and reveal its potential for biased signaling. Iscience. 25: 103870. PMID 35243233 DOI: 10.1016/j.isci.2022.103870  0.215
2016 Bhatia S, Hirsch K, Sharma J, Oweida A, Griego A, Keysar S, Jimeno A, Raben D, Krasnoperov V, Gill PS, Pasquale EB, Wang XJ, Karam SD. Enhancing radiosensitization in EphB4 receptor-expressing Head and Neck Squamous Cell Carcinomas. Scientific Reports. 6: 38792. PMID 27941840 DOI: 10.1038/Srep38792  0.213
2013 Incerti M, Tognolini M, Russo S, Pala D, Giorgio C, Hassan-Mohamed I, Noberini R, Pasquale EB, Vicini P, Piersanti S, Rivara S, Barocelli E, Mor M, Lodola A. Amino acid conjugates of lithocholic acid as antagonists of the EphA2 receptor. Journal of Medicinal Chemistry. 56: 2936-47. PMID 23489211 DOI: 10.1021/jm301890k  0.213
1994 Shao H, Lou L, Pandey A, Pasquale EB, Dixit VM. cDNA cloning and characterization of a ligand for the Cek5 receptor protein-tyrosine kinase. The Journal of Biological Chemistry. 269: 26606-9. PMID 7929389  0.213
2016 Singh DR, Pasquale EB, Hristova K. A small peptide promotes EphA2 kinase-dependent signaling by stabilizing EphA2 dimers. Biochimica Et Biophysica Acta. PMID 27281300 DOI: 10.1016/J.Bbagen.2016.06.004  0.21
2010 Pasquale EB. Eph receptors and ephrins in cancer: bidirectional signalling and beyond. Nature Reviews. Cancer. 10: 165-80. PMID 20179713 DOI: 10.1038/nrc2806  0.208
2010 Nie D, Di Nardo A, Han JM, Baharanyi H, Kramvis I, Huynh T, Dabora S, Codeluppi S, Pandolfi PP, Pasquale EB, Sahin M. Tsc2-Rheb signaling regulates EphA-mediated axon guidance. Nature Neuroscience. 13: 163-72. PMID 20062052 DOI: 10.1038/Nn.2477  0.207
2015 Bhatia S, Baig NA, Timofeeva O, Pasquale EB, Hirsch K, MacDonald TJ, Dritschilo A, Lee YC, Henkemeyer M, Rood B, Jung M, Wang XJ, Kool M, Rodriguez O, Albanese C, et al. Knockdown of EphB1 receptor decreases medulloblastoma cell growth and migration and increases cellular radiosensitization. Oncotarget. 6: 8929-46. PMID 25879388 DOI: 10.18632/Oncotarget.3369  0.206
2005 Miao H, Strebhardt K, Pasquale EB, Shen TL, Guan JL, Wang B. Inhibition of integrin-mediated cell adhesion but not directional cell migration requires catalytic activity of EphB3 receptor tyrosine kinase. Role of Rho family small GTPases. The Journal of Biological Chemistry. 280: 923-32. PMID 15536074 DOI: 10.1074/jbc.M411383200  0.203
2014 Barile E, Wang S, Das SK, Noberini R, Dahl R, Stebbins JL, Pasquale EB, Fisher PB, Pellecchia M. Cover Picture: Design, Synthesis and Bioevaluation of an EphA2 Receptor-Based Targeted Delivery System (ChemMedChem 7/2014) Chemmedchem. 9: 1333-1333. DOI: 10.1002/Cmdc.201490024  0.202
2014 Hassan-Mohamed I, Giorgio C, Incerti M, Russo S, Pala D, Pasquale EB, Zanotti I, Vicini P, Barocelli E, Rivara S, Mor M, Lodola A, Tognolini M. UniPR129 is a competitive small molecule Eph-ephrin antagonist blocking in vitro angiogenesis at low micromolar concentrations. British Journal of Pharmacology. 171: 5195-208. PMID 24597515 DOI: 10.1111/bph.12669  0.2
1990 Pasquale EB. A distinctive family of embryonic protein-tyrosine kinase receptors. Proceedings of the National Academy of Sciences of the United States of America. 87: 5812-6. PMID 2165604  0.2
2010 Browne CD, Hoefer MM, Chintalapati SK, Cato MH, Wallez Y, Ostertag DV, Pasquale EB, Rickert RC. SHEP1 partners with CasL to promote marginal zone B-cell maturation. Proceedings of the National Academy of Sciences of the United States of America. 107: 18944-9. PMID 20956287 DOI: 10.1073/Pnas.1007558107  0.199
1998 Zisch AH, Kalo MS, Chong LD, Pasquale EB. Complex formation between EphB2 and Src requires phosphorylation of tyrosine 611 in the EphB2 juxtamembrane region. Oncogene. 16: 2657-70. PMID 9632142 DOI: 10.1038/sj.onc.1201823  0.197
2008 Bouvier D, Corera AT, Tremblay ME, Riad M, Chagnon M, Murai KK, Pasquale EB, Fon EA, Doucet G. Pre-synaptic and post-synaptic localization of EphA4 and EphB2 in adult mouse forebrain. Journal of Neurochemistry. 106: 682-95. PMID 18410519 DOI: 10.1111/J.1471-4159.2008.05416.X  0.195
1994 Soans C, Holash JA, Pasquale EB. Characterization of the expression of the Cek8 receptor-type tyrosine kinase during development and in tumor cell lines. Oncogene. 9: 3353-61. PMID 7936661  0.194
2001 Menzel P, Valencia F, Godement P, Dodelet VC, Pasquale EB. Ephrin-A6, a new ligand for EphA receptors in the developing visual system. Developmental Biology. 230: 74-88. PMID 11161563 DOI: 10.1006/dbio.2000.0109  0.193
2013 Duggineni S, Mitra S, Noberini R, Han X, Lin N, Xu Y, Tian W, An J, Pasquale EB, Huang Z. Design, synthesis and characterization of novel small molecular inhibitors of ephrin-B2 binding to EphB4. Biochemical Pharmacology. 85: 507-13. PMID 23253822 DOI: 10.1016/J.Bcp.2012.12.005  0.193
2018 Lechtenberg BC, Dawson PE, Pasquale EB, Riedl SJ. Structure-based characterization and optimization of Eph receptor-targeting peptides Acta Crystallographica Section a Foundations and Advances. 74: a403-a403. DOI: 10.1107/s0108767318095971  0.193
2021 Lechtenberg BC, Gehring MP, Light TP, Horne CR, Matsumoto MW, Hristova K, Pasquale EB. Regulation of the EphA2 receptor intracellular region by phosphomimetic negative charges in the kinase-SAM linker. Nature Communications. 12: 7047. PMID 34857764 DOI: 10.1038/s41467-021-27343-z  0.19
2010 Bouvier D, Tremblay ME, Riad M, Corera AT, Gingras D, Horn KE, Fotouhi M, Girard M, Murai KK, Kennedy TE, McPherson PS, Pasquale EB, Fon EA, Doucet G. EphA4 is localized in clathrin-coated and synaptic vesicles in adult mouse brain. Journal of Neurochemistry. 113: 153-65. PMID 20067584 DOI: 10.1111/J.1471-4159.2010.06582.X  0.186
2019 Wirth D, Hristova K, Pasquale E. Investigating the Role of the Transmembrane Helix of EphA2 in Signal Transduction across the Plasma Membrane Biophysical Journal. 116: 233a. DOI: 10.1016/J.Bpj.2018.11.1280  0.184
2011 Murai KK, Pasquale EB. Eph receptors and ephrins in neuron-astrocyte communication at synapses. Glia. 59: 1567-78. PMID 21850709 DOI: 10.1002/Glia.21226  0.184
2016 Barquilla A, Lamberto I, Noberini R, Heynen-Genel S, Brill LM, Pasquale EB. Protein kinase A can block EphA2 receptor-mediated cell repulsion by increasing EphA2 S897 phosphorylation. Molecular Biology of the Cell. PMID 27385333 DOI: 10.1091/mbc.E16-01-0048  0.183
2000 Ogawa K, Pasqualini R, Lindberg RA, Kain R, Freeman AL, Pasquale EB. The ephrin-A1 ligand and its receptor, EphA2, are expressed during tumor neovascularization. Oncogene. 19: 6043-52. PMID 11146556 DOI: 10.1038/Sj.Onc.1204004  0.178
1999 Zou JX, Wang B, Kalo MS, Zisch AH, Pasquale EB, Ruoslahti E. An Eph receptor regulates integrin activity through R-Ras. Proceedings of the National Academy of Sciences of the United States of America. 96: 13813-8. PMID 10570155 DOI: 10.1073/Pnas.96.24.13813  0.177
2014 Vargas LM, Leal N, Estrada LD, González A, Serrano F, Araya K, Gysling K, Inestrosa NC, Pasquale EB, Alvarez AR. EphA4 activation of c-Abl mediates synaptic loss and LTP blockade caused by amyloid-β oligomers. Plos One. 9: e92309. PMID 24658113 DOI: 10.1371/journal.pone.0092309  0.175
2020 Romero C, Lambert LJ, Sheffler DJ, De Backer LJ, Raveendra-Panickar D, Celeridad M, Grotegut S, Rodiles S, Holleran J, Sergienko E, Pasquale EB, Cosford NDP, Tautz L. A cellular target engagement assay for the characterization of SHP2 (PTPN11) phosphatase inhibitors. The Journal of Biological Chemistry. PMID 31953320 DOI: 10.1074/jbc.RA119.010838  0.175
2009 Tremblay ME, Riad M, Chierzi S, Murai KK, Pasquale EB, Doucet G. Developmental course of EphA4 cellular and subcellular localization in the postnatal rat hippocampus. The Journal of Comparative Neurology. 512: 798-813. PMID 19086003 DOI: 10.1002/Cne.21922  0.175
2002 Cramer KS, Karam SD, Bothwell M, Cerretti DP, Pasquale EB, Rubel EW. Expression of EphB receptors and EphrinB ligands in the developing chick auditory brainstem. The Journal of Comparative Neurology. 452: 51-64. PMID 12205709 DOI: 10.1002/Cne.10399  0.173
2007 Bourgin C, Murai KK, Richter M, Pasquale EB. The EphA4 receptor regulates dendritic spine remodeling by affecting beta1-integrin signaling pathways. The Journal of Cell Biology. 178: 1295-307. PMID 17875741 DOI: 10.1083/Jcb.200610139  0.172
2002 St John JA, Pasquale EB, Key B. EphA receptors and ephrin-A ligands exhibit highly regulated spatial and temporal expression patterns in the developing olfactory system. Brain Research. Developmental Brain Research. 138: 1-14. PMID 12234653 DOI: 10.1016/S0165-3806(02)00454-6  0.171
2002 Karam SD, Dottori M, Ogawa K, Henderson JT, Boyd AW, Pasquale EB, Bothwell M. EphA4 is not required for Purkinje cell compartmentation. Brain Research. Developmental Brain Research. 135: 29-38. PMID 11978390 DOI: 10.1016/S0165-3806(02)00278-X  0.168
2010 Qin H, Noberini R, Huan X, Shi J, Pasquale EB, Song J. Structural characterization of the EphA4-Ephrin-B2 complex reveals new features enabling Eph-ephrin binding promiscuity. The Journal of Biological Chemistry. 285: 644-54. PMID 19875447 DOI: 10.1074/jbc.M109.064824  0.168
1995 Connor RJ, Pasquale EB. Genomic organization and alternatively processed forms of Cek5, a receptor protein-tyrosine kinase of the Eph subfamily. Oncogene. 11: 2429-38. PMID 8570195  0.167
1997 Martone ME, Holash JA, Bayardo A, Pasquale EB, Ellisman MH. Immunolocalization of the receptor tyrosine kinase EphA4 in the adult rat central nervous system. Brain Research. 771: 238-50. PMID 9401744 DOI: 10.1016/S0006-8993(97)00792-0  0.167
2004 Noren NK, Lu M, Freeman AL, Koolpe M, Pasquale EB. Interplay between EphB4 on tumor cells and vascular ephrin-B2 regulates tumor growth. Proceedings of the National Academy of Sciences of the United States of America. 101: 5583-8. PMID 15067119 DOI: 10.1073/Pnas.0401381101  0.165
1991 Pasquale EB. Identification of chicken embryo kinase 5, a developmentally regulated receptor-type tyrosine kinase of the Eph family. Cell Regulation. 2: 523-34. PMID 1664238  0.165
2006 Dail M, Richter M, Godement P, Pasquale EB. Eph receptors inactivate R-Ras through different mechanisms to achieve cell repulsion. Journal of Cell Science. 119: 1244-54. PMID 16522685 DOI: 10.1242/jcs.02842  0.164
2006 Kasemeier-Kulesa JC, Bradley R, Pasquale EB, Lefcort F, Kulesa PM. Eph/ephrins and N-cadherin coordinate to control the pattern of sympathetic ganglia. Development (Cambridge, England). 133: 4839-47. PMID 17108003 DOI: 10.1242/Dev.02662  0.164
2001 Kalo MS, Yu HH, Pasquale EB. In vivo tyrosine phosphorylation sites of activated ephrin-B1 and ephB2 from neural tissue. The Journal of Biological Chemistry. 276: 38940-8. PMID 11466320 DOI: 10.1074/jbc.M105815200  0.163
2016 Olson EJ, Lechtenberg BC, Zhao C, Rubio de la Torre E, Lamberto I, Riedl SJ, Dawson PE, Pasquale EB. Modifications of a Nanomolar Cyclic Peptide Antagonist for the EphA4 Receptor To Achieve High Plasma Stability. Acs Medicinal Chemistry Letters. 7: 841-6. PMID 27660688 DOI: 10.1021/Acsmedchemlett.6B00132  0.162
2022 Wolff DW, Deng Z, Bianchi-Smiraglia A, Foley CE, Han Z, Wang X, Shen S, Rosenberg MM, Moparthy S, Yun DH, Chen J, Baker BK, Roll MV, Magiera AJ, Li J, ... ... Pasquale EB, et al. Phosphorylation of guanosine monophosphate reductase triggers a GTP-dependent switch from pro- to anti-oncogenic function of EPHA4. Cell Chemical Biology. PMID 35148834 DOI: 10.1016/j.chembiol.2022.01.007  0.16
2004 Dail M, Kalo MS, Seddon JA, Côté JF, Vuori K, Pasquale EB. SHEP1 function in cell migration is impaired by a single amino acid mutation that disrupts association with the scaffolding protein cas but not with Ras GTPases. The Journal of Biological Chemistry. 279: 41892-902. PMID 15272013 DOI: 10.1074/Jbc.M402929200  0.156
2012 Binda E, Visioli A, Giani F, Lamorte G, Copetti M, Pitter KL, Huse JT, Cajola L, Zanetti N, DiMeco F, De Filippis L, Mangiola A, Maira G, Anile C, De Bonis P, ... ... Pasquale EB, et al. The EphA2 receptor drives self-renewal and tumorigenicity in stem-like tumor-propagating cells from human glioblastomas. Cancer Cell. 22: 765-80. PMID 23238013 DOI: 10.1016/J.Ccr.2012.11.005  0.155
2017 Huang TY, Zhao Y, Jiang LL, Li X, Liu Y, Sun Y, Piña-Crespo JC, Zhu B, Masliah E, Willnow TE, Pasquale EB, Xu H. SORLA attenuates EphA4 signaling and amyloid β-induced neurodegeneration. The Journal of Experimental Medicine. PMID 29114064 DOI: 10.1084/Jem.20171413  0.154
1995 Holash JA, Pasquale EB. Polarized expression of the receptor protein tyrosine kinase Cek5 in the developing avian visual system. Developmental Biology. 172: 683-93. PMID 8612982 DOI: 10.1006/dbio.1995.8039  0.152
2010 Yang NY, Lopez-Bergami P, Goydos JS, Yip D, Walker AM, Pasquale EB, Ethell IM. The EphB4 receptor promotes the growth of melanoma cells expressing the ephrin-B2 ligand. Pigment Cell & Melanoma Research. 23: 684-7. PMID 20649938 DOI: 10.1111/J.1755-148X.2010.00745.X  0.152
2013 Mace PD, Wallez Y, Egger MF, Dobaczewska MK, Robinson H, Pasquale EB, Riedl SJ. Structure of ERK2 bound to PEA-15 reveals a mechanism for rapid release of activated MAPK. Nature Communications. 4: 1681. PMID 23575685 DOI: 10.1038/ncomms2687  0.151
2008 Leone M, Yu EC, Liddington RC, Pasquale EB, Pellecchia M. The PTB domain of tensin: NMR solution structure and phosphoinositides binding studies. Biopolymers. 89: 86-92. PMID 17922498 DOI: 10.1002/bip.20862  0.151
2009 Filosa A, Paixão S, Honsek SD, Carmona MA, Becker L, Feddersen B, Gaitanos L, Rudhard Y, Schoepfer R, Klopstock T, Kullander K, Rose CR, Pasquale EB, Klein R. Neuron-glia communication via EphA4/ephrin-A3 modulates LTP through glial glutamate transport. Nature Neuroscience. 12: 1285-92. PMID 19734893 DOI: 10.1038/Nn.2394  0.15
2009 Carmona MA, Murai KK, Wang L, Roberts AJ, Pasquale EB. Glial ephrin-A3 regulates hippocampal dendritic spine morphology and glutamate transport. Proceedings of the National Academy of Sciences of the United States of America. 106: 12524-9. PMID 19592509 DOI: 10.1073/Pnas.0903328106  0.149
1997 Zisch AH, Stallcup WB, Chong LD, Dahlin-Huppe K, Voshol J, Schachner M, Pasquale EB. Tyrosine phosphorylation of L1 family adhesion molecules: implication of the Eph kinase Cek5. Journal of Neuroscience Research. 47: 655-65. PMID 9089215 DOI: 10.1002/(SICI)1097-4547(19970315)47:6<655::AID-JNR12>3.0.CO;2-U  0.149
2021 Raveendra-Panickar D, Finlay D, Layng FI, Lambert LJ, Celeridad M, Zhao M, Barbosa K, De Backer LJS, Kwong E, Gosalia P, Rodiles S, Holleran J, Ardecky R, Grotegut S, Olson S, ... ... Pasquale EB, et al. Discovery of novel furanylbenzamide inhibitors that target oncogenic tyrosine phosphatase SHP2 in leukemia cells. The Journal of Biological Chemistry. 101477. PMID 34896393 DOI: 10.1016/j.jbc.2021.101477  0.146
2024 Sasine JP, Kozlova NY, Valicente L, Dukov J, Tran DH, Himburg HA, Kumar S, Khorsandi S, Chan A, Grohe S, Li M, Kan J, Sehl ME, Schiller GJ, Reinhardt B, ... ... Pasquale EB, et al. Inhibition of Ephrin B2 Reverse Signaling Suppresses Multiple Myeloma Pathogenesis. Cancer Research. PMID 38231476 DOI: 10.1158/0008-5472.CAN-23-1950  0.144
2000 Küry P, Gale N, Connor R, Pasquale E, Guthrie S. Eph receptors and ephrin expression in cranial motor neurons and the branchial arches of the chick embryo. Molecular and Cellular Neurosciences. 15: 123-40. PMID 10673322 DOI: 10.1006/mcne.1999.0812  0.143
2007 Tremblay ME, Riad M, Bouvier D, Murai KK, Pasquale EB, Descarries L, Doucet G. Localization of EphA4 in axon terminals and dendritic spines of adult rat hippocampus. The Journal of Comparative Neurology. 501: 691-702. PMID 17299751 DOI: 10.1002/Cne.21263  0.141
2000 Cramer KS, Rosenberger MH, Frost DM, Cochran SL, Pasquale EB, Rubel EW. Developmental regulation of EphA4 expression in the chick auditory brainstem. The Journal of Comparative Neurology. 426: 270-8. PMID 10982468 DOI: 10.1002/1096-9861(20001016)426:2<270::AID-CNE8>3.0.CO;2-8  0.14
1994 Pasquale EB, Connor RJ, Rocholl D, Schnürch H, Risau W. Cek5, a tyrosine kinase of the Eph subclass, is activated during neural retina differentiation. Developmental Biology. 163: 491-502. PMID 7515363 DOI: 10.1006/dbio.1994.1165  0.138
2017 Stammes MA, Prevoo HA, Ter Horst MC, Groot SA, Van de Velde CJ, Chan AB, de Geus-Oei LF, Kuppen PJ, Vahrmeijer AL, Pasquale EB, Sier CF. Evaluation of EphA2 and EphB4 as Targets for Image-Guided Colorectal Cancer Surgery. International Journal of Molecular Sciences. 18. PMID 28165374 DOI: 10.3390/ijms18020307  0.138
2014 Barile E, Wang S, Das SK, Noberini R, Dahl R, Stebbins JL, Pasquale EB, Fisher PB, Pellecchia M. Design, synthesis and bioevaluation of an EphA2 receptor-based targeted delivery system. Chemmedchem. 9: 1403-12. PMID 24677792 DOI: 10.1002/Cmdc.201400067  0.137
2021 Light TP, Gomez-Soler M, Wang Z, Karl K, Zapata-Mercado E, Gehring MP, Lechtenberg BC, Pogorelov TV, Hristova K, Pasquale EB. A Cancer Mutation Promotes EphA4 Oligomerization and Signaling by Altering the Conformation of the SAM Domain. The Journal of Biological Chemistry. 100876. PMID 34139238 DOI: 10.1016/j.jbc.2021.100876  0.135
1988 Pasquale EB, Maher PA, Singer SJ. Comparative study of the tyrosine phosphorylation of proteins in Swiss 3T3 fibroblasts stimulated by a variety of mitogenic agents. Journal of Cellular Physiology. 137: 146-56. PMID 2459139 DOI: 10.1002/jcp.1041370118  0.134
2010 Wang L, Vervoort V, Wallez Y, Coré N, Cremer H, Pasquale EB. The SRC homology 2 domain protein Shep1 plays an important role in the penetration of olfactory sensory axons into the forebrain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 13201-10. PMID 20881139 DOI: 10.1523/JNEUROSCI.3289-10.2010  0.134
2016 Amegandjin CA, Jammow W, Laforest S, Riad M, Baharnoori M, Badeaux F, DesGroseillers L, Murai KK, Pasquale EB, Drolet G, Doucet G. Regional expression and ultrastructural localization of EphA7 in the hippocampus and cerebellum of adult rat. The Journal of Comparative Neurology. PMID 26780036 DOI: 10.1002/Cne.23962  0.133
2007 Vervoort VS, Roselli S, Oshima RG, Pasquale EB. Splice variants and expression patterns of SHEP1, BCAR3 and NSP1, a gene family involved in integrin and receptor tyrosine kinase signaling. Gene. 391: 161-70. PMID 17270363 DOI: 10.1016/J.Gene.2006.12.016  0.129
2011 Prigozhina NL, Heisel A, Wei K, Noberini R, Hunter EA, Calzolari D, Seldeen JR, Pasquale EB, Ruiz-Lozano P, Mercola M, Price JH. Characterization of a novel angiogenic model based on stable, fluorescently labelled endothelial cell lines amenable to scale-up for high content screening. Biology of the Cell / Under the Auspices of the European Cell Biology Organization. 103: 467-81. PMID 21732911 DOI: 10.1042/Bc20100146  0.128
2010 Roselli S, Wallez Y, Wang L, Vervoort V, Pasquale EB. The SH2 domain protein Shep1 regulates the in vivo signaling function of the scaffolding protein Cas. Cellular Signalling. 22: 1745-52. PMID 20603213 DOI: 10.1016/j.cellsig.2010.06.015  0.125
2009 Codeluppi S, Svensson CI, Hefferan MP, Valencia F, Silldorff MD, Oshiro M, Marsala M, Pasquale EB. The Rheb-mTOR pathway is upregulated in reactive astrocytes of the injured spinal cord. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 1093-104. PMID 19176818 DOI: 10.1523/Jneurosci.4103-08.2009  0.124
2012 Wang S, Placzek WJ, Stebbins JL, Mitra S, Noberini R, Koolpe M, Zhang Z, Dahl R, Pasquale EB, Pellecchia M. Novel targeted system to deliver chemotherapeutic drugs to EphA2-expressing cancer cells. Journal of Medicinal Chemistry. 55: 2427-36. PMID 22329578 DOI: 10.1021/Jm201743S  0.123
2012 Wallez Y, Mace PD, Pasquale EB, Riedl SJ. NSP-CAS Protein Complexes: Emerging Signaling Modules in Cancer. Genes & Cancer. 3: 382-93. PMID 23226576 DOI: 10.1177/1947601912460050  0.122
1997 Monschau B, Kremoser C, Ohta K, Tanaka H, Kaneko T, Yamada T, Handwerker C, Hornberger MR, Löschinger J, Pasquale EB, Siever DA, Verderame MF, Müller BK, Bonhoeffer F, Drescher U. Shared and distinct functions of RAGS and ELF-1 in guiding retinal axons. The Embo Journal. 16: 1258-67. PMID 9135142 DOI: 10.1093/emboj/16.6.1258  0.122
2000 Barritt DS, Pearn MT, Zisch AH, Lee SS, Javier RT, Pasquale EB, Stallcup WB. The multi-PDZ domain protein MUPP1 is a cytoplasmic ligand for the membrane-spanning proteoglycan NG2. Journal of Cellular Biochemistry. 79: 213-24. PMID 10967549 DOI: 10.1002/1097-4644(20001101)79:2<213::Aid-Jcb50>3.0.Co;2-G  0.121
2023 Gomez-Soler M, Olson EJ, de la Torre ER, Zhao C, Lamberto I, Flood DT, Danho W, Lechtenberg BC, Riedl SJ, Dawson PE, Pasquale EB. Lipidation and PEGylation Strategies to Prolong the Half-Life of a Nanomolar EphA4 Receptor Antagonist. European Journal of Medicinal Chemistry. 262. PMID 38523699 DOI: 10.1016/j.ejmech.2023.115876  0.12
1985 Maher PA, Pasquale EB, Wang JY, Singer SJ. Phosphotyrosine-containing proteins are concentrated in focal adhesions and intercellular junctions in normal cells. Proceedings of the National Academy of Sciences of the United States of America. 82: 6576-80. PMID 2413441  0.119
2020 Zhang C, Smalley I, Emmons MF, Sharma R, Izumi V, Messina J, Koomen JM, Pasquale EB, Forsyth PA, Smalley KSM. Non-canonical EphA2 signaling is a driver of tumor-endothelial cell interactions and metastatic dissemination in BRAF inhibitor resistant melanoma. The Journal of Investigative Dermatology. PMID 32890629 DOI: 10.1016/J.Jid.2020.08.012  0.119
2020 Gehring MP, Pasquale EB. Protein kinase C phosphorylates the EphA2 receptor on serine 892 in the regulatory linker connecting the kinase and SAM domains. Cellular Signalling. 109668. PMID 32413552 DOI: 10.1016/j.cellsig.2020.109668  0.118
2004 Eberhart J, Barr J, O'Connell S, Flagg A, Swartz ME, Cramer KS, Tosney KW, Pasquale EB, Krull CE. Ephrin-A5 exerts positive or inhibitory effects on distinct subsets of EphA4-positive motor neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 1070-8. PMID 14762125 DOI: 10.1523/Jneurosci.4719-03.2004  0.117
2019 Bhatia S, Oweida A, Lennon S, Darragh LB, Milner D, Phan AV, Mueller AC, Van Court B, Raben D, Serkova NJ, Wang XJ, Jimeno A, Clambey ET, Pasquale EB, Karam SD. Inhibition of EphB4-ephrin-B2 signaling reprograms the tumor immune microenvironment in head and neck cancers. Cancer Research. PMID 30894369 DOI: 10.1158/0008-5472.Can-18-3257  0.117
2008 Biliran H, Jan Y, Chen R, Pasquale EB, Ruoslahti E. Protein kinase D is a positive regulator of Bit1 apoptotic function. The Journal of Biological Chemistry. 283: 28029-37. PMID 18703509 DOI: 10.1074/Jbc.M803139200  0.116
2022 Bhatia S, Nguyen D, Darragh LB, Van Court B, Sharma J, Knitz MW, Piper M, Bukkapatnam S, Gadwa J, Bickett TE, Bhuvane S, Corbo S, Wu B, Lee Y, Fujita M, ... ... Pasquale EB, et al. EphB4 and ephrinB2 act in opposition in the head and neck tumor microenvironment. Nature Communications. 13: 3535. PMID 35725568 DOI: 10.1038/s41467-022-31124-7  0.115
2005 Ethell IM, Pasquale EB. Molecular mechanisms of dendritic spine development and remodeling. Progress in Neurobiology. 75: 161-205. PMID 15882774 DOI: 10.1016/J.Pneurobio.2005.02.003  0.111
2000 Karam SD, Burrows RC, Logan C, Koblar S, Pasquale EB, Bothwell M. Eph receptors and ephrins in the developing chick cerebellum: relationship to sagittal patterning and granule cell migration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 6488-500. PMID 10964955  0.109
2008 Vervoort VS, Lu M, Valencia F, Lesperance J, Breier G, Oshima R, Pasquale EB. A novel Flk1-TVA transgenic mouse model for gene delivery to angiogenic vasculature. Transgenic Research. 17: 403-15. PMID 18027100 DOI: 10.1007/S11248-007-9156-1  0.109
2000 Eberhart J, Swartz M, Koblar SA, Pasquale EB, Tanaka H, Krull CE. Expression of EphA4, ephrin-A2 and ephrin-A5 during axon outgrowth to the hindlimb indicates potential roles in pathfinding. Developmental Neuroscience. 22: 237-50. PMID 10894987 DOI: 10.1159/000017446  0.107
2000 Karam SD, Burrows RC, Logan C, Koblar S, Pasquale EB, Bothwell M. Eph Receptors and Ephrins in the Developing Chick Cerebellum: Relationship to Sagittal Patterning and Granule Cell Migration The Journal of Neuroscience. 20: 6488-6500. DOI: 10.1523/Jneurosci.20-17-06488.2000  0.106
2020 Fattet L, Jung HY, Matsumoto MW, Aubol BE, Kumar A, Adams JA, Chen AC, Sah RL, Engler AJ, Pasquale EB, Yang J. Matrix Rigidity Controls Epithelial-Mesenchymal Plasticity and Tumor Metastasis via a Mechanoresponsive EPHA2/LYN Complex. Developmental Cell. PMID 32574556 DOI: 10.1016/J.Devcel.2020.05.031  0.105
1989 Maher PA, Pasquale EB. Heat shock induces protein tyrosine phosphorylation in cultured cells. The Journal of Cell Biology. 108: 2029-35. PMID 2472399  0.103
2017 Lechtenberg BC, Mace PD, Sessions EH, Williamson R, Stalder R, Wallez Y, Roth GP, Riedl SJ, Pasquale EB. Structure-Guided Strategy for the Development of Potent Bivalent ERK Inhibitors. Acs Medicinal Chemistry Letters. 8: 726-731. PMID 28740606 DOI: 10.1021/Acsmedchemlett.7B00127  0.102
2004 Person AL, Cerretti DP, Pasquale EB, Rubel EW, Cramer KS. Tonotopic gradients of Eph family proteins in the chick nucleus laminaris during synaptogenesis. Journal of Neurobiology. 60: 28-39. PMID 15188270 DOI: 10.1002/neu.10330  0.101
1986 Pasquale EB, Maher PA, Singer SJ. Talin is phosphorylated on tyrosine in chicken embryo fibroblasts transformed by Rous sarcoma virus. Proceedings of the National Academy of Sciences of the United States of America. 83: 5507-11. PMID 2426700  0.1
2014 Wallez Y, Riedl SJ, Pasquale EB. Association of the breast cancer antiestrogen resistance protein 1 (BCAR1) and BCAR3 scaffolding proteins in cell signaling and antiestrogen resistance. The Journal of Biological Chemistry. 289: 10431-44. PMID 24584939 DOI: 10.1074/jbc.M113.541839  0.099
1989 Pasquale EB, Singer SJ. Identification of a developmentally regulated protein-tyrosine kinase by using anti-phosphotyrosine antibodies to screen a cDNA expression library. Proceedings of the National Academy of Sciences of the United States of America. 86: 5449-53. PMID 2473471  0.099
2000 Koblar SA, Krull CE, Pasquale EB, McLennan R, Peale FD, Cerretti DP, Bothwell M. Spinal motor axons and neural crest cells use different molecular guides for segmental migration through the rostral half-somite. Journal of Neurobiology. 42: 437-47. PMID 10699981 DOI: 10.1002/(Sici)1097-4695(200003)42:4<437::Aid-Neu5>3.0.Co;2-O  0.098
2002 Eberhart J, Swartz ME, Koblar SA, Pasquale EB, Krull CE. EphA4 constitutes a population-specific guidance cue for motor neurons. Developmental Biology. 247: 89-101. PMID 12074554 DOI: 10.1006/Dbio.2002.0695  0.093
2015 Paraiso KH, Das Thakur M, Fang B, Koomen JM, Fedorenko IV, John JK, Tsao H, Flaherty KT, Sondak VK, Messina JL, Pasquale EB, Villagra A, Rao UN, Kirkwood JM, Meier F, et al. Ligand-independent EPHA2 signaling drives the adoption of a targeted therapy-mediated metastatic melanoma phenotype. Cancer Discovery. 5: 264-73. PMID 25542447 DOI: 10.1158/2159-8290.Cd-14-0293  0.09
2001 Swartz ME, Eberhart J, Pasquale EB, Krull CE. EphA4/ephrin-A5 interactions in muscle precursor cell migration in the avian forelimb. Development (Cambridge, England). 128: 4669-80. PMID 11731448  0.088
2015 Arioli F, Pasquale E, Panseri S, Bonizzi L, Labella GF, Casati A, Foschini S, Chiesa L. Pseudoendogenous origin of prednisolone in pigs from the food chain. Food Additives & Contaminants. Part a, Chemistry, Analysis, Control, Exposure & Risk Assessment. 32: 833-40. PMID 25768050 DOI: 10.1080/19440049.2015.1028482  0.088
2002 Zou JX, Liu Y, Pasquale EB, Ruoslahti E. Activated SRC oncogene phosphorylates R-ras and suppresses integrin activity. The Journal of Biological Chemistry. 277: 1824-7. PMID 11682467 DOI: 10.1074/Jbc.M103133200  0.088
2019 Zapata-Mercado EA, Rainwater R, Pasquale EB, Hristova K. Mechanism of EphA2 Dimerization in Response to Monomeric Ligands Biophysical Journal. 116: 233a. DOI: 10.1016/J.Bpj.2018.11.1279  0.088
2008 Murai KK, Pasquale EB. Neuroscience. Axons seek neighborly advice. Science (New York, N.Y.). 320: 185-6. PMID 18403698 DOI: 10.1126/Science.1157605  0.086
2013 Wu B, Zhang Z, Noberini R, Barile E, Giulianotti M, Pinilla C, Houghten RA, Pasquale EB, Pellecchia M. HTS by NMR of combinatorial libraries: a fragment-based approach to ligand discovery. Chemistry & Biology. 20: 19-33. PMID 23352136 DOI: 10.1016/j.chembiol.2012.10.015  0.086
2006 Derunes C, Burgess R, Iraheta E, Kellerer R, Becherer K, Gessner CR, Li S, Hewitt K, Vuori K, Pasquale EB, Woods VL, Ely KR. Molecular determinants for interaction of SHEP1 with Cas localize to a highly solvent-protected region in the complex. Febs Letters. 580: 175-8. PMID 16364304 DOI: 10.1016/J.Febslet.2005.11.070  0.086
2011 Mace PD, Wallez Y, Dobaczewska MK, Lee JJ, Robinson H, Pasquale EB, Riedl SJ. NSP-Cas protein structures reveal a promiscuous interaction module in cell signaling. Nature Structural & Molecular Biology. 18: 1381-7. PMID 22081014 DOI: 10.1038/nsmb.2152  0.085
2006 Kasemeier‐Kulesa J, Bradley R, Pasquale E, Lefcort F, Kulesa P. [S2]: Sculpting the sympathetic ganglia: Revealing the interplay of cell movements and molecular signals International Journal of Developmental Neuroscience. 24: 471-472. DOI: 10.1016/j.ijdevneu.2006.09.005  0.085
1994 Johansson MW, Larsson E, Lüning B, Pasquale EB, Ruoslahti E. Altered localization and cytoplasmic domain-binding properties of tyrosine-phosphorylated beta 1 integrin. The Journal of Cell Biology. 126: 1299-309. PMID 7520449  0.083
2013 Wang S, Noberini R, Stebbins JL, Das S, Zhang Z, Wu B, Mitra S, Billet S, Fernandez A, Bhowmick NA, Kitada S, Pasquale EB, Fisher PB, Pellecchia M. Targeted delivery of paclitaxel to EphA2-expressing cancer cells. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 19: 128-37. PMID 23155185 DOI: 10.1158/1078-0432.Ccr-12-2654  0.079
2014 Baig N, Timofeeva O, Zhao X, Dritschilo A, Pasquale E, Henkemeyer M, Kool M, Rood B, Jung M, Rodriguez O, Albanese C, Karam S. EphB1 Inhibits Migration and Proliferation of Medulloblastoma Tumor Cells and Sensitizes Them to Ionizing Radiation by Mediating a G1 Arrest International Journal of Radiation Oncology*Biology*Physics. 90: S36. DOI: 10.1016/J.Ijrobp.2014.05.150  0.076
1993 Sajjadi FG, Pasquale EB. Five novel avian Eph-related tyrosine kinases are differentially expressed. Oncogene. 8: 1807-13. PMID 8510926  0.074
1991 Lindberg RA, Pasquale EB. Isolation of cDNA clones that encode active protein-tyrosine kinases using antibodies against phosphotyrosine. Methods in Enzymology. 200: 557-64. PMID 1720190  0.074
2015 Chiesa L, Pavlovic R, Dusi G, Pasquale E, Casati A, Panseri S, Arioli F. Determination of α- and β-boldenone sulfate, glucuronide and free forms, and androstadienedione in bovine urine using immunoaffinity columns clean-up and liquid chromatography tandem mass spectrometry analysis. Talanta. 131: 163-9. PMID 25281088 DOI: 10.1016/j.talanta.2014.07.035  0.072
2015 Chiesa L, Pasquale E, Panseri S, Cannizzo FT, Biolatti B, Pavlovic R, Arioli F. Pseudoendogenous presence of β-boldenone sulphate and glucuronide in untreated young bulls from the food chain. Food Additives & Contaminants. Part a, Chemistry, Analysis, Control, Exposure & Risk Assessment. 32: 825-32. PMID 25768316 DOI: 10.1080/19440049.2015.1027965  0.067
1988 Maher PA, Pasquale EB. Tyrosine phosphorylated proteins in different tissues during chick embryo development. The Journal of Cell Biology. 106: 1747-55. PMID 2453521  0.067
2010 Huang FJ, You WK, Bonaldo P, Seyfried TN, Pasquale EB, Stallcup WB. Pericyte deficiencies lead to aberrant tumor vascularizaton in the brain of the NG2 null mouse. Developmental Biology. 344: 1035-46. PMID 20599895 DOI: 10.1016/j.ydbio.2010.06.023  0.064
2014 Chiesa L, Pavlovic R, Fidani M, Panseri S, Pasquale E, Casati A, Arioli F. The presence of prednisolone in complementary feedstuffs for bovine husbandry. Journal of the Science of Food and Agriculture. 94: 2331-7. PMID 24415459 DOI: 10.1002/jsfa.6568  0.061
2000 Pasquale E. Neurobiology. Turning attraction into repulsion. Science (New York, N.Y.). 289: 1308-10. PMID 10979856 DOI: 10.1126/science.289.5483.1308  0.059
1971 Pasquale EA. The patient, the hospital, and the double-bind. Journal of Psychiatric Nursing and Mental Health Services. 9: 15-7. PMID 4324380  0.058
2014 Baig NA, Rodriguez O, Pasquale E, Dritschilo A, Donoghue M, Timofeeva O, Albanese C, Karam SD. Role of the EphA4 and EphA7 genes in mediating the growth and aggressiveness of medulloblastoma tumors in the Smo/Smo medulloblastoma mouse model. Journal of Clinical Oncology. 32: e22137-e22137. DOI: 10.1200/Jco.2014.32.15_Suppl.E22137  0.054
2011 Biliran H, Jan Y, Chen R, Pasquale EB, Ruoslahti E. Protein kinase D is a positive regulator of Bit1 apoptotic function (The Journal OF Biological Chemistry (2008) 283 (28029-28037)) Journal of Biological Chemistry. 286: 7714. DOI: 10.1074/jbc.A110.803139  0.046
1993 Bartfeld NS, Pasquale EB, Geltosky JE, Languino LR. The alpha v beta 3 integrin associates with a 190-kDa protein that is phosphorylated on tyrosine in response to platelet-derived growth factor. The Journal of Biological Chemistry. 268: 17270-6. PMID 7688723  0.043
2014 Salati S, D'Imporzano G, Panseri S, Pasquale E, Adani F. Degradation of aflatoxin B1 during anaerobic digestion and its effect on process stability International Biodeterioration and Biodegradation. 94: 19-23. DOI: 10.1016/j.ibiod.2014.06.011  0.043
2017 Lechtenberg BC, Mace PD, Sessions EH, Williamson R, Stalder R, Wallez Y, Roth GP, Riedl SJ, Pasquale EB. Design and structural characterization of a bivalent MAP kinase inhibitor Acta Crystallographica Section a Foundations and Advances. 73: a357-a357. DOI: 10.1107/S0108767317096519  0.039
2006 Nefzi A, Hoesl CE, Pinilla C, Kauffman GB, Maggiora GM, Pasquale E, Houghten RA. Synthesis of platinum(II) chiral tetraamine coordination complexes. Journal of Combinatorial Chemistry. 8: 780-3. PMID 16961414 DOI: 10.1021/cc060045h  0.038
1998 Lunghi F, Lunghi M, Bovo R, Biasiato R, Campolieti G, Di Franco R, Ieva G, Pasquale E, Perissinotto M. [Gastric pull-up in pharyngo-esophageal reconstruction: a personal experience]. Acta Otorhinolaryngologica Italica : Organo Ufficiale Della Societã  Italiana Di Otorinolaringologia E Chirurgia Cervico-Facciale. 18: 392-7. PMID 10388153  0.033
2019 de Boer A, Storm A, Soler MG, Smolders S, Rué L, Poppe L, Pasquale E, Robberecht W, Lemmens R. Environmental enrichment during the chronic phase after experimental stroke promotes functional recovery without synergistic effects of EphA4 targeted therapy. Human Molecular Genetics. PMID 31814004 DOI: 10.1093/hmg/ddz288  0.03
2004 Pasquale EB. Eph-ephrin promiscuity is now crystal clear. Nature Neuroscience. 7: 417-8. PMID 15114347 DOI: 10.1038/nn0504-417  0.025
2001 Amendolara M, Perri S, Pasquale E, Biasiato R. [Surgical treatment in acute cholecystitis emergencies]. Chirurgia Italiana. 53: 375-81. PMID 11452824  0.018
1982 Torsello G, Pasquale E, Giunta C, Pasquale S, Giarin P, Borelli G. [Giant duplication of the transverse colon. Case report]. La Radiologia Medica. 68: 668-71. PMID 7146509  0.014
2009 Corona C, Pasquale ED, Poggi A, Ruzzi M, Savo DF. When DL-Lite met OWL.. Ceur Workshop Proceedings. 432.  0.01
2000 Pasquale E, Mazzarello V, Fenu G, Rubino C. Leukonychia from 2-ethyl-cyanoacrylate glue Contact Dermatitis. 42: 105-106. PMID 10703637  0.01
1984 Pasquale EA. The evil eye phenomenon: its implications for community health nursing. Home Healthcare Nurse. 2: 32-5. PMID 6564124  0.01
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