Beverley A. Orser - Publications

University of Toronto, Toronto, ON, Canada 
GABA, anesthetics, memory, pain, extrasynaptic receptors

117 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Ariza A, Naeini SM, Khodaei S, Ba J, Wang DS, Orser BA. Cell-surface biotinylation of GABA receptors in mouse hippocampal slices after sevoflurane anesthesia. Star Protocols. 4: 102450. PMID 37480561 DOI: 10.1016/j.xpro.2023.102450  0.774
2022 Khodaei S, Wang DS, Ariza A, Syed RM, Orser BA. The Impact of Inflammation and General Anesthesia on Memory and Executive Function in Mice. Anesthesia and Analgesia. PMID 36469752 DOI: 10.1213/ANE.0000000000006221  0.754
2022 Khodaei S, Wang DS, Lee Y, Chung W, Orser BA. Sevoflurane and lipopolysaccharide-induced inflammation differentially affect γ-aminobutyric acid type A receptor-mediated tonic inhibition in the hippocampus of male mice. British Journal of Anaesthesia. PMID 36336522 DOI: 10.1016/j.bja.2022.09.013  0.811
2021 Chung W, Wang DS, Khodaei S, Pinguelo A, Orser BA. GABA Receptors in Astrocytes Are Targets for Commonly Used Intravenous and Inhalational General Anesthetic Drugs. Frontiers in Aging Neuroscience. 13: 802582. PMID 35087395 DOI: 10.3389/fnagi.2021.802582  0.809
2020 Manzo MA, Wang DS, Li WW, Pinguelo A, Popa MO, Khodaei S, Atack JR, Ross RA, Orser BA. Inhibition of a tonic inhibitory conductance in mouse hippocampal neurones by negative allosteric modulators of α5 subunit-containing γ-aminobutyric acid type A receptors: implications for treating cognitive deficits. British Journal of Anaesthesia. PMID 33388140 DOI: 10.1016/j.bja.2020.11.032  0.811
2020 Khodaei S, Avramescu S, Wang DS, Sheng H, Chan NK, Lecker I, Fernandez-Escobar A, Lei G, Dewar MB, Whissell PD, Baker AJ, Orser BA. Inhibiting α5 Subunit-Containing γ-Aminobutyric Acid Type A Receptors Attenuates Cognitive Deficits After Traumatic Brain Injury. Critical Care Medicine. 48: 533-544. PMID 32205600 DOI: 10.1097/Ccm.0000000000004161  0.794
2019 Khodaei S, Avramescu S, Wang DS, Sheng H, Chan NK, Lecker I, Fernandez-Escobar A, Lei G, Dewar MB, Whissell PD, Baker AJ, Orser BA. Inhibiting α5 Subunit-Containing γ-Aminobutyric Acid Type A Receptors Attenuates Cognitive Deficits After Traumatic Brain Injury. Critical Care Medicine. PMID 31850927 DOI: 10.1097/CCM.0000000000004161  0.795
2019 Orser BA. Musings from an Unlikely Clinician-Scientist: 2018 American Society of Anesthesiologists Excellence in Research Award. Anesthesiology. PMID 31335546 DOI: 10.1097/ALN.0000000000002881  0.351
2019 Hemmings HC, Riegelhaupt PM, Kelz MB, Solt K, Eckenhoff RG, Orser BA, Goldstein PA. Towards a Comprehensive Understanding of Anesthetic Mechanisms of Action: A Decade of Discovery. Trends in Pharmacological Sciences. PMID 31147199 DOI: 10.1016/J.Tips.2019.05.001  0.337
2019 Yu J, Wang DS, Bonin RP, Penna A, Alavian-Ghavanini A, Zurek AA, Rauw G, Baker GB, Orser BA. Gabapentin increases expression of δ subunit-containing GABA receptors. Ebiomedicine. PMID 30878595 DOI: 10.1016/J.Ebiom.2019.03.008  0.82
2019 Orser BA, Wang DS. GABAA Receptor Theory of Perioperative Neurocognitive Disorders. Anesthesiology. 130: 618-619. PMID 30870211 DOI: 10.1097/Aln.0000000000002562  0.323
2018 Untereiner A, Abdo S, Bhattacharjee A, Gohil H, Pourasgari F, Ibeh N, Lai M, Batchuluun B, Wong A, Khuu N, Liu Y, Al Rijjal D, Winegarden N, Virtanen C, Orser BA, et al. GABA promotes β-cell proliferation, but does not overcome impaired glucose homeostasis associated with diet-induced obesity. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201801397R. PMID 30509117 DOI: 10.1096/Fj.201801397R  0.352
2018 Wang DS, Kaneshwaran K, Lei G, Mostafa F, Wang J, Lecker I, Avramescu S, Xie YF, Chan NK, Fernandez-Escobar A, Woo J, Chan D, Ramsey AJ, Sivak JM, Lee CJ, ... ... Orser BA, et al. Dexmedetomidine Prevents Excessive γ-Aminobutyric Acid Type A Receptor Function after Anesthesia. Anesthesiology. PMID 29889105 DOI: 10.1097/Aln.0000000000002311  0.806
2017 Montandon G, Wu H, Liu H, Vu MT, Orser BA, Horner RL. δ-Subunit Containing GABAA Receptors Modulate Respiratory Networks. Scientific Reports. 7: 18105. PMID 29273726 DOI: 10.1038/s41598-017-17379-x  0.399
2017 Lecker I, Wang DS, Kaneshwaran K, Mazer CD, Orser BA. High Concentrations of Tranexamic Acid Inhibit Ionotropic Glutamate Receptors. Anesthesiology. PMID 28475556 DOI: 10.1097/ALN.0000000000001665  0.397
2016 Wang DS, Penna A, Orser BA. Ketamine Increases the Function of γ-Aminobutyric Acid Type A Receptors in Hippocampal and Cortical Neurons. Anesthesiology. PMID 27984263 DOI: 10.1097/ALN.0000000000001483  0.509
2016 Piantadosi SC, French BJ, Poe MM, Timić T, Marković BD, Pabba M, Seney ML, Oh H, Orser BA, Savić MM, Cook JM, Sibille E. Sex-Dependent Anti-Stress Effect of an α5 Subunit Containing GABAA Receptor Positive Allosteric Modulator. Frontiers in Pharmacology. 7: 446. PMID 27920723 DOI: 10.3389/Fphar.2016.00446  0.328
2016 Perez-Sanchez J, Lorenzo LE, Lecker I, Zurek AA, Labrakakis C, Bridgwater EM, Orser BA, De Koninck Y, Bonin RP. α5GABAA Receptors Mediate Tonic Inhibition in the Spinal Cord Dorsal Horn and Contribute to the Resolution Of Hyperalgesia. Journal of Neuroscience Research. PMID 27792253 DOI: 10.1002/Jnr.23981  0.8
2016 Whissell PD, Avramescu S, Wang DS, Orser BA. δGABAA Receptors Are Necessary for Synaptic Plasticity in the Hippocampus: Implications for Memory Behavior. Anesthesia and Analgesia. PMID 27464975 DOI: 10.1213/Ane.0000000000001373  0.434
2016 Zurek AA, Kemp SW, Aga Z, Walker S, Milenkovic M, Ramsey AJ, Sibille E, Scherer SW, Orser BA. α5GABAA receptor deficiency causes autism-like behaviors. Annals of Clinical and Translational Neurology. 3: 392-8. PMID 27231709 DOI: 10.1002/Acn3.303  0.781
2015 Avramescu S, Wang DS, Lecker I, To WT, Penna A, Whissell PD, Mesbah-Oskui L, Horner RL, Orser BA. Inflammation Increases Neuronal Sensitivity to General Anesthetics. Anesthesiology. PMID 26566283 DOI: 10.1097/Aln.0000000000000943  0.617
2015 Accardi MV, Brown PM, Miraucourt LS, Orser BA, Bowie D. α6-Containing GABAA Receptors Are the Principal Mediators of Inhibitory Synapse Strengthening by Insulin in Cerebellar Granule Cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 9676-88. PMID 26134650 DOI: 10.1523/Jneurosci.0513-15.2015  0.423
2015 Whissell PD, Lecker I, Wang DS, Yu J, Orser BA. Altered expression of δGABAA receptors in health and disease. Neuropharmacology. 88: 24-35. PMID 25128850 DOI: 10.1016/J.Neuropharm.2014.08.003  0.687
2015 Zurek AA, Orser BA. Understanding anesthesia-induced memory loss Essentials of Pharmacology For Anesthesia, Pain Medicine, and Critical Care. 847-858. DOI: 10.1007/978-1-4614-8948-1_54  0.737
2014 Zurek AA, Yu J, Wang DS, Haffey SC, Bridgwater EM, Penna A, Lecker I, Lei G, Chang T, Salter EW, Orser BA. Sustained increase in α5GABAA receptor function impairs memory after anesthesia. The Journal of Clinical Investigation. 124: 5437-41. PMID 25365226 DOI: 10.1172/Jci76669  0.814
2014 Penna A, Wang DS, Yu J, Lecker I, Brown PM, Bowie D, Orser BA. Hydrogen peroxide increases GABAA receptor-mediated tonic current in hippocampal neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 10624-34. PMID 25100596 DOI: 10.1523/Jneurosci.0335-14.2014  0.707
2014 Diaz MR, Vollmer CC, Zamudio-Bulcock PA, Vollmer W, Blomquist SL, Morton RA, Everett JC, Zurek AA, Yu J, Orser BA, Valenzuela CF. Repeated intermittent alcohol exposure during the third trimester-equivalent increases expression of the GABA(A) receptor δ subunit in cerebellar granule neurons and delays motor development in rats. Neuropharmacology. 79: 262-74. PMID 24316160 DOI: 10.1016/J.Neuropharm.2013.11.020  0.79
2013 Whissell PD, Eng D, Lecker I, Martin LJ, Wang DS, Orser BA. Acutely increasing δGABA(A) receptor activity impairs memory and inhibits synaptic plasticity in the hippocampus. Frontiers in Neural Circuits. 7: 146. PMID 24062648 DOI: 10.3389/Fncir.2013.00146  0.656
2013 Whissell PD, Rosenzweig S, Lecker I, Wang DS, Wojtowicz JM, Orser BA. γ-aminobutyric acid type A receptors that contain the δ subunit promote memory and neurogenesis in the dentate gyrus. Annals of Neurology. 74: 611-21. PMID 23686887 DOI: 10.1002/Ana.23941  0.455
2013 Lecker I, Yin Y, Wang DS, Orser BA. Potentiation of GABAA receptor activity by volatile anaesthetics is reduced by α5GABAA receptor-preferring inverse agonists. British Journal of Anaesthesia. 110: i73-81. PMID 23535829 DOI: 10.1093/bja/aet038  0.489
2013 Bonin RP, Zurek AA, Yu J, Bayliss DA, Orser BA. Hyperpolarization-activated current (In) is reduced in hippocampal neurons from Gabra5-/- mice. Plos One. 8: e58679. PMID 23516534 DOI: 10.1371/Journal.Pone.0058679  0.809
2013 Xiang YY, Chen X, Li J, Wang S, Faclier G, Macdonald JF, Hogg JC, Orser BA, Lu WY. Isoflurane regulates atypical type-A γ-aminobutyric acid receptors in alveolar type II epithelial cells. Anesthesiology. 118: 1065-75. PMID 23485993 DOI: 10.1097/ALN.0b013e31828e180e  0.611
2013 Clarke H, Wijeysundera DN, Bonin RP, Orser B, Englesakis M, Katz J. Pregabalin effective for the prevention of chronic postsurgical pain: really? Reply. Anesthesia and Analgesia. 116: 508-9. PMID 23460947 DOI: 10.1213/Ane.0B013E3182799186  0.628
2012 Lecker I, Wang DS, Romaschin AD, Peterson M, Mazer CD, Orser BA. Tranexamic acid concentrations associated with human seizures inhibit glycine receptors. The Journal of Clinical Investigation. 122: 4654-66. PMID 23187124 DOI: 10.1172/Jci63375  0.37
2012 Wang DS, Zurek AA, Lecker I, Yu J, Abramian AM, Avramescu S, Davies PA, Moss SJ, Lu WY, Orser BA. Memory deficits induced by inflammation are regulated by α5-subunit-containing GABAA receptors. Cell Reports. 2: 488-96. PMID 22999935 DOI: 10.1016/J.Celrep.2012.08.022  0.837
2012 Clarke H, Bonin RP, Orser BA, Englesakis M, Wijeysundera DN, Katz J. The prevention of chronic postsurgical pain using gabapentin and pregabalin: a combined systematic review and meta-analysis. Anesthesia and Analgesia. 115: 428-42. PMID 22415535 DOI: 10.1213/Ane.0B013E318249D36E  0.631
2012 Zurek AA, Bridgwater EM, Orser BA. Inhibition of α5 γ-Aminobutyric acid type A receptors restores recognition memory after general anesthesia. Anesthesia and Analgesia. 114: 845-55. PMID 22383672 DOI: 10.1213/ANE.0b013e31824720da  0.79
2012 Yang K, Trepanier C, Sidhu B, Xie YF, Li H, Lei G, Salter MW, Orser BA, Nakazawa T, Yamamoto T, Jackson MF, Macdonald JF. Metaplasticity gated through differential regulation of GluN2A versus GluN2B receptors by Src family kinases. The Embo Journal. 31: 805-16. PMID 22187052 DOI: 10.1038/Emboj.2011.453  0.799
2011 Chen X, Li M, Xiong ZG, Orser BA, Macdonald JF, Lu WY. An anti-coagulation agent Futhan preferentially targets GABA(A) receptors in lungepithelia: implication in treating asthma. International Journal of Physiology, Pathophysiology and Pharmacology. 3: 249-56. PMID 22162781  0.6
2011 Chen X, Whissell P, Orser BA, MacDonald JF. Functional modifications of acid-sensing ion channels by ligand-gated chloride channels. Plos One. 6: e21970. PMID 21789198 DOI: 10.1371/journal.pone.0021970  0.645
2011 Bonin RP, Labrakakis C, Eng DG, Whissell PD, De Koninck Y, Orser BA. Pharmacological enhancement of δ-subunit-containing GABA(A) receptors that generate a tonic inhibitory conductance in spinal neurons attenuates acute nociception in mice. Pain. 152: 1317-26. PMID 21396779 DOI: 10.1016/J.Pain.2011.02.011  0.796
2011 Wang DS, Orser BA. Inhibition of learning and memory by general anesthetics. Canadian Journal of Anaesthesia = Journal Canadien D'Anesthã©Sie. 58: 167-77. PMID 21181566 DOI: 10.1007/S12630-010-9428-8  0.37
2011 Martin LJ, Zurek AA, Bonin RP, Oh GH, Kim JH, Mount HT, Orser BA. The sedative but not the memory-blocking properties of ethanol are modulated by α5-subunit-containing γ-aminobutyric acid type A receptors. Behavioural Brain Research. 217: 379-85. PMID 21070817 DOI: 10.1016/j.bbr.2010.11.008  0.8
2011 Li HB, Jackson MF, Yang K, Trepanier C, Salter MW, Orser BA, Macdonald JF. Plasticity of synaptic GluN receptors is required for the Src-dependent induction of long-term potentiation at CA3-CA1 synapses. Hippocampus. 21: 1053-61. PMID 20865743 DOI: 10.1002/Hipo.20818  0.79
2011 Chen X, Li M, Xiong ZG, Orser BA, MacDonald JF, Lu WY. An anti-coagulation agent futhan preferentially targets GABA A receptors in lung epithelia: Implication in treating asthma International Journal of Physiology, Pathophysiology and Pharmacology. 3: 249-256.  0.505
2010 Chen X, Numata T, Li M, Mori Y, Orser BA, Jackson MF, Xiong ZG, MacDonald JF. The modulation of TRPM7 currents by nafamostat mesilate depends directly upon extracellular concentrations of divalent cations. Molecular Brain. 3: 38. PMID 21122141 DOI: 10.1186/1756-6606-3-38  0.671
2010 Saab BJ, Maclean AJ, Kanisek M, Zurek AA, Martin LJ, Roder JC, Orser BA. Short-term memory impairment after isoflurane in mice is prevented by the α5 γ-aminobutyric acid type A receptor inverse agonist L-655,708. Anesthesiology. 113: 1061-71. PMID 20966663 DOI: 10.1097/Aln.0B013E3181F56228  0.805
2010 Chen X, Orser BA, MacDonald JF. Design and screening of ASIC inhibitors based on aromatic diamidines for combating neurological disorders. European Journal of Pharmacology. 648: 15-23. PMID 20854810 DOI: 10.1016/j.ejphar.2010.09.005  0.532
2010 Martin LJ, Zurek AA, MacDonald JF, Roder JC, Jackson MF, Orser BA. Alpha5GABAA receptor activity sets the threshold for long-term potentiation and constrains hippocampus-dependent memory. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 5269-82. PMID 20392949 DOI: 10.1523/Jneurosci.4209-09.2010  0.821
2010 Chen X, Qiu L, Li M, Dürrnagel S, Orser BA, Xiong ZG, MacDonald JF. Diarylamidines: high potency inhibitors of acid-sensing ion channels. Neuropharmacology. 58: 1045-53. PMID 20114056 DOI: 10.1016/j.neuropharm.2010.01.011  0.537
2010 Vargas-Caballero M, Martin LJ, Salter MW, Orser BA, Paulsen O. alpha5 Subunit-containing GABA(A) receptors mediate a slowly decaying inhibitory synaptic current in CA1 pyramidal neurons following Schaffer collateral activation. Neuropharmacology. 58: 668-75. PMID 19941877 DOI: 10.1016/j.neuropharm.2009.11.005  0.708
2009 Li GH, Jackson MF, Orser BA, Macdonald JF. Reciprocal and activity-dependent regulation of surface AMPA and NMDA receptors in cultured neurons. International Journal of Physiology, Pathophysiology and Pharmacology. 2: 47-56. PMID 21383896  0.669
2009 Martin LJ, Bonin RP, Orser BA. The physiological properties and therapeutic potential of alpha5-GABAA receptors. Biochemical Society Transactions. 37: 1334-7. PMID 19909271 DOI: 10.1042/BST0371334  0.783
2009 Martin LJ, Oh GH, Orser BA. Etomidate targets alpha5 gamma-aminobutyric acid subtype A receptors to regulate synaptic plasticity and memory blockade. Anesthesiology. 111: 1025-35. PMID 19809285 DOI: 10.1097/ALN.0b013e3181bbc961  0.583
2009 Sun HS, Jackson MF, Martin LJ, Jansen K, Teves L, Cui H, Kiyonaka S, Mori Y, Jones M, Forder JP, Golde TE, Orser BA, Macdonald JF, Tymianski M. Suppression of hippocampal TRPM7 protein prevents delayed neuronal death in brain ischemia. Nature Neuroscience. 12: 1300-7. PMID 19734892 DOI: 10.1038/Nn.2395  0.748
2009 Ju YH, Guzzo A, Chiu MW, Taylor P, Moran MF, Gurd JW, MacDonald JF, Orser BA. Distinct properties of murine alpha 5 gamma-aminobutyric acid type a receptors revealed by biochemical fractionation and mass spectroscopy. Journal of Neuroscience Research. 87: 1737-47. PMID 19156871 DOI: 10.1002/Jnr.21991  0.573
2008 Bonin RP, Orser BA. GABA(A) receptor subtypes underlying general anesthesia. Pharmacology, Biochemistry, and Behavior. 90: 105-12. PMID 18201756 DOI: 10.1016/j.pbb.2007.12.011  0.743
2007 Wei WL, Sun HS, Olah ME, Sun X, Czerwinska E, Czerwinski W, Mori Y, Orser BA, Xiong ZG, Jackson MF, Tymianski M, MacDonald JF. TRPM7 channels in hippocampal neurons detect levels of extracellular divalent cations. Proceedings of the National Academy of Sciences of the United States of America. 104: 16323-8. PMID 17913893 DOI: 10.1073/Pnas.0701149104  0.679
2007 Bonin RP, Martin LJ, MacDonald JF, Orser BA. Alpha5GABAA receptors regulate the intrinsic excitability of mouse hippocampal pyramidal neurons. Journal of Neurophysiology. 98: 2244-54. PMID 17715197 DOI: 10.1152/jn.00482.2007  0.82
2007 Xiang YY, Wang S, Liu M, Hirota JA, Li J, Ju W, Fan Y, Kelly MM, Ye B, Orser B, O'Byrne PM, Inman MD, Yang X, Lu WY. A GABAergic system in airway epithelium is essential for mucus overproduction in asthma. Nature Medicine. 13: 862-7. PMID 17589520 DOI: 10.1038/nm1604  0.492
2007 Caraiscos VB, Bonin RP, Newell JG, Czerwinska E, Macdonald JF, Orser BA. Insulin increases the potency of glycine at ionotropic glycine receptors. Molecular Pharmacology. 71: 1277-87. PMID 17308032 DOI: 10.1124/Mol.106.033563  0.803
2007 Guzzo A, Ju W, Chiu M, Taylor P, Moran M, Orser BA. Probing the identity of gabaa receptors that underlie amnestic properties of anesthetics Canadian Journal of Anesthesia/Journal Canadien D'AnesthéSie. 54: 44361-44361. DOI: 10.1007/BF03019935  0.566
2006 Orser BA. Extrasynaptic GABAA receptors are critical targets for sedative-hypnotic drugs. Journal of Clinical Sleep Medicine : Jcsm : Official Publication of the American Academy of Sleep Medicine. 2: S12-8. PMID 17557502 DOI: 10.5664/Jcsm.26526  0.465
2006 Cheng VY, Bonin RP, Chiu MW, Newell JG, MacDonald JF, Orser BA. Gabapentin increases a tonic inhibitory conductance in hippocampal pyramidal neurons. Anesthesiology. 105: 325-33. PMID 16871066 DOI: 10.1097/00000542-200608000-00015  0.811
2006 Cheng VY, Martin LJ, Elliott EM, Kim JH, Mount HT, Taverna FA, Roder JC, Macdonald JF, Bhambri A, Collinson N, Wafford KA, Orser BA. Alpha5GABAA receptors mediate the amnestic but not sedative-hypnotic effects of the general anesthetic etomidate. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 3713-20. PMID 16597725 DOI: 10.1523/Jneurosci.5024-05.2006  0.69
2006 Orser B, Martin L, Cheng V, MacDonald J. The amnestic and sedative-hypnotic properties of etomidate in mice can be dissociated based on gaba(a) receptor subtype pharmacology Canadian Journal of Anesthesia/Journal Canadien D'AnesthéSie. 53: 26485-26485. DOI: 10.1007/BF03017071  0.561
2006 Ju Y, Chiu M, Orser B. Novel extrasynaptic gabaa receptor populations in murine spinal cord Canadian Journal of Anesthesia/Journal Canadien D'AnesthéSie. 53: 26468-26468. DOI: 10.1007/BF03017057  0.311
2006 Eng D, Bonin R, Macdonald J, Orser B. A tonic inhibitory conductance in murine spinal neurons: a novel site for anesthetics? Canadian Journal of Anesthesia/Journal Canadien D'AnesthéSie. 53: 26317-26317. DOI: 10.1007/BF03016961  0.734
2006 Lu W, Xiang Y, Ju W, Liu M, Orser B. A-type gamma-aminobutyric acid receptor (gabaar) and glutamic acid decarboxylase (gad) in type ii pneumocytes Canadian Journal of Anesthesia/Journal Canadien D'AnesthéSie. 53: 26167-26167. DOI: 10.1007/Bf03016925  0.541
2005 Macdonald DS, Weerapura M, Beazely MA, Martin L, Czerwinski W, Roder JC, Orser BA, MacDonald JF. Modulation of NMDA receptors by pituitary adenylate cyclase activating peptide in CA1 neurons requires G alpha q, protein kinase C, and activation of Src. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 11374-84. PMID 16339032 DOI: 10.1523/Jneurosci.3871-05.2005  0.689
2005 Hemmings HC, Akabas MH, Goldstein PA, Trudell JR, Orser BA, Harrison NL. Emerging molecular mechanisms of general anesthetic action. Trends in Pharmacological Sciences. 26: 503-10. PMID 16126282 DOI: 10.1016/J.Tips.2005.08.006  0.376
2005 Orser BA, Caraiscos VB, Elliott E, Cheng VY, Newell JG, MacDonald JF. Anesthetic sensitivity is reduced in hippocampal pyramidal neurons from GABAA receptor α5 subunit null mutant mice International Congress Series. 1283: 38-42. DOI: 10.1016/j.ics.2005.07.070  0.823
2005 Orser BA, Caraiscos VB, You-Ten EK, Cheng VY, Newell JG, MacDonald JF. The α5 GABAA receptor subunit confers resistance to isoflurane inhibition International Congress Series. 1283: 189-192. DOI: 10.1016/j.ics.2005.06.085  0.803
2004 Caraiscos VB, Newell JG, You-Ten KE, Elliott EM, Rosahl TW, Wafford KA, MacDonald JF, Orser BA. Selective enhancement of tonic GABAergic inhibition in murine hippocampal neurons by low concentrations of the volatile anesthetic isoflurane. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 8454-8. PMID 15456818 DOI: 10.1523/Jneurosci.2063-04.2004  0.833
2004 Xing Y, Sonner J, Laster MJ, Abaigar W, Caraiscos VB, Orser B, Eger EI. Insulin decreases isoflurane minimum alveolar anesthetic concentration in rats independently of an effect on the spinal cord. Anesthesia and Analgesia. 98: 1712-7, table of con. PMID 15155333 DOI: 10.1213/01.Ane.0000113550.47942.47  0.738
2004 Caraiscos VB, Elliott EM, You-Ten KE, Cheng VY, Belelli D, Newell JG, Jackson MF, Lambert JJ, Rosahl TW, Wafford KA, MacDonald JF, Orser BA. Tonic inhibition in mouse hippocampal CA1 pyramidal neurons is mediated by alpha5 subunit-containing gamma-aminobutyric acid type A receptors. Proceedings of the National Academy of Sciences of the United States of America. 101: 3662-7. PMID 14993607 DOI: 10.1073/Pnas.0307231101  0.833
2003 Sonner JM, Antognini JF, Dutton RC, Flood P, Gray AT, Harris RA, Homanics GE, Kendig J, Orser B, Raines DE, Rampil IJ, Trudell J, Vissel B, Eger EI. Inhaled anesthetics and immobility: mechanisms, mysteries, and minimum alveolar anesthetic concentration. Anesthesia and Analgesia. 97: 718-40. PMID 12933393 DOI: 10.1213/01.Ane.0000081063.76651.33  0.377
2003 Jackson MF, Joo DT, Al-Mahrouki AA, Orser BA, Macdonald JF. Desensitization of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors facilitates use-dependent inhibition by pentobarbital. Molecular Pharmacology. 64: 395-406. PMID 12869644 DOI: 10.1124/Mol.64.2.395  0.806
2003 Kotecha SA, Jackson MF, Al-Mahrouki A, Roder JC, Orser BA, MacDonald JF. Co-stimulation of mGluR5 and N-methyl-D-aspartate receptors is required for potentiation of excitatory synaptic transmission in hippocampal neurons. The Journal of Biological Chemistry. 278: 27742-9. PMID 12740378 DOI: 10.1074/Jbc.M301946200  0.72
2003 Yeung JY, Canning KJ, Zhu G, Pennefather P, MacDonald JF, Orser BA. Tonically activated GABAA receptors in hippocampal neurons are high-affinity, low-conductance sensors for extracellular GABA. Molecular Pharmacology. 63: 2-8. PMID 12488530 DOI: 10.1124/Mol.63.1.2  0.674
2002 Orser BA, Canning KJ, Macdonald JF. Mechanisms of general anesthesia. Current Opinion in Anaesthesiology. 15: 427-33. PMID 17019234 DOI: 10.1097/00001503-200208000-00004  0.649
2002 Baker PM, Pennefather PS, Orser BA, Skinner FK. Disruption of coherent oscillations in inhibitory networks with anesthetics: role of GABA(A) receptor desensitization. Journal of Neurophysiology. 88: 2821-33. PMID 12424315 DOI: 10.1152/jn.00052.2002  0.404
2002 Kotecha SA, Oak JN, Jackson MF, Perez Y, Orser BA, Van Tol HH, MacDonald JF. A D2 class dopamine receptor transactivates a receptor tyrosine kinase to inhibit NMDA receptor transmission. Neuron. 35: 1111-22. PMID 12354400 DOI: 10.1016/S0896-6273(02)00859-0  0.713
2002 Caraiscos VB, Mihic SJ, MacDonald JF, Orser BA. Tyrosine kinases enhance the function of glycine receptors in rat hippocampal neurons and human alpha(1)beta glycine receptors. The Journal of Physiology. 539: 495-502. PMID 11882681 DOI: 10.1113/Jphysiol.2001.013508  0.809
2002 Caraiscos VB, MacDonald JF, Orser BA. Insulin Enhancement of Glycine Receptors in Spinal Neurons: A Novel Strategy for Pain Therapy Anesthesiology. 96: A769. DOI: 10.1097/00000542-200209002-00769  0.791
2002 Yeung J, Canning K, MacDonald JF, Orser BA. Blockade of Tonic and Synaptic GABAergic Current in Murine Hippocampal Neurons Reveals Two Populations of GABA-A Receptors Anesthesiology. 96: A768. DOI: 10.1097/00000542-200209002-00768  0.643
2001 Naik V, Matsumoto E, Houston P, Hamstra S, Yeung R, Mallon J, Martire T, Zwack RM, Campbell DC, Breen TW, Yip RW, Roy JD, Girard M, Drolet P, Guay J, ... ... Orser BA, et al. Learning fiberoptic intubation on a simple model transfers to the O.R. Canadian Journal of Anaesthesia = Journal Canadien D'Anesthesie. 48: A2-A50. PMID 27688127 DOI: 10.1007/Bf03028184  0.747
2001 Toong S, Xiong ZG, Zavorin SI, Bai D, Orser BA, Thatcher GR, Reynolds JN, MacDonald JF. Modulation of AMPA receptors by a novel organic nitrate. Canadian Journal of Physiology and Pharmacology. 79: 422-9. PMID 11405246 DOI: 10.1139/cjpp-79-5-422  0.612
2001 Joo DT, Gong D, Sonner JM, Jia Z, MacDonald JF, Eger EI, Orser BA. Blockade of AMPA receptors and volatile anesthetics: reduced anesthetic requirements in GluR2 null mutant mice for loss of the righting reflex and antinociception but not minimum alveolar concentration. Anesthesiology. 94: 478-88. PMID 11374610 DOI: 10.1097/00000542-200103000-00020  0.827
2001 Lei S, Orser BA, Thatcher GR, Reynolds JN, MacDonald JF. Positive allosteric modulators of AMPA receptors reduce proton-induced receptor desensitization in rat hippocampal neurons. Journal of Neurophysiology. 85: 2030-8. PMID 11353019 DOI: 10.1152/jn.2001.85.5.2030  0.637
2001 Iihara K, Joo DT, Henderson J, Sattler R, Taverna FA, Lourensen S, Orser BA, Roder JC, Tymianski M. The influence of glutamate receptor 2 expression on excitotoxicity in Glur2 null mutant mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 2224-39. PMID 11264298 DOI: 10.1523/Jneurosci.21-07-02224.2001  0.815
2001 Bai D, Zhu G, Pennefather P, Jackson MF, MacDonald JF, Orser BA. Distinct functional and pharmacological properties of tonic and quantal inhibitory postsynaptic currents mediated by gamma-aminobutyric acid(A) receptors in hippocampal neurons. Molecular Pharmacology. 59: 814-24. PMID 11259626 DOI: 10.1124/Mol.59.4.814  0.755
2001 Toong S, Xiong Z, Zavorin SI, Bai D, Orser BA, Thatcher GR, Reynolds JN, MacDonald JF. Modulation of AMPA receptors by a novel organic nitrate Canadian Journal of Physiology and Pharmacology. 79: 422-429. DOI: 10.1139/y01-009  0.552
2001 Baker PM, Grigull J, Pennefather PS, Orser BA, Skinner FK. Frequency switches in inhibitory networks with anesthetics Neurocomputing. 38: 467-474. DOI: 10.1016/S0925-2312(01)00385-X  0.303
2000 Joo DT, Orser BA. Anesthetics and glutamate co-transporters in the central nervous system. Canadian Journal of Anaesthesia = Journal Canadien D'Anesthã©Sie. 47: 725-9. PMID 10958087  0.744
2000 Lu WY, Jackson MF, Bai D, Orser BA, MacDonald JF. In CA1 pyramidal neurons of the hippocampus protein kinase C regulates calcium-dependent inactivation of NMDA receptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 4452-61. PMID 10844014 DOI: 10.1523/Jneurosci.20-12-04452.2000  0.674
2000 Joo DT, Orser BA. External compression of a nasotracheal tube due to the displaced bony fragments of multiple LeFort fractures. Anesthesiology. 92: 1830-2. PMID 10839937 DOI: 10.1097/00000542-200006000-00045  0.733
2000 Lei S, Jackson MF, Jia Z, Roder J, Bai D, Orser BA, MacDonald JF. Cyclic GMP-dependent feedback inhibition of AMPA receptors is independent of PKG. Nature Neuroscience. 3: 559-65. PMID 10816311 DOI: 10.1038/75729  0.716
1999 Bai D, Pennefather PS, MacDonald JF, Orser BA. The general anesthetic propofol slows deactivation and desensitization of GABA(A) receptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 10635-46. PMID 10594047 DOI: 10.1523/Jneurosci.19-24-10635.1999  0.608
1999 Joo DT, Xiong Z, MacDonald JF, Jia Z, Roder J, Sonner J, Orser BA. Blockade of glutamate receptors and barbiturate anesthesia: increased sensitivity to pentobarbital-induced anesthesia despite reduced inhibition of AMPA receptors in GluR2 null mutant mice. Anesthesiology. 91: 1329-41. PMID 10551584 DOI: 10.1097/00000542-199911000-00025  0.841
1999 Lei S, Lu WY, Xiong ZG, Orser BA, Valenzuela CF, MacDonald JF. Platelet-derived growth factor receptor-induced feed-forward inhibition of excitatory transmission between hippocampal pyramidal neurons. The Journal of Biological Chemistry. 274: 30617-23. PMID 10521446 DOI: 10.1074/Jbc.274.43.30617  0.595
1999 Lu WY, Xiong ZG, Lei S, Orser BA, Dudek E, Browning MD, MacDonald JF. G-protein-coupled receptors act via protein kinase C and Src to regulate NMDA receptors. Nature Neuroscience. 2: 331-8. PMID 10204539 DOI: 10.1038/7243  0.601
1999 Bai D, Pennefather PS, MacDonald JF, Orser BA. The General Anesthetic Propofol Slows Deactivation and Desensitization of GABAAReceptors The Journal of Neuroscience. 19: 10635-10646. DOI: 10.1523/JNEUROSCI.19-24-10635.1999  0.443
1998 Orser BA, McAdam LC, Roder S, MacDonald JF. General anaesthetics and their effects on GABA(A) receptor desensitization. Toxicology Letters. 100: 217-24. PMID 10049145 DOI: 10.1016/S0378-4274(98)00188-X  0.627
1998 MacDonald JF, Xiong XG, Lu WY, Raouf R, Orser BA. Modulation of NMDA receptors. Progress in Brain Research. 116: 191-208. PMID 9932378 DOI: 10.1016/S0079-6123(08)60438-0  0.557
1998 McAdam LC, MacDonald JF, Orser BA. Isobolographic analysis of the interactions between midazolam and propofol at GABA(A) receptors in embryonic mouse neurons. Anesthesiology. 89: 1444-54. PMID 9856719 DOI: 10.1097/00000542-199812000-00022  0.609
1998 Xiong ZG, Raouf R, Lu WY, Wang LY, Orser BA, Dudek EM, Browning MD, MacDonald JF. Regulation of N-methyl-D-aspartate receptor function by constitutively active protein kinase C. Molecular Pharmacology. 54: 1055-63. PMID 9855634 DOI: 10.1124/Mol.54.6.1055  0.687
1998 Lu WY, Xiong ZG, Orser BA, MacDonald JF. Multiple sites of action of neomycin, Mg2+ and spermine on the NMDA receptors of rat hippocampal CA1 pyramidal neurones. The Journal of Physiology. 512: 29-46. PMID 9729615 DOI: 10.1111/j.1469-7793.1998.029bf.x  0.628
1998 Orser B. Physostigmine, propofol and the GABAA receptor. Canadian Journal of Anaesthesia = Journal Canadien D'Anesthesie. 45: 496-7. PMID 9598270 DOI: 10.1007/BF03012592  0.307
1997 Orser B, Smith D, Henderson S, Gelb A. Magnesium deficiency increases ketamine sensitivity in rats. Canadian Journal of Anaesthesia = Journal Canadien D'Anesthesie. 44: 883-90. PMID 9260017 DOI: 10.1007/Bf03013166  0.376
1997 Orser BA, Pennefather PS, MacDonald JF. Multiple mechanisms of ketamine blockade of N-methyl-D-aspartate receptors. Anesthesiology. 86: 903-17. PMID 9105235 DOI: 10.1097/00000542-199704000-00021  0.553
1996 Orser BA, MacDonald JF. Reconciling differences between in vitro and in vivo effects of propofol. Anesthesiology. 84: 749-50. PMID 8659808 DOI: 10.1097/00000542-199603000-00036  0.489
1995 Orser BA, Bertlik M, Wang LY, MacDonald JF. Inhibition by propofol (2,6 di-isopropylphenol) of the N-methyl-D-aspartate subtype of glutamate receptor in cultured hippocampal neurones. British Journal of Pharmacology. 116: 1761-8. PMID 8528557 DOI: 10.1111/J.1476-5381.1995.Tb16660.X  0.675
1994 Wang LY, Orser BA, Brautigan DL, MacDonald JF. Regulation of NMDA receptors in cultured hippocampal neurons by protein phosphatases 1 and 2A. Nature. 369: 230-2. PMID 8183343 DOI: 10.1038/369230A0  0.633
1994 Orser B. Propofol-induced neuroexcitation and receptor desensitization. Canadian Journal of Anaesthesia = Journal Canadien D'Anesthesie. 41: 366-71. PMID 8055602 DOI: 10.1007/BF03009857  0.412
1994 Orser BA, Wang LY, Pennefather PS, MacDonald JF. Propofol modulates activation and desensitization of GABAA receptors in cultured murine hippocampal neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 14: 7747-60. PMID 7996209 DOI: 10.1523/Jneurosci.14-12-07747.1994  0.707
1994 Orser B, Wang L, Pennefather P, MacDonald J. Propofol modulates activation and desensitization of GABAA receptors in cultured murine hippocampal neurons The Journal of Neuroscience. 14: 7747-7760. DOI: 10.1523/JNEUROSCI.14-12-07747.1994  0.661
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