| Year |
Citation |
Score |
| 2023 |
Jin LW, di Lucente J, Ruiz Mendiola U, Tang X, Zivkovic AM, Lebrilla CB, Maezawa I. The role of FUT8-catalyzed core fucosylation in Alzheimer's amyloid-β oligomer-induced activation of human microglia. Glia. PMID 36692036 DOI: 10.1002/glia.24345 |
0.322 |
|
| 2020 |
Nguyen HM, di Lucente J, Chen YJ, Cui Y, Ibrahim RH, Pennington MW, Jin LW, Maezawa I, Wulff H. Biophysical basis for Kv1.3 regulation of membrane potential changes induced by P2X4-mediated calcium entry in microglia. Glia. PMID 32525239 DOI: 10.1002/Glia.23847 |
0.343 |
|
| 2019 |
Jin LW, Lucente JD, Nguyen HM, Singh V, Singh L, Chavez M, Bushong T, Wulff H, Maezawa I. Repurposing the KCa3.1 inhibitor senicapoc for Alzheimer's disease. Annals of Clinical and Translational Neurology. 6: 723-738. PMID 31019997 DOI: 10.1002/Acn3.754 |
0.396 |
|
| 2019 |
Wulff H, Di Lucente J, Nguyen HM, Singh V, Jin L, Maezawa I. Repursposing the Kca3.1 Blocker Senicapoc as a Microglia-Targeted Therapeutic for Alzheimer's Disease Biophysical Journal. 116: 246a. DOI: 10.1016/J.Bpj.2018.11.1345 |
0.358 |
|
| 2018 |
Hilt S, Altman R, Kálai T, Maezawa I, Gong Q, Wachsmann-Hogiu S, Jin LW, Voss JC. A Bifunctional Anti-Amyloid Blocks Oxidative Stress and the Accumulation of Intraneuronal Amyloid-Beta. Molecules (Basel, Switzerland). 23. PMID 30103547 DOI: 10.3390/Molecules23082010 |
0.426 |
|
| 2018 |
Di Lucente J, Nguyen HM, Wulff H, Jin LW, Maezawa I. The voltage-gated potassium channel Kv1.3 is required for microglial pro-inflammatory activation in vivo. Glia. PMID 30043400 DOI: 10.1002/Glia.23457 |
0.349 |
|
| 2018 |
Chen YJ, Nguyen HM, Maezawa I, Jin LW, Wulff H. Inhibition of the potassium channel Kv1.3 reduces infarction and inflammation in ischemic stroke. Annals of Clinical and Translational Neurology. 5: 147-161. PMID 29468176 DOI: 10.1016/J.Bpj.2017.11.1133 |
0.324 |
|
| 2018 |
Jena PK, Sheng L, Di Lucente J, Jin LW, Maezawa I, Wan YY. Dysregulated bile acid synthesis and dysbiosis are implicated in Western diet-induced systemic inflammation, microglial activation, and reduced neuroplasticity. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201700984RR. PMID 29401580 DOI: 10.1096/Fj.201700984Rr |
0.306 |
|
| 2017 |
Maezawa I, Nguyen HM, Di Lucente J, Jenkins DP, Singh V, Hilt S, Kim K, Rangaraju S, Levey AI, Wulff H, Jin LW. Kv1.3 inhibition as a potential microglia-targeted therapy for Alzheimer's disease: preclinical proof of concept. Brain : a Journal of Neurology. PMID 29272333 DOI: 10.1093/Brain/Awx346 |
0.466 |
|
| 2017 |
Maezawa I, Zou B, Di Lucente J, Cao W, Pascual C, Weerasekara S, Zhang M, Xie XS, Hua DH, Jin LW. The Anti-Amyloid-β and Neuroprotective Properties of a Novel Tricyclic Pyrone Molecule. Journal of Alzheimer's Disease : Jad. PMID 28482635 DOI: 10.3233/Jad-161175 |
0.408 |
|
| 2017 |
Wulff H, Di Lucente J, Nguyen HM, Singh V, Jin L, Maezawa I. Kv1.3 Inhibition Reduces Amyloid-Beta Induced Microglial Neurotoxicity Biophysical Journal. 112: 548a. DOI: 10.1016/J.Bpj.2016.11.2961 |
0.375 |
|
| 2016 |
Hilt S, Tang T, Walton JH, Budamagunta M, Maezawa I, Kálai T, Hideg K, Singh V, Wulff H, Gong Q, Jin LW, Louie A, Voss JC. A Metal-Free Method for Producing MRI Contrast at Amyloid-β. Journal of Alzheimer's Disease : Jad. PMID 27911291 DOI: 10.3233/Jad-160279 |
0.381 |
|
| 2016 |
Nguyen HM, Grössinger EM, Horiuchi M, Davis KW, Jin LW, Maezawa I, Wulff H. Differential Kv1.3, KCa3.1, and Kir2.1 expression in "classically" and "alternatively" activated microglia. Glia. PMID 27696527 DOI: 10.1002/Glia.23078 |
0.337 |
|
| 2016 |
Horiuchi M, Smith L, Maezawa I, Jin LW. CX3CR1 ablation ameliorates motor and respiratory dysfunctions and improves survival of a Rett syndrome mouse model. Brain, Behavior, and Immunity. PMID 26883520 DOI: 10.1016/J.Bbi.2016.02.014 |
0.353 |
|
| 2016 |
Chen Y, Nguyen HM, Maezawa I, Jin L, Wulff H. The Voltage-Gated Potassium Channel Kv1.3 as a Target for Inhibiting Detrimental M1 Microglia Functions Biophysical Journal. 110: 527a-528a. DOI: 10.1016/J.Bpj.2015.11.2821 |
0.362 |
|
| 2015 |
Chen YJ, Nguyen HM, Maezawa I, Grössinger EM, Garing AL, Köhler R, Jin LW, Wulff H. The potassium channel KCa3.1 constitutes a pharmacological target for neuroinflammation associated with ischemia/reperfusion stroke. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. PMID 26661208 DOI: 10.1177/0271678X15611434 |
0.338 |
|
| 2015 |
Hong HS, Maezawa I, Petrlova J, Zhao XY, Voss JC, Jin LW. Tomoregulin (TMEFF2) Binds Alzheimer's Disease Amyloid-β (Aβ) Oligomer and AβPP and Protects Neurons from Aβ-Induced Toxicity. Journal of Alzheimer's Disease : Jad. PMID 26402097 DOI: 10.3233/Jad-150318 |
0.421 |
|
| 2015 |
Altman R, Ly S, Hilt S, Petrlova J, Maezawa I, Kálai T, Hideg K, Jin LW, Laurence TA, Voss JC. Protective spin-labeled fluorenes maintain amyloid beta peptide in small oligomers and limit transitions in secondary structure. Biochimica Et Biophysica Acta. 1854: 1860-1870. PMID 26374940 DOI: 10.1016/J.Bbapap.2015.09.002 |
0.4 |
|
| 2015 |
Zhang L, Zhang S, Maezawa I, Trushin S, Minhas P, Pinto M, Jin LW, Prasain K, Nguyen TD, Yamazaki Y, Kanekiyo T, Bu G, Gateno B, Chang KO, Nath KA, et al. Modulation of mitochondrial complex I activity averts cognitive decline in multiple animal models of familial Alzheimer's Disease. Ebiomedicine. 2: 294-305. PMID 26086035 DOI: 10.1016/J.Ebiom.2015.03.009 |
0.402 |
|
| 2015 |
Jin LW, Horiuchi M, Wulff H, Liu XB, Cortopassi GA, Erickson JD, Maezawa I. Dysregulation of glutamine transporter SNAT1 in Rett syndrome microglia: a mechanism for mitochondrial dysfunction and neurotoxicity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 2516-29. PMID 25673846 DOI: 10.1523/Jneurosci.2778-14.2015 |
0.332 |
|
| 2015 |
Grossinger EM, Nguyen HM, Chen Y, Maezawa I, Wulff H. M1 and M2 Microglia Exhibit Significant Differences in their K+ Channel Expression Biophysical Journal. 108: 586a. DOI: 10.1016/J.Bpj.2014.11.3195 |
0.31 |
|
| 2014 |
Lu J, Maezawa I, Weerasekara S, Erenler R, Nguyen TD, Nguyen J, Swisher LZ, Li J, Jin LW, Ranjan A, Srivastava SK, Hua DH. Syntheses, neural protective activities, and inhibition of glycogen synthase kinase-3β of substituted quinolines. Bioorganic & Medicinal Chemistry Letters. 24: 3392-7. PMID 24951331 DOI: 10.1016/J.Bmcl.2014.05.085 |
0.301 |
|
| 2014 |
Kálai T, Altman R, Maezawa I, Balog M, Morisseau C, Petrlova J, Hammock BD, Jin LW, Trudell JR, Voss JC, Hideg K. Synthesis and functional survey of new Tacrine analogs modified with nitroxides or their precursors. European Journal of Medicinal Chemistry. 77: 343-50. PMID 24657571 DOI: 10.1016/J.Ejmech.2014.03.026 |
0.309 |
|
| 2012 |
Pokhrel L, Maezawa I, Nguyen TD, Chang KO, Jin LW, Hua DH. Inhibition of Acyl-CoA: cholesterol acyltransferase (ACAT), overexpression of cholesterol transporter gene, and protection of amyloid β (Aβ) oligomers-induced neuronal cell death by tricyclic pyrone molecules. Journal of Medicinal Chemistry. 55: 8969-73. PMID 23025824 DOI: 10.1021/Jm3012189 |
0.361 |
|
| 2012 |
Maezawa I, Jenkins DP, Jin BE, Wulff H. Microglial KCa3.1 Channels as a Potential Therapeutic Target for Alzheimer's Disease. International Journal of Alzheimer's Disease. 2012: 868972. PMID 22675649 DOI: 10.1155/2012/868972 |
0.403 |
|
| 2012 |
Horiuchi M, Maezawa I, Itoh A, Wakayama K, Jin LW, Itoh T, Decarli C. Amyloid β1-42 oligomer inhibits myelin sheet formation in vitro. Neurobiology of Aging. 33: 499-509. PMID 20594620 DOI: 10.1016/J.Neurobiolaging.2010.05.007 |
0.334 |
|
| 2012 |
Modak S, Sims P, Khan F, Jin L, Maezawa I, Doig A. Drug repositioning for Alzheimer's disease and effects of beta-amyloid on the proteome in cell culture for Alzheimer's disease Alzheimers & Dementia. 8. DOI: 10.1016/J.Jalz.2013.08.062 |
0.378 |
|
| 2012 |
Jenkins DP, Maezawa I, Wulff H, Jin L. Microglial Kv1.3 Channels as a Potential Target for Alzheimer's Disease Biophysical Journal. 102: 679a. DOI: 10.1016/J.Bpj.2011.11.3691 |
0.474 |
|
| 2011 |
Maezawa I, Zimin PI, Wulff H, Jin LW. Amyloid-beta protein oligomer at low nanomolar concentrations activates microglia and induces microglial neurotoxicity. The Journal of Biological Chemistry. 286: 3693-706. PMID 20971854 DOI: 10.1074/Jbc.M110.135244 |
0.428 |
|
| 2010 |
Maezawa I, Jin LW. Rett syndrome microglia damage dendrites and synapses by the elevated release of glutamate. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 5346-56. PMID 20392956 DOI: 10.1523/Jneurosci.5966-09.2010 |
0.33 |
|
| 2010 |
Hong HS, Maezawa I, Budamagunta M, Rana S, Shi A, Vassar R, Liu R, Lam KS, Cheng RH, Hua DH, Voss JC, Jin LW. Candidate anti-A beta fluorene compounds selected from analogs of amyloid imaging agents. Neurobiology of Aging. 31: 1690-9. PMID 19022536 DOI: 10.1016/J.Neurobiolaging.2008.09.019 |
0.399 |
|
| 2009 |
Maezawa I, Swanberg S, Harvey D, LaSalle JM, Jin LW. Rett syndrome astrocytes are abnormal and spread MeCP2 deficiency through gap junctions. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 5051-61. PMID 19386901 DOI: 10.1523/Jneurosci.0324-09.2009 |
0.345 |
|
| 2008 |
Maezawa I, Hong HS, Liu R, Wu CY, Cheng RH, Kung MP, Kung HF, Lam KS, Oddo S, Laferla FM, Jin LW. Congo red and thioflavin-T analogs detect Abeta oligomers. Journal of Neurochemistry. 104: 457-68. PMID 17953662 DOI: 10.1111/J.1471-4159.2007.04972.X |
0.365 |
|
| 2007 |
Hong HS, Maezawa I, Yao N, Xu B, Diaz-Avalos R, Rana S, Hua DH, Cheng RH, Lam KS, Jin LW. Combining the rapid MTT formazan exocytosis assay and the MC65 protection assay led to the discovery of carbazole analogs as small molecule inhibitors of Aβ oligomer-induced cytotoxicity Brain Research. 1130: 223-234. PMID 17157826 DOI: 10.1016/J.Brainres.2006.10.093 |
0.384 |
|
| 2006 |
Maezawa I, Zaja-Milatovic S, Milatovic D, Stephen C, Sokal I, Maeda N, Montine TJ, Montine KS. Apolipoprotein E isoform-dependent dendritic recovery of hippocampal neurons following activation of innate immunity. Journal of Neuroinflammation. 3: 21. PMID 16934151 DOI: 10.1186/1742-2094-3-21 |
0.513 |
|
| 2006 |
Maezawa I, Hong HS, Wu HC, Battina SK, Rana S, Iwamoto T, Radke GA, Pettersson E, Martin GM, Hua DH, Jin LW. A novel tricyclic pyrone compound ameliorates cell death associated with intracellular amyloid-beta oligomeric complexes. Journal of Neurochemistry. 98: 57-67. PMID 16805796 DOI: 10.1111/J.1471-4159.2006.03862.X |
0.403 |
|
| 2006 |
Maezawa I, Maeda N, Montine TJ, Montine KS. Apolipoprotein E-specific innate immune response in astrocytes from targeted replacement mice. Journal of Neuroinflammation. 3: 10. PMID 16603079 DOI: 10.1186/1742-2094-3-10 |
0.534 |
|
| 2006 |
Maezawa I, Nivison M, Montine KS, Maeda N, Montine TJ. Neurotoxicity from innate immune response is greatest with targeted replacement of E4 allele of apolipoprotein E gene and is mediated by microglial p38MAPK. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 20: 797-9. PMID 16481366 DOI: 10.1096/Fj.05-5423Fje |
0.518 |
|
| 2006 |
Jin L, Di Lucente J, Nguyen HM, Singh V, Chavez M, Wulff H, Maezawa I. O5-05-05: REPURPOSING THE KCA3.1 INHIBITOR SENICAPOC AS A MICROGLIA-TARGETED THERAPEUTIC CANDIDATE FOR ALZHEIMER'S DISEASE Alzheimer's & Dementia. 14: P1656-P1657. DOI: 10.1016/J.Jalz.2018.06.3023 |
0.337 |
|
| 2006 |
Montine KS, Maezawa I, Nivison M, Maeda N, Montine TJ. P1-010: Apolipoprotein E isoform-specific modulation of innate immune response neurotoxicity in a targeted replacement APOE mouse model Alzheimer's & Dementia. 2: S97-S97. DOI: 10.1016/J.Jalz.2006.05.385 |
0.452 |
|
| 2005 |
Woltjer RL, Nghiem W, Maezawa I, Milatovic D, Vaisar T, Montine KS, Montine TJ. Role of glutathione in intracellular amyloid-alpha precursor protein/carboxy-terminal fragment aggregation and associated cytotoxicity. Journal of Neurochemistry. 93: 1047-56. PMID 15857408 DOI: 10.1111/J.1471-4159.2005.03109.X |
0.527 |
|
| 2004 |
Maezawa I, Jin LW, Woltjer RL, Maeda N, Martin GM, Montine TJ, Montine KS. Apolipoprotein E isoforms and apolipoprotein AI protect from amyloid precursor protein carboxy terminal fragment-associated cytotoxicity. Journal of Neurochemistry. 91: 1312-21. PMID 15584908 DOI: 10.1111/J.1471-4159.2004.02818.X |
0.543 |
|
| 2004 |
Shie FS, Neely MD, Maezawa I, Wu H, Olson SJ, Jürgens G, Montine KS, Montine TJ. Oxidized low-density lipoprotein is present in astrocytes surrounding cerebral infarcts and stimulates astrocyte interleukin-6 secretion. The American Journal of Pathology. 164: 1173-81. PMID 15039206 DOI: 10.1016/S0002-9440(10)63205-1 |
0.472 |
|
| 2004 |
Jin LW, Shie FS, Maezawa I, Vincent I, Bird T. Intracellular accumulation of amyloidogenic fragments of amyloid-beta precursor protein in neurons with Niemann-Pick type C defects is associated with endosomal abnormalities. The American Journal of Pathology. 164: 975-85. PMID 14982851 DOI: 10.1016/S0002-9440(10)63185-9 |
0.409 |
|
| 2003 |
Woltjer RL, Maezawa I, Ou JJ, Montine KS, Montine TJ. Advanced glycation endproduct precursor alters intracellular amyloid-beta/A beta PP carboxy-terminal fragment aggregation and cytotoxicity. Journal of Alzheimer's Disease : Jad. 5: 467-76. PMID 14757937 DOI: 10.3233/Jad-2003-5607 |
0.608 |
|
| 2003 |
Jin LW, Claborn KA, Kurimoto M, Geday MA, Maezawa I, Sohraby F, Estrada M, Kaminksy W, Kahr B. Imaging linear birefringence and dichroism in cerebral amyloid pathologies. Proceedings of the National Academy of Sciences of the United States of America. 100: 15294-8. PMID 14668440 DOI: 10.1073/Pnas.2534647100 |
0.336 |
|
| 2002 |
Maezawa I, Wang B, Hu Q, Martin GM, Jin LW, Oshima J. Alterations of chaperone protein expression in presenilin mutant neurons in response to glutamate excitotoxicity. Pathology International. 52: 551-4. PMID 12406183 DOI: 10.1046/J.1440-1827.2002.01398.X |
0.331 |
|
| 2002 |
Jin LW, Hua DH, Shie FS, Maezawa I, Sopher B, Martin GM. Novel tricyclic pyrone compounds prevent intracellular APP C99-induced cell death. Journal of Molecular Neuroscience : Mn. 19: 57-61. PMID 12212794 DOI: 10.1007/S12031-002-0011-9 |
0.441 |
|
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