Jae-Won Shin, Ph.D. - Publications

Affiliations: 
University of Pennsylvania, Philadelphia, PA, United States 
Area:
cell biophysics and polymer engineering

52 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Newman PLH, Yip Q, Osteil P, Anderson TA, Sun JQJ, Kempe D, Biro M, Shin JW, Tam PPL, Zreiqat H. Programming of Multicellular Patterning with Mechano-Chemically Microstructured Cell Niches. Advanced Science (Weinheim, Baden-Wurttemberg, Germany). e2204741. PMID 36998105 DOI: 10.1002/advs.202204741  0.31
2022 Cho IS, Gupta P, Mostafazadeh N, Wong SW, Saichellappa S, Lenzini S, Peng Z, Shin JW. Deterministic Single Cell Encapsulation in Asymmetric Microenvironments to Direct Cell Polarity. Advanced Science (Weinheim, Baden-Wurttemberg, Germany). e2206014. PMID 36453581 DOI: 10.1002/advs.202206014  0.362
2021 Lenzini S, Debnath K, Joshi JC, Wong SW, Srivastava K, Geng X, Cho IS, Song A, Bargi R, Lee JC, Mo GCH, Mehta D, Shin JW. Cell-Matrix Interactions Regulate Functional Extracellular Vesicle Secretion from Mesenchymal Stromal Cells. Acs Nano. PMID 34677951 DOI: 10.1021/acsnano.1c03231  0.507
2021 Wong SW, Lenzini S, Giovanni R, Knowles K, Shin JW. Matrix biophysical cues direct mesenchymal stromal cell functions in immunity. Acta Biomaterialia. PMID 34365041 DOI: 10.1016/j.actbio.2021.07.075  0.326
2021 Wong SW, Tamatam CR, Cho IS, Toth PT, Bargi R, Belvitch P, Lee JC, Rehman J, Reddy SP, Shin JW. Inhibition of aberrant tissue remodelling by mesenchymal stromal cells singly coated with soft gels presenting defined chemomechanical cues. Nature Biomedical Engineering. PMID 34083763 DOI: 10.1038/s41551-021-00740-x  0.44
2020 Shin JW, Lee JC. Roles of microglial membranes in Alzheimer's disease. Current Topics in Membranes. 86: 301-314. PMID 33837697 DOI: 10.1016/bs.ctm.2020.08.007  0.314
2020 Wong SW, Lenzini S, Bargi R, Feng Z, Macaraniag C, Lee JC, Peng Z, Shin JW. Controlled Deposition of 3D Matrices to Direct Single Cell Functions. Advanced Science (Weinheim, Baden-Wurttemberg, Germany). 7: 2001066. PMID 33101850 DOI: 10.1002/Advs.202001066  0.589
2020 Devine D, Vijayakumar V, Wong SW, Lenzini S, Newman P, Shin JW. Hydrogel Micropost Arrays with Single Post Tunability to Study Cell Volume and Mechanotransduction. Advanced Biosystems. e2000012. PMID 33053274 DOI: 10.1002/adbi.202000012  0.354
2020 Wong SW, Lenzini S, Cooper MH, Mooney DJ, Shin JW. Soft extracellular matrix enhances inflammatory activation of mesenchymal stromal cells to induce monocyte production and trafficking. Science Advances. 6: eaaw0158. PMID 32284989 DOI: 10.1126/Sciadv.Aaw0158  0.428
2020 Lenzini S, Bargi R, Chung G, Shin JW. Matrix mechanics and water permeation regulate extracellular vesicle transport. Nature Nanotechnology. PMID 32066904 DOI: 10.1038/S41565-020-0636-2  0.328
2020 Hayes BH, Tsai RK, Dooling LJ, Kadu S, Lee JY, Pantano D, Rodriguez PL, Subramanian S, Shin JW, Discher DE. Macrophages eat more after disruption of interactions between CD47 and the checkpoint receptor SIRPα. Journal of Cell Science. PMID 31964705 DOI: 10.1242/Jcs.237800  0.704
2020 Wong S, Bargi R, Macaraniag C, Peng Z, Shin J. Engineered Pericellular Matrix Deposition Controls Mesenchymal Stromal Cell Volume Expansion and Fate Biophysical Journal. 118: 602a-603a. DOI: 10.1016/J.Bpj.2019.11.3256  0.372
2019 Lenzini S, Devine D, Shin JW. Leveraging Biomaterial Mechanics to Improve Pluripotent Stem Cell Applications for Tissue Engineering. Frontiers in Bioengineering and Biotechnology. 7: 260. PMID 31649928 DOI: 10.3389/Fbioe.2019.00260  0.451
2019 Mao AS, Özkale B, Shah NJ, Vining KH, Descombes T, Zhang L, Tringides CM, Wong SW, Shin JW, Scadden DT, Weitz DA, Mooney DJ. Programmable microencapsulation for enhanced mesenchymal stem cell persistence and immunomodulation. Proceedings of the National Academy of Sciences of the United States of America. PMID 31311862 DOI: 10.1073/Pnas.1819415116  0.429
2018 Shin JW. Squeezing cells through the epigenetic machinery. Proceedings of the National Academy of Sciences of the United States of America. PMID 30093390 DOI: 10.1073/Pnas.1811184115  0.497
2017 Buxboim A, Irianto J, Swift J, Athirasala A, Shin JW, Rehfeldt F, Discher DE. Coordinated increase of nuclear tension and lamin-A with matrix stiffness out-competes Lamin-B Receptor which favors soft tissue phenotypes. Molecular Biology of the Cell. PMID 28931598 DOI: 10.1091/Mbc.E17-06-0393  0.626
2016 Mao AS, Shin JW, Utech S, Wang H, Uzun O, Li W, Cooper M, Hu Y, Zhang L, Weitz DA, Mooney DJ. Deterministic encapsulation of single cells in thin tunable microgels for niche modelling and therapeutic delivery. Nature Materials. PMID 27798621 DOI: 10.1038/Nmat4781  0.449
2016 Shin JW, Mooney DJ. Extracellular matrix stiffness causes systematic variations in proliferation and chemosensitivity in myeloid leukemias. Proceedings of the National Academy of Sciences of the United States of America. 113: 12126-12131. PMID 27790998 DOI: 10.1073/Pnas.1611338113  0.422
2016 Mao AS, Shin JW, Mooney DJ. Effects of substrate stiffness and cell-cell contact on mesenchymal stem cell differentiation. Biomaterials. 98: 184-191. PMID 27203745 DOI: 10.1016/J.Biomaterials.2016.05.004  0.477
2016 Shin J, Kim TW, Kim H, Kim HJ, Suh MY, Lee S, Lee HT, Kwak S, Lee SE, Lee JH, Jang H, Cho EJ, Youn HD. Aurkb/PP1-mediated resetting of Oct4 during the cell cycle determines the identity of embryonic stem cells. Elife. 5. PMID 26880562 DOI: 10.7554/Elife.10877  0.303
2015 Hong S, Lee JY, Hwang CM, Shin J, Park Y. Inhibition of Rho-associated protein kinase increases the angiogenic potential of mesenchymal stem cell aggregates via paracrine effects. Tissue Engineering. Part A. PMID 26592750 DOI: 10.1089/ten.TEA.2015.0289  0.303
2015 Kang YG, Shin JW, Park SH, Kim YM, Gu SR, Wu Y, Ban HY, Shin JW. A three-dimensional hierarchical scaffold fabricated by a combined rapid prototyping technique and electrospinning process to expand hematopoietic stem/progenitor cells. Biotechnology Letters. PMID 26346661 DOI: 10.1007/s10529-015-1952-8  0.351
2015 Ivanovska IL, Shin JW, Swift J, Discher DE. Stem cell mechanobiology: diverse lessons from bone marrow. Trends in Cell Biology. PMID 26045259 DOI: 10.1016/J.Tcb.2015.04.003  0.568
2015 Shin JW, Discher DE. Blood and immune cell engineering: Cytoskeletal contractility and nuclear rheology impact cell lineage and localization: Biophysical regulation of hematopoietic differentiation and trafficking. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 37: 633-42. PMID 25810145 DOI: 10.1002/Bies.201400166  0.564
2015 Spinler KR, Shin JW, Lambert MP, Discher DE. Myosin-II repression favors pre/proplatelets but shear activation generates platelets and fails in macrothrombocytopenia. Blood. 125: 525-33. PMID 25395423 DOI: 10.1182/Blood-2014-05-576462  0.746
2014 Buxboim A, Swift J, Irianto J, Spinler KR, Dingal PC, Athirasala A, Kao YR, Cho S, Harada T, Shin JW, Discher DE. Matrix elasticity regulates lamin-A,C phosphorylation and turnover with feedback to actomyosin. Current Biology : Cb. 24: 1909-17. PMID 25127216 DOI: 10.1016/J.Cub.2014.07.001  0.779
2014 Tomaru Y, Hasegawa R, Suzuki T, Sato T, Kubosaki A, Suzuki M, Kawaji H, Forrest AR, Hayashizaki Y, Shin JW, Suzuki H. A transient disruption of fibroblastic transcriptional regulatory network facilitates trans-differentiation. Nucleic Acids Research. 42: 8905-13. PMID 25013174 DOI: 10.1093/nar/gku567  0.303
2014 Chaudhuri O, Koshy ST, Branco da Cunha C, Shin JW, Verbeke CS, Allison KH, Mooney DJ. Extracellular matrix stiffness and composition jointly regulate the induction of malignant phenotypes in mammary epithelium. Nature Materials. 13: 970-8. PMID 24930031 DOI: 10.1038/Nmat4009  0.386
2014 Harada T, Swift J, Irianto J, Shin JW, Spinler KR, Athirasala A, Diegmiller R, Dingal PC, Ivanovska IL, Discher DE. Nuclear lamin stiffness is a barrier to 3D migration, but softness can limit survival. The Journal of Cell Biology. 204: 669-82. PMID 24567359 DOI: 10.1083/Jcb.201308029  0.794
2014 Shin JW, Buxboim A, Spinler KR, Swift J, Christian DA, Hunter CA, Léon C, Gachet C, Dingal PC, Ivanovska IL, Rehfeldt F, Chasis JA, Discher DE. Contractile forces sustain and polarize hematopoiesis from stem and progenitor cells. Cell Stem Cell. 14: 81-93. PMID 24268694 DOI: 10.1016/J.Stem.2013.10.009  0.812
2014 Harada T, Swift J, Irianto J, Shin JW, Spinler KR, Athirasala A, Diegmiller R, Dingal PCDP, Ivanovska IL, Discher DE. Nuclear lamin stiffness is a barrier to 3D-migration, but softness can limit survival Proceedings of the Ieee Annual Northeast Bioengineering Conference, Nebec. 2014. DOI: 10.1109/NEBEC.2014.6972810  0.742
2014 Discher DE, Swift J, Spinler K, Shin J. Lamins Regulate Cell Trafficking and Lineage Maturation of Hematopoietic Cells Biophysical Journal. 106: 571a. DOI: 10.1016/J.Bpj.2013.11.3169  0.795
2013 Swift J, Harada T, Buxboim A, Shin JW, Tang HY, Speicher DW, Discher DE. Label-free mass spectrometry exploits dozens of detected peptides to quantify lamins in wildtype and knockdown cells. Nucleus (Austin, Tex.). 4: 450-9. PMID 24448480 DOI: 10.4161/Nucl.27413  0.612
2013 Shin JW, Spinler KR, Swift J, Chasis JA, Mohandas N, Discher DE. Lamins regulate cell trafficking and lineage maturation of adult human hematopoietic cells. Proceedings of the National Academy of Sciences of the United States of America. 110: 18892-7. PMID 24191023 DOI: 10.1073/Pnas.1304996110  0.796
2013 Swift J, Ivanovska IL, Buxboim A, Harada T, Dingal PC, Pinter J, Pajerowski JD, Spinler KR, Shin JW, Tewari M, Rehfeldt F, Speicher DW, Discher DE. Nuclear lamin-A scales with tissue stiffness and enhances matrix-directed differentiation. Science (New York, N.Y.). 341: 1240104. PMID 23990565 DOI: 10.1126/Science.1240104  0.761
2013 Suzuki A, Shin JW, Wang Y, Min SH, Poncz M, Choi JK, Discher DE, Carpenter CL, Lian L, Zhao L, Wang Y, Abrams CS. RhoA is essential for maintaining normal megakaryocyte ploidy and platelet generation. Plos One. 8: e69315. PMID 23935982 DOI: 10.1371/Journal.Pone.0069315  0.457
2013 Shin JW, Swift J, Ivanovska I, Spinler KR, Buxboim A, Discher DE. Mechanobiology of bone marrow stem cells: from myosin-II forces to compliance of matrix and nucleus in cell forms and fates. Differentiation; Research in Biological Diversity. 86: 77-86. PMID 23790394 DOI: 10.1016/J.Diff.2013.05.001  0.777
2013 Spinler KR, Shin J, Discher DE. Platelet-Like-Particles Sheared From Myosin-II-Inhibited Megakaryocytes Highlights The Elevated Thrombocrit Of May-Hegglin Anomaly Blood. 122: 2426-2426. DOI: 10.1182/Blood.V122.21.2426.2426  0.757
2013 Dingal PDP, Raab M, Shah P, Shin J, Discher D. Fibrillar Collagen is Equivalent to Stiff Matrix in Driving Marrow Stromal Cell Differentiation into a Matrix-Deficient, Myofibroblastic-Like Phenotype Biophysical Journal. 104: 686a-687a. DOI: 10.1016/J.Bpj.2012.11.3793  0.808
2012 Raab M, Swift J, Dingal PC, Shah P, Shin JW, Discher DE. Crawling from soft to stiff matrix polarizes the cytoskeleton and phosphoregulates myosin-II heavy chain. The Journal of Cell Biology. 199: 669-83. PMID 23128239 DOI: 10.1083/Jcb.201205056  0.796
2012 Shin JW, Discher DE. Cell culture: Soft gels select tumorigenic cells. Nature Materials. 11: 662-3. PMID 22825018 DOI: 10.1038/Nmat3388  0.533
2012 Suzuki A, Shin J, Wang Y, Poncz M, Choi JK, Discher DE, Carpenter CL, Lian L, Zhao L, Wang Y, Abrams CS. RhoA Is Essential for Maintaining Normal Megakaryocyte Ploidy Distribution and Platelet Generation Blood. 120: 385-385. DOI: 10.1182/Blood.V120.21.385.385  0.553
2012 Shin J, Spinler KR, Swift J, Discher DE. Hierarchical Determination of Nuclear Deformability by Lamin Isoforms During Adult Hematopoiesis: Implications in Blood Cell Trafficking Blood. 120: 1200-1200. DOI: 10.1182/Blood.V120.21.1200.1200  0.789
2012 Spinler K, Shin JW, Discher DE. Platelet generation under shear force modulated by site-specific phosphorylation of myosin-IIA heavy chain 2012 38th Annual Northeast Bioengineering Conference, Nebec 2012. 217-218. DOI: 10.1182/Blood.V118.21.3262.3262  0.768
2012 Spinler KR, Shin J, Discher DE. Shear-Optimized Platelet-Like-Particles From High Ploidy Mks: From Segregation to Composition and Activation Blood. 120: 3456-3456. DOI: 10.1016/J.Bpj.2012.11.806  0.775
2012 Swift J, Harada T, Pinter J, Shin J, Ivanovska I, Buxbiom A, Discher DE. Lamin-A/C is a Nuclear Rheostat that Couples Microenvironment Rigidity to Cell Lineage Biophysical Journal. 102: 48a. DOI: 10.1016/J.Bpj.2011.11.293  0.691
2011 Shin JW, Swift J, Spinler KR, Discher DE. Myosin-II inhibition and soft 2D matrix maximize multinucleation and cellular projections typical of platelet-producing megakaryocytes. Proceedings of the National Academy of Sciences of the United States of America. 108: 11458-63. PMID 21709232 DOI: 10.1073/Pnas.1017474108  0.783
2011 Shin J, Buxboim A, Discher DE. Myosin-II Is a Major Modulator of Human Hematopoietic Stem Cell Proliferation and Differentiation Blood. 118: 2343-2343. DOI: 10.1182/Blood.V118.21.2343.2343  0.643
2011 Swift J, Harada T, Shin J, Tang H, Speicher D, Discher DE. Optimized Quantitation from Proteomic Datasets - Application to Lamin Knockdown and Isoform Modulation During Stem Cell Differentiation Biophysical Journal. 100: 50a. DOI: 10.1016/J.Bpj.2010.12.470  0.652
2011 Shin J, Spinler KR, Swift J, Discher DE. Differentiation of Hematopoietic Stem Cell Modulated by Actomyosin Forces Biophysical Journal. 100: 442a-443a. DOI: 10.1016/J.Bpj.2010.12.2606  0.806
2010 Raab M, Shin JW, Discher DE. Matrix elasticity in vitro controls muscle stem cell fate in vivo. Stem Cell Research & Therapy. 1: 38. PMID 21144011 DOI: 10.1186/Scrt38  0.783
2010 Shin J, Spinler KR, Swift J, Discher DE. Myosin-II Plays Central Roles In Cell Life and Death Decisions During Adult Hematopoiesis. Blood. 116: 1595-1595. DOI: 10.1182/Blood.V116.21.1595.1595  0.794
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