David J. Wyllie - Publications

Affiliations: 
University of Edinburgh, Edinburgh, Scotland, United Kingdom 
Area:
glutamate receptors

47 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Lipscombe D, Wyllie DJ. Editorial overview: Ion channels Current Opinion in Physiology. 2: iv-vii. DOI: 10.1016/J.COPHYS.2018.02.012  0.332
2017 McQueen J, Ryan TJ, McKay S, Marwick KF, Baxter PE, Carpanini SM, Wishart TM, Gillingwater TH, Manson JC, Wyllie DJ, Grant SG, McColl B, Komiyama N, Hardingham GE. Pro-death NMDA receptor signaling is promoted by the GluN2B C-terminus independently of DAPK1. Elife. 6. PMID 28731405 DOI: 10.7554/Elife.17161  0.38
2017 Johnstone M, Vasistha N, Livesey M, Burr K, Whalley H, Clair DS, Blackwood D, Wyllie D, Lawrie S, Johnstone EC, McIntosh AM, Chandran S. Modelling a Genetic Risk for Schizophrenia in Human Induced Pluripotent Stem Cells (Ipscs): Phenotypic Differences in Patients with Mutations in Nde1 European Neuropsychopharmacology. 27: S509-S510. DOI: 10.1016/J.Euroneuro.2016.09.618  0.315
2016 Marwick K, Skehel P, Hardingham G, Wyllie D. Effect of a GRIN2A de novo mutation associated with epilepsy and intellectual disability on NMDA receptor currents and Mg(2+) block in cultured primary cortical neurons. Lancet (London, England). S65. PMID 26312887 DOI: 10.1016/S0140-6736(15)60380-4  0.478
2013 McKay S, Bengtson CP, Bading H, Wyllie DJ, Hardingham GE. Recovery of NMDA receptor currents from MK-801 blockade is accelerated by Mg2+ and memantine under conditions of agonist exposure. Neuropharmacology. 74: 119-25. PMID 23402996 DOI: 10.1016/J.Neuropharm.2013.01.024  0.499
2013 Wyllie DJ, Livesey MR, Hardingham GE. Influence of GluN2 subunit identity on NMDA receptor function. Neuropharmacology. 74: 4-17. PMID 23376022 DOI: 10.1016/J.Neuropharm.2013.01.016  0.489
2012 Chia PW, Livesey MR, Slawin AM, van Mourik T, Wyllie DJ, O'Hagan D. 3-Fluoro-N-methyl-D-aspartic acid (3F-NMDA) stereoisomers as conformational probes for exploring agonist binding at NMDA receptors. Chemistry (Weinheim An Der Bergstrasse, Germany). 18: 8813-9. PMID 22692769 DOI: 10.1002/Chem.201200071  0.366
2012 McMahon AC, Barnett MW, O'Leary TS, Stoney PN, Collins MO, Papadia S, Choudhary JS, Komiyama NH, Grant SG, Hardingham GE, Wyllie DJ, Kind PC. SynGAP isoforms exert opposing effects on synaptic strength. Nature Communications. 3: 900. PMID 22692543 DOI: 10.1038/Ncomms1900  0.341
2012 Edman S, McKay S, Macdonald LJ, Samadi M, Livesey MR, Hardingham GE, Wyllie DJ. TCN 201 selectively blocks GluN2A-containing NMDARs in a GluN1 co-agonist dependent but non-competitive manner. Neuropharmacology. 63: 441-9. PMID 22579927 DOI: 10.1016/J.Neuropharm.2012.04.027  0.667
2012 Wyllie DJ, Traynelis SF. NMDA receptor permeation: a light in the tunnel. Nature Neuroscience. 15: 343-4. PMID 22362102 DOI: 10.1038/nn.3058  0.632
2012 McKay S, Griffiths NH, Butters PA, Thubron EB, Hardingham GE, Wyllie DJ. Direct pharmacological monitoring of the developmental switch in NMDA receptor subunit composition using TCN 213, a GluN2A-selective, glycine-dependent antagonist. British Journal of Pharmacology. 166: 924-37. PMID 22022974 DOI: 10.1111/J.1476-5381.2011.01748.X  0.518
2011 Otton HJ, Lawson McLean A, Pannozzo MA, Davies CH, Wyllie DJ. Quantification of the Mg2+-induced potency shift of amantadine and memantine voltage-dependent block in human recombinant GluN1/GluN2A NMDARs. Neuropharmacology. 60: 388-96. PMID 20955720 DOI: 10.1016/J.Neuropharm.2010.10.008  0.326
2010 Léveillé F, Papadia S, Fricker M, Bell KF, Soriano FX, Martel MA, Puddifoot C, Habel M, Wyllie DJ, Ikonomidou C, Tolkovsky AM, Hardingham GE. Suppression of the intrinsic apoptosis pathway by synaptic activity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 2623-35. PMID 20164347 DOI: 10.1523/Jneurosci.5115-09.2010  0.346
2009 O'Leary T, Wyllie DJ. Single-channel properties of N-methyl-D-aspartate receptors containing chimaeric GluN2A/GluN2D subunits. Biochemical Society Transactions. 37: 1347-54. PMID 19909274 DOI: 10.1042/BST0371347  0.438
2009 Otton HJ, Janssen A, O'Leary T, Chen PE, Wyllie DJ. Inhibition of rat recombinant GluN1/GluN2A and GluN1/GluN2B NMDA receptors by ethanol at concentrations based on the US/UK drink-drive limit. European Journal of Pharmacology. 614: 14-21. PMID 19394328 DOI: 10.1016/j.ejphar.2009.04.034  0.407
2009 Martel MA, Soriano FX, Baxter P, Rickman C, Duncan R, Wyllie DJ, Hardingham GE. Inhibiting pro-death NMDA receptor signaling dependent on the NR2 PDZ ligand may not affect synaptic function or synaptic NMDA receptor signaling to gene expression. Channels (Austin, Tex.). 3: 12-5. PMID 19221512 DOI: 10.4161/Chan.3.1.7864  0.375
2009 Puddifoot CA, Chen PE, Schoepfer R, Wyllie DJ. Pharmacological characterization of recombinant NR1/NR2A NMDA receptors with truncated and deleted carboxy termini expressed in Xenopus laevis oocytes. British Journal of Pharmacology. 156: 509-18. PMID 19154422 DOI: 10.1111/j.1476-5381.2008.00040.x  0.425
2009 Martel MA, Wyllie DJ, Hardingham GE. In developing hippocampal neurons, NR2B-containing N-methyl-D-aspartate receptors (NMDARs) can mediate signaling to neuronal survival and synaptic potentiation, as well as neuronal death. Neuroscience. 158: 334-43. PMID 18378405 DOI: 10.1016/J.Neuroscience.2008.01.080  0.498
2008 Papadia S, Soriano FX, Léveillé F, Martel MA, Dakin KA, Hansen HH, Kaindl A, Sifringer M, Fowler J, Stefovska V, McKenzie G, Craigon M, Corriveau R, Ghazal P, Horsburgh K, ... ... Wyllie DJ, et al. Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses. Nature Neuroscience. 11: 476-87. PMID 18344994 DOI: 10.1038/Nn2071  0.31
2008 Wrighton DC, Baker EJ, Chen PE, Wyllie DJ. Mg2+ and memantine block of rat recombinant NMDA receptors containing chimeric NR2A/2D subunits expressed in Xenopus laevis oocytes. The Journal of Physiology. 586: 211-25. PMID 17962329 DOI: 10.1113/jphysiol.2007.143164  0.471
2008 Chen PE, Geballe MT, Katz E, Erreger K, Livesey MR, O'Toole KK, Le P, Lee CJ, Snyder JP, Traynelis SF, Wyllie DJ. Modulation of glycine potency in rat recombinant NMDA receptors containing chimeric NR2A/2D subunits expressed in Xenopus laevis oocytes. The Journal of Physiology. 586: 227-45. PMID 17962328 DOI: 10.1113/Jphysiol.2007.143172  0.603
2007 Erreger K, Geballe MT, Kristensen A, Chen PE, Hansen KB, Lee CJ, Yuan H, Le P, Lyuboslavsky PN, Micale N, Jørgensen L, Clausen RP, Wyllie DJ, Snyder JP, Traynelis SF. Subunit-specific agonist activity at NR2A-, NR2B-, NR2C-, and NR2D-containing N-methyl-D-aspartate glutamate receptors. Molecular Pharmacology. 72: 907-20. PMID 17622578 DOI: 10.1124/Mol.107.037333  0.64
2007 Wyllie DJ, Chen PE. Taking the time to study competitive antagonism. British Journal of Pharmacology. 150: 541-51. PMID 17245371 DOI: 10.1038/sj.bjp.0706997  0.358
2006 Frizelle PA, Chen PE, Wyllie DJ. Equilibrium constants for (R)-[(S)-1-(4-bromo-phenyl)-ethylamino]-(2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)-methyl]-phosphonic acid (NVP-AAM077) acting at recombinant NR1/NR2A and NR1/NR2B N-methyl-D-aspartate receptors: Implications for studies of synaptic transmission. Molecular Pharmacology. 70: 1022-32. PMID 16778008 DOI: 10.1124/mol.106.024042  0.496
2006 Wyllie DJ, Johnston AR, Lipscombe D, Chen PE. Single-channel analysis of a point mutation of a conserved serine residue in the S2 ligand-binding domain of the NR2A NMDA receptor subunit. The Journal of Physiology. 574: 477-89. PMID 16709630 DOI: 10.1113/jphysiol.2006.112193  0.525
2006 Baxter AW, Wyllie DJ. Phosphatidylinositol 3 kinase activation and AMPA receptor subunit trafficking underlie the potentiation of miniature EPSC amplitudes triggered by the activation of L-type calcium channels. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 5456-69. PMID 16707798 DOI: 10.1523/JNEUROSCI.4101-05.2006  0.368
2006 Chen PE, Wyllie DJ. Pharmacological insights obtained from structure-function studies of ionotropic glutamate receptors. British Journal of Pharmacology. 147: 839-53. PMID 16474411 DOI: 10.1038/sj.bjp.0706689  0.409
2005 Erreger K, Geballe MT, Dravid SM, Snyder JP, Wyllie DJ, Traynelis SF. Mechanism of partial agonism at NMDA receptors for a conformationally restricted glutamate analog. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 7858-66. PMID 16120788 DOI: 10.1523/Jneurosci.1613-05.2005  0.682
2005 Vickers CA, Dickson KS, Wyllie DJ. Induction and maintenance of late-phase long-term potentiation in isolated dendrites of rat hippocampal CA1 pyramidal neurones. The Journal of Physiology. 568: 803-13. PMID 16109729 DOI: 10.1113/Jphysiol.2005.092924  0.301
2005 Chen PE, Geballe MT, Stansfeld PJ, Johnston AR, Yuan H, Jacob AL, Snyder JP, Traynelis SF, Wyllie DJ. Structural features of the glutamate binding site in recombinant NR1/NR2A N-methyl-D-aspartate receptors determined by site-directed mutagenesis and molecular modeling. Molecular Pharmacology. 67: 1470-84. PMID 15703381 DOI: 10.1124/Mol.104.008185  0.652
2005 Erreger K, Dravid SM, Banke TG, Wyllie DJ, Traynelis SF. Subunit-specific gating controls rat NR1/NR2A and NR1/NR2B NMDA channel kinetics and synaptic signalling profiles. The Journal of Physiology. 563: 345-58. PMID 15649985 DOI: 10.1113/Jphysiol.2004.080028  0.686
2004 Erreger K, Chen PE, Wyllie DJ, Traynelis SF. Glutamate receptor gating. Critical Reviews in Neurobiology. 16: 187-224. PMID 15701057 DOI: 10.1615/Critrevneurobiol.V16.I3.10  0.649
2004 Chen PE, Johnston AR, Mok MH, Schoepfer R, Wyllie DJ. Influence of a threonine residue in the S2 ligand binding domain in determining agonist potency and deactivation rate of recombinant NR1a/NR2D NMDA receptors. The Journal of Physiology. 558: 45-58. PMID 15107472 DOI: 10.1113/jphysiol.2004.063800  0.539
2000 Anson LC, Schoepfer R, Colquhoun D, Wyllie DJ. Single-channel analysis of an NMDA receptor possessing a mutation in the region of the glutamate binding site. The Journal of Physiology. 527: 225-37. PMID 10970425 DOI: 10.1111/J.1469-7793.2000.00225.X  0.484
2000 Misra C, Brickley SG, Wyllie DJ, Cull-Candy SG. Slow deactivation kinetics of NMDA receptors containing NR1 and NR2D subunits in rat cerebellar Purkinje cells. The Journal of Physiology. 525: 299-305. PMID 10835034 DOI: 10.1111/j.1469-7793.2000.t01-1-00299.x  0.714
1998 Wyllie DJ, Béhé P, Colquhoun D. Single-channel activations and concentration jumps: comparison of recombinant NR1a/NR2A and NR1a/NR2D NMDA receptors. The Journal of Physiology. 510: 1-18. PMID 9625862 DOI: 10.1111/j.1469-7793.1998.001bz.x  0.433
1998 Anson LC, Chen PE, Wyllie DJ, Colquhoun D, Schoepfer R. Identification of amino acid residues of the NR2A subunit that control glutamate potency in recombinant NR1/NR2A NMDA receptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 581-9. PMID 9425000 DOI: 10.1523/Jneurosci.18-02-00581.1998  0.499
1997 Gibb AJ, Wyllie DJ. Single cell RT-PCR reaches out to the NMDA receptor. The Journal of Physiology. 499: 1. PMID 16993278 DOI: 10.1113/Jphysiol.1997.Sp021906  0.438
1996 Wyllie DJ, Béhé P, Nassar M, Schoepfer R, Colquhoun D. Single-channel currents from recombinant NMDA NR1a/NR2D receptors expressed in Xenopus oocytes. Proceedings. Biological Sciences / the Royal Society. 263: 1079-86. PMID 8805841 DOI: 10.1098/rspb.1996.0159  0.515
1995 Béhé P, Stern P, Wyllie DJ, Nassar M, Schoepfer R, Colquhoun D. Determination of NMDA NR1 subunit copy number in recombinant NMDA receptors. Proceedings. Biological Sciences / the Royal Society. 262: 205-13. PMID 8524912 DOI: 10.1098/rspb.1995.0197  0.455
1994 Wyllie DJ, Nicoll RA. A role for protein kinases and phosphatases in the Ca(2+)-induced enhancement of hippocampal AMPA receptor-mediated synaptic responses. Neuron. 13: 635-43. PMID 7917294 DOI: 10.1016/0896-6273(94)90031-0  0.561
1994 Wyllie DJ, Cull-Candy SG. A comparison of non-NMDA receptor channels in type-2 astrocytes and granule cells from rat cerebellum. The Journal of Physiology. 475: 95-114. PMID 7514667 DOI: 10.1113/Jphysiol.1994.Sp020052  0.693
1994 Wyllie DJ, Manabe T, Nicoll RA. A rise in postsynaptic Ca2+ potentiates miniature excitatory postsynaptic currents and AMPA responses in hippocampal neurons. Neuron. 12: 127-38. PMID 7507335 DOI: 10.1016/0896-6273(94)90158-9  0.667
1993 Manabe T, Wyllie DJ, Perkel DJ, Nicoll RA. Modulation of synaptic transmission and long-term potentiation: effects on paired pulse facilitation and EPSC variance in the CA1 region of the hippocampus. Journal of Neurophysiology. 70: 1451-9. PMID 7904300 DOI: 10.1152/Jn.1993.70.4.1451  0.697
1993 Wyllie DJ, Traynelis SF, Cull-Candy SG. Evidence for more than one type of non-NMDA receptor in outside-out patches from cerebellar granule cells of the rat. The Journal of Physiology. 463: 193-226. PMID 7504104 DOI: 10.1113/jphysiol.1993.sp019591  0.718
1991 Cull-Candy SG, Wyllie DJ. Glutamate-receptor channels in mammalian glial cells. Annals of the New York Academy of Sciences. 633: 458-74. PMID 1686383 DOI: 10.1111/j.1749-6632.1991.tb15636.x  0.679
1991 Wyllie DJ, Mathie A, Symonds CJ, Cull-Candy SG. Activation of glutamate receptors and glutamate uptake in identified macroglial cells in rat cerebellar cultures. The Journal of Physiology. 432: 235-58. PMID 1653320 DOI: 10.1113/Jphysiol.1991.Sp018383  0.662
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