David J. Wyllie - Publications

Affiliations: 
University of Edinburgh, Edinburgh, Scotland, United Kingdom 
Area:
glutamate receptors

63 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Rzechorzek NM, Connick P, Livesey MR, Borooah S, Patani R, Burr K, Story D, Wyllie DJ, Hardingham GE, Chandran S. Hypothermic Preconditioning Reverses Tau Ontogenesis in Human Cortical Neurons and is Mimicked by Protein Phosphatase 2A Inhibition. Ebiomedicine. 3: 141-54. PMID 26870825 DOI: 10.1016/j.ebiom.2015.12.010  0.8
2016 Livesey MR, Magnani D, Cleary EM, Vasistha NA, James OT, Selvaraj BT, Burr K, Story D, Shaw CE, Kind PC, Hardingham GE, Wyllie DJ, Chandran S. Maturation and electrophysiological properties of human pluripotent stem cell-derived oligodendrocytes. Stem Cells (Dayton, Ohio). PMID 26763608 DOI: 10.1002/stem.2273  0.8
2015 Livesey MR, Magnani D, Hardingham GE, Chandran S, Wyllie DJ. Functional properties of in vitro excitatory cortical neurons derived from human pluripotent stem cells. The Journal of Physiology. PMID 26608229 DOI: 10.1113/JP270660  0.8
2015 Barnes SA, Wijetunge LS, Jackson AD, Katsanevaki D, Osterweil EK, Komiyama NH, Grant SG, Bear MF, Nägerl UV, Kind PC, Wyllie DJ. Convergence of Hippocampal Pathophysiology in Syngap+/- and Fmr1-/y Mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 15073-81. PMID 26558778 DOI: 10.1523/JNEUROSCI.1087-15.2015  0.8
2015 Till SM, Asiminas A, Jackson AD, Katsanevaki D, Barnes SA, Osterweil EK, Bear MF, Chattarji S, Wood ER, Wyllie DJ, Kind PC. Conserved hippocampal cellular pathophysiology but distinct behavioural deficits in a new rat model of FXS. Human Molecular Genetics. PMID 26243794 DOI: 10.1093/hmg/ddv299  0.8
2015 Bell KF, Al-Mubarak B, Martel MA, McKay S, Wheelan N, Hasel P, Márkus NM, Baxter P, Deighton RF, Serio A, Bilican B, Chowdhry S, Meakin PJ, Ashford ML, Wyllie DJ, et al. Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2. Nature Communications. 6: 7066. PMID 25967870 DOI: 10.1038/ncomms8066  0.8
2014 James OT, Livesey MR, Qiu J, Dando O, Bilican B, Haghi G, Rajan R, Burr K, Hardingham GE, Chandran S, Kind PC, Wyllie DJ. Ionotropic GABA and glycine receptor subunit composition in human pluripotent stem cell-derived excitatory cortical neurones. The Journal of Physiology. 592: 4353-63. PMID 25172951 DOI: 10.1113/jphysiol.2014.278994  0.8
2014 Livesey MR, Bilican B, Qiu J, Rzechorzek NM, Haghi G, Burr K, Hardingham GE, Chandran S, Wyllie DJ. Maturation of AMPAR composition and the GABAAR reversal potential in hPSC-derived cortical neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 4070-5. PMID 24623784 DOI: 10.1523/JNEUROSCI.5410-13.2014  0.8
2014 Bilican B, Livesey MR, Haghi G, Qiu J, Burr K, Siller R, Hardingham GE, Wyllie DJ, Chandran S. Physiological normoxia and absence of EGF is required for the long-term propagation of anterior neural precursors from human pluripotent cells. Plos One. 9: e85932. PMID 24465796 DOI: 10.1371/journal.pone.0085932  0.8
2013 Qiu J, Tan YW, Hagenston AM, Martel MA, Kneisel N, Skehel PA, Wyllie DJ, Bading H, Hardingham GE. Mitochondrial calcium uniporter Mcu controls excitotoxicity and is transcriptionally repressed by neuroprotective nuclear calcium signals. Nature Communications. 4: 2034. PMID 23774321 DOI: 10.1038/ncomms3034  0.8
2013 Bilican B, Serio A, Barmada SJ, Nishimura AL, Sullivan GJ, Carrasco M, Phatnani HP, Puddifoot CA, Story D, Fletcher J, Park IH, Friedman BA, Daley GQ, Wyllie DJ, Hardingham GE, et al. Comment on "Drug screening for ALS using patient-specific induced pluripotent stem cells". Science Translational Medicine. 5: 188le2. PMID 23740897 DOI: 10.1126/scitranslmed.3005065  0.8
2013 McKay S, Bengtson CP, Bading H, Wyllie DJ, Hardingham GE. Recovery of NMDA receptor currents from MK-801 blockade is accelerated by Mg2+ and memantine under conditions of agonist exposure. Neuropharmacology. 74: 119-25. PMID 23402996 DOI: 10.1016/j.neuropharm.2013.01.024  0.8
2013 Wyllie DJ, Livesey MR, Hardingham GE. Influence of GluN2 subunit identity on NMDA receptor function. Neuropharmacology. 74: 4-17. PMID 23376022 DOI: 10.1016/j.neuropharm.2013.01.016  0.8
2013 Wijetunge LS, Chattarji S, Wyllie DJ, Kind PC. Fragile X syndrome: from targets to treatments. Neuropharmacology. 68: 83-96. PMID 23257237 DOI: 10.1016/j.neuropharm.2012.11.028  0.8
2012 McMahon AC, Barnett MW, O'Leary TS, Stoney PN, Collins MO, Papadia S, Choudhary JS, Komiyama NH, Grant SG, Hardingham GE, Wyllie DJ, Kind PC. SynGAP isoforms exert opposing effects on synaptic strength. Nature Communications. 3: 900. PMID 22692543 DOI: 10.1038/ncomms1900  0.8
2012 Patani R, Lewis PA, Trabzuni D, Puddifoot CA, Wyllie DJ, Walker R, Smith C, Hardingham GE, Weale M, Hardy J, Chandran S, Ryten M. Investigating the utility of human embryonic stem cell-derived neurons to model ageing and neurodegenerative disease using whole-genome gene expression and splicing analysis. Journal of Neurochemistry. 122: 738-51. PMID 22681703 DOI: 10.1111/j.1471-4159.2012.07825.x  0.8
2012 Puddifoot C, Martel MA, Soriano FX, Camacho A, Vidal-Puig A, Wyllie DJ, Hardingham GE. PGC-1α negatively regulates extrasynaptic NMDAR activity and excitotoxicity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 6995-7000. PMID 22593067 DOI: 10.1523/JNEUROSCI.6407-11.2012  0.8
2012 Edman S, McKay S, Macdonald LJ, Samadi M, Livesey MR, Hardingham GE, Wyllie DJ. TCN 201 selectively blocks GluN2A-containing NMDARs in a GluN1 co-agonist dependent but non-competitive manner. Neuropharmacology. 63: 441-9. PMID 22579927 DOI: 10.1016/j.neuropharm.2012.04.027  0.8
2012 Martel MA, Ryan TJ, Bell KF, Fowler JH, McMahon A, Al-Mubarak B, Komiyama NH, Horsburgh K, Kind PC, Grant SG, Wyllie DJ, Hardingham GE. The subtype of GluN2 C-terminal domain determines the response to excitotoxic insults. Neuron. 74: 543-56. PMID 22578505 DOI: 10.1016/j.neuron.2012.03.021  0.8
2012 Bilican B, Serio A, Barmada SJ, Nishimura AL, Sullivan GJ, Carrasco M, Phatnani HP, Puddifoot CA, Story D, Fletcher J, Park IH, Friedman BA, Daley GQ, Wyllie DJ, Hardingham GE, et al. Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability. Proceedings of the National Academy of Sciences of the United States of America. 109: 5803-8. PMID 22451909 DOI: 10.1073/pnas.1202922109  0.8
2012 Wyllie DJ, Traynelis SF. NMDA receptor permeation: a light in the tunnel. Nature Neuroscience. 15: 343-4. PMID 22362102 DOI: 10.1038/nn.3058  0.8
2012 McKay S, Griffiths NH, Butters PA, Thubron EB, Hardingham GE, Wyllie DJ. Direct pharmacological monitoring of the developmental switch in NMDA receptor subunit composition using TCN 213, a GluN2A-selective, glycine-dependent antagonist. British Journal of Pharmacology. 166: 924-37. PMID 22022974 DOI: 10.1111/j.1476-5381.2011.01748.x  0.8
2011 O'Leary T, Wyllie DJ. Neuronal homeostasis: time for a change? The Journal of Physiology. 589: 4811-26. PMID 21825033 DOI: 10.1113/jphysiol.2011.210179  0.8
2011 Patani R, Hollins AJ, Wishart TM, Puddifoot CA, Alvarez S, de Lera AR, Wyllie DJ, Compston DA, Pedersen RA, Gillingwater TH, Hardingham GE, Allen ND, Chandran S. Retinoid-independent motor neurogenesis from human embryonic stem cells reveals a medial columnar ground state. Nature Communications. 2: 214. PMID 21364553 DOI: 10.1038/ncomms1216  0.8
2011 Otton HJ, Lawson McLean A, Pannozzo MA, Davies CH, Wyllie DJ. Quantification of the Mg2+-induced potency shift of amantadine and memantine voltage-dependent block in human recombinant GluN1/GluN2A NMDARs. Neuropharmacology. 60: 388-96. PMID 20955720 DOI: 10.1016/j.neuropharm.2010.10.008  0.8
2010 Clayton EL, Sue N, Smillie KJ, O'Leary T, Bache N, Cheung G, Cole AR, Wyllie DJ, Sutherland C, Robinson PJ, Cousin MA. Dynamin I phosphorylation by GSK3 controls activity-dependent bulk endocytosis of synaptic vesicles. Nature Neuroscience. 13: 845-51. PMID 20526333 DOI: 10.1038/nn.2571  0.8
2010 Hardingham GE, Patani R, Baxter P, Wyllie DJ, Chandran S. Human embryonic stem cell-derived neurons as a tool for studying neuroprotection and neurodegeneration. Molecular Neurobiology. 42: 97-102. PMID 20431962 DOI: 10.1007/s12035-010-8136-2  0.8
2010 Perkins EM, Clarkson YL, Sabatier N, Longhurst DM, Millward CP, Jack J, Toraiwa J, Watanabe M, Rothstein JD, Lyndon AR, Wyllie DJ, Dutia MB, Jackson M. Loss of beta-III spectrin leads to Purkinje cell dysfunction recapitulating the behavior and neuropathology of spinocerebellar ataxia type 5 in humans. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 4857-67. PMID 20371805 DOI: 10.1523/JNEUROSCI.6065-09.2010  0.8
2010 Léveillé F, Papadia S, Fricker M, Bell KF, Soriano FX, Martel MA, Puddifoot C, Habel M, Wyllie DJ, Ikonomidou C, Tolkovsky AM, Hardingham GE. Suppression of the intrinsic apoptosis pathway by synaptic activity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 2623-35. PMID 20164347 DOI: 10.1523/JNEUROSCI.5115-09.2010  0.8
2010 O'Leary T, van Rossum MC, Wyllie DJ. Homeostasis of intrinsic excitability in hippocampal neurones: dynamics and mechanism of the response to chronic depolarization. The Journal of Physiology. 588: 157-70. PMID 19917565 DOI: 10.1113/jphysiol.2009.181024  0.8
2009 O'Leary T, Wyllie DJ. Single-channel properties of N-methyl-D-aspartate receptors containing chimaeric GluN2A/GluN2D subunits. Biochemical Society Transactions. 37: 1347-54. PMID 19909274 DOI: 10.1042/BST0371347  0.8
2009 Patani R, Compston A, Puddifoot CA, Wyllie DJ, Hardingham GE, Allen ND, Chandran S. Activin/Nodal inhibition alone accelerates highly efficient neural conversion from human embryonic stem cells and imposes a caudal positional identity. Plos One. 4: e7327. PMID 19806200 DOI: 10.1371/journal.pone.0007327  0.8
2009 Otton HJ, Janssen A, O'Leary T, Chen PE, Wyllie DJ. Inhibition of rat recombinant GluN1/GluN2A and GluN1/GluN2B NMDA receptors by ethanol at concentrations based on the US/UK drink-drive limit. European Journal of Pharmacology. 614: 14-21. PMID 19394328 DOI: 10.1016/j.ejphar.2009.04.034  0.8
2009 Martel MA, Soriano FX, Baxter P, Rickman C, Duncan R, Wyllie DJ, Hardingham GE. Inhibiting pro-death NMDA receptor signaling dependent on the NR2 PDZ ligand may not affect synaptic function or synaptic NMDA receptor signaling to gene expression. Channels (Austin, Tex.). 3: 12-5. PMID 19221512  0.8
2009 Puddifoot CA, Chen PE, Schoepfer R, Wyllie DJ. Pharmacological characterization of recombinant NR1/NR2A NMDA receptors with truncated and deleted carboxy termini expressed in Xenopus laevis oocytes. British Journal of Pharmacology. 156: 509-18. PMID 19154422 DOI: 10.1111/j.1476-5381.2008.00040.x  0.8
2009 Martel MA, Wyllie DJ, Hardingham GE. In developing hippocampal neurons, NR2B-containing N-methyl-D-aspartate receptors (NMDARs) can mediate signaling to neuronal survival and synaptic potentiation, as well as neuronal death. Neuroscience. 158: 334-43. PMID 18378405 DOI: 10.1016/j.neuroscience.2008.01.080  0.8
2008 O'Leary T, Wyllie DJ. The ups and downs of synaptic plasticity: influences on this particular 'market'. The Journal of Physiology. 586: 5839-40. PMID 19074816 DOI: 10.1113/jphysiol.2008.165720  0.8
2008 Soriano FX, Martel MA, Papadia S, Vaslin A, Baxter P, Rickman C, Forder J, Tymianski M, Duncan R, Aarts M, Clarke P, Wyllie DJ, Hardingham GE. Specific targeting of pro-death NMDA receptor signals with differing reliance on the NR2B PDZ ligand. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 10696-710. PMID 18923045 DOI: 10.1523/JNEUROSCI.1207-08.2008  0.8
2008 Wilbrey AL, Haley JE, Wishart TM, Conforti L, Morreale G, Beirowski B, Babetto E, Adalbert R, Gillingwater TH, Smith T, Wyllie DJ, Ribchester RR, Coleman MP. VCP binding influences intracellular distribution of the slow Wallerian degeneration protein, Wld(S). Molecular and Cellular Neurosciences. 38: 325-40. PMID 18468455 DOI: 10.1016/j.mcn.2008.03.004  0.8
2008 Papadia S, Soriano FX, Léveillé F, Martel MA, Dakin KA, Hansen HH, Kaindl A, Sifringer M, Fowler J, Stefovska V, McKenzie G, Craigon M, Corriveau R, Ghazal P, Horsburgh K, ... ... Wyllie DJ, et al. Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses. Nature Neuroscience. 11: 476-87. PMID 18344994 DOI: 10.1038/nn2071  0.8
2008 Chen PE, Geballe MT, Katz E, Erreger K, Livesey MR, O'Toole KK, Le P, Lee CJ, Snyder JP, Traynelis SF, Wyllie DJ. Modulation of glycine potency in rat recombinant NMDA receptors containing chimeric NR2A/2D subunits expressed in Xenopus laevis oocytes. The Journal of Physiology. 586: 227-45. PMID 17962328 DOI: 10.1113/jphysiol.2007.143172  0.8
2007 Erreger K, Geballe MT, Kristensen A, Chen PE, Hansen KB, Lee CJ, Yuan H, Le P, Lyuboslavsky PN, Micale N, Jørgensen L, Clausen RP, Wyllie DJ, Snyder JP, Traynelis SF. Subunit-specific agonist activity at NR2A-, NR2B-, NR2C-, and NR2D-containing N-methyl-D-aspartate glutamate receptors. Molecular Pharmacology. 72: 907-20. PMID 17622578 DOI: 10.1124/mol.107.037333  0.8
2006 Wyllie DJ, Johnston AR, Lipscombe D, Chen PE. Single-channel analysis of a point mutation of a conserved serine residue in the S2 ligand-binding domain of the NR2A NMDA receptor subunit. The Journal of Physiology. 574: 477-89. PMID 16709630 DOI: 10.1113/jphysiol.2006.112193  0.8
2006 Gillingwater TH, Wishart TM, Chen PE, Haley JE, Robertson K, MacDonald SH, Middleton S, Wawrowski K, Shipston MJ, Melmed S, Wyllie DJ, Skehel PA, Coleman MP, Ribchester RR. The neuroprotective WldS gene regulates expression of PTTG1 and erythroid differentiation regulator 1-like gene in mice and human cells. Human Molecular Genetics. 15: 625-35. PMID 16403805 DOI: 10.1093/hmg/ddi478  0.8
2005 Erreger K, Geballe MT, Dravid SM, Snyder JP, Wyllie DJ, Traynelis SF. Mechanism of partial agonism at NMDA receptors for a conformationally restricted glutamate analog. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 7858-66. PMID 16120788 DOI: 10.1523/JNEUROSCI.1613-05.2005  0.8
2005 Chen PE, Geballe MT, Stansfeld PJ, Johnston AR, Yuan H, Jacob AL, Snyder JP, Traynelis SF, Wyllie DJ. Structural features of the glutamate binding site in recombinant NR1/NR2A N-methyl-D-aspartate receptors determined by site-directed mutagenesis and molecular modeling. Molecular Pharmacology. 67: 1470-84. PMID 15703381 DOI: 10.1124/mol.104.008185  0.8
2005 Erreger K, Dravid SM, Banke TG, Wyllie DJ, Traynelis SF. Subunit-specific gating controls rat NR1/NR2A and NR1/NR2B NMDA channel kinetics and synaptic signalling profiles. The Journal of Physiology. 563: 345-58. PMID 15649985 DOI: 10.1113/jphysiol.2004.080028  0.8
2004 Erreger K, Chen PE, Wyllie DJ, Traynelis SF. Glutamate receptor gating. Critical Reviews in Neurobiology. 16: 187-224. PMID 15701057 DOI: 10.1615/CritRevNeurobiol.v16.i3.10  0.8
2004 Chen PE, Johnston AR, Mok MH, Schoepfer R, Wyllie DJ. Influence of a threonine residue in the S2 ligand binding domain in determining agonist potency and deactivation rate of recombinant NR1a/NR2D NMDA receptors. The Journal of Physiology. 558: 45-58. PMID 15107472 DOI: 10.1113/jphysiol.2004.063800  0.8
2000 Anson LC, Schoepfer R, Colquhoun D, Wyllie DJ. Single-channel analysis of an NMDA receptor possessing a mutation in the region of the glutamate binding site. The Journal of Physiology. 527: 225-37. PMID 10970425  0.8
2000 Misra C, Brickley SG, Wyllie DJ, Cull-Candy SG. Slow deactivation kinetics of NMDA receptors containing NR1 and NR2D subunits in rat cerebellar Purkinje cells. The Journal of Physiology. 525: 299-305. PMID 10835034  0.8
1998 Wyllie DJ, Béhé P, Colquhoun D. Single-channel activations and concentration jumps: comparison of recombinant NR1a/NR2A and NR1a/NR2D NMDA receptors. The Journal of Physiology. 510: 1-18. PMID 9625862 DOI: 10.1111/j.1469-7793.1998.001bz.x  0.8
1998 Anson LC, Chen PE, Wyllie DJ, Colquhoun D, Schoepfer R. Identification of amino acid residues of the NR2A subunit that control glutamate potency in recombinant NR1/NR2A NMDA receptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 581-9. PMID 9425000  0.8
1996 Wyllie DJ, Béhé P, Nassar M, Schoepfer R, Colquhoun D. Single-channel currents from recombinant NMDA NR1a/NR2D receptors expressed in Xenopus oocytes. Proceedings. Biological Sciences / the Royal Society. 263: 1079-86. PMID 8805841 DOI: 10.1098/rspb.1996.0159  0.8
1995 Béhé P, Stern P, Wyllie DJ, Nassar M, Schoepfer R, Colquhoun D. Determination of NMDA NR1 subunit copy number in recombinant NMDA receptors. Proceedings. Biological Sciences / the Royal Society. 262: 205-13. PMID 8524912 DOI: 10.1098/rspb.1995.0197  0.8
1994 Wyllie DJ, Nicoll RA. A role for protein kinases and phosphatases in the Ca(2+)-induced enhancement of hippocampal AMPA receptor-mediated synaptic responses. Neuron. 13: 635-43. PMID 7917294 DOI: 10.1016/0896-6273(94)90031-0  0.8
1994 Wyllie DJ, Cull-Candy SG. A comparison of non-NMDA receptor channels in type-2 astrocytes and granule cells from rat cerebellum. The Journal of Physiology. 475: 95-114. PMID 7514667  0.8
1994 Wyllie DJ, Manabe T, Nicoll RA. A rise in postsynaptic Ca2+ potentiates miniature excitatory postsynaptic currents and AMPA responses in hippocampal neurons. Neuron. 12: 127-38. PMID 7507335  1
1993 Manabe T, Wyllie DJ, Perkel DJ, Nicoll RA. Modulation of synaptic transmission and long-term potentiation: effects on paired pulse facilitation and EPSC variance in the CA1 region of the hippocampus. Journal of Neurophysiology. 70: 1451-9. PMID 7904300  0.8
1993 Wyllie DJ, Traynelis SF, Cull-Candy SG. Evidence for more than one type of non-NMDA receptor in outside-out patches from cerebellar granule cells of the rat. The Journal of Physiology. 463: 193-226. PMID 7504104 DOI: 10.1113/jphysiol.1993.sp019591  0.8
1991 Cull-Candy SG, Wyllie DJ. Glutamate-receptor channels in mammalian glial cells. Annals of the New York Academy of Sciences. 633: 458-74. PMID 1686383  0.8
1991 Lightstone EB, Wyllie D, Marvel J. In the mouse the maturation stage of the peripheral CD4+CD45RA+ subset is different from that of the CD8+CD45RA+ subset European Journal of Immunology. 21: 2161-2165. PMID 1679713  0.8
1991 Wyllie DJ, Mathie A, Symonds CJ, Cull-Candy SG. Activation of glutamate receptors and glutamate uptake in identified macroglial cells in rat cerebellar cultures. The Journal of Physiology. 432: 235-58. PMID 1653320  0.8
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