Mark Rowland Hutchinson - Publications

Affiliations: 
Discipline of Physiology University of Adelaide, Adelaide, South Australia, Australia 
Area:
Neuroimmunopharmacology, Neuroscience, Immunology, Pharmacology

149 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Mustafa S, Evans S, Barry B, Barratt D, Wang Y, Lin C, Wang X, Hutchinson MR. Toll-Like Receptor 4 in Pain: Bridging Molecules-to-Cells-to-Systems. Handbook of Experimental Pharmacology. PMID 35434749 DOI: 10.1007/164_2022_587  0.396
2022 Gilron I, Xiao MZX, Balanaser M, Carley M, Ghasemlou N, Salter MW, Hutchinson MR, Moulin DE, Moore RA, Ross-White A. Glial-modulating agents for the treatment of pain: protocol for a systematic review. Bmj Open. 12: e055713. PMID 35387818 DOI: 10.1136/bmjopen-2021-055713  0.342
2022 Thomas JHL, Lui L, Abell A, Tieu W, Somogyi AA, Bajic JE, Hutchinson MR. Toll-Like Receptors change morphine-induced antinociception, tolerance and dependence: studies using male and female TLR and Signalling gene KO mice. Brain, Behavior, and Immunity. PMID 35131445 DOI: 10.1016/j.bbi.2022.02.001  0.807
2021 Moh ESX, Nishtala K, Iqbal S, Staikopoulos V, Kapur D, Hutchinson MR, Packer NH. Long-term intrathecal administration of morphine vs. baclofen: Differences in CSF glycoconjugate profiles using multiglycomics. Glycobiology. PMID 34969075 DOI: 10.1093/glycob/cwab098  0.347
2021 Li H, Peng Y, Lin C, Zhang X, Zhang T, Wang Y, Li Y, Wu S, Wang H, Hutchinson MR, Watkins LR, Wang X. Nicotine and its metabolite cotinine target MD2 and inhibit TLR4 signaling. Innovation (New York, N.Y.). 2: 100111. PMID 34557761 DOI: 10.1016/j.xinn.2021.100111  0.632
2021 Bajic JE, Howarth GS, Mashtoub S, Whittaker AL, Bobrovskaya L, Hutchinson MR. Neuroimmunological complications arising from chemotherapy-induced gut toxicity and opioid exposure in female dark agouti rats. Journal of Neuroscience Research. PMID 34510524 DOI: 10.1002/jnr.24959  0.39
2021 Evans SF, Kwok Y, Solterbeck A, Pyragius C, Hull ML, Hutchinson MR, Rolan P. The Relationship Between Androgens and Days per Month of Period Pain, Pelvic Pain, Headache, and TLR4 Responsiveness of Peripheral Blood Mononuclear Cells in Young Women with Dysmenorrhoea. Journal of Pain Research. 14: 585-599. PMID 33688248 DOI: 10.2147/JPR.S279253  0.642
2020 Grace PM, Tawfik VL, Svensson CI, Burton MD, Loggia ML, Hutchinson MR. The Neuroimmunology of Chronic Pain: From Rodents to Humans. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 33239404 DOI: 10.1523/JNEUROSCI.1650-20.2020  0.784
2020 Zabolocki M, McCormack K, van den Hurk M, Milky B, Shoubridge AP, Adams R, Tran J, Mahadevan-Jansen A, Reineck P, Thomas J, Hutchinson MR, Mak CKH, Añonuevo A, Chew LH, Hirst AJ, et al. BrainPhys neuronal medium optimized for imaging and optogenetics in vitro. Nature Communications. 11: 5550. PMID 33144563 DOI: 10.1038/s41467-020-19275-x  0.529
2020 Doyle TM, Hutchinson MR, Braden K, Janes K, Staikopoulos V, Chen Z, Neumann WL, Spiegel S, Salvemini D. Sphingosine-1-phosphate receptor subtype 1 activation in the central nervous system contributes to morphine withdrawal in rodents. Journal of Neuroinflammation. 17: 314. PMID 33092620 DOI: 10.1186/s12974-020-01975-2  0.38
2020 Frank MG, Baratta MV, Zhang K, Fallon IP, Pearson MA, Liu G, Hutchinson MR, Watkins LR, Goldys EM, Maier SF. Acute stress induces the rapid and transient induction of caspase-1, gasdermin D and release of constitutive IL-1β protein in dorsal hippocampus. Brain, Behavior, and Immunity. PMID 32750541 DOI: 10.1016/J.Bbi.2020.07.042  0.638
2020 Doyle TM, Largent-Milnes TM, Chen Z, Staikopoulos V, Esposito E, Delgarno R, Fan C, Tosh DK, Cuzzocrea S, Jacobson KA, Trang T, Hutchinson MR, Bennett GJ, Vanderah TW, Salvemini D. The Journal of Pharmacology and Experimental Therapeutics. PMID 32434943 DOI: 10.1124/Jpet.120.000004  0.525
2020 Robertson SA, Hutchinson MR, Rice KC, Chin PY, Moldenhauer LM, Stark MJ, Olson DM, Keelan JA. Targeting Toll-like receptor-4 to tackle preterm birth and fetal inflammatory injury. Clinical & Translational Immunology. 9: e1121. PMID 32313651 DOI: 10.1002/Cti2.1121  0.518
2020 Arman A, Deng F, Goldys EM, Liu G, Hutchinson MR. In vivo intrathecal IL-1β quantification in rats: monitoring the molecular signals of neuropathic pain. Brain, Behavior, and Immunity. PMID 32272226 DOI: 10.1016/J.Bbi.2020.04.009  0.409
2020 Wang Y, Zhang S, Li H, Wang H, Zhang T, Hutchinson MR, Yin H, Wang X. Small-Molecule Modulators of Toll-like Receptors. Accounts of Chemical Research. PMID 32233400 DOI: 10.1021/Acs.Accounts.9B00631  0.432
2020 Evans SF, Kwok YH, Solterbeck A, Liu J, Hutchinson MR, Hull ML, Rolan PE. Toll-Like Receptor Responsiveness of Peripheral Blood Mononuclear Cells in Young Women with Dysmenorrhea. Journal of Pain Research. 13: 503-516. PMID 32210607 DOI: 10.2147/Jpr.S219684  0.663
2020 Chia JSM, Izham NAM, Farouk AAO, Sulaiman MR, Mustafa S, Hutchinson MR, Perimal EK. Zerumbone Modulates α-Adrenergic, TRPV1, and NMDA NR2B Receptors Plasticity in CCI-Induced Neuropathic Pain and LPS-Induced SH-SY5Y Neuroblastoma Models. Frontiers in Pharmacology. 11: 92. PMID 32194397 DOI: 10.3389/fphar.2020.00092  0.367
2020 Williams B, Lees F, Tsangari H, Hutchinson MR, Perilli E, Crotti TN. Assessing the Effects of Parthenolide on Inflammation, Bone Loss, and Glial Cells within a Collagen Antibody-Induced Arthritis Mouse Model. Mediators of Inflammation. 2020: 6245798. PMID 32189995 DOI: 10.1155/2020/6245798  0.349
2020 Wahid HH, Chin PY, Sharkey DJ, Diener KR, Hutchinson MR, Rice KC, Moldenhauer LM, Robertson SA. Toll-like receptor-4 antagonist (+)-naltrexone protects against carbamyl-platelet activating factor (Cpaf)-induced preterm labor in mice. The American Journal of Pathology. PMID 32084361 DOI: 10.1016/J.Ajpath.2020.01.008  0.513
2019 Iqbal S, Parker LM, Everest-Dass AV, Moh ESX, Sayyadi N, Hutchinson MR, Packer NH. Lipopolysaccharide and Morphine-3-Glucuronide-Induced Immune Signalling Increases the Expression of Polysialic Acid in PC12 Cells. Molecular Neurobiology. PMID 31646464 DOI: 10.1007/S12035-019-01791-7  0.378
2019 Peng Y, Zhang X, Zhang T, Grace PM, Li H, Wang Y, Li H, Chen H, Watkins LR, Hutchinson MR, Yin H, Wang X. Lovastatin inhibits Toll-like receptor 4 signaling in microglia by targeting its co-receptor myeloid differentiation protein 2 and attenuates neuropathic pain. Brain, Behavior, and Immunity. PMID 31542403 DOI: 10.1016/J.Bbi.2019.09.013  0.833
2019 Chin PY, Dorian C, Sharkey DJ, Hutchinson MR, Rice KC, Moldenhauer LM, Robertson SA. Toll-like receptor-4 antagonist (+)-naloxone confers sexually dimorphic protection from inflammation-induced fetal programming in mice. Endocrinology. PMID 31504393 DOI: 10.1210/En.2019-00493  0.523
2019 Wang X, Northcutt AL, Cochran TA, Zhang X, Fabisiak TJ, Haas ME, Amat J, Li H, Rice KC, Maier S, Bachtell RK, Hutchinson MR, Watkins LR. Methamphetamine activates Toll-like receptor 4 to induce central immune signaling within the ventral tegmental area and contributes to extracellular dopamine increase in the nucleus accumbens shell. Acs Chemical Neuroscience. PMID 31282647 DOI: 10.1021/Acschemneuro.9B00225  0.822
2019 Zhang X, Peng Y, Grace PM, Metcalf MD, Kwilasz AJ, Wang Y, Zhang T, Wu S, Selfridge BR, Portoghese PS, Rice KC, Watkins LR, Hutchinson MR, Wang X. Stereochemistry and innate immune recognition: (+)-norbinaltorphimine targets myeloid differentiation protein 2 and inhibits toll-like receptor 4 signaling. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201900173RRR. PMID 31162938 DOI: 10.1096/Fj.201900173Rrr  0.823
2019 Parker LM, Sayyadi N, Staikopoulos V, Shrestha A, Hutchinson MR, Packer NH. Visualizing neuroinflammation with fluorescence and luminescent lanthanide-based in situ hybridization. Journal of Neuroinflammation. 16: 65. PMID 30898121 DOI: 10.1186/S12974-019-1451-2  0.328
2018 Iacopetta K, Collins-Praino LE, Buisman-Pijlman FTA, Hutchinson MR. Can neuroimmune mechanisms explain the link between ultraviolet light (UV) exposure and addictive behavior? Brain, Behavior, and Immunity. PMID 30009997 DOI: 10.1016/J.Bbi.2018.07.008  0.379
2018 Bajic JE, Johnston IN, Howarth GS, Hutchinson MR. From the Bottom-Up: Chemotherapy and Gut-Brain Axis Dysregulation. Frontiers in Behavioral Neuroscience. 12: 104. PMID 29872383 DOI: 10.3389/fnbeh.2018.00104  0.319
2018 Dodds KN, Beckett EAH, Evans SF, Hutchinson MR. Spinal Glial Adaptations Occur in a Minimally Invasive Mouse Model of Endometriosis: Potential Implications for Lesion Etiology and Persistent Pelvic Pain. Reproductive Sciences (Thousand Oaks, Calif.). 1933719118773405. PMID 29730970 DOI: 10.1177/1933719118773405  0.382
2018 Zhang K, Baratta MV, Liu G, Frank MG, Leslie NR, Watkins LR, Maier SF, Hutchinson MR, Goldys EM. A novel platform for in vivo detection of cytokine release within discrete brain regions. Brain, Behavior, and Immunity. PMID 29678795 DOI: 10.1016/J.Bbi.2018.04.011  0.648
2018 Beckett EAH, Staikopoulos V, Hutchinson MR. Differential effect of morphine on gastrointestinal transit, colonic contractions and nerve-evoked relaxations in Toll-Like Receptor deficient mice. Scientific Reports. 8: 5923. PMID 29651005 DOI: 10.1038/s41598-018-23717-4  0.463
2018 Zhang X, Cui F, Chen H, Zhang T, Yang K, Wang Y, Jiang Z, Rice KC, Watkins LR, Hutchinson MR, Li Y, Peng Y, Wang X. Dissecting the Innate Immune Recognition of Opioid Inactive Isomer (+)-Naltrexone Derived Toll-like Receptor 4 (TLR4) Antagonists. Journal of Chemical Information and Modeling. PMID 29518316 DOI: 10.1021/Acs.Jcim.7B00717  0.769
2018 Liu J, Mustafa S, Barratt DT, Hutchinson MR. Corticosterone Preexposure Increases NF-κB Translocation and Sensitizes IL-1β Responses in BV2 Microglia-Like Cells. Frontiers in Immunology. 9: 3. PMID 29403490 DOI: 10.3389/fimmu.2018.00003  0.368
2018 Robertson SA, Wahid HH, Chin PY, Hutchinson MR, Moldenhauer LM, Keelan JA. Toll-like receptor-4: A new target for preterm labour pharmacotherapies? Current Pharmaceutical Design. PMID 29384054 DOI: 10.2174/1381612824666180130122450  0.36
2017 Jacobsen JH, Buisman-Pijlman F, Mustafa S, Rice KC, Hutchinson MR. Antagonising TLR4-TRIF signalling before or after a low-dose alcohol binge during adolescence prevents alcohol drinking but not seeking behaviour in adulthood. Neuropharmacology. PMID 28947376 DOI: 10.1016/J.Neuropharm.2017.09.028  0.432
2017 Jacobsen JHW, Buisman-Pijlman FT, Mustafa S, Rice KC, Hutchinson MR. The efficacy of (+)-Naltrexone on alcohol preference and seeking behaviour is dependent on light-cycle. Brain, Behavior, and Immunity. PMID 28864261 DOI: 10.1016/J.Bbi.2017.08.021  0.517
2016 Lewis SS, Grace PM, Hutchinson MR, Maier SF, Watkins LR. Constriction of the buccal branch of the facial nerve produces unilateral craniofacial allodynia. Brain, Behavior, and Immunity. PMID 27993689 DOI: 10.1016/J.Bbi.2016.12.004  0.801
2016 Grace PM, Gaudet AD, Staikopoulos V, Maier SF, Hutchinson MR, Salvemini D, Watkins LR. Nitroxidative Signaling Mechanisms in Pathological Pain. Trends in Neurosciences. PMID 27842920 DOI: 10.1016/J.Tins.2016.10.003  0.83
2016 Chin PY, Dorian CL, Hutchinson MR, Olson DM, Rice KC, Moldenhauer LM, Robertson SA. Novel Toll-like receptor-4 antagonist (+)-naloxone protects mice from inflammation-induced preterm birth. Scientific Reports. 6: 36112. PMID 27819333 DOI: 10.1038/Srep36112  0.536
2016 Somogyi AA, Sia AT, Tan EC, Coller JK, Hutchinson MR, Barratt DT. Ethnicity-dependent influence of innate immune genetic markers on morphine PCA requirements and adverse effects in postoperative pain. Pain. PMID 27649267 DOI: 10.1097/j.pain.0000000000000661  0.74
2016 Dodds KN, Beckett EA, Evans SF, Grace PM, Watkins LR, Hutchinson MR. Glial contributions to visceral pain: implications for disease etiology and the female predominance of persistent pain. Translational Psychiatry. 6: e888. PMID 27622932 DOI: 10.1038/Tp.2016.168  0.823
2016 Ellis A, Grace PM, Wieseler J, Favret J, Springer K, Skarda B, Hutchinson MR, Falci S, Rice KC, Maier SF, Watkins LR. Morphine amplifies mechanical allodynia via TLR4 in a rat model of spinal cord injury. Brain, Behavior, and Immunity. PMID 27519154 DOI: 10.1016/J.Bbi.2016.08.004  0.828
2016 Lee SM, Hutchinson M, Saint DA. The role of Toll-like receptor 4 (TLR4) in cardiac ischaemic-reperfusion injury, cardioprotection and preconditioning. Clinical and Experimental Pharmacology & Physiology. PMID 27249055 DOI: 10.1111/1440-1681.12602  0.37
2016 Wardill HR, Gibson RJ, Van Sebille YZ, Secombe KR, Coller JK, White IA, Manavis J, Hutchinson MR, Staikopoulos V, Logan RM, Bowen JM. Irinotecan-induced gastrointestinal dysfunction and pain are mediated by common TLR4-dependent mechanisms. Molecular Cancer Therapeutics. PMID 27197307 DOI: 10.1158/1535-7163.MCT-15-0990  0.433
2016 Whittaker AL, Bajic JE, Bobrovskaya L, Hutchinson MR, Howarth GS. 200 Chemotherapy Induces Intestinal Inflammation and Central Changes Which Are Modified by Analgesics via Neuro-Immune Mechanisms Gastroenterology. 150: S52. DOI: 10.1016/S0016-5085(16)30301-8  0.363
2015 Jacobsen JH, Hutchinson MR, Mustafa S. Drug addiction: targeting dynamic neuroimmune receptor interactions as a potential therapeutic strategy. Current Opinion in Pharmacology. 26: 131-137. PMID 26657076 DOI: 10.1016/j.coph.2015.10.010  0.332
2015 Wang X, Zhang Y, Peng Y, Hutchinson MR, Rice KC, Yin H, Watkins LR. Pharmacological characterization of the opioid inactive isomers (+)-naltrexone and (+)-naloxone as Toll-like receptor 4 antagonists. British Journal of Pharmacology. PMID 26603732 DOI: 10.1111/Bph.13394  0.802
2015 Gibson RJ, Coller JK, Wardill HR, Hutchinson MR, Smid S, Bowen JM. Chemotherapy-induced gut toxicity and pain: involvement of TLRs. Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer. PMID 26581898 DOI: 10.1007/s00520-015-3020-2  0.471
2015 Johnson JL, Kwok YH, Sumracki NM, Swift JE, Hutchinson MR, Johnson K, Williams DB, Tuke J, Rolan PE. Glial Attenuation With Ibudilast in the Treatment of Medication Overuse Headache: A Double-Blind, Randomized, Placebo-Controlled Pilot Trial of Efficacy and Safety. Headache. PMID 26367865 DOI: 10.1111/Head.12655  0.703
2015 Wahid HH, Dorian C, Yin Chin P, Hutchinson MR, Rice KC, Olson DM, Moldenhauer LM, Robertson SA. Toll-like receptor 4 is an essential upstream regulator of on-time parturition and perinatal viability in mice. Endocrinology. EN20151089. PMID 26151355 DOI: 10.1210/En.2015-1089  0.515
2015 Bachtell R, Hutchinson MR, Wang X, Rice KC, Maier SF, Watkins LR. Targeting the Toll of Drug Abuse: The Translational Potential of Toll-Like Receptor 4. Cns & Neurological Disorders Drug Targets. 14: 692-9. PMID 26022268 DOI: 10.2174/1871527314666150529132503  0.751
2015 Thomas J, Mustafa S, Johnson J, Nicotra L, Hutchinson M. The relationship between opioids and immune signalling in the spinal cord. Handbook of Experimental Pharmacology. 227: 207-38. PMID 25846621 DOI: 10.1007/978-3-662-46450-2_11  0.844
2015 Li Y, Jackson KA, Slon B, Hardy JR, Franco M, William L, Poon P, Coller JK, Hutchinson MR, Currow DC, Somogyi AA. CYP2B6*6 allele and age substantially reduce steady-state ketamine clearance in chronic pain patients: impact on adverse effects. British Journal of Clinical Pharmacology. PMID 25702819 DOI: 10.1111/bcp.12614  0.717
2015 Northcutt AL, Hutchinson MR, Wang X, Baratta MV, Hiranita T, Cochran TA, Pomrenze MB, Galer EL, Kopajtic TA, Li CM, Amat J, Larson G, Cooper DC, Huang Y, O'Neill CE, et al. DAT isn't all that: cocaine reward and reinforcement require Toll-like receptor 4 signaling. Molecular Psychiatry. PMID 25644383 DOI: 10.1038/Mp.2014.177  0.77
2015 Corrigan F, Wu Y, Tuke J, Coller JK, Rice KC, Diener KR, Hayball JD, Watkins LR, Somogyi AA, Hutchinson MR. Alcohol-induced sedation and synergistic interactions between alcohol and morphine: a key mechanistic role for Toll-like receptors and MyD88-dependent signaling. Brain, Behavior, and Immunity. 45: 245-52. PMID 25542736 DOI: 10.1016/J.Bbi.2014.12.019  0.821
2015 Lewis SS, Hutchinson MR, Frick MM, Zhang Y, Maier SF, Sammakia T, Rice KC, Watkins LR. Select steroid hormone glucuronide metabolites can cause toll-like receptor 4 activation and enhanced pain. Brain, Behavior, and Immunity. 44: 128-36. PMID 25218902 DOI: 10.1016/J.Bbi.2014.09.004  0.846
2015 Bachtell R, Hutchinson MR, Wang X, Rice KC, Maier SF, Watkins LR. Targeting the toll of drug abuse: The translational potential of toll-like receptor 4 Cns and Neurological Disorders - Drug Targets. 14: 692-698.  0.686
2014 Johnson JL, Rolan PE, Johnson ME, Bobrovskaya L, Williams DB, Johnson K, Tuke J, Hutchinson MR. Codeine-induced hyperalgesia and allodynia: investigating the role of glial activation. Translational Psychiatry. 4: e482. PMID 25386959 DOI: 10.1038/Tp.2014.121  0.754
2014 Liu J, Buisman-Pijlman F, Hutchinson MR. Toll-like receptor 4: innate immune regulator of neuroimmune and neuroendocrine interactions in stress and major depressive disorder. Frontiers in Neuroscience. 8: 309. PMID 25324715 DOI: 10.3389/Fnins.2014.00309  0.356
2014 Grace PM, Ramos KM, Rodgers KM, Wang X, Hutchinson MR, Lewis MT, Morgan KN, Kroll JL, Taylor FR, Strand KA, Zhang Y, Berkelhammer D, Huey MG, Greene LI, Cochran TA, et al. Activation of adult rat CNS endothelial cells by opioid-induced toll-like receptor 4 (TLR4) signaling induces proinflammatory, biochemical, morphological, and behavioral sequelae. Neuroscience. 280: 299-317. PMID 25241065 DOI: 10.1016/J.Neuroscience.2014.09.020  0.834
2014 Jacobsen JH, Watkins LR, Hutchinson MR. Discovery of a novel site of opioid action at the innate immune pattern-recognition receptor TLR4 and its role in addiction. International Review of Neurobiology. 118: 129-63. PMID 25175864 DOI: 10.1016/B978-0-12-801284-0.00006-3  0.761
2014 Watkins LR, Wang X, Mustafa S, Hutchinson MR. In vivo veritas: (+)-Naltrexone's actions define translational importance: A letter in response to Skolnick et al. 'Translational potential of naloxone and naltrexone as TLR4 antagonists'. Trends in Pharmacological Sciences. 35: 432-3. PMID 25109571 DOI: 10.1016/J.Tips.2014.07.002  0.731
2014 Zwicker JD, Zhang Y, Ren J, Hutchinson MR, Rice KC, Watkins LR, Greer JJ, Funk GD. Glial TLR4 signaling does not contribute to opioid-induced depression of respiration. Journal of Applied Physiology (Bethesda, Md. : 1985). 117: 857-68. PMID 25103966 DOI: 10.1152/Japplphysiol.00534.2014  0.761
2014 Hutchinson MR. Want more pain? Just add a dash of endotoxin to enhance your clinical pain model. Brain, Behavior, and Immunity. 41: 44-5. PMID 24972264 DOI: 10.1016/j.bbi.2014.06.008  0.418
2014 Ingman WV, Glynn DJ, Hutchinson MR. Inflammatory mediators in mastitis and lactation insufficiency. Journal of Mammary Gland Biology and Neoplasia. 19: 161-7. PMID 24961655 DOI: 10.1007/s10911-014-9325-9  0.37
2014 Glynn DJ, Hutchinson MR, Ingman WV. Toll-like receptor 4 regulates lipopolysaccharide-induced inflammation and lactation insufficiency in a mouse model of mastitis. Biology of Reproduction. 90: 91. PMID 24671877 DOI: 10.1095/biolreprod.114.117663  0.361
2014 Watkins LR, Hutchinson MR. A concern on comparing 'apples' and 'oranges' when differences between microglia used in human and rodent studies go far, far beyond simply species: comment on Smith and Dragunow. Trends in Neurosciences. 37: 189-90. PMID 24612510 DOI: 10.1016/j.tins.2014.02.004  0.628
2014 Nicotra L, Tuke J, Grace PM, Rolan PE, Hutchinson MR. Sex differences in mechanical allodynia: how can it be preclinically quantified and analyzed? Frontiers in Behavioral Neuroscience. 8: 40. PMID 24592221 DOI: 10.3389/Fnbeh.2014.00040  0.801
2014 Grace PM, Hutchinson MR, Maier SF, Watkins LR. Pathological pain and the neuroimmune interface. Nature Reviews. Immunology. 14: 217-31. PMID 24577438 DOI: 10.1038/Nri3621  0.831
2014 Sumracki NM, Buisman-Pijlman FT, Hutchinson MR, Gentgall M, Rolan P. Reduced response to the thermal grill illusion in chronic pain patients. Pain Medicine (Malden, Mass.). 15: 647-60. PMID 24517126 DOI: 10.1111/Pme.12379  0.658
2014 Narayan DS, Casson RJ, Ebneter A, Chidlow G, Grace PM, Hutchinson MR, Wood JP. Immune priming and experimental glaucoma: the effect of prior systemic lipopolysaccharide challenge on tissue outcomes after optic nerve injury. Clinical & Experimental Ophthalmology. 42: 539-54. PMID 24373007 DOI: 10.1111/Ceo.12289  0.742
2014 Mulholland CV, Somogyi AA, Barratt DT, Coller JK, Hutchinson MR, Jacobson GM, Cursons RT, Sleigh JW. Association of innate immune single-nucleotide polymorphisms with the electroencephalogram during desflurane general anaesthesia. Journal of Molecular Neuroscience : Mn. 52: 497-506. PMID 24352713 DOI: 10.1007/s12031-013-0201-7  0.673
2014 Hutchinson MR, Watkins LR. Why is neuroimmunopharmacology crucial for the future of addiction research? Neuropharmacology. 76: 218-27. PMID 23764149 DOI: 10.1016/j.neuropharm.2013.05.039  0.716
2013 Kwok YH, Tuke J, Nicotra LL, Grace PM, Rolan PE, Hutchinson MR. TLR 2 and 4 responsiveness from isolated peripheral blood mononuclear cells from rats and humans as potential chronic pain biomarkers. Plos One. 8: e77799. PMID 24204973 DOI: 10.1371/Journal.Pone.0077799  0.828
2013 Della Vedova C, Cathcart S, Dohnalek A, Lee V, Hutchinson MR, Immink MA, Hayball J. Peripheral interleukin-1ß levels are elevated in chronic tension-type headache patients. Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Sociã©Tã© Canadienne Pour Le Traitement De La Douleur. 18: 301-6. PMID 23957020 DOI: 10.1155/2013/796161  0.335
2013 Li Y, Coller JK, Hutchinson MR, Klein K, Zanger UM, Stanley NJ, Abell AD, Somogyi AA. The CYP2B6*6 allele significantly alters the N-demethylation of ketamine enantiomers in vitro. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 41: 1264-72. PMID 23550066 DOI: 10.1124/Dmd.113.051631  0.641
2013 Hutchinson MR, Buijs M, Tuke J, Kwok YH, Gentgall M, Williams D, Rolan P. Low-dose endotoxin potentiates capsaicin-induced pain in man: evidence for a pain neuroimmune connection. Brain, Behavior, and Immunity. 30: 3-11. PMID 23499731 DOI: 10.1016/J.Bbi.2013.03.002  0.704
2013 Theberge FR, Li X, Kambhampati S, Pickens CL, St Laurent R, Bossert JM, Baumann MH, Hutchinson MR, Rice KC, Watkins LR, Shaham Y. Effect of chronic delivery of the Toll-like receptor 4 antagonist (+)-naltrexone on incubation of heroin craving. Biological Psychiatry. 73: 729-37. PMID 23384483 DOI: 10.1016/J.Biopsych.2012.12.019  0.722
2013 Lewis SS, Hutchinson MR, Zhang Y, Hund DK, Maier SF, Rice KC, Watkins LR. Glucuronic acid and the ethanol metabolite ethyl-glucuronide cause toll-like receptor 4 activation and enhanced pain. Brain, Behavior, and Immunity. 30: 24-32. PMID 23348028 DOI: 10.1016/J.Bbi.2013.01.005  0.841
2013 Johnson JL, Hutchinson MR, Williams DB, Rolan P. Medication-overuse headache and opioid-induced hyperalgesia: A review of mechanisms, a neuroimmune hypothesis and a novel approach to treatment. Cephalalgia : An International Journal of Headache. 33: 52-64. PMID 23144180 DOI: 10.1177/0333102412467512  0.714
2013 Hutchinson M, Buijs M, Nillsen A, Williams D, Gentgall M, Tuke S, Rolan P. 144. First demonstration of the neuroimmune link in humans using IV endotoxin and intradermal capsaicin in the face and arm Brain, Behavior, and Immunity. 32: e42. DOI: 10.1186/1129-2377-14-S1-P221  0.656
2012 Thomas J, Hutchinson MR. Exploring neuroinflammation as a potential avenue to improve the clinical efficacy of opioids. Expert Review of Neurotherapeutics. 12: 1311-24. PMID 23234393 DOI: 10.1586/Ern.12.125  0.711
2012 Jalleh R, Koh K, Choi B, Liu E, Maddison J, Hutchinson MR. Role of microglia and toll-like receptor 4 in the pathophysiology of delirium. Medical Hypotheses. 79: 735-9. PMID 22975447 DOI: 10.1016/j.mehy.2012.08.013  0.319
2012 Kwok YH, Hutchinson MR, Gentgall MG, Rolan PE. Increased responsiveness of peripheral blood mononuclear cells to in vitro TLR 2, 4 and 7 ligand stimulation in chronic pain patients. Plos One. 7: e44232. PMID 22937165 DOI: 10.1371/Journal.Pone.0044232  0.739
2012 Hutchinson MR, Northcutt AL, Hiranita T, Wang X, Lewis SS, Thomas J, van Steeg K, Kopajtic TA, Loram LC, Sfregola C, Galer E, Miles NE, Bland ST, Amat J, Rozeske RR, et al. Opioid activation of toll-like receptor 4 contributes to drug reinforcement. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 11187-200. PMID 22895704 DOI: 10.1523/Jneurosci.0684-12.2012  0.825
2012 Grace PM, Hurley D, Barratt DT, Tsykin A, Watkins LR, Rolan PE, Hutchinson MR. Harnessing pain heterogeneity and RNA transcriptome to identify blood-based pain biomarkers: a novel correlational study design and bioinformatics approach in a graded chronic constriction injury model. Journal of Neurochemistry. 122: 976-94. PMID 22697386 DOI: 10.1111/J.1471-4159.2012.07833.X  0.814
2012 Sumracki NM, Hutchinson MR, Gentgall M, Briggs N, Williams DB, Rolan P. The effects of pregabalin and the glial attenuator minocycline on the response to intradermal capsaicin in patients with unilateral sciatica. Plos One. 7: e38525. PMID 22685578 DOI: 10.1371/Journal.Pone.0038525  0.683
2012 Lewis SS, Loram LC, Hutchinson MR, Li CM, Zhang Y, Maier SF, Huang Y, Rice KC, Watkins LR. (+)-naloxone, an opioid-inactive toll-like receptor 4 signaling inhibitor, reverses multiple models of chronic neuropathic pain in rats. The Journal of Pain : Official Journal of the American Pain Society. 13: 498-506. PMID 22520687 DOI: 10.1016/J.Jpain.2012.02.005  0.858
2012 Wang X, Loram LC, Ramos K, de Jesus AJ, Thomas J, Cheng K, Reddy A, Somogyi AA, Hutchinson MR, Watkins LR, Yin H. Morphine activates neuroinflammation in a manner parallel to endotoxin. Proceedings of the National Academy of Sciences of the United States of America. 109: 6325-30. PMID 22474354 DOI: 10.1073/Pnas.1200130109  0.834
2012 Corrigan F, Hutchinson M. Are the effects of alcohol on the CNS influenced by Toll-like receptor signaling? Expert Review of Clinical Immunology. 8: 201-203. PMID 22390481 DOI: 10.1586/Eci.11.99  0.319
2012 Coller JK, Hutchinson MR. Implications of central immune signaling caused by drugs of abuse: mechanisms, mediators and new therapeutic approaches for prediction and treatment of drug dependence. Pharmacology & Therapeutics. 134: 219-45. PMID 22316499 DOI: 10.1016/j.pharmthera.2012.01.008  0.381
2012 Watkins LR, Hutchinson MR, Johnson KW. Commentary on Landry et al.: "Propentofylline, a CNS glial modulator, does not decrease pain in post-herpetic neuralgia patients: in vitro evidence for differential responses in human and rodent microglia and macrophages". Experimental Neurology. 234: 351-3. PMID 22269389 DOI: 10.1016/j.expneurol.2012.01.006  0.685
2012 Nicotra L, Loram LC, Watkins LR, Hutchinson MR. Toll-like receptors in chronic pain. Experimental Neurology. 234: 316-29. PMID 22001158 DOI: 10.1016/J.Expneurol.2011.09.038  0.838
2012 Wu Y, Lousberg EL, Moldenhauer LM, Hayball JD, Coller JK, Rice KC, Watkins LR, Somogyi AA, Hutchinson MR. Inhibiting the TLR4-MyD88 signalling cascade by genetic or pharmacological strategies reduces acute alcohol-induced sedation and motor impairment in mice. British Journal of Pharmacology. 165: 1319-29. PMID 21955045 DOI: 10.1111/J.1476-5381.2011.01572.X  0.798
2012 Coller J, Hutchinson M, Tuke J, White J, Somogyi A. 65. Association between immune genetic markers and opioid dependence Brain Behavior and Immunity. 26. DOI: 10.1016/J.Bbi.2012.07.089  0.728
2011 Schwarz JM, Hutchinson MR, Bilbo SD. Early-life experience decreases drug-induced reinstatement of morphine CPP in adulthood via microglial-specific epigenetic programming of anti-inflammatory IL-10 expression. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 17835-47. PMID 22159099 DOI: 10.1523/Jneurosci.3297-11.2011  0.657
2011 Hutchinson MR, Shavit Y, Grace PM, Rice KC, Maier SF, Watkins LR. Exploring the neuroimmunopharmacology of opioids: an integrative review of mechanisms of central immune signaling and their implications for opioid analgesia. Pharmacological Reviews. 63: 772-810. PMID 21752874 DOI: 10.1124/Pr.110.004135  0.85
2011 Liu L, Ghosh N, Slivka PF, Fiorini Z, Hutchinson MR, Watkins LR, Yin H. An MD2 hot-spot-mimicking peptide that suppresses TLR4-mediated inflammatory response in vitro and in vivo. Chembiochem : a European Journal of Chemical Biology. 12: 1827-31. PMID 21678541 DOI: 10.1002/Cbic.201100211  0.681
2011 Grace PM, Rolan PE, Hutchinson MR. Peripheral immune contributions to the maintenance of central glial activation underlying neuropathic pain. Brain, Behavior, and Immunity. 25: 1322-32. PMID 21496480 DOI: 10.1016/J.Bbi.2011.04.003  0.828
2011 Liu L, Coller JK, Watkins LR, Somogyi AA, Hutchinson MR. Naloxone-precipitated morphine withdrawal behavior and brain IL-1β expression: comparison of different mouse strains. Brain, Behavior, and Immunity. 25: 1223-32. PMID 21447380 DOI: 10.1016/j.bbi.2011.03.016  0.818
2011 Wu Y, Lousberg EL, Moldenhauer LM, Hayball JD, Robertson SA, Coller JK, Watkins LR, Somogyi AA, Hutchinson MR. Attenuation of microglial and IL-1 signaling protects mice from acute alcohol-induced sedation and/or motor impairment. Brain, Behavior, and Immunity. 25: S155-64. PMID 21276848 DOI: 10.1016/j.bbi.2011.01.012  0.776
2011 Grace PM, Hutchinson MR, Bishop A, Somogyi AA, Mayrhofer G, Rolan PE. Adoptive transfer of peripheral immune cells potentiates allodynia in a graded chronic constriction injury model of neuropathic pain. Brain, Behavior, and Immunity. 25: 503-13. PMID 21134441 DOI: 10.1016/J.Bbi.2010.11.018  0.822
2011 Sumracki NM, Nicotra L, Kwok YH, Liu L, Van Steeg K, R.Watkins L, Hutchinson MR. The future: New concepts and potential therapies Neuropathic Pain: Causes, Management, and Understanding. 341-356. DOI: 10.1017/CBO9781139152211.030  0.748
2011 Watkins L, Northcutt A, Loram L, Lewis S, Hutchinson M, Rice K, Maier S. 210. Rethinking CNS innate immune responses: Sex, pain and drugs of abuse Brain, Behavior, and Immunity. 25: S239. DOI: 10.1016/J.Bbi.2011.07.213  0.813
2011 Hutchinson M, Wu Y, Jaehne E, Liu L, Diener K, Hayball J, Rice K, Watkins L, Somogyi A. 97. Contributions of innate immune signaling to opioid & alcohol responses Brain, Behavior, and Immunity. 25: S206-S207. DOI: 10.1016/J.Bbi.2011.07.100  0.814
2011 Schwarz J, Hutchinson M, Bilbo S. 88. Early-life experience decreases potential abuse liability of morphine via microglial-specific epigenetic programming of anti-inflammatory IL-10 expression Brain, Behavior, and Immunity. 25: S204. DOI: 10.1016/J.Bbi.2011.07.091  0.6
2011 Coller J, Hutchinson M, Daly A, White J, Somogyi A. 81. Association between immune genetic markers and alcohol dependence Brain, Behavior, and Immunity. 25: S202. DOI: 10.1016/j.bbi.2011.07.084  0.665
2011 Grace P, Rolan P, Hutchinson M. Harnessing pain heterogeneity and RNA transcriptome to explore chronic pain mechanisms Brain, Behavior, and Immunity. 25: S193-S194. DOI: 10.1016/J.Bbi.2011.07.055  0.811
2011 Northcutt A, Stregola C, Bland S, Amat J, Hutchinson M, Miles N, Rosezke R, Loeffler M, Maier S, Rice K, Watkins L. Novel toll like receptor 4 (TLR4) involvement in drug reward Brain Behavior and Immunity. 25. DOI: 10.1016/J.Bbi.2011.07.040  0.795
2011 Liu L, Ghosh N, Slivka PF, Fiorini Z, Hutchinson MR, Watkins LR, Yin H. Inside Cover: An MD2 Hot-Spot-Mimicking Peptide that Suppresses TLR4-Mediated Inflammatory Response in vitro and in vivo (ChemBioChem 12/2011) Chembiochem. 12: 1786-1786. DOI: 10.1002/Cbic.201190054  0.656
2010 Grace PM, Hutchinson MR, Manavis J, Somogyi AA, Rolan PE. A novel animal model of graded neuropathic pain: utility to investigate mechanisms of population heterogeneity. Journal of Neuroscience Methods. 193: 47-53. PMID 20817038 DOI: 10.1016/J.Jneumeth.2010.08.025  0.816
2010 Joce C, Stahl JA, Shridhar M, Hutchinson MR, Watkins LR, Fedichev PO, Yin H. Application of a novel in silico high-throughput screen to identify selective inhibitors for protein-protein interactions. Bioorganic & Medicinal Chemistry Letters. 20: 5411-3. PMID 20709548 DOI: 10.1016/J.Bmcl.2010.07.103  0.618
2010 Stanley NJ, Hutchinson MR, Kvist T, Nielsen B, Mathiesen JM, Bräuner-Osborne H, Avery TD, Tiekink ER, Pedersen DS, Irvine RJ, Abell AD, Taylor DK. A new metabotropic glutamate receptor agonist with in vivo anti-allodynic activity. Bioorganic & Medicinal Chemistry. 18: 6089-98. PMID 20638290 DOI: 10.1016/J.Bmc.2010.06.051  0.393
2010 Buchanan MM, Hutchinson M, Watkins LR, Yin H. Toll-like receptor 4 in CNS pathologies. Journal of Neurochemistry. 114: 13-27. PMID 20402965 DOI: 10.1111/J.1471-4159.2010.06736.X  0.695
2010 Hutchinson MR, Loram LC, Zhang Y, Shridhar M, Rezvani N, Berkelhammer D, Phipps S, Foster PS, Landgraf K, Falke JJ, Rice KC, Maier SF, Yin H, Watkins LR. Evidence that tricyclic small molecules may possess toll-like receptor and myeloid differentiation protein 2 activity. Neuroscience. 168: 551-63. PMID 20381591 DOI: 10.1016/J.Neuroscience.2010.03.067  0.784
2010 Hutchinson MR, Lewis SS, Coats BD, Rezvani N, Zhang Y, Wieseler JL, Somogyi AA, Yin H, Maier SF, Rice KC, Watkins LR. Possible involvement of toll-like receptor 4/myeloid differentiation factor-2 activity of opioid inactive isomers causes spinal proinflammation and related behavioral consequences. Neuroscience. 167: 880-93. PMID 20178837 DOI: 10.1016/J.Neuroscience.2010.02.011  0.843
2010 Lewis SS, Hutchinson MR, Rezvani N, Loram LC, Zhang Y, Maier SF, Rice KC, Watkins LR. Evidence that intrathecal morphine-3-glucuronide may cause pain enhancement via toll-like receptor 4/MD-2 and interleukin-1beta. Neuroscience. 165: 569-83. PMID 19833175 DOI: 10.1016/J.Neuroscience.2009.10.011  0.852
2010 Hutchinson MR, Zhang Y, Shridhar M, Evans JH, Buchanan MM, Zhao TX, Slivka PF, Coats BD, Rezvani N, Wieseler J, Hughes TS, Landgraf KE, Chan S, Fong S, Phipps S, et al. Evidence that opioids may have toll-like receptor 4 and MD-2 effects. Brain, Behavior, and Immunity. 24: 83-95. PMID 19679181 DOI: 10.1016/J.Bbi.2009.08.004  0.779
2010 Somogyi A, Hutchinson M, Liu L, Coller J. 107 PROINFLAMMATORY CYTOKINE GENETICS IN THE DEVELOPMENT OF PERIPHERAL NEUROPATHY AND POTENTIAL TREATMENT STRATEGIES European Journal of Pain Supplements. 4: 32-32. DOI: 10.1016/S1754-3207(10)70112-7  0.66
2010 Coller J, Wu Y, White J, Hutchinson M, Somogyi A. TLR4 haplotypes in alcohol and opioid dependent populations Brain, Behavior, and Immunity. 24: S25. DOI: 10.1016/j.bbi.2010.07.082  0.711
2010 Hutchinson M, Wu Y, Liu L, Phipps S, Rice K, Coller J, Watkins L, Somogyi A. Opioid and alcohol action: The role of brain and spinal cord innate immune signalling Brain, Behavior, and Immunity. 24: S19. DOI: 10.1016/J.Bbi.2010.07.060  0.809
2009 Rolan P, Hutchinson MR, Johnson KW. Ibudilast: A review of its pharmacology, efficacy and safety in respiratory and neurological disease Expert Opinion On Pharmacotherapy. 10: 2897-2904. PMID 19929708 DOI: 10.1517/14656560903426189  0.639
2009 Loram LC, Harrison JA, Sloane EM, Hutchinson MR, Sholar P, Taylor FR, Berkelhammer D, Coats BD, Poole S, Milligan ED, Maier SF, Rieger J, Watkins LR. Enduring reversal of neuropathic pain by a single intrathecal injection of adenosine 2A receptor agonists: a novel therapy for neuropathic pain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 14015-25. PMID 19890011 DOI: 10.1523/Jneurosci.3447-09.2009  0.82
2009 Liu L, Hutchinson MR, White JM, Somogyi AA, Coller JK. Association of IL-1B genetic polymorphisms with an increased risk of opioid and alcohol dependence. Pharmacogenetics and Genomics. 19: 869-76. PMID 19801958 DOI: 10.1097/FPC.0b013e328331e68f  0.682
2009 Hutchinson MR, Ramos KM, Loram LC, Wieseler J, Sholar PW, Kearney JJ, Lewis MT, Crysdale NY, Zhang Y, Harrison JA, Maier SF, Rice KC, Watkins LR. Evidence for a role of heat shock protein-90 in toll like receptor 4 mediated pain enhancement in rats. Neuroscience. 164: 1821-32. PMID 19788917 DOI: 10.1016/J.Neuroscience.2009.09.046  0.796
2009 Watkins LR, Hutchinson MR, Rice KC, Maier SF. The "toll" of opioid-induced glial activation: improving the clinical efficacy of opioids by targeting glia. Trends in Pharmacological Sciences. 30: 581-91. PMID 19762094 DOI: 10.1016/J.Tips.2009.08.002  0.808
2009 Rodgers KM, Hutchinson MR, Northcutt A, Maier SF, Watkins LR, Barth DS. The cortical innate immune response increases local neuronal excitability leading to seizures. Brain : a Journal of Neurology. 132: 2478-86. PMID 19567702 DOI: 10.1093/Brain/Awp177  0.788
2009 Bland ST, Hutchinson MR, Maier SF, Watkins LR, Johnson KW. The glial activation inhibitor AV411 reduces morphine-induced nucleus accumbens dopamine release. Brain, Behavior, and Immunity. 23: 492-7. PMID 19486648 DOI: 10.1016/J.Bbi.2009.01.014  0.691
2009 Slivka PF, Shridhar M, Lee GI, Sammond DW, Hutchinson MR, Martinko AJ, Buchanan MM, Sholar PW, Kearney JJ, Harrison JA, Watkins LR, Yin H. A peptide antagonist of the TLR4-MD2 interaction. Chembiochem : a European Journal of Chemical Biology. 10: 645-9. PMID 19184989 DOI: 10.1002/Cbic.200800769  0.727
2009 Hutchinson MR, Lewis SS, Coats BD, Skyba DA, Crysdale NY, Berkelhammer DL, Brzeski A, Northcutt A, Vietz CM, Judd CM, Maier SF, Watkins LR, Johnson KW. Reduction of opioid withdrawal and potentiation of acute opioid analgesia by systemic AV411 (ibudilast). Brain, Behavior, and Immunity. 23: 240-50. PMID 18938237 DOI: 10.1016/J.Bbi.2008.09.012  0.816
2009 Loram L, Sholar P, Taylor F, Harrison J, Hutchinson M, Maier S, Rieger J, Watkins L, Sloane E. Adenosine 2A receptor agonist produces long-duration reversal of neuropathic pain via sustained release of spinal interleukin-10 The Journal of Pain. 10: S39. DOI: 10.1016/J.Jpain.2009.01.165  0.816
2009 Loram L, Sloane E, Harrison J, Sholar P, Taylor F, Hutchinson M, Maier S, Rieger J, Watkins L. 80. Long-duration reversal of neuropathic pain via sustained release of spinal interleukin-10 is mediated by adenosine 2A receptor activation Brain, Behavior, and Immunity. 23: S47. DOI: 10.1016/J.Bbi.2009.06.085  0.814
2008 Hutchinson MR, Northcutt AL, Chao LW, Kearney JJ, Zhang Y, Berkelhammer DL, Loram LC, Rozeske RR, Bland ST, Maier SF, Gleeson TT, Watkins LR. Minocycline suppresses morphine-induced respiratory depression, suppresses morphine-induced reward, and enhances systemic morphine-induced analgesia. Brain, Behavior, and Immunity. 22: 1248-56. PMID 18706994 DOI: 10.1016/J.Bbi.2008.07.008  0.818
2008 Hutchinson MR, Zhang Y, Brown K, Coats BD, Shridhar M, Sholar PW, Patel SJ, Crysdale NY, Harrison JA, Maier SF, Rice KC, Watkins LR. Non-stereoselective reversal of neuropathic pain by naloxone and naltrexone: involvement of toll-like receptor 4 (TLR4). The European Journal of Neuroscience. 28: 20-9. PMID 18662331 DOI: 10.1111/J.1460-9568.2008.06321.X  0.811
2008 Hutchinson MR, Coats BD, Lewis SS, Zhang Y, Sprunger DB, Rezvani N, Baker EM, Jekich BM, Wieseler JL, Somogyi AA, Martin D, Poole S, Judd CM, Maier SF, Watkins LR. Proinflammatory cytokines oppose opioid-induced acute and chronic analgesia. Brain, Behavior, and Immunity. 22: 1178-89. PMID 18599265 DOI: 10.1016/J.Bbi.2008.05.004  0.849
2008 Tomás R, Hutchinson M. Wrist Pain In A Baseball Player Medicine & Science in Sports & Exercise. 40: S157. DOI: 10.1249/01.mss.0000322148.32950.25  0.3
2007 Hutchinson MR, Bland ST, Johnson KW, Rice KC, Maier SF, Watkins LR. Opioid-induced glial activation: mechanisms of activation and implications for opioid analgesia, dependence, and reward. Thescientificworldjournal. 7: 98-111. PMID 17982582 DOI: 10.1100/Tsw.2007.230  0.799
2007 Watkins LR, Hutchinson MR, Milligan ED, Maier SF. "Listening" and "talking" to neurons: implications of immune activation for pain control and increasing the efficacy of opioids. Brain Research Reviews. 56: 148-69. PMID 17706291 DOI: 10.1016/J.Brainresrev.2007.06.006  0.822
2007 Ledeboer A, Hutchinson MR, Watkins LR, Johnson KW. Ibudilast (AV-411). A new class therapeutic candidate for neuropathic pain and opioid withdrawal syndromes. Expert Opinion On Investigational Drugs. 16: 935-50. PMID 17594181 DOI: 10.1517/13543784.16.7.935  0.764
2007 Der-Avakian A, Bland ST, Rozeske RR, Tamblyn JP, Hutchinson MR, Watkins LR, Maier SF. The effects of a single exposure to uncontrollable stress on the subsequent conditioned place preference responses to oxycodone, cocaine, and ethanol in rats. Psychopharmacology. 191: 909-17. PMID 17211647 DOI: 10.1007/S00213-006-0678-7  0.67
2007 Watkins LR, Hutchinson MR, Ledeboer A, Wieseler-Frank J, Milligan ED, Maier SF. Norman Cousins Lecture. Glia as the "bad guys": implications for improving clinical pain control and the clinical utility of opioids. Brain, Behavior, and Immunity. 21: 131-46. PMID 17175134 DOI: 10.1016/J.Bbi.2006.10.011  0.832
2007 Watkins LR, Wieseler-Frank J, Hutchinson MR, Ledeboer A, Spataro L, Milligan ED, Sloane EM, Maier SF. Neuroimmune interactions and pain: The role of immune and glial cells Psychoneuroimmunology, Two-Volume Set. 1: 393-414. DOI: 10.1016/B978-012088576-3/50023-X  0.81
2005 Watkins LR, Hutchinson MR, Johnston IN, Maier SF. Glia: novel counter-regulators of opioid analgesia. Trends in Neurosciences. 28: 661-9. PMID 16246435 DOI: 10.1016/j.tins.2005.10.001  0.769
2005 Hutchinson MR, Somogyi AA. Characterisation of the in vitro modulation of splenocyte proliferation by non-4,5-epoxymorphinan opioids. International Immunopharmacology. 5: 1713-22. PMID 16102521 DOI: 10.1016/j.intimp.2005.05.006  0.739
2004 Hutchinson MR, Somogyi AA. (S)-(+)-methadone is more immunosuppressive than the potent analgesic (R)-(--)-methadone. International Immunopharmacology. 4: 1525-30. PMID 15351321 DOI: 10.1016/j.intimp.2004.07.011  0.737
2004 Hutchinson MR, La Vincente SF, Somogyi AA. In vitro opioid induced proliferation of peripheral blood immune cells correlates with in vivo cold pressor pain tolerance in humans: a biological marker of pain tolerance. Pain. 110: 751-5. PMID 15288416 DOI: 10.1016/j.pain.2004.05.017  0.783
2004 Hutchinson MR, Somogyi AA. Relationship between 4,5-epoxymorphinan structure and in vitro modulation of cell proliferation. European Journal of Pharmacology. 494: 251-62. PMID 15212982 DOI: 10.1016/j.ejphar.2004.04.049  0.737
2004 Hutchinson MR, Menelaou A, Foster DJ, Coller JK, Somogyi AA. CYP2D6 and CYP3A4 involvement in the primary oxidative metabolism of hydrocodone by human liver microsomes. British Journal of Clinical Pharmacology. 57: 287-97. PMID 14998425 DOI: 10.1046/j.1365-2125.2003.02002.x  0.639
2003 Menelaou A, Hutchinson MR, Quinn I, Christensen A, Somogyi AA. Quantification of the O- and N-demethylated metabolites of hydrocodone and oxycodone in human liver microsomes using liquid chromatography with ultraviolet absorbance detection. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 785: 81-8. PMID 12535841 DOI: 10.1016/S1570-0232(02)00856-5  0.622
2002 Hutchinson MR, Somogyi AA. Diacetylmorphine degradation to 6-monoacetylmorphine and morphine in cell culture: implications for in vitro studies. European Journal of Pharmacology. 453: 27-32. PMID 12393056 DOI: 10.1016/S0014-2999(02)02365-8  0.677
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