Lutz Hein - Publications

1996-2004 Pharmacology University of Freiburg, Germany, Freiburg im Breisgau, Baden-Württemberg, Germany 

114 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Lindau A, Härdtner C, Hergeth SP, Blanz KD, Dufner B, Hoppe N, Anto-Michel N, Kornemann J, Zou J, Gerhardt LM, Heidt T, Willecke F, Geis S, Stachon P, Wolf D, ... ... Hein L, et al. Atheroprotection through SYK inhibition fails in established disease when local macrophage proliferation dominates lesion progression. Basic Research in Cardiology. 111: 20. PMID 26891724 DOI: 10.1007/s00395-016-0535-8  0.84
2016 Schmid E, Neef S, Berlin C, Tomasovic A, Kahlert K, Nordbeck P, Deiss K, Denzinger S, Herrmann S, Wettwer E, Weidendorfer M, Becker D, Schäfer F, Wagner N, Ergün S, ... ... Hein L, et al. Erratum: Cardiac RKIP induces a beneficial β-adrenoceptor-dependent positive inotropy. Nature Medicine. 22: 217. PMID 26845407 DOI: 10.1038/nm0216-217c  0.84
2015 Lother A, Fürst D, Bergemann S, Gilsbach R, Grahammer F, Huber TB, Hilgendorf I, Bode C, Moser M, Hein L. Deoxycorticosterone Acetate/Salt-Induced Cardiac But Not Renal Injury Is Mediated By Endothelial Mineralocorticoid Receptors Independently From Blood Pressure. Hypertension. PMID 26553231 DOI: 10.1161/HYPERTENSIONAHA.115.06530  0.84
2015 Koentges C, Pfeil K, Meyer-Steenbuck M, Lother A, Hoffmann MM, Odening KE, Hein L, Bode C, Bugger H. Preserved recovery of cardiac function following ischemia-reperfusion in mice lacking SIRT3. Canadian Journal of Physiology and Pharmacology. 1-9. PMID 26524632 DOI: 10.1139/cjpp-2015-0152  0.84
2015 Schmid E, Neef S, Berlin C, Tomasovic A, Kahlert K, Nordbeck P, Deiss K, Denzinger S, Herrmann S, Wettwer E, Weidendorfer M, Becker D, Schäfer F, Wagner N, Ergün S, ... ... Hein L, et al. Cardiac RKIP induces a beneficial β-adrenoceptor-dependent positive inotropy. Nature Medicine. PMID 26479924 DOI: 10.1038/nm.3972  0.84
2015 Mayer S, Gilsbach R, Preissl S, Monroy Ordonez EB, Schnick T, Beetz N, Lother A, Rommel C, Ihle HM, Bugger H, Rühle F, Schrepper A, Schwarzer M, Heilmann C, Bönisch U, ... ... Hein L, et al. Adrenergic Repression of the Epigenetic Reader MeCP2 Facilitates Cardiac Adaptation in Chronic Heart Failure. Circulation Research. PMID 26195221 DOI: 10.1161/CIRCRESAHA.115.306721  0.84
2015 Anlauf M, Hein L, Hense HW, Köbberling J, Lasek R, Leidl R, Schöne-Seifert B. Complementary and alternative drug therapy versus science-oriented medicine. German Medical Science : Gms E-Journal. 13: Doc05. PMID 26161049 DOI: 10.3205/000209  0.84
2015 Preissl S, Schwaderer M, Raulf A, Hesse M, Grüning BA, Köbele C, Backofen R, Fleischmann BK, Hein L, Gilsbach R. Deciphering the Epigenetic Code of Cardiac Myocyte Transcription. Circulation Research. 117: 413-23. PMID 26105955 DOI: 10.1161/CIRCRESAHA.115.306337  0.84
2015 Nührenberg TG, Hammann N, Schnick T, Preißl S, Witten A, Stoll M, Gilsbach R, Neumann FJ, Hein L. Cardiac Myocyte De Novo DNA Methyltransferases 3a/3b Are Dispensable for Cardiac Function and Remodeling after Chronic Pressure Overload in Mice. Plos One. 10: e0131019. PMID 26098432 DOI: 10.1371/journal.pone.0131019  0.84
2015 Vähätalo LH, Ruohonen ST, Mäkelä S, Kovalainen M, Huotari A, Mäkelä KA, Määttä JA, Miinalainen I, Gilsbach R, Hein L, Ailanen L, Mattila M, Eerola K, Röyttä M, Ruohonen S, et al. Neuropeptide Y in the noradrenergic neurones induces obesity and inhibits sympathetic tone in mice. Acta Physiologica (Oxford, England). 213: 902-19. PMID 25482272 DOI: 10.1111/apha.12436  0.84
2015 Lother A, Moser M, Bode C, Feldman RD, Hein L. Mineralocorticoids in the heart and vasculature: new insights for old hormones. Annual Review of Pharmacology and Toxicology. 55: 289-312. PMID 25251996 DOI: 10.1146/annurev-pharmtox-010814-124302  0.84
2015 Weise M, Vettel C, Spiger K, Gilsbach R, Hein L, Lorenz K, Wieland T, Aktories K, Orth JHC. A systemic Pasteurella multocida toxin aggravates cardiac hypertrophy and fibrosis in mice Cellular Microbiology. 17: 1320-1331. DOI: 10.1111/cmi.12436  0.84
2015 Koentges C, König A, Pfeil K, Hölscher ME, Schnick T, Wende AR, Schrepper A, Cimolai MC, Kersting S, Hoffmann MM, Asal J, Osterholt M, Odening KE, Doenst T, Hein L, et al. Myocardial mitochondrial dysfunction in mice lacking adiponectin receptor 1 Basic Research in Cardiology. 110. DOI: 10.1007/s00395-015-0495-4  0.84
2015 Koentges C, Pfeil K, Schnick T, Wiese S, Dahlbock R, Cimolai MC, Meyer-Steenbuck M, Cenkerova K, Hoffmann MM, Jaeger C, Odening KE, Kammerer B, Hein L, Bode C, Bugger H. SIRT3 deficiency impairs mitochondrial and contractile function in the heart Basic Research in Cardiology. 110: 1-20. DOI: 10.1007/s00395-015-0493-6  0.84
2014 Strack J, Heni H, Gilsbach R, Hein L, Aktories K, Orth JHC. Noncanonical G-protein-dependent modulation of osteoclast differentiation and bone resorption mediated by pasteurella multocida toxin Mbio. 5. PMID 25389180 DOI: 10.1128/mBio.02190-14  0.84
2014 Gilsbach R, Preissl S, Grüning BA, Schnick T, Burger L, Benes V, Würch A, Bönisch U, Günther S, Backofen R, Fleischmann BK, Schübeler D, Hein L. Dynamic DNA methylation orchestrates cardiomyocyte development, maturation and disease. Nature Communications. 5: 5288. PMID 25335909 DOI: 10.1038/ncomms6288  0.84
2014 Nührenberg T, Gilsbach R, Preissl S, Schnick T, Hein L. Epigenetics in cardiac development, function, and disease. Cell and Tissue Research. 356: 585-600. PMID 24817102 DOI: 10.1007/s00441-014-1887-8  0.84
2014 Hurt CM, Björk S, Ho VK, Gilsbach R, Hein L, Angelotti T. REEP1 and REEP2 proteins are preferentially expressed in neuronal and neuronal-like exocytotic tissues. Brain Research. 1545: 12-22. PMID 24355597 DOI: 10.1016/j.brainres.2013.12.008  0.84
2013 Bohren Y, Tessier LH, Megat S, Petitjean H, Hugel S, Daniel D, Kremer M, Fournel S, Hein L, Schlichter R, Freund-Mercier MJ, Yalcin I, Barrot M. Antidepressants suppress neuropathic pain by a peripheral β2-adrenoceptor mediated anti-TNFα mechanism. Neurobiology of Disease. 60: 39-50. PMID 23978467 DOI: 10.1016/j.nbd.2013.08.012  0.84
2013 Volkmann I, Kumarswamy R, Pfaff N, Fiedler J, Dangwal S, Holzmann A, Batkai S, Geffers R, Lother A, Hein L, Thum T. MicroRNA-mediated epigenetic silencing of sirtuin1 contributes to impaired angiogenic responses. Circulation Research. 113: 997-1003. PMID 23960241 DOI: 10.1161/CIRCRESAHA.113.301702  0.84
2013 Guenther F, Herr N, Mauler M, Witsch T, Roming F, Hein L, Boeynaems JM, Robaye B, Idzko M, Bode C, Von Zur Muhlen C, Duerschmied D. Contrast ultrasound for the quantification of deep vein thrombosis in living mice: effects of enoxaparin and P2Y12 receptor inhibition. Journal of Thrombosis and Haemostasis : Jth. 11: 1154-62. PMID 23551896 DOI: 10.1111/jth.12206  0.84
2013 Zádori ZS, Fehér Á, Al-Khrasani M, Lackó E, Tóth VE, Brancati SB, Hein L, Mátyus P, Gyires K. Imidazoline versus alpha₂-adrenoceptors in the control of gastric motility in mice. European Journal of Pharmacology. 705: 61-7. PMID 23499689 DOI: 10.1016/j.ejphar.2013.02.043  0.84
2013 Rössler J, Haubold M, Gilsbach R, Jüttner E, Schmitt D, Niemeyer CM, Hein L. β1-Adrenoceptor mRNA level reveals distinctions between infantile hemangioma and vascular malformations. Pediatric Research. 73: 409-13. PMID 23370410 DOI: 10.1038/pr.2013.16  0.84
2012 Biermann D, Heilmann A, Didié M, Schlossarek S, Wahab A, Grimm M, Römer M, Reichenspurner H, Sultan KR, Steenpass A, Ergün S, Donzelli S, Carrier L, Ehmke H, Zimmermann WH, ... Hein L, et al. Impact of AT2 receptor deficiency on postnatal cardiovascular development. Plos One. 7: e47916. PMID 23144713 DOI: 10.1371/journal.pone.0047916  0.84
2012 Riccio O, Hurni N, Murthy S, Vutskits L, Hein L, Dayer A. Alpha2-adrenergic receptor activation regulates cortical interneuron migration. The European Journal of Neuroscience. 36: 2879-87. PMID 22805283 DOI: 10.1111/j.1460-9568.2012.08231.x  0.84
2012 Ruohonen ST, Ruohonen S, Gilsbach R, Savontaus E, Scheinin M, Hein L. Involvement of α2-adrenoceptor subtypes A and C in glucose homeostasis and adrenaline-induced hyperglycaemia. Neuroendocrinology. 96: 51-9. PMID 22327786 DOI: 10.1159/000334629  0.84
2012 Broese M, Riemann D, Hein L, Nissen C. α-Adrenergic receptor function, arousal and sleep: mechanisms and therapeutic implications. Pharmacopsychiatry. 45: 209-16. PMID 22290201 DOI: 10.1055/s-0031-1299728  0.84
2012 Gilsbach R, Hein L. Are the pharmacology and physiology of α₂ adrenoceptors determined by α₂-heteroreceptors and autoreceptors respectively? British Journal of Pharmacology. 165: 90-102. PMID 21658028 DOI: 10.1111/j.1476-5381.2011.01533.x  0.84
2011 Hein L. [Structure and evolution of adrenergic receptors]. Pharmazie in Unserer Zeit. 40: 470-3. PMID 22028130 DOI: 10.1002/pauz.201100441  0.84
2011 Gilsbach R, Preissl S, Hein L. [α -Adrenoceptors: three subtypes for a broad spectrum of activity]. Pharmazie in Unserer Zeit. 40: 462-8. PMID 22028129 DOI: 10.1002/pauz.201100440  0.84
2011 Hein L, Holzgrabe U. [Editorial: Pharmazie in unserer Zeit 6/2011]. Pharmazie in Unserer Zeit. 40: 447. PMID 22024940 DOI: 10.1002/pauz.201190069  0.84
2011 Zádori ZS, Shujaa N, Brancati SB, Hein L, Gyires K. Both α2B- and α2C-adrenoceptor subtypes are involved in the mediation of centrally induced gastroprotection in mice. European Journal of Pharmacology. 669: 115-20. PMID 21816147 DOI: 10.1016/j.ejphar.2011.07.018  0.84
2011 Brede M, Braeuninger S, Langhauser F, Hein L, Roewer N, Stoll G, Kleinschnitz C. α(2)-adrenoceptors do not mediate neuroprotection in acute ischemic stroke in mice. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 31: e1-7. PMID 21792243 DOI: 10.1038/jcbfm.2011.110  0.84
2011 Gilsbach R, Albarrán-Juárez J, Hein L. Pre- versus postsynaptic signaling by α(2)-adrenoceptors. Current Topics in Membranes. 67: 139-60. PMID 21771489 DOI: 10.1016/B978-0-12-384921-2.00007-0  0.84
2011 Schneider J, Lother A, Hein L, Gilsbach R. Chronic cardiac pressure overload induces adrenal medulla hypertrophy and increased catecholamine synthesis. Basic Research in Cardiology. 106: 591-602. PMID 21547520 DOI: 10.1007/s00395-011-0166-z  0.84
2011 Choucair-Jaafar N, Beetz N, Gilsbach R, Yalcin I, Waltisperger E, Freund-Mercier MJ, Monassier L, Hein L, Barrot M. Cardiovascular effects of chronic treatment with a β2-adrenoceptor agonist relieving neuropathic pain in mice. Neuropharmacology. 61: 51-60. PMID 21352833 DOI: 10.1016/j.neuropharm.2011.02.015  0.84
2011 Shujaa N, Al-Khrasani M, Zádori ZS, Rossi M, Mátyus P, Németh J, Hein L, Gyires K. α(2)-adrenoceptor agonist-induced inhibition of gastric motor activity is mediated by α(2A)-adrenoceptor subtype in the mouse. Neurochemistry International. 58: 708-13. PMID 21333706 DOI: 10.1016/j.neuint.2011.02.011  0.84
2011 Lother A, Berger S, Gilsbach R, Rösner S, Ecke A, Barreto F, Bauersachs J, Schütz G, Hein L. Ablation of mineralocorticoid receptors in myocytes but not in fibroblasts preserves cardiac function. Hypertension. 57: 746-54. PMID 21321305 DOI: 10.1161/HYPERTENSIONAHA.110.163287  0.84
2011 Hoch H, Stegbauer J, Potthoff SA, Hein L, Quack I, Rump LC, Vonend O. Regulation of renal sympathetic neurotransmission by renal α(2A)-adrenoceptors is impaired in chronic renal failure. British Journal of Pharmacology. 163: 438-46. PMID 21244368 DOI: 10.1111/j.1476-5381.2011.01223.x  0.84
2011 Fraccarollo D, Berger S, Galuppo P, Kneitz S, Hein L, Schütz G, Frantz S, Ertl G, Bauersachs J. Deletion of cardiomyocyte mineralocorticoid receptor ameliorates adverse remodeling after myocardial infarction. Circulation. 123: 400-8. PMID 21242479 DOI: 10.1161/CIRCULATIONAHA.110.983023  0.84
2011 Broeckel U, Stoll M, Hein L. The identification of phosducin as a novel candidate gene for hypertension and its role in sympathetic activation. Current Opinion in Nephrology and Hypertension. 20: 118-24. PMID 21191291 DOI: 10.1097/MNH.0b013e3283432e05  0.84
2011 Beetz N, Hein L. The physiological roles of phosducin: from retinal function to stress-dependent hypertension. Cellular and Molecular Life Sciences : Cmls. 68: 599-612. PMID 21069424 DOI: 10.1007/s00018-010-0550-0  0.84
2011 Faerber G, Barreto-Perreia F, Schoepe M, Gilsbach R, Schrepper A, Schwarzer M, Mohr FW, Hein L, Doenst T. Induction of heart failure by minimally invasive aortic constriction in mice: reduced peroxisome proliferator-activated receptor γ coactivator levels and mitochondrial dysfunction. The Journal of Thoracic and Cardiovascular Surgery. 141: 492-500, 500.e1. PMID 20447656 DOI: 10.1016/j.jtcvs.2010.03.029  0.84
2010 Leemhuis J, Bouché E, Frotscher M, Henle F, Hein L, Herz J, Meyer DK, Pichler M, Roth G, Schwan C, Bock HH. Reelin signals through apolipoprotein E receptor 2 and Cdc42 to increase growth cone motility and filopodia formation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 14759-72. PMID 21048135 DOI: 10.1523/JNEUROSCI.4036-10.2010  0.84
2010 Haubold M, Gilsbach R, Hein L. {Alpha}2B-adrenoceptor deficiency leads to postnatal respiratory failure in mice. The Journal of Biological Chemistry. 285: 34213-9. PMID 20729197 DOI: 10.1074/jbc.M110.129205  0.84
2010 Clere N, Corre I, Faure S, Guihot AL, Vessières E, Chalopin M, Morel A, Coqueret O, Hein L, Delneste Y, Paris F, Henrion D. Deficiency or blockade of angiotensin II type 2 receptor delays tumorigenesis by inhibiting malignant cell proliferation and angiogenesis. International Journal of Cancer. Journal International Du Cancer. 127: 2279-91. PMID 20143398 DOI: 10.1002/ijc.25234  0.84
2010 Yanpallewar SU, Fernandes K, Marathe SV, Vadodaria KC, Jhaveri D, Rommelfanger K, Ladiwala U, Jha S, Muthig V, Hein L, Bartlett P, Weinshenker D, Vaidya VA. Alpha2-adrenoceptor blockade accelerates the neurogenic, neurotrophic, and behavioral effects of chronic antidepressant treatment. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 1096-109. PMID 20089918 DOI: 10.1523/JNEUROSCI.2309-09.2010  0.84
2010 Gilsbach R, Schneider J, Lother A, Schickinger S, Leemhuis J, Hein L. Sympathetic alpha(2)-adrenoceptors prevent cardiac hypertrophy and fibrosis in mice at baseline but not after chronic pressure overload. Cardiovascular Research. 86: 432-42. PMID 20083574 DOI: 10.1093/cvr/cvq014  0.84
2010 Yalcin I, Tessier LH, Petit-Demoulière N, Waltisperger E, Hein L, Freund-Mercier MJ, Barrot M. Chronic treatment with agonists of beta(2)-adrenergic receptors in neuropathic pain. Experimental Neurology. 221: 115-21. PMID 19840789 DOI: 10.1016/j.expneurol.2009.10.008  0.84
2009 Beetz N, Harrison MD, Brede M, Zong X, Urbanski MJ, Sietmann A, Kaufling J, Lorkowski S, Barrot M, Seeliger MW, Vieira-Coelho MA, Hamet P, Gaudet D, Seda O, Tremblay J, ... ... Hein L, et al. Phosducin influences sympathetic activity and prevents stress-induced hypertension in humans and mice. The Journal of Clinical Investigation. 119: 3597-3612. PMID 19959875 DOI: 10.1172/JCI38433  0.84
2009 Boettger T, Beetz N, Kostin S, Schneider J, Krüger M, Hein L, Braun T. Acquisition of the contractile phenotype by murine arterial smooth muscle cells depends on the Mir143/145 gene cluster. The Journal of Clinical Investigation. 119: 2634-47. PMID 19690389 DOI: 10.1172/JCI38864  0.84
2009 Beetz N, Hein L, Meszaros J, Gilsbach R, Barreto F, Meissner M, Hoppe UC, Schwartz A, Herzig S, Matthes J. Transgenic simulation of human heart failure-like L-type Ca2+-channels: implications for fibrosis and heart rate in mice. Cardiovascular Research. 84: 396-406. PMID 19620129 DOI: 10.1093/cvr/cvp251  0.84
2009 Albarrán-Juárez J, Gilsbach R, Piekorz RP, Pexa K, Beetz N, Schneider J, Nürnberg B, Birnbaumer L, Hein L. Modulation of alpha2-adrenoceptor functions by heterotrimeric Galphai protein isoforms. The Journal of Pharmacology and Experimental Therapeutics. 331: 35-44. PMID 19589951 DOI: 10.1124/jpet.109.157230  0.84
2009 Yalcin I, Choucair-Jaafar N, Benbouzid M, Tessier LH, Muller A, Hein L, Freund-Mercier MJ, Barrot M. beta(2)-adrenoceptors are critical for antidepressant treatment of neuropathic pain. Annals of Neurology. 65: 218-25. PMID 19259968 DOI: 10.1002/ana.21542  0.84
2009 Gilsbach R, Röser C, Beetz N, Brede M, Hadamek K, Haubold M, Leemhuis J, Philipp M, Schneider J, Urbanski M, Szabo B, Weinshenker D, Hein L. Genetic dissection of alpha2-adrenoceptor functions in adrenergic versus nonadrenergic cells. Molecular Pharmacology. 75: 1160-70. PMID 19251826 DOI: 10.1124/mol.109.054544  0.84
2009 Benndorf RA, Krebs C, Hirsch-Hoffmann B, Schwedhelm E, Cieslar G, Schmidt-Haupt R, Steinmetz OM, Meyer-Schwesinger C, Thaiss F, Haddad M, Fehr S, Heilmann A, Helmchen U, Hein L, Ehmke H, et al. Angiotensin II type 2 receptor deficiency aggravates renal injury and reduces survival in chronic kidney disease in mice. Kidney International. 75: 1039-49. PMID 19212419 DOI: 10.1038/ki.2009.2  0.84
2009 Schmitt JP, Ahmad F, Lorenz K, Hein L, Schulz S, Asahi M, Maclennan DH, Seidman CE, Seidman JG, Lohse MJ. Alterations of phospholamban function can exhibit cardiotoxic effects independent of excessive sarcoplasmic reticulum Ca2+-ATPase inhibition. Circulation. 119: 436-44. PMID 19139388 DOI: 10.1161/CIRCULATIONAHA.108.783506  0.84
2009 Yalcin I, Tessier LH, Petit-Demoulière N, Doridot S, Hein L, Freund-Mercier MJ, Barrot M. Beta2-adrenoceptors are essential for desipramine, venlafaxine or reboxetine action in neuropathic pain. Neurobiology of Disease. 33: 386-94. PMID 19084064 DOI: 10.1016/j.nbd.2008.11.003  0.84
2009 Beetz N, Hein L. Adrenaline and Noradrenaline Cardiovascular Hormone Systems. 233-250. DOI: 10.1002/9783527626236.ch10  0.84
2009 Hein L. Long QT syndrome: When the heart goes off the beat | Long-QT-Syndrom: Wenn das Herz aus dem Takt gerat Pharmazeutische Zeitung. 154.  0.84
2009 Weiß S, Gilsbach R, Hein L. DNA methylation: Queen or worker? Epigenetics decides | Konigin oder arbeiterin? epigenetik entscheidet Biospektrum. 15: 282-284.  0.84
2008 Hein L. [Alpha 1 adrenergic antagonists]. Pharmazie in Unserer Zeit. 37: 290-5. PMID 18570283 DOI: 10.1002/pauz.200700271  0.84
2008 Dahmani S, Paris A, Jannier V, Hein L, Rouelle D, Scholz J, Gressens P, Mantz J. Dexmedetomidine increases hippocampal phosphorylated extracellular signal-regulated protein kinase 1 and 2 content by an alpha 2-adrenoceptor-independent mechanism: evidence for the involvement of imidazoline I1 receptors. Anesthesiology. 108: 457-66. PMID 18292683 DOI: 10.1097/ALN.0b013e318164ca81  0.84
2008 Gilsbach R, Hein L. Presynaptic metabotropic receptors for acetylcholine and adrenaline/noradrenaline. Handbook of Experimental Pharmacology. 261-88. PMID 18064417 DOI: 10.1007/978-3-540-74805-2_9  0.84
2008 Krause W, Kusnick C, Von Wolff M, Hadji P, Schwenkhagen A, Uhl D, Unger C, Kaufmann M, Reitz A, Krege S, Schaible HG, Herdegen T, Caesar W, Güttler K, Klotz U, ... ... Hein L, et al. Interpharm 2008 - A very large training congress of Germany, April 18-20, 2008 in Stuttgart | Fortbildung ganz groß: Interpharm 2008 18. bis 20. April in Stuttgart Deutsche Apotheker Zeitung. 148: 44-97.  0.84
2007 Paris A, Hein L, Brede M, Brand PA, Scholz J, Tonner PH. The anesthetic effects of etomidate: species-specific interaction with alpha 2-adrenoceptors. Anesthesia and Analgesia. 105: 1644-9, table of con. PMID 18042862 DOI: 10.1213/  0.84
2007 Muthig V, Gilsbach R, Haubold M, Philipp M, Ivacevic T, Gessler M, Hein L. Upregulation of soluble vascular endothelial growth factor receptor 1 contributes to angiogenesis defects in the placenta of alpha 2B-adrenoceptor deficient mice. Circulation Research. 101: 682-91. PMID 17673674 DOI: 10.1161/CIRCRESAHA.107.151563  0.84
2007 Kuba K, Zhang L, Imai Y, Arab S, Chen M, Maekawa Y, Leschnik M, Leibbrandt A, Markovic M, Makovic M, Schwaighofer J, Beetz N, Musialek R, Neely GG, Komnenovic V, ... ... Hein L, et al. Impaired heart contractility in Apelin gene-deficient mice associated with aging and pressure overload. Circulation Research. 101: e32-42. PMID 17673668 DOI: 10.1161/CIRCRESAHA.107.158659  0.84
2007 Knaus AE, Muthig V, Schickinger S, Moura E, Beetz N, Gilsbach R, Hein L. Alpha2-adrenoceptor subtypes--unexpected functions for receptors and ligands derived from gene-targeted mouse models. Neurochemistry International. 51: 277-81. PMID 17664025 DOI: 10.1016/j.neuint.2007.06.036  0.84
2007 Gilsbach R, Brede M, Beetz N, Moura E, Muthig V, Gerstner C, Barreto F, Neubauer S, Vieira-Coelho MA, Hein L. Heterozygous alpha 2C-adrenoceptor-deficient mice develop heart failure after transverse aortic constriction. Cardiovascular Research. 75: 728-37. PMID 17597596 DOI: 10.1016/j.cardiores.2007.05.017  0.84
2007 Hullin R, Matthes J, von Vietinghoff S, Bodi I, Rubio M, D'Souza K, Friedrich Khan I, Rottländer D, Hoppe UC, Mohacsi P, Schmitteckert E, Gilsbach R, Bünemann M, Hein L, Schwartz A, et al. Increased expression of the auxiliary beta(2)-subunit of ventricular L-type Ca(2)+ channels leads to single-channel activity characteristic of heart failure. Plos One. 2: e292. PMID 17356701 DOI: 10.1371/journal.pone.0000292  0.84
2007 Munk VC, Sanchez de Miguel L, Petrimpol M, Butz N, Banfi A, Eriksson U, Hein L, Humar R, Battegay EJ. Angiotensin II induces angiogenesis in the hypoxic adult mouse heart in vitro through an AT2-B2 receptor pathway. Hypertension. 49: 1178-85. PMID 17339539 DOI: 10.1161/HYPERTENSIONAHA.106.080242  0.84
2007 Knaus A, Zong X, Beetz N, Jahns R, Lohse MJ, Biel M, Hein L. Direct inhibition of cardiac hyperpolarization-activated cyclic nucleotide-gated pacemaker channels by clonidine. Circulation. 115: 872-80. PMID 17261653 DOI: 10.1161/CIRCULATIONAHA.106.667675  0.84
2007 Vonend O, Habbel S, Stegbauer J, Roth J, Hein L, Rump LC. α 2A-adrenoceptors regulate sympathetic transmitter release in mice kidneys British Journal of Pharmacology. 150: 121-127. PMID 17115069 DOI: 10.1038/sj.bjp.0706961  0.84
2007 Hein L. Heart failure: New power for a weak heart | Herzinsuffizienz: Neue kraft für ein schwaches herz Pharmazeutische Zeitung. 152: 18-25.  0.84
2006 Moura E, Afonso J, Hein L, Vieira-Coelho MA. α 2-adrenoceptor subtypes involved in the regulation of catecholamine release from the adrenal medulla of mice British Journal of Pharmacology. 149: 1049-1058. PMID 17075569 DOI: 10.1038/sj.bjp.0706950  0.84
2006 Störk S, Boivin V, Horf R, Hein L, Lohse MJ, Angermann CE, Jahns R. Stimulating autoantibodies directed against the cardiac beta1-adrenergic receptor predict increased mortality in idiopathic cardiomyopathy. American Heart Journal. 152: 697-704. PMID 16996841 DOI: 10.1016/j.ahj.2006.05.004  0.84
2006 Hallhuber M, Burkard N, Wu R, Buch MH, Engelhardt S, Hein L, Neyses L, Schuh K, Ritter O. Inhibition of nuclear import of calcineurin prevents myocardial hypertrophy. Circulation Research. 99: 626-35. PMID 16931796 DOI: 10.1161/01.RES.0000243208.59795.d8  0.84
2006 Hein L. Adrenoceptors and signal transduction in neurons. Cell and Tissue Research. 326: 541-51. PMID 16896948 DOI: 10.1007/s00441-006-0285-2  0.84
2006 Pozgajová M, Sachs UJ, Hein L, Nieswandt B. Reduced thrombus stability in mice lacking the alpha2A-adrenergic receptor. Blood. 108: 510-4. PMID 16507775 DOI: 10.1182/blood-2005-12-4835  0.84
2006 Paris A, Mantz J, Tonner PH, Hein L, Brede M, Gressens P. The effects of dexmedetomidine on perinatal excitotoxic brain injury are mediated by the alpha2A-adrenoceptor subtype. Anesthesia and Analgesia. 102: 456-61. PMID 16428542 DOI: 10.1213/01.ane.0000194301.79118.e9  0.84
2006 Regitz-Zagrosek V, Hocher B, Bettmann M, Brede M, Hadamek K, Gerstner C, Lehmkuhl HB, Hetzer R, Hein L. Alpha2C-adrenoceptor polymorphism is associated with improved event-free survival in patients with dilated cardiomyopathy. European Heart Journal. 27: 454-9. PMID 16299019 DOI: 10.1093/eurheartj/ehi659  0.84
2006 Hein L. Current treatment of heart infarction | Aktuelle therapie des herzinfarkts Pharmazeutische Zeitung. 151: 19-26.  0.84
2005 Imai Y, Kuba K, Rao S, Huan Y, Guo F, Guan B, Yang P, Sarao R, Wada T, Leong-Poi H, Crackower MA, Fukamizu A, Hui CC, Hein L, Uhlig S, et al. Angiotensin-converting enzyme 2 protects from severe acute lung failure. Nature. 436: 112-6. PMID 16001071 DOI: 10.1038/nature03712  0.84
2005 Hein L. Angiotensin II and cell-matrix adhesion: PKCepsilon is essential. Cardiovascular Research. 67: 6-8. PMID 15922318 DOI: 10.1016/j.cardiores.2005.05.008  0.84
2005 Brede M, Philipp M, Hein L. Measurement of function and regulation of adrenergic receptors Practical Methods in Cardiovascular Research. 829-847. DOI: 10.1007/3-540-26574-0_41  0.84
2004 Otto C, Hein L, Brede M, Jahns R, Engelhardt S, Gröne HJ, Schütz G. Pulmonary hypertension and right heart failure in pituitary adenylate cyclase-activating polypeptide type I receptor-deficient mice. Circulation. 110: 3245-51. PMID 15520307 DOI: 10.1161/01.CIR.0000147235.53360.59  0.84
2004 Fagerholm V, Philipp M, Hein L, Scheinin M. [Ethyl-3H]RS-79948-197 alpha2-adrenoceptor autoradiography validation in alpha2-adrenoceptor knockout mice. European Journal of Pharmacology. 497: 301-9. PMID 15336948 DOI: 10.1016/j.ejphar.2004.06.065  0.84
2004 Nikolaev VO, Bünemann M, Hein L, Hannawacker A, Lohse MJ. Novel single chain cAMP sensors for receptor-induced signal propagation. The Journal of Biological Chemistry. 279: 37215-8. PMID 15231839 DOI: 10.1074/jbc.C400302200  0.84
2004 Brede M, Philipp M, Knaus A, Muthig V, Hein L. alpha2-adrenergic receptor subtypes - novel functions uncovered in gene-targeted mouse models. Biology of the Cell / Under the Auspices of the European Cell Biology Organization. 96: 343-8. PMID 15207902 DOI: 10.1016/j.biolcel.2004.03.006  0.84
2004 Jahns R, Boivin V, Hein L, Triebel S, Angermann CE, Ertl G, Lohse MJ. Direct evidence for a beta 1-adrenergic receptor-directed autoimmune attack as a cause of idiopathic dilated cardiomyopathy. The Journal of Clinical Investigation. 113: 1419-29. PMID 15146239 DOI: 10.1172/JCI20149  0.84
2004 Bonaventure P, Nepomuceno D, Hein L, Sutcliffe JG, Lovenberg T, Hedlund PB. Radioligand binding analysis of knockout mice reveals 5-hydroxytryptamine(7) receptor distribution and uncovers 8-hydroxy-2-(di-n-propylamino)tetralin interaction with alpha(2) adrenergic receptors. Neuroscience. 124: 901-11. PMID 15026130 DOI: 10.1016/j.neuroscience.2004.01.014  0.84
2004 Kirchhefer U, Jones LR, Begrow F, Boknik P, Hein L, Lohse MJ, Riemann B, Schmitz W, Stypmann J, Neumann J. Transgenic triadin 1 overexpression alters SR Ca2+ handling and leads to a blunted contractile response to beta-adrenergic agonists. Cardiovascular Research. 62: 122-34. PMID 15023559 DOI: 10.1016/j.cardiores.2004.01.005  0.84
2004 Engelhardt S, Hein L, Dyachenkow V, Kranias EG, Isenberg G, Lohse MJ. Altered calcium handling is critically involved in the cardiotoxic effects of chronic beta-adrenergic stimulation. Circulation. 109: 1154-60. PMID 14967726 DOI: 10.1161/01.CIR.0000117254.68497.39  0.84
2004 Niederhoffer N, Hein L, Starke K. Modulation of the baroreceptor reflex by alpha 2A-adrenoceptors: a study in alpha 2A knockout mice. British Journal of Pharmacology. 141: 851-9. PMID 14769782 DOI: 10.1038/sj.bjp.0705636  0.84
2004 Philipp M, Hein L. Adrenergic receptor knockout mice: distinct functions of 9 receptor subtypes. Pharmacology & Therapeutics. 101: 65-74. PMID 14729393 DOI: 10.1016/j.pharmthera.2003.10.004  0.84
2003 Gaussin V, Tomlinson JE, Depre C, Engelhardt S, Antos CL, Takagi G, Hein L, Topper JN, Liggett SB, Olson EN, Lohse MJ, Vatner SF, Vatner DE. Common genomic response in different mouse models of beta-adrenergic-induced cardiomyopathy. Circulation. 108: 2926-33. PMID 14623810 DOI: 10.1161/01.CIR.0000101922.18151.7B  0.84
2003 Trendelenburg AU, Philipp M, Meyer A, Klebroff W, Hein L, Starke K. All three alpha2-adrenoceptor types serve as autoreceptors in postganglionic sympathetic neurons. Naunyn-Schmiedeberg's Archives of Pharmacology. 368: 504-12. PMID 14610637 DOI: 10.1007/s00210-003-0829-x  0.84
2003 Brede M, Roell W, Ritter O, Wiesmann F, Jahns R, Haase A, Fleischmann BK, Hein L. Cardiac hypertrophy is associated with decreased eNOS expression in angiotensin AT2 receptor-deficient mice. Hypertension. 42: 1177-82. PMID 14581297 DOI: 10.1161/01.HYP.0000100445.80029.8E  0.72
2003 Paris A, Philipp M, Tonner PH, Steinfath M, Lohse M, Scholz J, Hein L. Activation of alpha 2B-adrenoceptors mediates the cardiovascular effects of etomidate. Anesthesiology. 99: 889-95. PMID 14508322  0.84
2003 Eigenthaler M, Engelhardt S, Schinke B, Kobsar A, Schmitteckert E, Gambaryan S, Engelhardt CM, Krenn V, Eliava M, Jarchau T, Lohse MJ, Walter U, Hein L. Disruption of cardiac Ena-VASP protein localization in intercalated disks causes dilated cardiomyopathy. American Journal of Physiology. Heart and Circulatory Physiology. 285: H2471-81. PMID 12933343 DOI: 10.1152/ajpheart.00362.2003  0.84
2003 Brede M, Nagy G, Philipp M, Sorensen JB, Lohse MJ, Hein L. Differential control of adrenal and sympathetic catecholamine release by alpha 2-adrenoceptor subtypes. Molecular Endocrinology (Baltimore, Md.). 17: 1640-6. PMID 12764077 DOI: 10.1210/me.2003-0035  0.84
2003 Spindler M, Engelhardt S, Niebler R, Wagner H, Hein L, Lohse MJ, Neubauer S. Alterations in the myocardial creatine kinase system precede the development of contractile dysfunction in beta(1)-adrenergic receptor transgenic mice. Journal of Molecular and Cellular Cardiology. 35: 389-97. PMID 12689818 DOI: 10.1016/S0022-2828(03)00015-4  0.84
2002 Brede M, Wiesmann F, Jahns R, Hadamek K, Arnolt C, Neubauer S, Lohse MJ, Hein L. Feedback inhibition of catecholamine release by two different alpha2-adrenoceptor subtypes prevents progression of heart failure. Circulation. 106: 2491-6. PMID 12417548 DOI: 10.1161/01.CIR.0000036600.39600.66  0.84
2002 Philipp M, Brede M, Hein L. Physiological significance of alpha(2)-adrenergic receptor subtype diversity: one receptor is not enough. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 283: R287-95. PMID 12121839 DOI: 10.1152/ajpregu.00123.2002  0.84
2002 Philipp M, Brede ME, Hadamek K, Gessler M, Lohse MJ, Hein L. Placental alpha(2)-adrenoceptors control vascular development at the interface between mother and embryo. Nature Genetics. 31: 311-5. PMID 12068299 DOI: 10.1038/ng919  0.84
2002 Engelhardt S, Hein L, Keller U, Klämbt K, Lohse MJ. Inhibition of Na(+)-H(+) exchange prevents hypertrophy, fibrosis, and heart failure in beta(1)-adrenergic receptor transgenic mice. Circulation Research. 90: 814-9. PMID 11964375 DOI: 10.1161/01.RES.0000014966.97486.C0  0.84
2001 Brede M, Hadamek K, Meinel L, Wiesmann F, Peters J, Engelhardt S, Simm A, Haase A, Lohse MJ, Hein L. Vascular hypertrophy and increased P70S6 kinase in mice lacking the angiotensin II AT(2) receptor. Circulation. 104: 2602-7. PMID 11714657  0.84
2001 Chruscinski A, Brede ME, Meinel L, Lohse MJ, Kobilka BK, Hein L. Differential distribution of beta-adrenergic receptor subtypes in blood vessels of knockout mice lacking beta(1)- or beta(2)-adrenergic receptors. Molecular Pharmacology. 60: 955-62. PMID 11641423  0.84
2001 Engelhardt S, Boknik P, Keller U, Neumann J, Lohse MJ, Hein L. Early impairment of calcium handling and altered expression of junctin in hearts of mice overexpressing the beta1-adrenergic receptor. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 15: 2718-20. PMID 11606476 DOI: 10.1096/fj.01-0107fje  0.84
2001 Bünemann M, Bücheler MM, Philipp M, Lohse MJ, Hein L. Activation and deactivation kinetics of alpha 2A- and alpha 2C-adrenergic receptor-activated G protein-activated inwardly rectifying K+ channel currents. The Journal of Biological Chemistry. 276: 47512-7. PMID 11591725 DOI: 10.1074/jbc.M108652200  0.84
2001 Wiesmann F, Ruff J, Engelhardt S, Hein L, Dienesch C, Leupold A, Illinger R, Frydrychowicz A, Hiller KH, Rommel E, Haase A, Lohse MJ, Neubauer S. Dobutamine-stress magnetic resonance microimaging in mice : acute changes of cardiac geometry and function in normal and failing murine hearts. Circulation Research. 88: 563-9. PMID 11282889  0.84
1999 Engelhardt S, Hein L, Wiesmann F, Lohse MJ. Progressive hypertrophy and heart failure in beta1-adrenergic receptor transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. 96: 7059-64. PMID 10359838 DOI: 10.1073/pnas.96.12.7059  0.84
1997 Gabilondo AM, Hegler J, Krasel C, Boivin-Jahns V, Hein L, Lohse MJ. A dileucine motif in the C terminus of the beta2-adrenergic receptor is involved in receptor internalization. Proceedings of the National Academy of Sciences of the United States of America. 94: 12285-90. PMID 9356441  0.84
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