Toshiharu Suzuki - Related publications

University of Tokyo, Bunkyō-ku, Tōkyō-to, Japan 
 Hokkaido University, Sapporo-shi, Hokkaidō, Japan 
Alzheimers Disease
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50 most relevant papers in past 60 days:
Year Citation  Score
2019 Ali MA, Vuree S, Goud H, Hussain T, Nayarisseri A, Singh SK. Identification of High-affinity Small Molecules Targeting Gamma Secretase for the Treatment of Alzheimer's Disease. Current Topics in Medicinal Chemistry. PMID 31244427 DOI: 10.2174/1568026619666190617155326   
2019 Hu T, Li SS, Lu MN, Zhang L, Chen B, Mao R, Mei R, Tan YX, Li S, Xiyang YB. Neuroprotection induced by Navβ2‑knockdown in APP/PS1 transgenic neurons is associated with NEP regulation. Molecular Medicine Reports. PMID 31257483 DOI: 10.3892/mmr.2019.10406   
2019 Yao W, Tambini MD, Liu X, D'Adamio L. Tuning of glutamate, but not GABA, release by an intra-synaptic vesicles APP domain whose function can be modulated by β- or α-secretase cleavage. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 31235642 DOI: 10.1523/JNEUROSCI.0207-19.2019   
2019 Tang Y, Shao S, Guo Y, Zhou Y, Cao J, Xu A, Wu J, Li Z, Xiang D. Electroacupuncture Mitigates Hippocampal Cognitive Impairments by Reducing BACE1 Deposition and Activating PKA in APP/PS1 Double Transgenic Mice. Neural Plasticity. 2019: 2823679. PMID 31223308 DOI: 10.1155/2019/2823679   
2019 Heckmann BL, Teubner BJW, Tummers B, Boada-Romero E, Harris L, Yang M, Guy CS, Zakharenko SS, Green DR. LC3-Associated Endocytosis Facilitates β-Amyloid Clearance and Mitigates Neurodegeneration in Murine Alzheimer's Disease. Cell. PMID 31257024 DOI: 10.1016/j.cell.2019.05.056   
2019 Haass C, Levin J. [Did Alzheimer research fail entirely? : Failure of amyloid-based clinical studies]. Der Nervenarzt. PMID 31243509 DOI: 10.1007/s00115-019-0751-1   
2019 Suppiah S, Didier MA, Vinjamuri S. The Who, When, Why, and How of PET Amyloid Imaging in Management of Alzheimer's Disease-Review of Literature and Interesting Images. Diagnostics (Basel, Switzerland). 9. PMID 31242587 DOI: 10.3390/diagnostics9020065   
2019 Velazquez R, Meechoovet B, Ow A, Foley C, Shaw A, Smith B, Oddo S, Hulme C, Dunckley T. Chronic Dyrk1 Inhibition Delays the Onset of AD-Like Pathology in 3xTg-AD Mice. Molecular Neurobiology. PMID 31240602 DOI: 10.1007/s12035-019-01684-9   
2019 Do HQ, Hewetson A, Myers C, Khan NH, Hastert MC, M Harsini F, Latham MP, Wylie BJ, Sutton RB, Cornwall GA. The Functional Mammalian CRES (Cystatin-Related Epididymal Spermatogenic) Amyloid is Antiparallel β-Sheet Rich and Forms a Metastable Oligomer During Assembly. Scientific Reports. 9: 9210. PMID 31239483 DOI: 10.1038/s41598-019-45545-w   
2019 Lopez Lopez C, Tariot PN, Caputo A, Langbaum JB, Liu F, Riviere ME, Langlois C, Rouzade-Dominguez ML, Zalesak M, Hendrix S, Thomas RG, Viglietta V, Lenz R, Ryan JM, Graf A, et al. The Alzheimer's Prevention Initiative Generation Program: Study design of two randomized controlled trials for individuals at risk for clinical onset of Alzheimer's disease. Alzheimer's & Dementia (New York, N. Y.). 5: 216-227. PMID 31211217 DOI: 10.1016/j.trci.2019.02.005   
2019 Zhong Y, Zheng QY, Sun CY, Zhang Z, Han K, Jia N. Orientin Improves Cognition by Enhancing Autophagosome Clearance in an Alzheimer's Mouse Model. Journal of Molecular Neuroscience : Mn. PMID 31243684 DOI: 10.1007/s12031-019-01353-5   
2019 Pedrero-Prieto CM, Flores-Cuadrado A, Saiz-Sánchez D, Úbeda-Bañón I, Frontiñán-Rubio J, Alcaín FJ, Mateos-Hernández L, de la Fuente J, Durán-Prado M, Villar M, Martínez-Marcos A, Peinado JR. Human amyloid-β enriched extracts: evaluation of in vitro and in vivo internalization and molecular characterization. Alzheimer's Research & Therapy. 11: 56. PMID 31253170 DOI: 10.1186/s13195-019-0513-0   
2019 Chabert M, Rousset X, Colombat M, Lacasa M, Kakanakou H, Bourderioux M, Brousset P, Burlet-Schiltz O, Liepnieks JJ, Kluve-Beckerman B, Lambert G, Châtelet FP, Benson MD, Kalopissis AD. A transgenic mouse model reproduces human hereditary systemic amyloidosis. Kidney International. PMID 31200944 DOI: 10.1016/j.kint.2019.03.013   
2019 Shan SR, Jiang F, Xu SM. [Effects of H102 on the memory recognition ability and AMPK-mTOR autophagy-related pathway in AD mice]. Zhongguo Ying Yong Sheng Li Xue Za Zhi = Zhongguo Yingyong Shenglixue Zazhi = Chinese Journal of Applied Physiology. 35: 1-4. PMID 31245943 DOI: 10.12047/j.cjap.5749.2019.001   
2019 Blanco JA, Alonso A, Blanco J, Rojo E, Tellería JJ, Torres MA, Uribe F. Novel presenilin 1 mutation (p.Thr-Pro116-117Ser-Thr) in a Spanish family with early-onset Alzheimer's disease. Neurobiology of Aging. PMID 31204041 DOI: 10.1016/j.neurobiolaging.2019.05.012   
2019 Liberta F, Rennegarbe M, Rösler R, Bijzet J, Wiese S, Hazenberg BPC, Fändrich M. Morphological and primary structural consistency of fibrils from different AA patients (common variant). Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 1-7. PMID 31240945 DOI: 10.1080/13506129.2019.1628015   
2019 Al Rihani SB, Darakjian LI, Kaddoumi A. Oleocanthal-Rich Extra-Virgin Olive Oil Restores the Blood-Brain Barrier Function through NLRP3 Inflammasome Inhibition Simultaneously with Autophagy Induction in TgSwDI Mice. Acs Chemical Neuroscience. PMID 31244050 DOI: 10.1021/acschemneuro.9b00175   
2019 Chandra S, Pahan K. Gemfibrozil, a Lipid-Lowering Drug, Lowers Amyloid Plaque Pathology and Enhances Memory in a Mouse Model of Alzheimer's Disease via Peroxisome Proliferator-Activated Receptor . Journal of Alzheimer's Disease Reports. 3: 149-168. PMID 31259309 DOI: 10.3233/ADR-190104   
2019 Gaubert S, Raimondo F, Houot M, Corsi MC, Naccache L, Diego Sitt J, Hermann B, Oudiette D, Gagliardi G, Habert MO, Dubois B, De Vico Fallani F, Bakardjian H, Epelbaum S, . EEG evidence of compensatory mechanisms in preclinical Alzheimer's disease. Brain : a Journal of Neurology. PMID 31211359 DOI: 10.1093/brain/awz150   
2019 Sheng L, Chen M, Cai K, Song Y, Yu D, Zhang H, Xu G. Microglial Trem2 induces synaptic impairment at early stage and prevents amyloidosis at late stage in APP/PS1 mice. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201900527R. PMID 31219699 DOI: 10.1096/fj.201900527R   
2019 Balu DT, Pantazopoulos H, Huang CCY, Muszynski K, Harvey TL, Uno Y, Rorabaugh JM, Galloway CR, Botz-Zapp C, Berretta S, Weinshenker D, Coyle JT. Neurotoxic astrocytes express the d-serine synthesizing enzyme, serine racemase, in Alzheimer's disease. Neurobiology of Disease. 104511. PMID 31212068 DOI: 10.1016/j.nbd.2019.104511   
2019 Wang Y, Zhang Y, Zhang X, Yang T, Liu C, Wang P. Alcohol Dehydrogenase 1B Suppresses β-Amyloid-Induced Neuron Apoptosis. Frontiers in Aging Neuroscience. 11: 135. PMID 31231206 DOI: 10.3389/fnagi.2019.00135   
2019 Jović M, Lončarević-Vasiljković N, Ivković S, Dinić J, Milanović D, Zlokovic B, Kanazir S. Short-term fish oil supplementation applied in presymptomatic stage of Alzheimer's disease enhances microglial/macrophage barrier and prevents neuritic dystrophy in parietal cortex of 5xFAD mouse model. Plos One. 14: e0216726. PMID 31095617 DOI: 10.1371/journal.pone.0216726   
2019 Balczon R, Pittet JF, Wagener BM, Moser SA, Voth S, Vorhees CV, Williams MT, Bridges JP, Alvarez DF, Koloteva A, Xu Y, Zha XM, Audia JP, Stevens T, Lin MT. Infection-induced endothelial amyloids impair memory. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201900322R. PMID 31211919 DOI: 10.1096/fj.201900322R   
2019 Mendonça CF, Kuras M, Nogueira FCS, Plá I, Hortobágyi T, Csiba L, Palkovits M, Renner É, Döme P, Marko-Varga G, Domont GB, Rezeli M. Proteomic signatures of brain regions affected by tau pathology in early and late stages of Alzheimer's disease. Neurobiology of Disease. 104509. PMID 31207390 DOI: 10.1016/j.nbd.2019.104509   
2019 Higham JP, Malik BR, Buhl E, Dawson JM, Ogier AS, Lunnon K, Hodge JJL. Alzheimer's Disease Associated Genes Ankyrin and Tau Cause Shortened Lifespan and Memory Loss in . Frontiers in Cellular Neuroscience. 13: 260. PMID 31244615 DOI: 10.3389/fncel.2019.00260   
2019 Forest KH, Nichols RA. Assessing Neuroprotective Agents for Aβ-Induced Neurotoxicity. Trends in Molecular Medicine. PMID 31248781 DOI: 10.1016/j.molmed.2019.05.013   
2019 Michaels TCT, Weber CA, Mahadevan L. Optimal control strategies for inhibition of protein aggregation. Proceedings of the National Academy of Sciences of the United States of America. PMID 31253705 DOI: 10.1073/pnas.1904090116   
2019 Qiu Q, Jia L, Wang Q, Zhao L, Jin H, Li T, Quan M, Xu L, Li B, Li Y, Jia J. Identification of a novel PSEN1 Gly111Val missense mutation in a Chinese pedigree with early-onset Alzheimer's disease. Neurobiology of Aging. PMID 31235344 DOI: 10.1016/j.neurobiolaging.2019.05.018   
2019 Shen L, Qin W, Wu L, Zhou A, Tang Y, Wang Q, Jia L, Jia J. Two novel presenilin-1 mutations (I249L and P433S) in early onset Chinese Alzheimer's pedigrees and their functional characterization. Biochemical and Biophysical Research Communications. PMID 31235249 DOI: 10.1016/j.bbrc.2019.05.185   
2019 Fränzl M, Thalheim T, Adler J, Huster D, Posseckardt J, Mertig M, Cichos F. Thermophoretic trap for single amyloid fibril and protein aggregation studies. Nature Methods. 16: 611-614. PMID 31235884 DOI: 10.1038/s41592-019-0451-6   
2019 Albensi BC. Dysfunction of mitochondria: Implications for Alzheimer's disease. International Review of Neurobiology. 145: 13-27. PMID 31208523 DOI: 10.1016/bs.irn.2019.03.001   
2019 Ono K, Tsuji M. Pharmacological Potential of Cilostazol for Alzheimer's Disease. Frontiers in Pharmacology. 10: 559. PMID 31191308 DOI: 10.3389/fphar.2019.00559   
2019 Dani M, Wood M, Mizoguchi R, Fan Z, Edginton T, Hinz R, Win Z, Brooks DJ, Edison P. Tau Aggregation Correlates with Amyloid Deposition in Both Mild Cognitive Impairment and Alzheimer's Disease Subjects. Journal of Alzheimer's Disease : Jad. PMID 31256120 DOI: 10.3233/JAD-181168   
2019 Jiang Y, Jiang X, Shi X, Yang F, Cao Y, Qin X, Hou Z, Xie M, Liu N, Fang Q, Yin F, Han W, Li Z. α-Helical Motif as Inhibitors of Toxic Amyloid-β Oligomer Generation via Highly Specific Recognition of Amyloid Surface. Iscience. 17: 87-100. PMID 31255986 DOI: 10.1016/j.isci.2019.06.022   
2019 Zheng Q, Kebede MT, Kemeh MM, Islam S, Lee B, Bleck SD, Wurfl LA, Lazo ND. Inhibition of the Self-Assembly of Aβ and of Tau by Polyphenols: Mechanistic Studies. Molecules (Basel, Switzerland). 24. PMID 31234523 DOI: 10.3390/molecules24122316   
2019 Martín-Maestro P, Gargini R, García E, Simón D, Avila J, García-Escudero V. Mitophagy Failure in APP and Tau Overexpression Model of Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. PMID 31256128 DOI: 10.3233/JAD-190086   
2019 Xiao X, Chen Q, Zhu X, Wang Y. ABAD/17β-HSD10 reduction contributes to the protective mechanism of huperzine a on the cerebral mitochondrial function in APP/PS1 mice. Neurobiology of Aging. 81: 77-87. PMID 31252207 DOI: 10.1016/j.neurobiolaging.2019.05.016   
2019 Wang M, Jo J, Song J. Adiponectin improves long-term potentiation in the 5XFAD mouse brain. Scientific Reports. 9: 8918. PMID 31222110 DOI: 10.1038/s41598-019-45509-0   
2019 Paterson RW, Gabelle A, Lucey BP, Barthélemy NR, Leckey CA, Hirtz C, Lehmann S, Sato C, Patterson BW, West T, Yarasheski K, Rohrer JD, Wildburger NC, Schott JM, Karch CM, et al. SILK studies - capturing the turnover of proteins linked to neurodegenerative diseases. Nature Reviews. Neurology. PMID 31222062 DOI: 10.1038/s41582-019-0222-0   
2019 Perez C, Miti T, Hasecke F, Meisl G, Hoyer W, Muschol M, Ullah G. Mechanism of Fibril and Soluble Oligomer Formation in Amyloid Beta and Hen Egg White Lysozyme Proteins. The Journal of Physical Chemistry. B. PMID 31246474 DOI: 10.1021/acs.jpcb.9b02338   
2019 Wang M, Kwame AW, Guo L, Gong C, Zhao Y, Yao M, Ren J. Walnut-Derived Peptide PW5 Ameliorates Cognitive Impairments and Alters Gut Microbiota in APP/PS1 Transgenic Mice. Molecular Nutrition & Food Research. e1900326. PMID 31237989 DOI: 10.1002/mnfr.201900326   
2019 Martín-Maestro P, Sproul A, Martinez H, Paquet D, Gerges M, Noggle S, Starkov AA. Autophagy Induction by Bexarotene Promotes Mitophagy in Presenilin 1 Familial Alzheimer's Disease iPSC-Derived Neural Stem Cells. Molecular Neurobiology. PMID 31203573 DOI: 10.1007/s12035-019-01665-y   
2019 Shin SJ, Jeon SG, Kim JI, Jeong YO, Kim S, Park YH, Lee SK, Park HH, Hong SB, Oh S, Hwang JY, Kim HS, Park H, Nam Y, Lee YY, et al. Red Ginseng Attenuates Aβ-Induced Mitochondrial Dysfunction and Aβ-mediated Pathology in an Animal Model of Alzheimer's Disease. International Journal of Molecular Sciences. 20. PMID 31234321 DOI: 10.3390/ijms20123030   
2019 Morroni F, Sita G, Graziosi A, Ravegnini G, Molteni R, Paladini MS, Dias KST, Dos Santos AF, Viegas C, Camps I, Pruccoli L, Tarozzi A, Hrelia P. PQM130, a Novel Feruloyl-Donepezil Hybrid Compound, Effectively Ameliorates the Cognitive Impairments and Pathology in a Mouse Model of Alzheimer's Disease. Frontiers in Pharmacology. 10: 658. PMID 31244664 DOI: 10.3389/fphar.2019.00658   
2019 Shen L, Liu L, Li XY, Ji HF. Regulation of gut microbiota in Alzheimer's disease mice by silibinin and silymarin and their pharmacological implications. Applied Microbiology and Biotechnology. PMID 31236617 DOI: 10.1007/s00253-019-09950-5   
2019 Hou XH, Bi YL, Tan MS, Xu W, Li JQ, Shen XN, Dou KX, Tan CC, Tan L, , Yu JT. Genome-wide association study identifies Alzheimer's risk variant in MS4A6A influencing cerebrospinal fluid sTREM2 levels. Neurobiology of Aging. PMID 31204042 DOI: 10.1016/j.neurobiolaging.2019.05.008   
2019 Azevedo EP, Guimaraes-Costa AB, Bandeira-Melo C, Chimelli L, Waddington-Cruz M, Saraiva EM, Palhano FL, Foguel D. Inflammatory profiling of patients with familial amyloid polyneuropathy. Bmc Neurology. 19: 146. PMID 31253122 DOI: 10.1186/s12883-019-1369-4   
2019 Sasmita AO. Current viral-mediated gene transfer research for treatment of Alzheimer's disease. Biotechnology & Genetic Engineering Reviews. 35: 26-45. PMID 30317930 DOI: 10.1080/02648725.2018.1523521   
2019 Baik SH, Kang S, Lee W, Choi H, Chung S, Kim JI, Mook-Jung I. A Breakdown in Metabolic Reprogramming Causes Microglia Dysfunction in Alzheimer's Disease. Cell Metabolism. PMID 31257151 DOI: 10.1016/j.cmet.2019.06.005