| Year |
Citation |
Score |
| 2020 |
Zultanski SL, Kuhl N, Zhong W, Cohen RD, Reibarkh M, Jurica J, Kim J, Weisel L, Ekkati AR, Klapars A, Gauthier DR, Dunn JMM. Mechanistic Understanding of a Robust and Scalable Synthesis of Per(6-deoxy-6-halo)cyclodextrins, Versatile Intermediates for Cyclodextrin Modification Organic Process Research & Development. DOI: 10.1021/Acs.Oprd.0C00249 |
0.301 |
|
| 2017 |
DiRocco DA, Ji Y, Sherer EC, Klapars A, Reibarkh M, Dropinski J, Mathew R, Maligres P, Hyde AM, Limanto J, Brunskill A, Ruck RT, Campeau LC, Davies IW. A multifunctional catalyst that stereoselectively assembles prodrugs. Science (New York, N.Y.). 356: 426-430. PMID 28450641 DOI: 10.1126/Science.Aam7936 |
0.304 |
|
| 2017 |
Simmons B, Liu Z, Klapars A, Bellomo A, Silverman SM. Mechanism-Based Solution to the ProTide Synthesis Problem: Selective Access to Sofosbuvir, Acelarin, and INX-08189. Organic Letters. PMID 28418681 DOI: 10.1021/Acs.Orglett.7B00469 |
0.351 |
|
| 2016 |
Hyde AM, Liu Z, Kosjek B, Tan L, Klapars A, Ashley ER, Zhong YL, Alvizo O, Agard NJ, Liu G, Gu X, Yasuda N, Limanto J, Huffman MA, Tschaen DM. Synthesis of the GPR40 Partial Agonist MK-8666 through a Kinetically Controlled Dynamic Enzymatic Ketone Reduction. Organic Letters. PMID 27802043 DOI: 10.1021/Acs.Orglett.6B02910 |
0.361 |
|
| 2016 |
Chung JY, Shevlin M, Klapars A, Journet M. Asymmetric Synthesis of N-Boc-(R)-Silaproline via Rh-Catalyzed Intramolecular Hydrosilylation of Dehydroalanine and Continuous Flow N-Alkylation. Organic Letters. PMID 27015542 DOI: 10.1021/Acs.Orglett.6B00548 |
0.478 |
|
| 2014 |
Limanto J, Ashley ER, Yin J, Beutner GL, Grau BT, Kassim AM, Kim MM, Klapars A, Liu Z, Strotman HR, Truppo MD. A highly efficient asymmetric synthesis of vernakalant. Organic Letters. 16: 2716-9. PMID 24786635 DOI: 10.1021/Ol501002A |
0.402 |
|
| 2014 |
Mangion IK, Chen CY, Li H, Maligres P, Chen Y, Christensen M, Cohen R, Jeon I, Klapars A, Krska S, Nguyen H, Reamer RA, Sherry BD, Zavialov I. Enantioselective synthesis of an HCV NS5a antagonist. Organic Letters. 16: 2310-3. PMID 24724971 DOI: 10.1021/Ol500971C |
0.311 |
|
| 2014 |
Maddess ML, Scott JP, Alorati A, Baxter C, Bremeyer N, Brewer S, Campos K, Cleator E, Dieguez-Vazquez A, Gibb A, Gibson A, Howard M, Keen S, Klapars A, Lee J, et al. Enantioselective synthesis of a highly substituted tetrahydrofluorene derivative as a potent and selective estrogen receptor beta agonist Organic Process Research and Development. 18: 528-538. DOI: 10.1021/Op5000489 |
0.345 |
|
| 2011 |
Barker G, McGrath JL, Klapars A, Stead D, Zhou G, Campos KR, O'Brien P. Enantioselective, palladium-catalyzed α-arylation of N-Boc pyrrolidine: in situ react IR spectroscopic monitoring, scope, and synthetic applications. The Journal of Organic Chemistry. 76: 5936-53. PMID 21714542 DOI: 10.1021/Jo2011347 |
0.426 |
|
| 2011 |
Yasuda N, Klapars A, Kohmura Y, Campos KR, Ishibashi H, Pollard D, Takezawa A, Waldman JH, Wallace DJ, Chen GY, Mase T. Asymmetric synthesis of a potent hNK-1 receptor antagonist Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry. 69: 579-587. DOI: 10.5059/Yukigoseikyokaishi.69.579 |
0.364 |
|
| 2009 |
Chen YW, Liu Y, Novak T, Frey L, Campos K, Klapars A, Chen CY, Phenix B. Identification and structural elucidation of process impurities generated in the end-game synthesis of taranabant (MK-0364) via cyanuric chloride. Journal of Pharmaceutical and Biomedical Analysis. 49: 702-10. PMID 19188037 DOI: 10.1016/J.Jpba.2009.01.003 |
0.307 |
|
| 2008 |
Klapars A, Campos KR, Waldman JH, Zewge D, Dormer PG, Chen CY. Enantioselective Pd-catalyzed alpha-arylation of N-Boc-pyrrolidine: the key to an efficient and practical synthesis of a glucokinase activator. The Journal of Organic Chemistry. 73: 4986-93. PMID 18507444 DOI: 10.1021/Jo8006804 |
0.431 |
|
| 2007 |
Warner DL, Hibberd AM, Kalman M, Klapars A, Vedejs E. N-silyl protecting groups for labile aziridines: application toward the synthesis of N-H aziridinomitosenes. The Journal of Organic Chemistry. 72: 8519-22. PMID 17910500 DOI: 10.1021/Jo7013615 |
0.67 |
|
| 2006 |
Campos KR, Klapars A, Waldman JH, Dormer PG, Chen CY. Enantioselective, palladium-catalyzed alpha-arylation of N-Boc-pyrrolidine. Journal of the American Chemical Society. 128: 3538-9. PMID 16536525 DOI: 10.1021/ja0605265 |
0.357 |
|
| 2005 |
Klapars A, Waldman JH, Campos KR, Jensen MS, McLaughlin M, Chung JY, Cvetovich RJ, Chen CY. Mild and practical method for the alpha-arylation of nitriles with heteroaryl halides. The Journal of Organic Chemistry. 70: 10186-9. PMID 16292870 DOI: 10.1021/Jo051737F |
0.321 |
|
| 2005 |
Rink SM, Warner DL, Klapars A, Vedejs E. Sequence-specific DNA interstrand cross-linking by an aziridinomitosene in the absence of exogenous reductant. Biochemistry. 44: 13981-6. PMID 16229487 DOI: 10.1021/Bi050426W |
0.628 |
|
| 2005 |
Klapars A, Campos KR, Chen CY, Volante RP. Preparation of enamides via palladium-catalyzed amidation of enol tosylates. Organic Letters. 7: 1185-8. PMID 15760170 DOI: 10.1021/Ol050117Y |
0.301 |
|
| 2004 |
Klapars A, Vedejs E. Activation of pyridinium salts for electrophilic acylation: A method for conversion of pyridines into 3-acylpyridines Khimiya Geterotsiklicheskikh Soedinenii. 887-894. DOI: 10.1023/B:Cohc.0000040772.13427.0B |
0.579 |
|
| 2004 |
Klapars A, Vedejs E. Activation of pyridinium salts for electrophilic acylation: A method for conversion of pyridines into 3-acylpyridines Khimiya Geterotsiklicheskikh Soedinenii. 887-894. DOI: 10.1023/B:COHC.0000040772.13427.0b |
0.482 |
|
| 2003 |
Vedejs E, Naidu BN, Klapars A, Warner DL, Li VS, Na Y, Kohn H. Synthetic enantiopure aziridinomitosenes: preparation, reactivity, and DNA alkylation studies. Journal of the American Chemical Society. 125: 15796-806. PMID 14677970 DOI: 10.1021/Ja030452M |
0.668 |
|
| 2003 |
Jiang L, Job GE, Klapars A, Buchwald SL. Copper-catalyzed coupling of amides and carbamates with vinyl halides. Organic Letters. 5: 3667-9. PMID 14507200 DOI: 10.1021/Ol035355C |
0.327 |
|
| 2003 |
Zanon J, Klapars A, Buchwald SL. Copper-catalyzed domino halide exchange-cyanation of aryl bromides. Journal of the American Chemical Society. 125: 2890-1. PMID 12617652 DOI: 10.1021/Ja0299708 |
0.314 |
|
| 2002 |
Klapars A, Buchwald SL. Copper-catalyzed halogen exchange in aryl halides: an aromatic Finkelstein reaction. Journal of the American Chemical Society. 124: 14844-5. PMID 12475315 DOI: 10.1021/Ja028865V |
0.358 |
|
| 2002 |
Antilla JC, Klapars A, Buchwald SL. The copper-catalyzed N-arylation of indoles. Journal of the American Chemical Society. 124: 11684-8. PMID 12296734 DOI: 10.1021/Ja027433H |
0.383 |
|
| 2002 |
Klapars A, Huang X, Buchwald SL. A general and efficient copper catalyst for the amidation of aryl halides. Journal of the American Chemical Society. 124: 7421-8. PMID 12071751 DOI: 10.1021/Ja0260465 |
0.306 |
|
| 2002 |
Kwong FY, Klapars A, Buchwald SL. Copper-catalyzed coupling of alkylamines and aryl iodides: an efficient system even in an air atmosphere. Organic Letters. 4: 581-4. PMID 11843596 DOI: 10.1021/Ol0171867 |
0.306 |
|
| 2001 |
Wolter M, Klapars A, Buchwald SL. Synthesis of N-aryl hydrazides by copper-catalyzed coupling of hydrazides with aryl iodides. Organic Letters. 3: 3803-5. PMID 11700143 DOI: 10.1021/Ol0168216 |
0.398 |
|
| 2001 |
Vedejs E, Klapars A, Warner DL, Weiss AH. Reductive deprotection of N-tritylaziridines. The Journal of Organic Chemistry. 66: 7542-6. PMID 11681978 DOI: 10.1021/jo0106243 |
0.64 |
|
| 2000 |
Vedejs E, Klapars A, Naidu BN, Piotrowski DW, Tucci FC. Enantiocontrolled synthesis of (1S,2S)-6-desmethyl- (methylaziridino)mitosene [8] Journal of the American Chemical Society. 122: 5401-5402. DOI: 10.1021/ja994504c |
0.443 |
|
| 1996 |
Vedejs E, Lin S, Klapars A, Wang J. Heteroarene-2-sulfonyl chlorides (BtsCl; ThsCl): Reagents for nitrogen protection of >99% racemization-free phenylglycine activation with SOCl2 Journal of the American Chemical Society. 118: 9796-9797. DOI: 10.1021/Ja961485N |
0.494 |
|
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