Ana Garcia-Osta - Publications

Affiliations: 
CIMA, Pamplona, Pamplona, Navarra, Spain 

37 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Pérez-González M, Mendioroz M, Badesso S, Sucunza D, Roldan M, Espelosín M, Ursua S, Luján R, Cuadrado-Tejedor M, Garcia-Osta A. PLA2G4E, a candidate gene for resilience in Alzheimer´s disease and a new target for dementia treatment. Progress in Neurobiology. 101818. PMID 32380223 DOI: 10.1016/j.pneurobio.2020.101818  0.56
2019 Rabal O, Sánchez-Arias JA, Cuadrado-Tejedor M, De Miguel I, Pérez-González M, García-Barroso C, Ugarte A, Estella-Hermoso de Mendoza A, Sáez E, Espelosin M, Ursua S, Tan H, Wu W, Xu M, Pineda-Lucena A, ... Garcia-Osta A, et al. Multitarget Approach for the Treatment of Alzheimer`s Disease: Inhibition of Phosphodiesterase 9 (PDE9) and Histone Deacetylases (HDACs) covering diverse selectivity profiles. Acs Chemical Neuroscience. PMID 31441641 DOI: 10.1021/acschemneuro.9b00303  0.56
2019 Cuadrado-Tejedor M, Pérez-González M, García-Muñoz C, Muruzabal D, García-Barroso C, Rabal O, Segura V, Sánchez-Arias JA, Oyarzabal J, Garcia-Osta A. Taking Advantage of the Selectivity of Histone Deacetylases and Phosphodiesterase Inhibitors to Design Better Therapeutic Strategies to Treat Alzheimer's Disease. Frontiers in Aging Neuroscience. 11: 149. PMID 31281249 DOI: 10.3389/fnagi.2019.00149  0.56
2018 Rabal O, Sánchez-Arias JA, Cuadrado-Tejedor M, De Miguel I, Pérez-González M, García-Barroso C, Ugarte A, Estella A, Sáez E, Espelosin M, Ursua S, Tan H, Wu W, Xu M, Garcia-Osta A, et al. Discovery of in-vivo chemical probes for treating Alzheimer´s disease: Dual phosphodiesterase 5 (PDE5) and class I histone deacetylases-selective inhibitors. Acs Chemical Neuroscience. PMID 30525452 DOI: 10.1021/acschemneuro.8b00648  0.56
2018 Rabal O, Sánchez-Arias JA, Cuadrado-Tejedor M, de Miguel I, Pérez-González M, García-Barroso C, Ugarte A, Estella-Hermoso de Mendoza A, Sáez E, Espelosin M, Ursua S, Haizhong T, Wei W, Musheng X, Garcia-Osta A, et al. Design, synthesis, biological evaluation and in vivo testing of dual phosphodiesterase 5 (PDE5) and histone deacetylase 6 (HDAC6)-selective inhibitors for the treatment of Alzheimer's disease. European Journal of Medicinal Chemistry. 150: 506-524. PMID 29549837 DOI: 10.1016/j.ejmech.2018.03.005  0.56
2016 Sánchez-Arias JA, Rabal O, Cuadrado-Tejedor M, De Miguel I, Pérez-González M, Ugarte A, Sáez E, Espelosin M, Ursua S, Haizhong T, Wei W, Musheng X, Garcia-Osta A, Oyarzabal J. Impact of scaffold exploration on novel dual-acting histone deacetylases (HDACs) and phosphodiesterase 5 (PDE5) inhibitors for the treatment of Alzheimer's Disease. Acs Chemical Neuroscience. PMID 27936591 DOI: 10.1021/acschemneuro.6b00370  0.56
2016 Rabal O, Sánchez-Arias JA, Cuadrado-Tejedor M, De Miguel I, Pérez-González M, García-Barroso C, Ugarte A, Estella-Hermoso de Mendoza A, Sáez E, Espelosin M, Ursua S, Haizhong T, Wei W, Musheng X, Garcia-Osta A, et al. Design, synthesis, and biological evaluation of first-in-class dual acting histone deacetylases (HDACs) and phosphodiesterase 5 (PDE5) inhibitors for the treatment of Alzheimer's disease. Journal of Medicinal Chemistry. PMID 27606546 DOI: 10.1021/acs.jmedchem.6b00908  0.56
2016 Cuadrado-Tejedor M, Garcia-Barroso C, Sánchez-Arias JA, Rabal O, Pérez-González M, Mederos S, Ugarte A, Franco R, Segura V, Perea G, Oyarzabal J, Garcia-Osta A. A First-in-Class Small-Molecule that Acts as a Dual Inhibitor of HDAC and PDE5, and that Rescues Hippocampal Synaptic Impairment in Alzheimer's Disease Mice. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 27550730 DOI: 10.1038/npp.2016.163  0.56
2016 Cuadrado-Tejedor M, García-Osta A. Chronic Mild Stress Assay Leading to Early Onset and Propagation of Alzheimer's Disease Phenotype in Mouse Models. Methods in Molecular Biology (Clifton, N.J.). 1303: 241-6. PMID 26235071 DOI: 10.1007/978-1-4939-2627-5_14  0.56
2016 García-Osta A, Cuadrado-Tejedor M. Advanced Assay Monitoring APP-Carboxyl-Terminal Fragments as Markers of APP Processing in Alzheimer Disease Mouse Models. Methods in Molecular Biology (Clifton, N.J.). 1303: 117-23. PMID 26235062 DOI: 10.1007/978-1-4939-2627-5_5  0.56
2015 Peixoto CA, Nunes AK, Garcia-Osta A. Phosphodiesterase-5 Inhibitors: Action on the Signaling Pathways of Neuroinflammation, Neurodegeneration, and Cognition. Mediators of Inflammation. 2015: 940207. PMID 26770022 DOI: 10.1155/2015/940207  1
2015 Gómez-Vallejo V, Ugarte A, García-Barroso C, Cuadrado-Tejedor M, Szczupak B, Dopeso-Reyes IG, Lanciego JL, García-Osta A, Llop J, Oyarzabal J, Franco R. Pharmacokinetic investigation of sildenafil using positron emission tomography and determination of its effect on cerebrospinal fluid cGMP levels. Journal of Neurochemistry. PMID 26641206 DOI: 10.1111/jnc.13454  0.56
2015 Cuadrado-Tejedor M, Garcia-Barroso C, Sanzhez-Arias J, Mederos S, Rabal O, Ugarte A, Franco R, Pascual-Lucas M, Segura V, Perea G, Oyarzabal J, Garcia-Osta A. Concomitant histone deacetylase and phosphodiesterase 5 inhibition synergistically prevents the disruption in synaptic plasticity and it reverses cognitive impairment in a mouse model of Alzheimer's disease. Clinical Epigenetics. 7: 108. PMID 26457123 DOI: 10.1186/s13148-015-0142-9  1
2015 Ugarte A, Gil-Bea F, García-Barroso C, Cedazo-Minguez Á, Ramírez MJ, Franco R, García-Osta A, Oyarzabal J, Cuadrado-Tejedor M. Decreased levels of guanosine 3', 5'-monophosphate (cGMP) in cerebrospinal fluid (CSF) are associated with cognitive decline and amyloid pathology in Alzheimer's disease. Neuropathology and Applied Neurobiology. 41: 471-82. PMID 25488891 DOI: 10.1111/nan.12203  0.56
2014 Cuadrado-Tejedor M, García-Osta A. Current animal models of Alzheimer's disease: challenges in translational research. Frontiers in Neurology. 5: 182. PMID 25324824 DOI: 10.3389/fneur.2014.00182  0.56
2014 García-Barroso C, Ugarte A, Martínez M, Rico AJ, Lanciego JL, Franco R, Oyarzabal J, Cuadrado-Tejedor M, García-Osta A. Phosphodiesterase inhibition in cognitive decline. Journal of Alzheimer's Disease : Jad. 42: S561-73. PMID 25125473 DOI: 10.3233/JAD-141341  0.56
2014 Pascual-Lucas M, Viana da Silva S, Di Scala M, Garcia-Barroso C, González-Aseguinolaza G, Mulle C, Alberini CM, Cuadrado-Tejedor M, Garcia-Osta A. Insulin-like growth factor 2 reverses memory and synaptic deficits in APP transgenic mice. Embo Molecular Medicine. 6: 1246-62. PMID 25100745 DOI: 10.15252/emmm.201404228  1
2014 Gaja V, Gómez-Vallejo V, Puigivila M, Pérez-Campaña C, Martin A, García-Osta A, Calvo-Fernández T, Cuadrado-Tejedor M, Franco R, Llop J. Synthesis and evaluation of (13)N-labelled azo compounds for β-amyloid imaging in mice. Molecular Imaging and Biology : Mib : the Official Publication of the Academy of Molecular Imaging. 16: 538-49. PMID 24310721 DOI: 10.1007/s11307-013-0708-x  0.56
2013 Cuadrado-Tejedor M, Oyarzabal J, Lucas MP, Franco R, García-Osta A. Epigenetic drugs in Alzheimer's disease. Biomolecular Concepts. 4: 433-45. PMID 25436752 DOI: 10.1515/bmc-2013-0012  0.56
2013 Cuadrado-Tejedor M, Ricobaraza AL, Torrijo R, Franco R, Garcia-Osta A. Phenylbutyrate is a multifaceted drug that exerts neuroprotective effects and reverses the Alzheimer´s disease-like phenotype of a commonly used mouse model. Current Pharmaceutical Design. 19: 5076-84. PMID 23448463 DOI: 10.2174/1381612811319280006  1
2013 García-Barroso C, Ricobaraza A, Pascual-Lucas M, Unceta N, Rico AJ, Goicolea MA, Sallés J, Lanciego JL, Oyarzabal J, Franco R, Cuadrado-Tejedor M, García-Osta A. Tadalafil crosses the blood-brain barrier and reverses cognitive dysfunction in a mouse model of AD. Neuropharmacology. 64: 114-23. PMID 22776546 DOI: 10.1016/j.neuropharm.2012.06.052  0.56
2012 García-Osta A, Cuadrado-Tejedor M, García-Barroso C, Oyarzábal J, Franco R. Phosphodiesterases as therapeutic targets for Alzheimer's disease. Acs Chemical Neuroscience. 3: 832-44. PMID 23173065 DOI: 10.1021/cn3000907  0.56
2012 Cuadrado-Tejedor M, Ricobaraza A, Frechilla D, Franco R, Pérez-Mediavilla A, Garcia-Osta A. Chronic mild stress accelerates the onset and progression of the Alzheimer's disease phenotype in Tg2576 mice. Journal of Alzheimer's Disease : Jad. 28: 567-78. PMID 22045482 DOI: 10.3233/JAD-2011-110572  1
2012 Ricobaraza A, Cuadrado-Tejedor M, Marco S, Pérez-Otaño I, García-Osta A. Phenylbutyrate rescues dendritic spine loss associated with memory deficits in a mouse model of Alzheimer disease. Hippocampus. 22: 1040-50. PMID 21069780 DOI: 10.1002/hipo.20883  0.56
2011 Cuadrado-Tejedor M, García-Osta A, Ricobaraza A, Oyarzabal J, Franco R. Defining the mechanism of action of 4-phenylbutyrate to develop a small-molecule-based therapy for Alzheimer's disease. Current Medicinal Chemistry. 18: 5545-53. PMID 22172064  0.56
2011 Cuadrado-Tejedor M, Hervias I, Ricobaraza A, Puerta E, Pérez-Roldán JM, García-Barroso C, Franco R, Aguirre N, García-Osta A. Sildenafil restores cognitive function without affecting β-amyloid burden in a mouse model of Alzheimer's disease. British Journal of Pharmacology. 164: 2029-41. PMID 21627640 DOI: 10.1111/j.1476-5381.2011.01517.x  1
2011 Ricobaraza A, Cuadrado-Tejedor M, Garcia-Osta A. Long-term phenylbutyrate administration prevents memory deficits in Tg2576 mice by decreasing Abeta. Frontiers in Bioscience (Elite Edition). 3: 1375-84. PMID 21622143  1
2011 Chen DY, Stern SA, Garcia-Osta A, Saunier-Rebori B, Pollonini G, Bambah-Mukku D, Blitzer RD, Alberini CM. A critical role for IGF-II in memory consolidation and enhancement. Nature. 469: 491-7. PMID 21270887 DOI: 10.1038/nature09667  1
2011 Cuadrado-Tejedor M, Ricobaraza A, Del Río J, Frechilla D, Franco R, Pérez-Mediavilla A, Garcia-Osta A. Chronic mild stress in mice promotes cognitive impairment and CDK5-dependent tau hyperphosphorylation. Behavioural Brain Research. 220: 338-43. PMID 21238494 DOI: 10.1016/j.bbr.2011.01.005  1
2011 Okvist A, Fagergren P, Whittard J, Garcia-Osta A, Drakenberg K, Horvath MC, Schmidt CJ, Keller E, Bannon MJ, Hurd YL. Dysregulated postsynaptic density and endocytic zone in the amygdala of human heroin and cocaine abusers. Biological Psychiatry. 69: 245-52. PMID 21126734 DOI: 10.1016/j.biopsych.2010.09.037  1
2010 Taubenfeld SM, Muravieva EV, Garcia-Osta A, Alberini CM. Disrupting the memory of places induced by drugs of abuse weakens motivational withdrawal in a context-dependent manner. Proceedings of the National Academy of Sciences of the United States of America. 107: 12345-50. PMID 20566855 DOI: 10.1073/pnas.1003152107  1
2010 Escribano L, Simón AM, Gimeno E, Cuadrado-Tejedor M, López de Maturana R, García-Osta A, Ricobaraza A, Pérez-Mediavilla A, Del Río J, Frechilla D. Rosiglitazone rescues memory impairment in Alzheimer's transgenic mice: mechanisms involving a reduced amyloid and tau pathology. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 35: 1593-604. PMID 20336061 DOI: 10.1038/npp.2010.32  0.56
2010 Puerta E, Hervias I, Barros-Miñones L, Jordan J, Ricobaraza A, Cuadrado-Tejedor M, García-Osta A, Aguirre N. Sildenafil protects against 3-nitropropionic acid neurotoxicity through the modulation of calpain, CREB, and BDNF. Neurobiology of Disease. 38: 237-45. PMID 20109548 DOI: 10.1016/j.nbd.2010.01.013  1
2009 Garcia-Osta A, Alberini CM. Amyloid beta mediates memory formation. Learning & Memory (Cold Spring Harbor, N.Y.). 16: 267-72. PMID 19318468 DOI: 10.1101/lm.1310209  1
2009 Ricobaraza A, Cuadrado-Tejedor M, Pérez-Mediavilla A, Frechilla D, Del Río J, García-Osta A. Phenylbutyrate ameliorates cognitive deficit and reduces tau pathology in an Alzheimer's disease mouse model. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 34: 1721-32. PMID 19145227 DOI: 10.1038/npp.2008.229  0.56
2006 Garcia-Osta A, Tsokas P, Pollonini G, Landau EM, Blitzer R, Alberini CM. MuSK expressed in the brain mediates cholinergic responses, synaptic plasticity, and memory formation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 7919-32. PMID 16870737 DOI: 10.1523/JNEUROSCI.1674-06.2006  1
1997 Aguirre N, Frechilla D, García-Osta A, Lasheras B, Del Río J. Differential regulation by methylenedioxymethamphetamine of 5-hydroxytryptamine1A receptor density and mRNA expression in rat hippocampus, frontal cortex, and brainstem: the role of corticosteroids. Journal of Neurochemistry. 68: 1099-105. PMID 9048755  1
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