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Jonathan R. LaRochelle, Ph.D. - Publications

Affiliations: 
2014 Molecular, Cellular & Developmental Biology Yale University, New Haven, CT 
 2014- Biological Chemistry & Molecular Pharmacology Harvard University, Cambridge, MA, United States 
Area:
protein–protein and protein-small molecule interactions
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14 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Vemulapalli V, Chylek LA, Erickson A, Pfeiffer A, Gabriel KH, LaRochelle J, Subramanian K, Cao R, Stegmaier K, Mohseni M, LaMarche MJ, Acker MG, Sorger PK, Gygi SP, Blacklow SC. Time resolved phosphoproteomics reveals scaffolding and catalysis-responsive patterns of SHP2-dependent signaling. Elife. 10. PMID 33755016 DOI: 10.7554/eLife.64251  0.601
2019 Steinauer A, LaRochelle JR, Knox SL, Wissner RF, Berry S, Schepartz A. HOPS-dependent endosomal fusion required for efficient cytosolic delivery of therapeutic peptides and small proteins. Proceedings of the National Academy of Sciences of the United States of America. 116: 512-521. PMID 30610181 DOI: 10.1073/Pnas.1812044116  0.685
2018 LaRochelle JR, Fodor M, Vemulapalli V, Mohseni M, Wang P, Stams T, LaMarche MJ, Chopra R, Acker MG, Blacklow SC. Structural reorganization of SHP2 by oncogenic mutations and implications for oncoprotein resistance to allosteric inhibition. Nature Communications. 9: 4508. PMID 30375388 DOI: 10.1038/s41467-018-06823-9  0.57
2018 Fodor M, Price E, Wang P, Lu H, Argintaru A, Chen Z, Glick M, Hao HX, Kato M, Koenig R, LaRochelle JR, Liu G, McNeill E, Majumdar D, Nishiguchi GA, et al. Dual Allosteric Inhibition of SHP2 Phosphatase. Acs Chemical Biology. PMID 29304282 DOI: 10.1021/Acschembio.7B00980  0.609
2017 Quach K, LaRochelle J, Li XH, Rhoades E, Schepartz A. Unique arginine array improves cytosolic localization of hydrocarbon-stapled peptides. Bioorganic & Medicinal Chemistry. PMID 29150077 DOI: 10.1016/J.Bmc.2017.11.008  0.623
2017 LaRochelle JR, Fodor M, Ellegast JM, Liu X, Vemulapalli V, Mohseni M, Stams T, Buhrlage SJ, Stegmaier K, LaMarche MJ, Acker MG, Blacklow SC. Identification of an allosteric benzothiazolopyrimidone inhibitor of the oncogenic protein tyrosine phosphatase SHP2. Bioorganic & Medicinal Chemistry. PMID 29089257 DOI: 10.1016/J.Bmc.2017.10.025  0.634
2017 Acker MG, Chen YP, LaMarche MJ, Chan HM, Fekkes P, Garcia-Fortanet J, LaRochelle JR, Antonakos B, Chen CH, Chen Z, Cooke VG, Dobson JR, Deng Z, Feng F, Firestone B, et al. Abstract 2084: Conformational activation and allosteric inhibition of SHP2 in RTK-driven cancers Cancer Research. 77: 2084-2084. DOI: 10.1158/1538-7445.Am2017-2084  0.582
2016 LaRochelle JR, Fodor M, Xu X, Durzynska I, Fan L, Stams T, Chan H, LaMarche MJ, Chopra R, Wang P, Fortin PD, Acker MG, Blacklow SC. Structural and Functional Consequences of Three Cancer-Associated Mutations of the Oncogenic Phosphatase SHP2. Biochemistry. PMID 27030275 DOI: 10.1021/Acs.Biochem.5B01287  0.559
2015 Li M, Tao Y, Shu Y, LaRochelle JR, Steinauer A, Thompson D, Schepartz A, Chen ZY, Liu DR. Discovery and characterization of a peptide that enhances endosomal escape of delivered proteins in vitro and in vivo. Journal of the American Chemical Society. PMID 26465072 DOI: 10.1021/Jacs.5B05694  0.671
2015 LaRochelle JR, Cobb GB, Steinauer A, Rhoades E, Schepartz A. Fluorescence correlation spectroscopy reveals highly efficient cytosolic delivery of certain penta-arg proteins and stapled peptides. Journal of the American Chemical Society. 137: 2536-41. PMID 25679876 DOI: 10.1021/Ja510391N  0.613
2014 Qian Z, LaRochelle JR, Jiang B, Lian W, Hard RL, Selner NG, Luechapanichkul R, Barrios AM, Pei D. Early endosomal escape of a cyclic cell-penetrating peptide allows effective cytosolic cargo delivery. Biochemistry. 53: 4034-46. PMID 24896852 DOI: 10.1021/Bi5004102  0.44
2013 Holub JM, Larochelle JR, Appelbaum JS, Schepartz A. Improved assays for determining the cytosolic access of peptides, proteins, and their mimetics. Biochemistry. 52: 9036-46. PMID 24256505 DOI: 10.1021/Bi401069G  0.695
2012 Appelbaum JS, LaRochelle JR, Smith BA, Balkin DM, Holub JM, Schepartz A. Arginine topology controls escape of minimally cationic proteins from early endosomes to the cytoplasm. Chemistry & Biology. 19: 819-30. PMID 22840770 DOI: 10.1016/J.Chembiol.2012.05.022  0.658
2009 Sheftic SR, Croke RL, LaRochelle JR, Alexandrescu AT. Electrostatic contributions to the stabilities of native proteins and amyloid complexes. Methods in Enzymology. 466: 233-58. PMID 21609864 DOI: 10.1016/S0076-6879(09)66010-9  0.404
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