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Alexandre J. Buckmelter, Ph.D. - Publications

Affiliations: 
2000 University of California, Irvine, Irvine, CA 
Area:
Organic Chemistry, Synthesis and Structure Determination
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17 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Zak M, Liederer BM, Sampath D, Yuen PW, Bair KW, Baumeister T, Buckmelter AJ, Clodfelter KH, Cheng E, Crocker L, Fu B, Han B, Li G, Ho YC, Lin J, et al. Identification of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with no evidence of CYP3A4 time-dependent inhibition and improved aqueous solubility. Bioorganic & Medicinal Chemistry Letters. 25: 529-41. PMID 25556090 DOI: 10.1016/J.Bmcl.2014.12.026  0.35
2014 Zheng X, Baumeister T, Buckmelter AJ, Caligiuri M, Clodfelter KH, Han B, Ho YC, Kley N, Lin J, Reynolds DJ, Sharma G, Smith CC, Wang Z, Dragovich PS, Oh A, et al. Discovery of potent and efficacious cyanoguanidine-containing nicotinamide phosphoribosyltransferase (Nampt) inhibitors. Bioorganic & Medicinal Chemistry Letters. 24: 337-43. PMID 24279990 DOI: 10.1016/J.Bmcl.2013.11.006  0.322
2013 Newhouse BJ, Wenglowsky S, Grina J, Laird ER, Voegtli WC, Ren L, Ahrendt K, Buckmelter A, Gloor SL, Klopfenstein N, Rudolph J, Wen Z, Li X, Feng B. Imidazo[4,5-b]pyridine inhibitors of B-Raf kinase. Bioorganic & Medicinal Chemistry Letters. 23: 5896-9. PMID 24042006 DOI: 10.1016/J.Bmcl.2013.08.086  0.316
2013 Zheng X, Bair KW, Bauer P, Baumeister T, Bowman KK, Buckmelter AJ, Caligiuri M, Clodfelter KH, Feng Y, Han B, Ho YC, Kley N, Li H, Liang X, Liederer BM, et al. Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). Bioorganic & Medicinal Chemistry Letters. 23: 5488-97. PMID 24021463 DOI: 10.1016/J.Bmcl.2013.08.074  0.353
2013 Zheng X, Bauer P, Baumeister T, Buckmelter AJ, Caligiuri M, Clodfelter KH, Han B, Ho YC, Kley N, Lin J, Reynolds DJ, Sharma G, Smith CC, Wang Z, Dragovich PS, et al. Structure-based discovery of novel amide-containing nicotinamide phosphoribosyltransferase (nampt) inhibitors. Journal of Medicinal Chemistry. 56: 6413-33. PMID 23859118 DOI: 10.1021/Jm4008664  0.342
2013 Gunzner-Toste J, Zhao G, Bauer P, Baumeister T, Buckmelter AJ, Caligiuri M, Clodfelter KH, Fu B, Han B, Ho YC, Kley N, Liang X, Liederer BM, Lin J, Mukadam S, et al. Discovery of potent and efficacious urea-containing nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with reduced CYP2C9 inhibition properties. Bioorganic & Medicinal Chemistry Letters. 23: 3531-8. PMID 23668988 DOI: 10.1016/J.Bmcl.2013.04.040  0.338
2013 Zheng X, Bauer P, Baumeister T, Buckmelter AJ, Caligiuri M, Clodfelter KH, Han B, Ho YC, Kley N, Lin J, Reynolds DJ, Sharma G, Smith CC, Wang Z, Dragovich PS, et al. Structure-based identification of ureas as novel nicotinamide phosphoribosyltransferase (Nampt) inhibitors. Journal of Medicinal Chemistry. 56: 4921-37. PMID 23617784 DOI: 10.1021/Jm400186H  0.33
2012 Ren L, Ahrendt KA, Grina J, Laird ER, Buckmelter AJ, Hansen JD, Newhouse B, Moreno D, Wenglowsky S, Dinkel V, Gloor SL, Hastings G, Rana S, Rasor K, Risom T, et al. The discovery of potent and selective pyridopyrimidin-7-one based inhibitors of B-RafV600E kinase. Bioorganic & Medicinal Chemistry Letters. 22: 3387-91. PMID 22534450 DOI: 10.1016/J.Bmcl.2012.04.015  0.327
2012 Mathieu S, Gradl SN, Ren L, Wen Z, Aliagas I, Gunzner-Toste J, Lee W, Pulk R, Zhao G, Alicke B, Boggs JW, Buckmelter AJ, Choo EF, Dinkel V, Gloor SL, et al. Potent and selective aminopyrimidine-based B-Raf inhibitors with favorable physicochemical and pharmacokinetic properties. Journal of Medicinal Chemistry. 55: 2869-81. PMID 22335519 DOI: 10.1021/Jm300016V  0.363
2012 Ren L, Laird ER, Buckmelter AJ, Dinkel V, Gloor SL, Grina J, Newhouse B, Rasor K, Hastings G, Gradl SN, Rudolph J. Potent and selective pyrazolo[1,5-a]pyrimidine based inhibitors of B-Raf V600E kinase with favorable physicochemical and pharmacokinetic properties Bioorganic and Medicinal Chemistry Letters. 22: 1165-1168. PMID 22196124 DOI: 10.1016/J.Bmcl.2011.11.092  0.332
2011 Wenglowsky S, Ahrendt KA, Buckmelter AJ, Feng B, Gloor SL, Gradl S, Grina J, Hansen JD, Laird ER, Lunghofer P, Mathieu S, Moreno D, Newhouse B, Ren L, Risom T, et al. Pyrazolopyridine inhibitors of B-RafV600E. Part 2: structure-activity relationships. Bioorganic & Medicinal Chemistry Letters. 21: 5533-7. PMID 21802293 DOI: 10.1016/J.Bmcl.2011.06.097  0.331
2011 Buckmelter AJ, Ren L, Laird ER, Rast B, Miknis G, Wenglowsky S, Schlachter S, Welch M, Tarlton E, Grina J, Lyssikatos J, Brandhuber BJ, Morales T, Randolph N, Vigers G, et al. The discovery of furo[2,3-c]pyridine-based indanone oximes as potent and selective B-Raf inhibitors. Bioorganic & Medicinal Chemistry Letters. 21: 1248-52. PMID 21211972 DOI: 10.1016/J.Bmcl.2010.12.039  0.323
2005 Takaoka LR, Buckmelter AJ, LaCruz TE, Rychnovsky SD. Rational synthesis of contra-thermodynamic spiroacetals by reductive cyclizations. Journal of the American Chemical Society. 127: 528-9. PMID 15643869 DOI: 10.1021/Ja044642O  0.47
2001 Rychnovsky SD, Hata T, Kim AI, Buckmelter AJ. Use of a conformational radical clock for evaluating alkyllithium-mediated cyclization reactions. Organic Letters. 3: 807-10. PMID 11263887 DOI: 10.1021/Ol006866R  0.633
2000 Buckmelter AJ, Kim AI, Rychnovsky SD. Conformational memory in enantioselective radical reductions and a new radical clock reaction Journal of the American Chemical Society. 122: 9386-9390. DOI: 10.1021/Ja002068K  0.544
1999 Rychnovsky SD, Buckmelter AJ, Dahanukar VH, Skalitzky DJ. Synthesis, Equilibration, and Coupling of 4-Lithio-1,3-dioxanes: Synthons for syn- and anti-1,3-Diols. The Journal of Organic Chemistry. 64: 6849-6860. PMID 11674695 DOI: 10.1021/Jo9909352  0.566
1999 Buckmelter AJ, Powers JP, Rychnovsky SD, Christen DP, Curran DP. Nonequilibrium radical reductions Chemtracts. 12: 635-638. DOI: 10.1021/Ja980857K  0.53
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