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Andrew J. Souers, Ph.D. - Publications

Affiliations: 
2001 University of California, Berkeley, Berkeley, CA, United States 
Area:
chemical synthesis
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31 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Bruncko M, Wang L, Sheppard GS, Phillips DC, Tahir SK, Xue J, Erickson S, Fidanze S, Fry E, Hasvold L, Jenkins GJ, Jin S, Judge RA, Kovar PJ, Madar D, ... ... Souers AJ, et al. Correction to Structure-Guided Design of a Series of MCL-1 Inhibitors with High Affinity and Selectivity. Journal of Medicinal Chemistry. 58: 4089. PMID 25933255 DOI: 10.1021/Acs.Jmedchem.5B00616  0.308
2014 Petros AM, Swann SL, Song D, Swinger K, Park C, Zhang H, Wendt MD, Kunzer AR, Souers AJ, Sun C. Fragment-based discovery of potent inhibitors of the anti-apoptotic MCL-1 protein. Bioorganic & Medicinal Chemistry Letters. 24: 1484-8. PMID 24582986 DOI: 10.1016/J.Bmcl.2014.02.010  0.327
2012 Yeh VS, Beno DW, Brodjian S, Brune ME, Cullen SC, Dayton BD, Dhaon MK, Falls HD, Gao J, Grihalde N, Hajduk P, Hansen TM, Judd AS, King AJ, Klix RC, ... ... Souers AJ, et al. Identification and preliminary characterization of a potent, safe, and orally efficacious inhibitor of acyl-CoA:diacylglycerol acyltransferase 1. Journal of Medicinal Chemistry. 55: 1751-7. PMID 22263872 DOI: 10.1021/Jm201524G  0.328
2010 Ravn MM, Wagaw SH, Engstrom KM, Mei J, Kotecki B, Souers AJ, Kym PR, Judd AS, Zhao G. Process development of a diacyl glycerolacyltransferase-1 inhibitor Organic Process Research and Development. 14: 417-424. DOI: 10.1021/Op900310V  0.342
2008 Judd AS, Souers AJ, Kym PR. Lead optimization of melanin concentrating hormone receptor 1 antagonists with low hERG channel activity. Current Topics in Medicinal Chemistry. 8: 1152-7. PMID 18782010 DOI: 10.2174/156802608785700052  0.345
2008 Zhao G, Souers AJ, Voorbach M, Falls HD, Droz B, Brodjian S, Lau YY, Iyengar RR, Gao J, Judd AS, Wagaw SH, Ravn MM, Engstrom KM, Lynch JK, Mulhern MM, et al. Validation of diacyl glycerolacyltransferase I as a novel target for the treatment of obesity and dyslipidemia using a potent and selective small molecule inhibitor. Journal of Medicinal Chemistry. 51: 380-3. PMID 18183944 DOI: 10.1021/Jm7013887  0.308
2007 Kym PR, Judd AS, Lynch JK, Iyengar R, Vasudevan A, Souers AJ. Lead optimization strategies and tactics applied to the discovery of melanin concentrating hormone receptor 1 antagonists. Current Topics in Medicinal Chemistry. 7: 1471-88. PMID 17897033 DOI: 10.2174/156802607782194699  0.373
2007 Judd AS, Souers AJ, Wodka D, Zhao G, Mulhern MM, Iyengar RR, Gao J, Lynch JK, Freeman JC, Falls HD, Brodjian S, Dayton BD, Reilly RM, Gintant G, Limberis JT, et al. Identification of diamino chromone-2-carboxamides as MCHr1 antagonists with minimal hERG channel activity. Bioorganic & Medicinal Chemistry Letters. 17: 2365-71. PMID 17350253 DOI: 10.1016/J.Bmcl.2006.11.068  0.322
2007 Iyengar RR, Lynch JK, Mulhern MM, Judd AS, Freeman JC, Gao J, Souers AJ, Zhao G, Wodka D, Doug Falls H, Brodjian S, Dayton BD, Reilly RM, Swanson S, Su Z, et al. An evaluation of 3,4-methylenedioxy phenyl replacements in the aminopiperidine chromone class of MCHr1 antagonists. Bioorganic & Medicinal Chemistry Letters. 17: 874-8. PMID 17234405 DOI: 10.1016/J.Bmcl.2006.11.065  0.384
2007 Souers AJ, Iyengar RR, Judd AS, Beno DW, Gao J, Zhao G, Brune ME, Napier JJ, Mulhern MM, Lynch JK, Freeman JC, Wodka D, Chen CJ, Falls HD, Brodjian S, et al. Constrained 7-fluorocarboxychromone-4-aminopiperidine based Melanin-concentrating hormone receptor 1 antagonists: the effects of chirality on substituted indan-1-ylamines. Bioorganic & Medicinal Chemistry Letters. 17: 884-9. PMID 17188866 DOI: 10.1016/J.Bmcl.2006.11.061  0.403
2007 Gao J, Henry RF, Pagano TG, Duerst RW, Souers AJ. A cascade reaction sequence en route to 7-substituted 2-aminopyrrolo[1,2-a]pyrimidine-4,6-diones and the corresponding acrylic acid derivatives Tetrahedron Letters. 48: 7395-7398. DOI: 10.1016/J.Tetlet.2007.08.003  0.329
2006 Kym PR, Souers AJ, Campbell TJ, Lynch JK, Judd AS, Iyengar R, Vasudevan A, Gao J, Freeman JC, Wodka D, Mulhern M, Zhao G, Wagaw SH, Napier JJ, Brodjian S, et al. Screening for cardiovascular safety: a structure-activity approach for guiding lead selection of melanin concentrating hormone receptor 1 antagonists. Journal of Medicinal Chemistry. 49: 2339-52. PMID 16570930 DOI: 10.1021/Jm0512286  0.343
2005 Vasudevan A, Souers AJ, Freeman JC, Verzal MK, Gao J, Mulhern MM, Wodka D, Lynch JK, Engstrom KM, Wagaw SH, Brodjian S, Dayton B, Falls DH, Bush E, Brune M, et al. Aminopiperidine indazoles as orally efficacious melanin concentrating hormone receptor-1 antagonists. Bioorganic & Medicinal Chemistry Letters. 15: 5293-7. PMID 16203136 DOI: 10.1016/J.Bmcl.2005.08.049  0.389
2005 Kym PR, Iyengar R, Souers AJ, Lynch JK, Judd AS, Gao J, Freeman J, Mulhern M, Zhao G, Vasudevan A, Wodka D, Blackburn C, Brown J, Che JL, Cullis C, et al. Discovery and characterization of aminopiperidinecoumarin melanin concentrating hormone receptor 1 antagonists. Journal of Medicinal Chemistry. 48: 5888-91. PMID 16161992 DOI: 10.1021/Jm050598R  0.305
2005 Vasudevan A, LaMarche MJ, Blackburn C, Che JL, Luchaco-Cullis CA, Lai S, Marsilje TH, Patane MA, Souers AJ, Wodka D, Geddes B, Chen S, Brodjian S, Falls DH, Dayton BD, et al. Identification of ortho-amino benzamides and nicotinamides as MCHr1 antagonists. Bioorganic & Medicinal Chemistry Letters. 15: 4174-9. PMID 16085414 DOI: 10.1016/J.Bmcl.2005.06.089  0.347
2005 Vasudevan A, Verzal MK, Wodka D, Souers AJ, Blackburn C, Che JL, Lai S, Brodjian S, Falls DH, Dayton BD, Govek E, Daniels T, Geddes B, Marsh KC, Hernandez LE, et al. Identification of aminopiperidine benzamides as MCHr1 antagonists. Bioorganic & Medicinal Chemistry Letters. 15: 3412-6. PMID 15950463 DOI: 10.1016/J.Bmcl.2005.05.023  0.336
2005 Souers AJ, Gao J, Wodka D, Judd AS, Mulhern MM, Napier JJ, Brune ME, Bush EN, Brodjian SJ, Dayton BD, Shapiro R, Hernandez LE, Marsh KC, Sham HL, Collins CA, et al. Synthesis and evaluation of urea-based indazoles as melanin-concentrating hormone receptor 1 antagonists for the treatment of obesity. Bioorganic & Medicinal Chemistry Letters. 15: 2752-7. PMID 15911251 DOI: 10.1016/J.Bmcl.2005.03.114  0.391
2005 Souers AJ, Gao J, Brune M, Bush E, Wodka D, Vasudevan A, Judd AS, Mulhern M, Brodjian S, Dayton B, Shapiro R, Hernandez LE, Marsh KC, Sham HL, Collins CA, et al. Identification of 2-(4-benzyloxyphenyl)-N- [1-(2-pyrrolidin-1-yl-ethyl)-1H-indazol-6-yl]acetamide, an orally efficacious melanin-concentrating hormone receptor 1 antagonist for the treatment of obesity. Journal of Medicinal Chemistry. 48: 1318-21. PMID 15743174 DOI: 10.1021/Jm0490890  0.388
2004 Souers AJ, Wodka D, Gao J, Lewis JC, Vasudevan A, Brodjian S, Dayton B, Ogiela CA, Fry D, Hernandez LE, Marsh KC, Collins CA, Kym PR. Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 3. Bioorganic & Medicinal Chemistry Letters. 14: 4883-6. PMID 15341944 DOI: 10.1016/J.Bmcl.2004.07.035  0.58
2004 Vasudevan A, Wodka D, Verzal MK, Souers AJ, Gao J, Brodjian S, Fry D, Dayton B, Marsh KC, Hernandez LE, Ogiela CA, Collins CA, Kym PR. Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 2. Bioorganic & Medicinal Chemistry Letters. 14: 4879-82. PMID 15341943 DOI: 10.1016/J.Bmcl.2004.07.034  0.43
2004 Souers AJ, Wodka D, Gao J, Lewis JC, Vasudevan A, Gentles R, Brodjian S, Dayton B, Ogiela CA, Fry D, Hernandez LE, Marsh KC, Collins CA, Kym PR. Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 1. Bioorganic & Medicinal Chemistry Letters. 14: 4873-7. PMID 15341942 DOI: 10.1016/J.Bmcl.2004.07.032  0.583
2003 Tan KL, Vasudevan A, Bergman RG, Ellman JA, Souers AJ. Microwave-assisted C-H bond activation: a rapid entry into functionalized heterocycles. Organic Letters. 5: 2131-4. PMID 12790546 DOI: 10.1021/Ol030050J  0.477
2003 Owens TD, Souers AJ, Ellman JA. The preparation and utility of bis(sulfinyl)imidoamidine ligands for the copper-catalyzed Diels-Alder reaction. The Journal of Organic Chemistry. 68: 3-10. PMID 12515453 DOI: 10.1021/Jo020524C  0.672
2001 Souers AJ, Owens TD, Oliver AG, Hollander FJ, Ellman JA. Synthesis and crystal structure of a unique and homochiral N,S-bonded N,N'-bis(tert-butanesulfinyl)amidinate rhodium(I) complex. Inorganic Chemistry. 40: 5299-301. PMID 11559098 DOI: 10.1021/Ic0104205  0.658
2001 Souers AJ, Ellman JA. β-Turn mimetic library synthesis: Scaffolds and applications Tetrahedron. 57: 7431-7448. DOI: 10.1016/S0040-4020(01)00680-9  0.472
2000 Souers AJ, Rosenquist A, Jarvie EM, Ladlow M, Feniuk W, Ellman JA. Optimization of a somatostatin mimetic via constrained amino acid and backbone incorporation. Bioorganic & Medicinal Chemistry Letters. 10: 2731-3. PMID 11133079 DOI: 10.1016/S0960-894X(00)00552-7  0.553
2000 Souers AJ, Ellman JA. Asymmetric synthesis of a C-3 substituted pipecolic acid. The Journal of Organic Chemistry. 65: 1222-4. PMID 10814077 DOI: 10.1021/Jo991293L  0.496
1999 Haskell-Luevano C, Rosenquist A, Souers A, Khong KC, Ellman JA, Cone RD. Compounds that activate the mouse melanocortin-1 receptor identified by screening a small molecule library based upon the beta-turn. Journal of Medicinal Chemistry. 42: 4380-7. PMID 10543881 DOI: 10.1021/Jm990190S  0.529
1999 Souers AJ, Schürer S, Kwack H, Virgilio AA, Ellman JA. Preparation of Enantioenriched α-Bromo Acids Incorporating Diverse Functionality Synthesis. 1999: 583-585. DOI: 10.1055/S-1999-3427  0.467
1999 Souers AJ, Virgilio AA, Rosenquist Å, Fenuik W, Ellman JA. Identification of a potent heterocyclic ligand to somatostatin receptor subtype 5 by the synthesis and screening of β-turn mimetic libraries Journal of the American Chemical Society. 121: 1817-1825. DOI: 10.1021/Ja983742P  0.575
1998 Souers AJ, Virgilio AA, Schürer SS, Ellman JA, Kogan TP, West HE, Ankener W, Vanderslice P. Novel inhibitors of alpha 4 beta 1 integrin receptor interactions through library synthesis and screening. Bioorganic & Medicinal Chemistry Letters. 8: 2297-302. PMID 9873531 DOI: 10.1016/S0960-894X(98)00416-8  0.504
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