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Year Citation  Score
2023 Dhamne SC, Modi ME, Gray A, Bonazzi S, Craig L, Bainbridge E, Lalani L, Super CE, Schaeffer S, Capre K, Lubicka D, Liang G, Burdette D, McTighe SM, Gurnani S, ... ... Sahin M, et al. Seizure reduction in TSC2-mutant mouse model by an mTOR catalytic inhibitor. Annals of Clinical and Translational Neurology. PMID 37545094 DOI: 10.1002/acn3.51868  0.722
2022 Chopra M, Modi ME, Dies KA, Chamberlin NL, Buttermore ED, Brewster SJ, Prock L, Sahin M. GENE TARGET: A framework for evaluating Mendelian neurodevelopmental disorders for gene therapy. Molecular Therapy. Methods & Clinical Development. 27: 32-46. PMID 36156879 DOI: 10.1016/j.omtm.2022.08.007  0.699
2022 Davidson BL, Gao G, Berry-Kravis E, Bradbury A, Bönnemann C, Buxbaum JD, Corcoran GR, Gray SJ, Gray-Edwards H, Kleiman RJ, Shaywitz A, Wang D, Zoghbi HY, Flotte TR, Tauscher-Wisniewski S, ... ... Sahin M, et al. GENE-BASED THERAPEUTICS FOR RARE GENETIC NEURODEVELOPMENTAL PSYCHIATRIC DISORDERS. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 35585789 DOI: 10.1016/j.ymthe.2022.05.014  0.662
2021 Cable J, Purcell RH, Robinson E, Vorstman JAS, Chung WK, Constantino JN, Sanders SJ, Sahin M, Dolmetsch RE, Shah BM, Thurm A, Martin CL, Bearden CE, Mulle JG. Harnessing rare variants in neuropsychiatric and neurodevelopment disorders-a Keystone Symposia report. Annals of the New York Academy of Sciences. PMID 34342000 DOI: 10.1111/nyas.14658  0.605
2021 Mariscal MG, Berry-Kravis E, Buxbaum JD, Ethridge LE, Filip-Dhima R, Foss-Feig JH, Kolevzon A, Modi ME, Mosconi MW, Nelson CA, Powell CM, Siper PM, Soorya L, Thaliath A, Thurm A, ... ... Sahin M, et al. Shifted phase of EEG cross-frequency coupling in individuals with Phelan-McDermid syndrome. Molecular Autism. 12: 29. PMID 33910615 DOI: 10.1186/s13229-020-00411-9  0.694
2020 Di Nardo A, Lenoël I, Winden KD, Rühmkorf A, Modi ME, Barrett L, Ercan-Herbst E, Venugopal P, Behne R, Lopes CAM, Kleiman RJ, Bettencourt-Dias M, Sahin M. Phenotypic Screen with TSC-Deficient Neurons Reveals Heat-Shock Machinery as a Druggable Pathway for mTORC1 and Reduced Cilia. Cell Reports. 31: 107780. PMID 32579942 DOI: 10.1016/J.Celrep.2020.107780  0.738
2020 Sundberg M, Sahin M. Modeling Neurodevelopmental Deficits in Tuberous Sclerosis Complex with Stem Cell Derived Neural Precursors and Neurons. Advances in Neurobiology. 25: 1-31. PMID 32578142 DOI: 10.1007/978-3-030-45493-7_1  0.378
2020 Gonçalves IDCG, Brecht J, Thelen MP, Rehorst WA, Peters M, Lee HJ, Motameny S, Torres-Benito L, Ebrahimi-Fakhari D, Kononenko NL, Altmüller J, Vilchez D, Sahin M, Wirth B, Kye MJ. Author Correction: Neuronal activity regulates DROSHA via autophagy in spinal muscular atrophy. Scientific Reports. 10: 8206. PMID 32398663 DOI: 10.1038/s41598-020-64694-x  0.693
2020 Modi ME, Sahin M. Tau: A Novel Entry Point for mTOR-Based Treatments in Autism Spectrum Disorder? Neuron. 106: 359-361. PMID 32380047 DOI: 10.1016/J.Neuron.2020.04.019  0.731
2020 O'Brien AM, Bayet L, Riley K, Nelson CA, Sahin M, Modi ME. Auditory Processing of Speech and Tones in Children With Tuberous Sclerosis Complex. Frontiers in Integrative Neuroscience. 14: 14. PMID 32327979 DOI: 10.3389/Fnint.2020.00014  0.692
2020 Uysal SP, Sahin M. Tuberous Sclerosis Complex: A review of the past, present and future. Turkish Journal of Medical Sciences. PMID 32222129 DOI: 10.3906/Sag-2002-133  0.346
2020 D'Amore A, Tessa A, Naef V, Bassi MT, Citterio A, Romaniello R, Fichi G, Galatolo D, Mero S, Battini R, Bertocci G, Baldacci J, Sicca F, Gemignani F, Ricca I, ... ... Sahin M, et al. Loss of ap4s1 in zebrafish leads to neurodevelopmental defects resembling spastic paraplegia 52. Annals of Clinical and Translational Neurology. PMID 32216065 DOI: 10.1002/Acn3.51018  0.351
2020 Kodani A, Kenny C, Lai A, Gonzalez DM, Stronge E, Sejourne GM, Isacco L, Partlow JN, O'Donnell A, McWalter K, Byrne AB, Barkovich AJ, Yang E, Hill RS, Gawlinski P, ... ... Sahin M, et al. Posterior Neocortex-Specific Regulation of Neuronal Migration by CEP85L Identifies Maternal Centriole-Dependent Activation of CDK5. Neuron. PMID 32097629 DOI: 10.1016/J.Neuron.2020.01.030  0.343
2020 Afshar Saber W, Sahin M. Recent advances in human stem cell-based modeling of Tuberous Sclerosis Complex. Molecular Autism. 11: 16. PMID 32075691 DOI: 10.1186/S13229-020-0320-2  0.31
2020 Behne R, Teinert J, Wimmer M, D'Amore A, Davies AK, Scarrott JM, Eberhardt K, Brechmann B, Chen IP, Buttermore ED, Barrett L, Dwyer S, Chen T, Hirst J, Wiesener A, ... ... Sahin M, et al. Adaptor protein complex 4 deficiency: a paradigm of childhood-onset hereditary spastic paraplegia caused by defective protein trafficking. Human Molecular Genetics. PMID 31915823 DOI: 10.1093/Hmg/Ddz310  0.708
2019 Schoenberger A, Capal JK, Ondracek A, Horn PS, Murray D, Byars AW, Pearson DA, Williams ME, Bebin M, Northrup H, Wu JY, Sahin M, Krueger DA. Language predictors of autism spectrum disorder in young children with tuberous sclerosis complex. Epilepsy & Behavior : E&B. 106844. PMID 31864941 DOI: 10.1016/J.Yebeh.2019.106844  0.312
2019 Prohl AK, Scherrer B, Tomas-Fernandez X, Davis PE, Filip-Dhima R, Prabhu SP, Peters JM, Bebin EM, Krueger DA, Northrup H, Wu JY, Sahin M, Warfield SK. Early white matter development is abnormal in tuberous sclerosis complex patients who develop autism spectrum disorder. Journal of Neurodevelopmental Disorders. 11: 36. PMID 31838998 DOI: 10.1186/S11689-019-9293-X  0.355
2019 Scherrer B, Prohl AK, Taquet M, Kapur K, Peters JM, Tomas-Fernandez X, Davis PE, M Bebin E, Krueger DA, Northrup H, Y Wu J, Sahin M, Warfield SK. The Connectivity Fingerprint of the Fusiform Gyrus Captures the Risk of Developing Autism in Infants with Tuberous Sclerosis Complex. Cerebral Cortex (New York, N.Y. : 1991). PMID 31812987 DOI: 10.1093/Cercor/Bhz233  0.313
2019 Cook IA, Wilson AC, Peters JM, Goyal MN, Bebin EM, Northrup H, Krueger D, Leuchter AF, Sahin M. EEG Spectral Features in Sleep of Autism Spectrum Disorders in Children with Tuberous Sclerosis Complex. Journal of Autism and Developmental Disorders. PMID 31811616 DOI: 10.1007/S10803-019-04326-0  0.306
2019 Busch RM, Srivastava S, Hogue O, Frazier TW, Klaas P, Hardan A, Martinez-Agosto JA, Sahin M, Eng C. Neurobehavioral phenotype of autism spectrum disorder associated with germline heterozygous mutations in PTEN. Translational Psychiatry. 9: 253. PMID 31594918 DOI: 10.1038/S41398-019-0588-1  0.34
2019 Winden KD, Sundberg M, Yang C, Wafa SMA, Dwyer S, Chen PF, Buttermore ED, Sahin M. Biallelic mutations in lead to abnormalities associated with cortical tubers in human iPSC-derived neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 31591157 DOI: 10.1523/Jneurosci.0642-19.2019  0.35
2019 Sanders SJ, Sahin M, Hostyk J, Thurm A, Jacquemont S, Avillach P, Douard E, Martin CL, Modi ME, Moreno-De-Luca A, Raznahan A, Anticevic A, Dolmetsch R, Feng G, Geschwind DH, et al. A framework for the investigation of rare genetic disorders in neuropsychiatry. Nature Medicine. PMID 31548702 DOI: 10.1038/S41591-019-0581-5  0.781
2019 Yuskaitis CJ, Rossitto LA, Gurnani S, Bainbridge E, Poduri A, Sahin M. Chronic mTORC1 inhibition rescues behavioral and biochemical deficits resulting from neuronal Depdc5 loss in mice. Human Molecular Genetics. PMID 31174205 DOI: 10.1093/Hmg/Ddz123  0.339
2019 Salussolia CL, Klonowska K, Kwiatkowski DJ, Sahin M. Genetic Etiologies, Diagnosis, and Treatment of Tuberous Sclerosis Complex. Annual Review of Genomics and Human Genetics. PMID 31018109 DOI: 10.1146/Annurev-Genom-083118-015354  0.349
2019 Williams ME, Pearson DA, Capal JK, Byars AW, Murray DS, Kissinger R, O'Kelley SE, Hanson E, Bing NM, Kent B, Wu JY, Northrup H, Bebin EM, Sahin M, Krueger D, et al. Impacting development in infants with tuberous sclerosis complex: Multidisciplinary research collaboration. The American Psychologist. 74: 356-367. PMID 30945897 DOI: 10.1037/Amp0000436  0.304
2018 Purtell H, Dhamne SC, Gurnani S, Bainbridge E, Modi ME, Lammers SHT, Super CE, Hameed MQ, Johnson EL, Sahin M, Rotenberg A. Electrographic spikes are common in wildtype mice. Epilepsy & Behavior : E&B. 89: 94-98. PMID 30399547 DOI: 10.1016/J.Yebeh.2018.09.003  0.756
2018 Qing B, Canovic EP, Mijailovic AS, Jagielska A, Whitfield MJ, Lowe AL, Kelly EH, Turner D, Sahin M, Van Vliet K. PROBING MECHANICAL PROPERTIES OF BRAIN IN A TUBEROUS SCLEROSIS MODEL OF AUTISM. Journal of Biomechanical Engineering. PMID 30347048 DOI: 10.1115/1.4040945  0.317
2018 Yu KH, Miron O, Palmer N, Lemos D, Fox K, Kou SC, Sahin M, Kohane IS. Data-driven analyses revealed the comorbidity landscape of tuberous sclerosis complex. Neurology. PMID 30333165 DOI: 10.1212/Wnl.0000000000006546  0.312
2018 Tsai PT, Rudolph S, Guo C, Ellegood J, Gibson JM, Schaeffer SM, Mogavero J, Lerch JP, Regehr W, Sahin M. Sensitive Periods for Cerebellar-Mediated Autistic-like Behaviors. Cell Reports. 25: 357-367.e4. PMID 30304677 DOI: 10.1016/J.Celrep.2018.09.039  0.773
2018 Modi ME, Sahin M. A Unified Circuit for Social Behavior. Neurobiology of Learning and Memory. PMID 30149055 DOI: 10.1016/J.Nlm.2018.08.010  0.699
2018 Modi ME, Sahin M. The Way Forward for Mechanism-Based Therapeutics in Genetically Defined Neurodevelopmental Disorders. Clinical Pharmacology and Therapeutics. PMID 30101418 DOI: 10.1002/Cpt.1181  0.728
2018 Di Nardo A, Sahin M. mTOR'ing across the Cortex by Chopping the Cilia. Neuron. 99: 3-5. PMID 30001510 DOI: 10.1016/J.Neuron.2018.06.042  0.312
2018 Gonçalves IDCG, Brecht J, Thelen MP, Rehorst WA, Peters M, Lee HJ, Motameny S, Torres-Benito L, Ebrahimi-Fakhari D, Kononenko NL, Altmüller J, Vilchez D, Sahin M, Wirth B, Kye MJ. Author Correction: Neuronal activity regulates DROSHA via autophagy in spinal muscular atrophy. Scientific Reports. 8: 10294. PMID 29967434 DOI: 10.1038/S41598-018-28202-6  0.707
2018 Heunis T, Aldrich C, Peters JM, Jeste SS, Sahin M, Scheffer C, de Vries PJ. Recurrence quantification analysis of resting state EEG signals in autism spectrum disorder - a systematic methodological exploration of technical and demographic confounders in the search for biomarkers. Bmc Medicine. 16: 101. PMID 29961422 DOI: 10.1186/S12916-018-1086-7  0.316
2018 Gonçalves IDCG, Brecht J, Thelen MP, Rehorst WA, Peters M, Lee HJ, Motameny S, Torres-Benito L, Ebrahimi-Fakhari D, Kononenko NL, Altmüller J, Vilchez D, Sahin M, Wirth B, Kye MJ. Neuronal activity regulates DROSHA via autophagy in spinal muscular atrophy. Scientific Reports. 8: 7907. PMID 29784949 DOI: 10.1038/S41598-018-26347-Y  0.728
2018 Winden KD, Ebrahimi-Fakhari D, Sahin M. Abnormal mTOR Activation in Autism. Annual Review of Neuroscience. PMID 29490194 DOI: 10.1146/Annurev-Neuro-080317-061747  0.355
2018 Sundberg M, Tochitsky I, Buchholz DE, Winden K, Kujala V, Kapur K, Cataltepe D, Turner D, Han MJ, Woolf CJ, Hatten ME, Sahin M. Purkinje cells derived from TSC patients display hypoexcitability and synaptic deficits associated with reduced FMRP levels and reversed by rapamycin. Molecular Psychiatry. PMID 29449635 DOI: 10.1038/S41380-018-0018-4  0.384
2017 Baumer FM, Peters JM, Clancy S, Prohl AK, Prabhu SP, Scherrer B, Jansen FE, Braun KPJ, Sahin M, Stamm A, Warfield SK. Corpus Callosum White Matter Diffusivity Reflects Cumulative Neurological Comorbidity in Tuberous Sclerosis Complex. Cerebral Cortex (New York, N.Y. : 1991). PMID 29939236 DOI: 10.1093/Cercor/Bhx247  0.302
2017 Yuskaitis CJ, Jones BM, Wolfson RL, Super CE, Dhamne SC, Rotenberg A, Sabatini DM, Sahin M, Poduri A. A mouse model of DEPDC5-related epilepsy: Neuronal loss of Depdc5 causes dysplastic and ectopic neurons, increased mTOR signaling, and seizure susceptibility. Neurobiology of Disease. PMID 29274432 DOI: 10.1016/J.Nbd.2017.12.010  0.784
2017 Kelly E, Schaeffer SM, Dhamne SC, Lipton JO, Lindemann L, Honer M, Jaeschke G, Super CE, Lammers SH, Modi ME, Silverman JL, Dreier JR, Kwiatkowski DJ, Rotenberg A, Sahin M. mGluR5 Modulation of Behavioral and Epileptic Phenotypes in a Mouse Model of Tuberous Sclerosis Complex. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 29206810 DOI: 10.1038/Npp.2017.295  0.774
2017 Ebrahimi-Fakhari D, Cheng C, Dies K, Diplock A, Pier DB, Ryan CS, Lanpher BC, Hirst J, Chung WK, Sahin M, Rosser E, Darras B, Bennett JT. Clinical and genetic characterization of AP4B1-associated SPG47. American Journal of Medical Genetics. Part A. PMID 29193663 DOI: 10.1002/Ajmg.A.38561  0.337
2017 Lipton JO, Boyle LM, Yuan ED, Hochstrasser KJ, Chifamba FF, Nathan A, Tsai PT, Davis F, Sahin M. Aberrant Proteostasis of BMAL1 Underlies Circadian Abnormalities in a Paradigmatic mTOR-opathy. Cell Reports. 20: 868-880. PMID 28746872 DOI: 10.1016/J.Celrep.2017.07.008  0.785
2017 Srivastava S, Sahin M. Autism spectrum disorder and epileptic encephalopathy: common causes, many questions. Journal of Neurodevelopmental Disorders. 9: 23. PMID 28649286 DOI: 10.1186/S11689-017-9202-0  0.363
2017 Dhamne SC, Silverman JL, Super CE, Lammers SHT, Hameed MQ, Modi ME, Copping NA, Pride MC, Smith DG, Rotenberg A, Crawley JN, Sahin M. Replicable in vivo physiological and behavioral phenotypes of the Shank3B null mutant mouse model of autism. Molecular Autism. 8: 26. PMID 28638591 DOI: 10.1186/S13229-017-0142-Z  0.779
2017 Modi ME, Sahin M. Translational use of event-related potentials to assess circuit integrity in ASD. Nature Reviews. Neurology. PMID 28211449 DOI: 10.1038/Nrneurol.2017.15  0.712
2017 Ercan E, Han JM, Di Nardo A, Winden K, Han MJ, Hoyo L, Saffari A, Leask A, Geschwind DH, Sahin M. Neuronal CTGF/CCN2 negatively regulates myelination in a mouse model of tuberous sclerosis complex. The Journal of Experimental Medicine. PMID 28183733 DOI: 10.1084/Jem.20160446  0.522
2017 Ebrahimi-Fakhari D, Saffari A, Wahlster L, Sahin M. Using tuberous sclerosis complex to understand the impact of MTORC1 signaling on mitochondrial dynamics and mitophagy in neurons. Autophagy. 0. PMID 28121223 DOI: 10.1080/15548627.2016.1277310  0.343
2016 Ebrahimi-Fakhari D, Saffari A, Wahlster L, DiNardo A, Turner D, Lewis TL, Conrad C, Rothberg JM, Lipton JO, Kölker S, Hoffmann GF, Han MJ, Polleux F, Sahin M. Impaired Mitochondrial Dynamics And Mitophagy In Neuronal Models Of Tuberous Sclerosis Complex. Cell Reports. 17: 2162. PMID 27851977 DOI: 10.1016/j.celrep.2016.10.051  0.666
2016 Ebrahimi-Fakhari D, Saffari A, Wahlster L, Di Nardo A, Turner D, Lewis TL, Conrad C, Rothberg JM, Lipton JO, Kölker S, Hoffmann GF, Han MJ, Polleux F, Sahin M. Impaired Mitochondrial Dynamics and Mitophagy in Neuronal Models of Tuberous Sclerosis Complex. Cell Reports. 17: 1053-1070. PMID 27760312 DOI: 10.1016/J.Celrep.2016.09.054  0.701
2016 Alexander MS, Gasperini MJ, Tsai PT, Gibbs DE, Spinazzola JM, Marshall JL, Feyder MJ, Pletcher MT, Chekler EL, Morris CA, Sahin M, Harms JF, Schmidt CJ, Kleiman RJ, Kunkel LM. Reversal of neurobehavioral social deficits in dystrophic mice using inhibitors of phosphodiesterases PDE5A and PDE9A. Translational Psychiatry. 6: e901. PMID 27676442 DOI: 10.1038/Tp.2016.174  0.593
2016 Jeste SS, Varcin KJ, Hellemann GS, Gulsrud AC, Bhatt R, Kasari C, Wu JY, Sahin M, Nelson CA. Symptom profiles of autism spectrum disorder in tuberous sclerosis complex. Neurology. PMID 27440144 DOI: 10.1212/Wnl.0000000000003002  0.334
2016 Sun Y, Lipton JO, Boyle LM, Madsen JR, Goldenberg MC, Pascual-Leone A, Sahin M, Rotenberg A. Direct current stimulation induces mGluR5-dependent neocortical plasticity. Annals of Neurology. PMID 27315032 DOI: 10.1002/Ana.24708  0.672
2016 Comi AM, Sahin M, Hammill A, Kaplan EH, Juhász C, North P, Ball KL, Levin AV, Cohen B, Morris J, Lo W, Roach ES. Leveraging a Sturge-Weber Gene Discovery: An Agenda for Future Research. Pediatric Neurology. 58: 12-24. PMID 27268758 DOI: 10.1016/J.Pediatrneurol.2015.11.009  0.3
2016 Dölen G, Sahin M. Editorial: Essential Pathways and Circuits of Autism Pathogenesis. Frontiers in Neuroscience. 10: 182. PMID 27199644 DOI: 10.3389/Fnins.2016.00182  0.369
2016 Pinto A, Sahin M, Pearl PL. Epileptogenesis in neurocutaneous disorders with focus in Sturge Weber syndrome. F1000research. 5. PMID 27019697 DOI: 10.12688/F1000Research.7605.1  0.331
2015 Ebrahimi-Fakhari D, Saffari A, Wahlster L, Lu J, Byrne S, Hoffmann GF, Jungbluth H, Sahin M. Congenital disorders of autophagy: an emerging novel class of inborn errors of neuro-metabolism. Brain : a Journal of Neurology. PMID 26715604 DOI: 10.1093/Brain/Awv371  0.348
2015 Mutch CA, Poduri A, Sahin M, Barry B, Walsh CA, Barkovich AJ. Disorders of Microtubule Function in Neurons: Imaging Correlates. Ajnr. American Journal of Neuroradiology. PMID 26564436 DOI: 10.3174/Ajnr.A4552  0.312
2015 Dies KA, Sahin M. Genetics of neurocutaneous disorders: basic principles of inheritance as they apply to neurocutaneous syndromes. Handbook of Clinical Neurology. 132: 3-8. PMID 26564068 DOI: 10.1016/B978-0-444-62702-5.00001-9  0.303
2015 Sahin M, Sur M. Genes, circuits, and precision therapies for autism and related neurodevelopmental disorders. Science (New York, N.Y.). PMID 26472761 DOI: 10.1126/Science.Aab3897  0.344
2015 Sundberg M, Sahin M. Cerebellar Development and Autism Spectrum Disorder in Tuberous Sclerosis Complex. Journal of Child Neurology. PMID 26303409 DOI: 10.1177/0883073815600870  0.371
2015 Nie D, Chen Z, Ebrahimi-Fakhari D, Di Nardo A, Julich K, Robson VK, Cheng YC, Woolf CJ, Heiman M, Sahin M. The Stress-Induced Atf3-Gelsolin Cascade Underlies Dendritic Spine Deficits in Neuronal Models of Tuberous Sclerosis Complex. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 10762-72. PMID 26224859 DOI: 10.1523/Jneurosci.4796-14.2015  0.379
2015 Kloth AD, Badura A, Li A, Cherskov A, Connolly SG, Giovannucci A, Bangash MA, Grasselli G, Peñagarikano O, Piochon C, Tsai PT, Geschwind DH, Hansel C, Sahin M, Takumi T, et al. Cerebellar associative sensory learning defects in five mouse autism models. Elife. 4. PMID 26158416 DOI: 10.7554/Elife.06085  0.638
2015 Neul JL, Sahin M. Therapeutic Advances in Autism and Other Neurodevelopmental Disorders. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 12: 519-20. PMID 26076992 DOI: 10.1007/S13311-015-0364-8  0.361
2015 Davis PE, Peters JM, Krueger DA, Sahin M. Tuberous Sclerosis: A New Frontier in Targeted Treatment of Autism. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 12: 572-83. PMID 25986747 DOI: 10.1007/S13311-015-0359-5  0.363
2015 Lipton JO, Yuan ED, Boyle LM, Ebrahimi-Fakhari D, Kwiatkowski E, Nathan A, Güttler T, Davis F, Asara JM, Sahin M. The Circadian Protein BMAL1 Regulates Translation in Response to S6K1-Mediated Phosphorylation. Cell. 161: 1138-51. PMID 25981667 DOI: 10.1016/J.Cell.2015.04.002  0.688
2015 Ebrahimi-Fakhari D, Sahin M. Autism and the synapse: emerging mechanisms and mechanism-based therapies. Current Opinion in Neurology. 28: 91-102. PMID 25695134 DOI: 10.1097/Wco.0000000000000186  0.349
2015 de Vries PJ, Whittemore VH, Leclezio L, Byars AW, Dunn D, Ess KC, Hook D, King BH, Sahin M, Jansen A. Tuberous sclerosis associated neuropsychiatric disorders (TAND) and the TAND Checklist. Pediatric Neurology. 52: 25-35. PMID 25532776 DOI: 10.1016/J.Pediatrneurol.2014.10.004  0.309
2015 Han M, Hoyo L, Kleiman R, Sahin M. TSC2 controls neuronal development through FOXO1 and mitochondrial function in Autism Spectrum Disorders patient derived human neurons Mitochondrion. 24: S36. DOI: 10.1016/J.Mito.2015.07.101  0.326
2014 Lipton JO, Sahin M. The neurology of mTOR. Neuron. 84: 275-91. PMID 25374355 DOI: 10.1016/J.Neuron.2014.09.034  0.717
2014 Greene-Colozzi EA, Sadowski AR, Chadwick E, Tsai PT, Sahin M. Both maternal and pup genotype influence ultrasonic vocalizations and early developmental milestones in tsc2 (+/-) mice. Epilepsy Research and Treatment. 2014: 784137. PMID 25165580 DOI: 10.1155/2014/784137  0.62
2014 Kye MJ, Niederst ED, Wertz MH, Gonçalves Ido C, Akten B, Dover KZ, Peters M, Riessland M, Neveu P, Wirth B, Kosik KS, Sardi SP, Monani UR, Passini MA, Sahin M. SMN regulates axonal local translation via miR-183/mTOR pathway. Human Molecular Genetics. 23: 6318-31. PMID 25055867 DOI: 10.1093/Hmg/Ddu350  0.762
2014 Olson H, Shen Y, Avallone J, Sheidley BR, Pinsky R, Bergin AM, Berry GT, Duffy FH, Eksioglu Y, Harris DJ, Hisama FM, Ho E, Irons M, Jacobsen CM, James P, ... ... Sahin M, et al. Copy number variation plays an important role in clinical epilepsy. Annals of Neurology. 75: 943-58. PMID 24811917 DOI: 10.1002/Ana.24178  0.764
2014 Clifford MA, Athar W, Leonard CE, Russo A, Sampognaro PJ, Van der Goes MS, Burton DA, Zhao X, Lalchandani RR, Sahin M, Vicini S, Donoghue MJ. EphA7 signaling guides cortical dendritic development and spine maturation. Proceedings of the National Academy of Sciences of the United States of America. 111: 4994-9. PMID 24707048 DOI: 10.1073/Pnas.1323793111  0.337
2014 Di Nardo A, Wertz MH, Kwiatkowski E, Tsai PT, Leech JD, Greene-Colozzi E, Goto J, Dilsiz P, Talos DM, Clish CB, Kwiatkowski DJ, Sahin M. Neuronal Tsc1/2 complex controls autophagy through AMPK-dependent regulation of ULK1. Human Molecular Genetics. 23: 3865-74. PMID 24599401 DOI: 10.1093/Hmg/Ddu101  0.631
2014 Kong SW, Sahin M, Collins CD, Wertz MH, Campbell MG, Leech JD, Krueger D, Bear MF, Kunkel LM, Kohane IS. Divergent dysregulation of gene expression in murine models of fragile X syndrome and tuberous sclerosis. Molecular Autism. 5: 16. PMID 24564913 DOI: 10.1186/2040-2392-5-16  0.325
2014 Jülich K, Sahin M. Mechanism-based treatment in tuberous sclerosis complex. Pediatric Neurology. 50: 290-6. PMID 24486221 DOI: 10.1016/J.Pediatrneurol.2013.12.002  0.404
2013 Peters JM, Taquet M, Prohl AK, Scherrer B, van Eeghen AM, Prabhu SP, Sahin M, Warfield SK. Diffusion tensor imaging and related techniques in tuberous sclerosis complex: review and future directions. Future Neurology. 8: 583-597. PMID 24489482 DOI: 10.2217/Fnl.13.37  0.322
2013 Zhang J, Kim J, Alexander A, Cai S, Tripathi DN, Dere R, Tee AR, Tait-Mulder J, Di Nardo A, Han JM, Kwiatkowski E, Dunlop EA, Dodd KM, Folkerth RD, Faust PL, ... ... Sahin M, et al. A tuberous sclerosis complex signalling node at the peroxisome regulates mTORC1 and autophagy in response to ROS. Nature Cell Biology. 15: 1186-96. PMID 23955302 DOI: 10.1038/Ncb2822  0.324
2013 Dimitriadi M, Kye MJ, Kalloo G, Yersak JM, Sahin M, Hart AC. The neuroprotective drug riluzole acts via small conductance Ca2+-activated K+ channels to ameliorate defects in spinal muscular atrophy models. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 6557-62. PMID 23575853 DOI: 10.1523/Jneurosci.1536-12.2013  0.724
2013 Peters JM, Taquet M, Vega C, Jeste SS, Fernández IS, Tan J, Nelson CA, Sahin M, Warfield SK. Brain functional networks in syndromic and non-syndromic autism: a graph theoretical study of EEG connectivity. Bmc Medicine. 11: 54. PMID 23445896 DOI: 10.1186/1741-7015-11-54  0.306
2013 Lipton J, Sahin M. Fragile X syndrome therapeutics: translation, meet translational medicine. Neuron. 77: 212-3. PMID 23352156 DOI: 10.1016/J.Neuron.2013.01.009  0.706
2013 Weisenfeld NI, Peters JM, Tsai PT, Prabhu SP, Dies KA, Sahin M, Warfield SK. A magnetic resonance imaging study of cerebellar volume in tuberous sclerosis complex. Pediatric Neurology. 48: 105-10. PMID 23337002 DOI: 10.1016/J.Pediatrneurol.2012.10.011  0.587
2013 Tsai PT, Greene-Colozzi E, Goto J, Anderl S, Kwiatkowski DJ, Sahin M. Prenatal rapamycin results in early and late behavioral abnormalities in wildtype C57BL/6 mice. Behavior Genetics. 43: 51-9. PMID 23229624 DOI: 10.1007/S10519-012-9571-9  0.621
2013 Lewis WW, Sahin M, Scherrer B, Peters JM, Suarez RO, Vogel-Farley VK, Jeste SS, Gregas MC, Prabhu SP, Nelson CA, Warfield SK. Impaired language pathways in tuberous sclerosis complex patients with autism spectrum disorders. Cerebral Cortex (New York, N.Y. : 1991). 23: 1526-32. PMID 22661408 DOI: 10.1093/Cercor/Bhs135  0.308
2012 Tsai PT, Hull C, Chu Y, Greene-Colozzi E, Sadowski AR, Leech JM, Steinberg J, Crawley JN, Regehr WG, Sahin M. Autistic-like behaviour and cerebellar dysfunction in Purkinje cell Tsc1 mutant mice. Nature. 488: 647-51. PMID 22763451 DOI: 10.1038/Nature11310  0.638
2012 Yuan E, Tsai PT, Greene-Colozzi E, Sahin M, Kwiatkowski DJ, Malinowska IA. Graded loss of tuberin in an allelic series of brain models of TSC correlates with survival, and biochemical, histological and behavioral features. Human Molecular Genetics. 21: 4286-300. PMID 22752306 DOI: 10.1093/Hmg/Dds262  0.615
2012 Poduri A, Chopra SS, Neilan EG, Elhosary PC, Kurian MA, Meyer E, Barry BJ, Khwaja OS, Salih MA, Stödberg T, Scheffer IE, Maher ER, Sahin M, Wu BL, Berry GT, et al. Homozygous PLCB1 deletion associated with malignant migrating partial seizures in infancy. Epilepsia. 53: e146-50. PMID 22690784 DOI: 10.1111/J.1528-1167.2012.03538.X  0.305
2012 Sahin M. Targeted treatment trials for tuberous sclerosis and autism: No longer a dream Current Opinion in Neurobiology. 22: 895-901. PMID 22560338 DOI: 10.1016/J.Conb.2012.04.008  0.344
2012 Nie D, Sahin M. A genetic model to dissect the role of Tsc-mTORC1 in neuronal cultures Methods in Molecular Biology. 821: 393-405. PMID 22125080 DOI: 10.1007/978-1-61779-430-8_25  0.38
2012 Ehninger D, Sano Y, de Vries PJ, Dies K, Franz D, Geschwind DH, Kaur M, Lee YS, Li W, Lowe JK, Nakagawa JA, Sahin M, Smith K, Whittemore V, Silva AJ. Gestational immune activation and Tsc2 haploinsufficiency cooperate to disrupt fetal survival and may perturb social behavior in adult mice. Molecular Psychiatry. 17: 62-70. PMID 21079609 DOI: 10.1038/Mp.2010.115  0.485
2012 Peters J, Sahin M, Vogel-Farley V, Jeste S, Nelson C, Gregas M, Prabhu S, Scherrer B, Warfield S. Loss of White Matter Microstructural Integrity Is Associated with Adverse Neurological Outcome in Tuberous Sclerosis Complex (S28.003) Neurology. 78. DOI: 10.1212/Wnl.78.1_Meetingabstracts.S28.003  0.303
2012 Ehninger D, Sano Y, De Vries PJ, Dies K, Franz D, Geschwind DH, Kaur M, Lee YS, Li W, Lowe JK, Nakagawa JA, Sahin M, Smith K, Whittemore V, Silva AJ. Gestational immune activation and Tsc2 haploinsufficiency cooperate to disrupt fetal survival and may perturb social behavior in adult mice (Molecular Psychiatry (2012) 17, (62-70) DOI:10.1038/mp.2010.115) Molecular Psychiatry. 17: 469-470. DOI: 10.1038/Mp.2011.39  0.437
2011 Goto J, Talos DM, Klein P, Qin W, Chekaluk YI, Anderl S, Malinowska IA, Di Nardo A, Bronson RT, Chan JA, Vinters HV, Kernie SG, Jensen FE, Sahin M, Kwiatkowski DJ. Regulable neural progenitor-specific Tsc1 loss yields giant cells with organellar dysfunction in a model of tuberous sclerosis complex. Proceedings of the National Academy of Sciences of the United States of America. 108: E1070-9. PMID 22025691 DOI: 10.1073/Pnas.1106454108  0.332
2011 Khwaja OS, Sahin M. Translational research: Rett syndrome and tuberous sclerosis complex. Current Opinion in Pediatrics. 23: 633-639. PMID 21970827 DOI: 10.1097/Mop.0B013E32834C9251  0.374
2011 Kye MJ, Neveu P, Lee YS, Zhou M, Steen JA, Sahin M, Kosik KS, Silva AJ. NMDA mediated contextual conditioning changes miRNA expression. Plos One. 6: e24682. PMID 21931811 DOI: 10.1371/Journal.Pone.0024682  0.739
2011 Akten B, Kye MJ, Hao le T, Wertz MH, Singh S, Nie D, Huang J, Merianda TT, Twiss JL, Beattie CE, Steen JA, Sahin M. Interaction of survival of motor neuron (SMN) and HuD proteins with mRNA cpg15 rescues motor neuron axonal deficits. Proceedings of the National Academy of Sciences of the United States of America. 108: 10337-42. PMID 21652774 DOI: 10.1073/Pnas.1104928108  0.729
2011 Han JM, Sahin M. TSC1/TSC2 signaling in the CNS. Febs Letters. 585: 973-80. PMID 21329690 DOI: 10.1016/J.Febslet.2011.02.001  0.32
2011 Tsai P, Sahin M. Mechanisms of neurocognitive dysfunction and therapeutic considerations in tuberous sclerosis complex Current Opinion in Neurology. 24: 106-113. PMID 21301339 DOI: 10.1097/Wco.0B013E32834451C4  0.648
2010 Neveu P, Kye MJ, Qi S, Buchholz DE, Clegg DO, Sahin M, Park IH, Kim KS, Daley GQ, Kornblum HI, Shraiman BI, Kosik KS. MicroRNA profiling reveals two distinct p53-related human pluripotent stem cell states. Cell Stem Cell. 7: 671-81. PMID 21112562 DOI: 10.1016/J.Stem.2010.11.012  0.735
2010 Margolis SS, Salogiannis J, Lipton DM, Mandel-Brehm C, Wills ZP, Mardinly AR, Hu L, Greer PL, Bikoff JB, Ho HY, Soskis MJ, Sahin M, Greenberg ME. EphB-mediated degradation of the RhoA GEF Ephexin5 relieves a developmental brake on excitatory synapse formation. Cell. 143: 442-55. PMID 21029865 DOI: 10.1016/J.Cell.2010.09.038  0.739
2010 Nie D, Di Nardo A, Han JM, Baharanyi H, Kramvis I, Huynh T, Dabora S, Codeluppi S, Pandolfi PP, Pasquale EB, Sahin M. Tsc2-Rheb signaling regulates EphA-mediated axon guidance. Nature Neuroscience. 13: 163-72. PMID 20062052 DOI: 10.1038/Nn.2477  0.784
2010 Poduri A, Chitsazzadeh V, D'Arrigo S, Fedrizzi E, Pantaleoni C, Riva D, Busse C, Küster H, Duplessis A, Gaitanis J, Sahin M, Garganta C, Topcu M, Dies KA, Barry BJ, et al. The syndrome of perisylvian polymicrogyria with congenital arthrogryposis. Brain & Development. 32: 550-5. PMID 19751967 DOI: 10.1016/J.Braindev.2009.08.005  0.312
2009 Di Nardo A, Kramvis I, Cho N, Sadowski A, Meikle L, Kwiatkowski DJ, Sahin M. Tuberous sclerosis complex activity is required to control neuronal stress responses in an mTOR-dependent manner. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 5926-37. PMID 19420259 DOI: 10.1523/Jneurosci.0778-09.2009  0.778
2008 Park KK, Liu K, Hu Y, Smith PD, Wang C, Cai B, Xu B, Connolly L, Kramvis I, Sahin M, He Z. Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathway. Science (New York, N.Y.). 322: 963-6. PMID 18988856 DOI: 10.1126/Science.1161566  0.764
2008 Choi YJ, Di Nardo A, Kramvis I, Meikle L, Kwiatkowski DJ, Sahin M, He X. Tuberous sclerosis complex proteins control axon formation. Genes & Development. 22: 2485-95. PMID 18794346 DOI: 10.1101/Gad.1685008  0.78
2008 Miyake N, Chilton J, Psatha M, Cheng L, Andrews C, Chan WM, Law K, Crosier M, Lindsay S, Cheung M, Allen J, Gutowski NJ, Ellard S, Young E, Iannaccone A, ... ... Sahin M, et al. Human CHN1 mutations hyperactivate alpha2-chimaerin and cause Duane's retraction syndrome. Science (New York, N.Y.). 321: 839-43. PMID 18653847 DOI: 10.1126/Science.1156121  0.302
2008 Meikle L, Pollizzi K, Egnor A, Kramvis I, Lane H, Sahin M, Kwiatkowski DJ. Response of a neuronal model of tuberous sclerosis to mammalian target of rapamycin (mTOR) inhibitors: effects on mTORC1 and Akt signaling lead to improved survival and function. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 5422-32. PMID 18495876 DOI: 10.1523/Jneurosci.0955-08.2008  0.785
2008 Ozcan U, Ozcan L, Yilmaz E, Düvel K, Sahin M, Manning BD, Hotamisligil GS. Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis. Molecular Cell. 29: 541-51. PMID 18342602 DOI: 10.1016/J.Molcel.2007.12.023  0.308
2007 Jozwiak J, Sahin M, Jozwiak S, Kotulska K, Ploski R, Szperl M, Wlodarski PK. Cardiac rhabdomyoma in tuberous sclerosis: hyperactive Erk signaling. International Journal of Cardiology. 132: 145-7. PMID 18037514 DOI: 10.1016/J.Ijcard.2007.07.152  0.309
2007 Meikle L, Talos DM, Onda H, Pollizzi K, Rotenberg A, Sahin M, Jensen FE, Kwiatkowski DJ. A mouse model of tuberous sclerosis: neuronal loss of Tsc1 causes dysplastic and ectopic neurons, reduced myelination, seizure activity, and limited survival. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 5546-58. PMID 17522300 DOI: 10.1523/Jneurosci.5540-06.2007  0.35
2007 Fu WY, Chen Y, Sahin M, Zhao XS, Shi L, Bikoff JB, Lai KO, Yung WH, Fu AK, Greenberg ME, Ip NY. Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism. Nature Neuroscience. 10: 67-76. PMID 17143272 DOI: 10.1038/Nn1811  0.776
2006 Zhang HH, Lipovsky AI, Dibble CC, Sahin M, Manning BD. S6K1 regulates GSK3 under conditions of mTOR-dependent feedback inhibition of Akt. Molecular Cell. 24: 185-97. PMID 17052453 DOI: 10.1016/J.Molcel.2006.09.019  0.305
2005 Egea J, Nissen UV, Dufour A, Sahin M, Greer P, Kullander K, Mrsic-Flogel TD, Greenberg ME, Kiehn O, Vanderhaeghen P, Klein R. Regulation of EphA 4 kinase activity is required for a subset of axon guidance decisions suggesting a key role for receptor clustering in Eph function. Neuron. 47: 515-28. PMID 16102535 DOI: 10.1016/J.Neuron.2005.06.029  0.77
2005 Cowan CW, Shao YR, Sahin M, Shamah SM, Lin MZ, Greer PL, Gao S, Griffith EC, Brugge JS, Greenberg ME. Vav family GEFs link activated Ephs to endocytosis and axon guidance. Neuron. 46: 205-17. PMID 15848800 DOI: 10.1016/J.Neuron.2005.03.019  0.768
2005 Sahin M, Greer PL, Lin MZ, Poucher H, Eberhart J, Schmidt S, Wright TM, Shamah SM, O'connell S, Cowan CW, Hu L, Goldberg JL, Debant A, Corfas G, Krull CE, et al. Eph-dependent tyrosine phosphorylation of ephexin1 modulates growth cone collapse. Neuron. 46: 191-204. PMID 15848799 DOI: 10.1016/J.Neuron.2005.01.030  0.775
2001 Shamah SM, Lin MZ, Goldberg JL, Estrach S, Sahin M, Hu L, Bazalakova M, Neve RL, Corfas G, Debant A, Greenberg ME. EphA receptors regulate growth cone dynamics through the novel guanine nucleotide exchange factor ephexin. Cell. 105: 233-44. PMID 11336673 DOI: 10.1016/S0092-8674(01)00314-2  0.621
1995 Sahin M, Dowling JJ, Hockfield S. Seven protein tyrosine phosphatases are differentially expressed in the developing rat brain. The Journal of Comparative Neurology. 351: 617-31. PMID 7721987 DOI: 10.1002/Cne.903510410  0.609
1995 Sahin M, Slaugenhaupt SA, Gusella JF, Hockfield S. Expression of PTPH1, a rat protein tyrosine phosphatase, is restricted to the derivatives of a specific diencephalic segment. Proceedings of the National Academy of Sciences of the United States of America. 92: 7859-63. PMID 7644504 DOI: 10.1073/Pnas.92.17.7859  0.584
1993 Sahin M, Hockfield S. Protein tyrosine phosphatases expressed in the developing rat brain. The Journal of Neuroscience. 13: 4968-4978. DOI: 10.1523/Jneurosci.13-11-04968.1993  0.616
1990 Sahin M, Hockfield S. Molecular identification of the Lugaro cell in the cat cerebellar cortex. The Journal of Comparative Neurology. 301: 575-84. PMID 2273099 DOI: 10.1002/Cne.903010407  0.589
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