Year |
Citation |
Score |
2010 |
Toth K, Amyes TL, Wood BM, Chan K, Gerlt JA, Richard JP. Product deuterium isotope effects for orotidine 5'-monophosphate decarboxylase: effect of changing substrate and enzyme structure on the partitioning of the vinyl carbanion reaction intermediate. Journal of the American Chemical Society. 132: 7018-24. PMID 20441167 DOI: 10.1021/Ja102408K |
0.685 |
|
2009 |
Toth K, Amyes TL, Wood BM, Chan KK, Gerlt JA, Richard JP. An examination of the relationship between active site loop size and thermodynamic activation parameters for orotidine 5'-monophosphate decarboxylase from mesophilic and thermophilic organisms. Biochemistry. 48: 8006-13. PMID 19618917 DOI: 10.1021/Bi901064K |
0.69 |
|
2009 |
Chan KK, Wood BM, Fedorov AA, Fedorov EV, Imker HJ, Amyes TL, Richard JP, Almo SC, Gerlt JA. Mechanism of the orotidine 5′-monophosphate decarboxylase-catalyzed reaction: Evidence for substrate destabilization Biochemistry. 48: 5518-5531. PMID 19435314 DOI: 10.1021/Bi900623R |
0.638 |
|
2009 |
Wood BM, Chan KK, Amyes TL, Richard JP, Gerlt JA. Mechanism of the orotidine 5′-monophosphate decarboxylase-catalyzed reaction: Effect of solvent viscosity on kinetic constants Biochemistry. 48: 5510-5517. PMID 19435313 DOI: 10.1021/Bi9006226 |
0.682 |
|
2008 |
Chan KK, Fedorov AA, Fedorov EV, Almo SC, Gerlt JA. Structural basis for substrate specificity in phosphate binding (β/α)8-barrels: D-allulose 6-phosphate 3-epimerase from Escherichia coli K-12 Biochemistry. 47: 9608-9617. PMID 18700786 DOI: 10.1021/Bi800821V |
0.641 |
|
2008 |
Amyes TL, Wood BM, Chan K, Gerlt JA, Richard JP. Formation and stability of a vinyl carbanion at the active site of orotidine 5′-monophosphate decarboxylase: pKa of the C-6 proton of enzyme-bound UMP Journal of the American Chemical Society. 130: 1574-1575. PMID 18186641 DOI: 10.1021/Ja710384T |
0.657 |
|
2007 |
Toth K, Amyes TL, Wood BM, Chan K, Gerlt JA, Richard JP. Product deuterium isotope effect for orotidine 5'-monophosphate decarboxylase: evidence for the existence of a short-lived carbanion intermediate. Journal of the American Chemical Society. 129: 12946-7. PMID 17918849 DOI: 10.1021/Ja076222F |
0.664 |
|
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