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Amit U. Sinha, Ph.D. - Publications

Affiliations: 
2008 University of Cincinnati, Cincinnati, OH 
Area:
bioinformatics, computational genomics, protein structure
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34 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Bamezai S, Demir D, Pulikkottil AJ, Ciccarone F, Fischbein E, Sinha A, Borga C, Te Kronnie G, Meyer LH, Mohr F, Götze M, Caiafa P, Debatin KM, Döhner K, Döhner H, et al. TET1 promotes growth of T-cell acute lymphoblastic leukemia and can be antagonized via PARP inhibition. Leukemia. PMID 32409690 DOI: 10.1038/S41375-020-0864-3  0.311
2017 Micol JB, Pastore A, Inoue D, Duployez N, Kim E, Lee SC, Durham BH, Chung YR, Cho H, Zhang XJ, Yoshimi A, Krivtsov A, Koche R, Solary E, Sinha A, et al. ASXL2 is essential for haematopoiesis and acts as a haploinsufficient tumour suppressor in leukemia. Nature Communications. 8: 15429. PMID 28516957 DOI: 10.1038/Ncomms15429  0.409
2017 Gala K, Sinha A, Sanchez-Vega F, Chung YR, Hseih J, Berger M, Schultz N, Pastore A, Abdel-Wahab O, Chandarlapaty S. Abstract 5500: KMT2C directs estrogen receptor activity in normal and transformed mammary cells Cancer Research. 77: 5500-5500. DOI: 10.1158/1538-7445.Am2017-5500  0.339
2016 Xu H, Valerio DG, Eisold ME, Sinha A, Koche RP, Hu W, Chen CW, Chu SH, Brien GL, Park CY, Hsieh JJ, Ernst P, Armstrong SA. NUP98 Fusion Proteins Interact with the NSL and MLL1 Complexes to Drive Leukemogenesis. Cancer Cell. PMID 27889185 DOI: 10.1016/J.Ccell.2016.10.019  0.43
2016 Kühn MW, Song E, Feng Z, Sinha A, Chen CW, Deshpande AJ, Cusan M, Farnoud N, Mupo A, Grove C, Koche R, Bradner JE, de Stanchina E, Vassiliou GS, Hoshii T, et al. Targeting Chromatin Regulators Inhibits Leukemogenic Gene Expression in NPM1 Mutant Leukemia. Cancer Discovery. PMID 27535106 DOI: 10.1158/2159-8290.Cd-16-0237  0.423
2016 Riedel SS, Haladyna JN, Bezzant M, Stevens B, Pollyea DA, Sinha AU, Armstrong SA, Wei Q, Pollock RM, Daigle SR, Jordan CT, Ernst P, Neff T, Bernt KM. MLL1 and DOT1L cooperate with meningioma-1 to induce acute myeloid leukemia. The Journal of Clinical Investigation. PMID 26927674 DOI: 10.1172/Jci80825  0.409
2016 Zhu N, Chen M, Eng R, DeJong J, Sinha AU, Rahnamay NF, Koche R, Al-Shahrour F, Minehart JC, Chen CW, Deshpande AJ, Xu H, Chu SH, Ebert BL, Roeder RG, et al. MLL-AF9- and HOXA9-mediated acute myeloid leukemia stem cell self-renewal requires JMJD1C. The Journal of Clinical Investigation. PMID 26878175 DOI: 10.1172/Jci82978  0.384
2015 Chen CW, Koche RP, Sinha AU, Deshpande AJ, Zhu N, Eng R, Doench JG, Xu H, Chu SH, Qi J, Wang X, Delaney C, Bernt KM, Root DE, Hahn WC, et al. DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia. Nature Medicine. 21: 335-43. PMID 25822366 DOI: 10.1038/Nm.3832  0.436
2014 Deshpande AJ, Deshpande A, Sinha AU, Chen L, Chang J, Cihan A, Fazio M, Chen CW, Zhu N, Koche R, Dzhekieva L, Ibáñez G, Dias S, Banka D, Krivtsov A, et al. AF10 regulates progressive H3K79 methylation and HOX gene expression in diverse AML subtypes. Cancer Cell. 26: 896-908. PMID 25464900 DOI: 10.1016/J.Ccell.2014.10.009  0.426
2014 Ng CE, Sinha A, Krivtsov A, Dias S, Chang J, Armstrong SA, Kalaitzidis D. KRas(G12D)-evoked leukemogenesis does not require β-catenin. Leukemia. 28: 698-702. PMID 24189294 DOI: 10.1038/Leu.2013.328  0.315
2014 Riedel S, Bernt KM, Haladyna J, Bezzant M, Stevens B, Pollyea DA, Sinha AU, Armstrong SA, Wei Q, Jordan CT, Neff T. Targeting Meningeoma-1 Driven AML through Epigenetic Modulation of the Cell of Origin Blood. 124: 838-838. DOI: 10.1182/Blood.V124.21.838.838  0.413
2014 Deshpande A, Deshpande A, Sinha A, Chen L, Chang J, Chen D, Koche R, Krivtsov A, Luo M, Bradner J, Bernt K, Armstrong S. Regulation of HOX gene expression by AF10-mediated conversion of H3K79me1 to H3K79me2 Experimental Hematology. 42: S30. DOI: 10.1016/J.Exphem.2014.07.107  0.366
2013 Ho LL, Sinha A, Verzi M, Bernt KM, Armstrong SA, Shivdasani RA. DOT1L-mediated H3K79 methylation in chromatin is dispensable for Wnt pathway-specific and other intestinal epithelial functions. Molecular and Cellular Biology. 33: 1735-45. PMID 23428873 DOI: 10.1128/Mcb.01463-12  0.421
2013 Deshpande AJ, Chen L, Fazio M, Sinha AU, Bernt KM, Banka D, Dias S, Chang J, Olhava EJ, Daigle SR, Richon VM, Pollock RM, Armstrong SA. Leukemic transformation by the MLL-AF6 fusion oncogene requires the H3K79 methyltransferase Dot1l. Blood. 121: 2533-41. PMID 23361907 DOI: 10.1182/Blood-2012-11-465120  0.398
2013 Krivtsov AV, Figueroa ME, Sinha AU, Stubbs MC, Feng Z, Valk PJM, Delwel R, Döhner K, Bullinger L, Kung AL, Melnick AM, Armstrong SA. Cell of origin determines clinically relevant subtypes of MLL-rearranged AML Leukemia. 27: 852-860. PMID 23235717 DOI: 10.1038/Leu.2012.363  0.417
2013 David Chen C, Sinha AU, Qi J, Deshpande AJ, Zhu N, Koche R, Eng R, Chang J, Hahn WC, Bradner JE, Armstrong SA. Genome-Wide RNAi Screen Identifies The Mechanistic Role For DOT1L In MLL-Rearranged Leukemia Blood. 122: 598-598. DOI: 10.1182/Blood.V122.21.598.598  0.468
2013 Deshpande AJ, Chen L, Sinha AU, Zhu N, Chen D, Chang J, Krivtsov AV, Bernt K, Bradner JE, Armstrong SA. Regulation Of Normal and Malignant Hoxa Gene Expression Through Higher H3K79 Methylated States Blood. 122: 2492-2492. DOI: 10.1182/Blood.V122.21.2492.2492  0.431
2013 Kühn MW, Hadler M, Daigle SR, Chen C, Sinha AU, Krivtsov AV, Olhava EJ, Caligiuri MA, Bradner JE, Pollock RM, Armstrong SA. Myeloid Leukemia Cells With MLL partial Tandem Duplication Are Sensitive To Pharmacological Inhibition Of The H3K79 Methyltransferase DOT1L Blood. 122: 1256-1256. DOI: 10.1182/Blood.V122.21.1256.1256  0.416
2012 Kalaitzidis D, Sykes SM, Wang Z, Punt N, Tang Y, Ragu C, Sinha AU, Lane SW, Souza AL, Clish CB, Anastasiou D, Gilliland DG, Scadden DT, Guertin DA, Armstrong SA. mTOR complex 1 plays critical roles in hematopoiesis and Pten-loss-evoked leukemogenesis. Cell Stem Cell. 11: 429-39. PMID 22958934 DOI: 10.1016/j.stem.2012.06.009  0.336
2012 Neff T, Sinha AU, Kluk MJ, Zhu N, Khattab MH, Stein L, Xie H, Orkin SH, Armstrong SA. Polycomb repressive complex 2 is required for MLL-AF9 leukemia. Proceedings of the National Academy of Sciences of the United States of America. 109: 5028-33. PMID 22396593 DOI: 10.1073/Pnas.1202258109  0.435
2012 Onder TT, Kara N, Cherry A, Sinha AU, Zhu N, Bernt KM, Cahan P, Marcarci BO, Unternaehrer J, Gupta PB, Lander ES, Armstrong SA, Daley GQ. Chromatin-modifying enzymes as modulators of reprogramming. Nature. 483: 598-602. PMID 22388813 DOI: 10.1038/Nature10953  0.392
2012 Trowbridge JJ, Sinha AU, Zhu N, Li M, Armstrong SA, Orkin SH. Haploinsufficiency of Dnmt1 impairs leukemia stem cell function through derepression of bivalent chromatin domains. Genes & Development. 26: 344-9. PMID 22345515 DOI: 10.1101/gad.184341.111  0.388
2012 Angus L, Moleirinho S, Herron L, Sinha A, Zhang X, Niestrata M, Dholakia K, Prystowsky MB, Harvey KF, Reynolds PA, Gunn-Moore FJ. Willin/FRMD6 expression activates the Hippo signaling pathway kinases in mammals and antagonizes oncogenic YAP. Oncogene. 31: 238-50. PMID 21666719 DOI: 10.1038/Onc.2011.224  0.316
2012 Deshpande AJ, Chen L, Bernt KM, Dias S, Banka D, Sinha AU, Chen D, Punt N, Bradner JE, Armstrong SA. The Interaction Between DOT1L and AF10 Is Required for H3K79 Dimethylation and MLL-AF9 Leukemia Blood. 120: 401-401. DOI: 10.1182/Blood.V120.21.401.401  0.423
2012 Deshpande AJ, Chen L, Fazio M, Sinha AU, Bernt KM, Banka D, Dias S, Olhava EJ, Daigle SR, Richon VM, Pollock RM, Armstrong SA. MLL-AF6 Mediated Transformation Is Dependent On the H3K79 Methyl-transferase Dot1l Blood. 120: 3502-3502. DOI: 10.1182/Blood.V120.21.3502.3502  0.425
2011 Sinha AU, Merrill E, Armstrong SA, Clark TW, Das S. eXframe: reusable framework for storage, analysis and visualization of genomics experiments. Bmc Bioinformatics. 12: 452. PMID 22103807 DOI: 10.1186/1471-2105-12-452  0.323
2011 Bernt KM, Zhu N, Sinha AU, Vempati S, Faber J, Krivtsov AV, Feng Z, Punt N, Daigle A, Bullinger L, Pollock RM, Richon VM, Kung AL, Armstrong SA. MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L. Cancer Cell. 20: 66-78. PMID 21741597 DOI: 10.1016/J.Ccr.2011.06.010  0.447
2010 Juszczynski P, Rodig SJ, Ouyang J, O'Donnell E, Takeyama K, Mlynarski W, Mycko K, Szczepanski T, Gaworczyk A, Krivtsov A, Faber J, Sinha AU, Rabinovich GA, Armstrong SA, Kutok JL, et al. MLL-rearranged B lymphoblastic leukemias selectively express the immunoregulatory carbohydrate-binding protein galectin-1. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 16: 2122-30. PMID 20332322 DOI: 10.1158/1078-0432.Ccr-09-2765  0.345
2009 Wang Y, Krivtsov AV, Sinha AU, North T, Goessling W, Zon LI, Armstrong S. β-Catenin Determines Developmental Stage Specific Transformation by Hox Genes. Blood. 114: 385-385. DOI: 10.1182/Blood.V114.22.385.385  0.328
2009 Krivtsov AV, Sinha AU, Stubbs MC, Kung A, Armstrong S. Cell of Origin Influences Leukemia Stem Cell Phenotype. Blood. 114: 3459-3459. DOI: 10.1182/Blood.V114.22.3459.3459  0.37
2008 Krivtsov AV, Feng Z, Lemieux ME, Faber J, Vempati S, Sinha AU, Xia X, Jesneck J, Bracken AP, Silverman LB, Kutok JL, Kung AL, Armstrong SA. H3K79 methylation profiles define murine and human MLL-AF4 leukemias. Cancer Cell. 14: 355-68. PMID 18977325 DOI: 10.1016/J.Ccr.2008.10.001  0.414
2008 Sinha AU, Meller J. Sensitivity analysis for reversal distance and breakpoint reuse in genome rearrangements. Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing. 37-48. PMID 18229675  0.439
2007 Sinha AU, Meller J. Cinteny: flexible analysis and visualization of synteny and genome rearrangements in multiple organisms. Bmc Bioinformatics. 8: 82. PMID 17343765 DOI: 10.1186/1471-2105-8-82  0.492
2007 Sinha AU, Phatak M, Bhatnagar R, Jegga AG. Identifying functional binding motifs of tumor protein p53 using support vector machines Proceedings - 6th International Conference On Machine Learning and Applications, Icmla 2007. 506-511. DOI: 10.1109/ICMLA.2007.53  0.524
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