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Peter S. Kutchukian, Ph.D. - Publications

Affiliations: 
2010 Harvard University, Cambridge, MA, United States 
Area:
Protein Folding and Design, Molecular Evolution, Drug Discovery
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20 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Lam PY, Kutchukian P, Anand R, Imbriglio J, Andrews C, Padilla H, Vohra A, Lane S, Parker DL, Taracido IC, Johns DG, Beerens M, MacRae CA, Caldwell J, Sorota S, et al. Cyp1 inhibition prevents doxorubicin-induced cardiomyopathy in a zebrafish heart failure model. Chembiochem : a European Journal of Chemical Biology. PMID 32003101 DOI: 10.1002/Cbic.201900741  0.35
2017 Kutchukian PS, Chang C, Fox SJ, Cook E, Barnard R, Tellers D, Wang H, Pertusi D, Glick M, Sheridan RP, Wallace I, Wassermann AM. CHEMGENIE: integration of chemogenomics data for applications in chemical biology. Drug Discovery Today. PMID 28917822 DOI: 10.1016/J.Drudis.2017.09.004  0.355
2017 Santa Maria JP, Park Y, Yang L, Murgolo N, Altman MD, Zuck P, Adam G, Chamberlin C, Saradjian P, Dandliker P, Boshoff HIM, Barry CE, Garlisi C, Olsen DB, Young K, ... ... Kutchukian PS, et al. Linking High-Throughput Screens to Identify MoAs and Novel Inhibitors of Mycobacterium tuberculosis Dihydrofolate Reductase. Acs Chemical Biology. PMID 28806050 DOI: 10.1021/Acschembio.7B00468  0.41
2017 Pertusi DA, O'Donnell G, Homsher MF, Solly K, Patel A, Stahler SL, Riley D, Finley MF, Finger EN, Adam GC, Meng J, Bell DJ, Zuck PD, Hudak EM, Weber MJ, ... ... Kutchukian PS, et al. Prospective Assessment of Virtual Screening Heuristics Derived Using a Novel Fusion Score. Slas Discovery. 2472555217706058. PMID 28426940 DOI: 10.1177/2472555217706058  0.306
2017 Filzen TM, Kutchukian PS, Hermes JD, Li J, Tudor M. Representing high throughput expression profiles via perturbation barcodes reveals compound targets. Plos Computational Biology. 13: e1005335. PMID 28182661 DOI: 10.1371/Journal.Pcbi.1005335  0.382
2016 Kutchukian PS, Dropinski JF, Dykstra KD, Li B, DiRocco DA, Streckfuss EC, Campeau LC, Cernak T, Vachal P, Davies IW, Krska SW, Dreher SD. Chemistry informer libraries: a chemoinformatics enabled approach to evaluate and advance synthetic methods. Chemical Science. 7: 2604-2613. PMID 28660032 DOI: 10.1039/C5Sc04751J  0.352
2016 Kutchukian PS, Warren L, Magliaro BC, Amoss A, Cassaday JA, O'Donnell G, Squadroni B, Zuck P, Pascarella D, Culberson JC, Cooke AJ, Hurzy D, Schlegel KS, Thomson F, Johnson EN, et al. Iterative Focused Screening with Biological Fingerprints Identifies Selective Asc-1 Inhibitors Distinct from Traditional High Throughput Screening. Acs Chemical Biology. PMID 28032990 DOI: 10.1021/Acschembio.6B00913  0.351
2016 Greshock TJ, Moore KP, McClain RT, Bellomo A, Chung CK, Dreher SD, Kutchukian PS, Peng Z, Davies IW, Vachal P, Ellwart M, Manolikakes SM, Knochel P, Nantermet PG. Synthesis of Complex Druglike Molecules by the Use of Highly Functionalized Bench-Stable Organozinc Reagents. Angewandte Chemie (International Ed. in English). PMID 27690172 DOI: 10.1002/Anie.201604652  0.34
2015 Kutchukian PS, So SS, Fischer C, Waller CL. Fragment library design: using cheminformatics and expert chemists to fill gaps in existing fragment libraries. Methods in Molecular Biology (Clifton, N.J.). 1289: 43-53. PMID 25709032 DOI: 10.1007/978-1-4939-2486-8_5  0.424
2015 Kutchukian PS, Wassermann AM, Lindvall MK, Wright SK, Ottl J, Jacob J, Scheufler C, Marzinzik A, Brooijmans N, Glick M. Large scale meta-analysis of fragment-based screening campaigns: privileged fragments and complementary technologies. Journal of Biomolecular Screening. 20: 588-96. PMID 25550355 DOI: 10.1177/1087057114565080  0.372
2014 Hilinski GJ, Kim YW, Hong J, Kutchukian PS, Crenshaw CM, Berkovitch SS, Chang A, Ham S, Verdine GL. Stitched α-helical peptides via bis ring-closing metathesis. Journal of the American Chemical Society. 136: 12314-22. PMID 25105213 DOI: 10.1021/Ja505141J  0.334
2013 Wassermann AM, Kutchukian PS, Lounkine E, Luethi T, Hamon J, Bocker MT, Malik HA, Cowan-Jacob SW, Glick M. Efficient search of chemical space: navigating from fragments to structurally diverse chemotypes. Journal of Medicinal Chemistry. 56: 8879-91. PMID 24117015 DOI: 10.1021/Jm401309Q  0.44
2013 Petrone PM, Wassermann AM, Lounkine E, Kutchukian P, Simms B, Jenkins J, Selzer P, Glick M. Biodiversity of small molecules--a new perspective in screening set selection. Drug Discovery Today. 18: 674-80. PMID 23454345 DOI: 10.1016/J.Drudis.2013.02.005  0.433
2012 Kutchukian PS, Vasilyeva NY, Xu J, Lindvall MK, Dillon MP, Glick M, Coley JD, Brooijmans N. Inside the mind of a medicinal chemist: the role of human bias in compound prioritization during drug discovery. Plos One. 7: e48476. PMID 23185259 DOI: 10.1371/Journal.Pone.0048476  0.388
2012 Petrone PM, Simms B, Nigsch F, Lounkine E, Kutchukian P, Cornett A, Deng Z, Davies JW, Jenkins JL, Glick M. Rethinking molecular similarity: comparing compounds on the basis of biological activity. Acs Chemical Biology. 7: 1399-409. PMID 22594495 DOI: 10.1021/Cb3001028  0.355
2012 Lounkine E, Kutchukian P, Petrone P, Davies JW, Glick M. Chemotography for multi-target SAR analysis in the context of biological pathways. Bioorganic & Medicinal Chemistry. 20: 5416-27. PMID 22405595 DOI: 10.1016/J.Bmc.2012.02.034  0.405
2011 Kutchukian PS, Lou D, Shakhnovich EI. In silico fragment-based generation of drug-like compounds Acs Symposium Series. 1076: 151-177. DOI: 10.1021/bk-2011-1076.ch008  0.482
2010 Kutchukian PS, Shakhnovich EI. De novo design: balancing novelty and confined chemical space. Expert Opinion On Drug Discovery. 5: 789-812. PMID 22827800 DOI: 10.1517/17460441.2010.497534  0.5
2009 Kutchukian PS, Lou D, Shakhnovich EI. FOG: Fragment Optimized Growth algorithm for the de novo generation of molecules occupying druglike chemical space. Journal of Chemical Information and Modeling. 49: 1630-42. PMID 19527020 DOI: 10.1021/Ci9000458  0.488
2009 Kutchukian PS, Yang JS, Verdine GL, Shakhnovich EI. All-atom model for stabilization of alpha-helical structure in peptides by hydrocarbon staples. Journal of the American Chemical Society. 131: 4622-7. PMID 19334772 DOI: 10.1021/Ja805037P  0.471
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